Abstract Number: 3105 • 2016 ACR/ARHP Annual Meeting
Relationships Between a Serum Biomarker of B Cell Differentiation and B Cell Activating Factor Suggest Possible Distinct Pathways of Response to Rituximab in Patients with Systemic Lupus Erythematosus
Background/Purpose: Rituximab (RTX) has been used off-label in refractory SLE with variable clinical outcomes in different cohorts, with no predictive response markers available. However, the…Abstract Number: 3106 • 2016 ACR/ARHP Annual Meeting
A Simple Test for Assessing and Monitoring SLE Disease Activity Status
Background/Purpose: SLE patients can experience chronically active disease, remissions and flares, or long periods of quiescence. Accurately assessing disease activity is crucial for prescribing appropriate…Abstract Number: 3107 • 2016 ACR/ARHP Annual Meeting
Switching from Anabolic to Catabolic Metabolism – a Novel Immunomodulatory Therapy in RA
Background/Purpose: Inflammatory activity in RA relies on numerous anabolic processes; including cellular proliferation, cell trafficking, secretion of proinflammatory cytokines and release of antibodies. Lasting reversal…Abstract Number: 3108 • 2016 ACR/ARHP Annual Meeting
Citrullinated Aggrecan Peptides Are Targets of Auto-Reactive CD4+ T-Cells in Rheumatoid Arthritis
Background/Purpose: T-cell frequencies against citrullinated epitopes derived from major auto-antibody targets (vimentin, fibrinogen, α-enolase) are increased in rheumatoid arthritis (RA). Emerging serologic data suggests antibody reactivity…Abstract Number: 3109 • 2016 ACR/ARHP Annual Meeting
Regulatory T Cells Deficient in Protein Phosphatase 2A Lose Suppressive Function and Convert to an Effector Phenotype
Background/Purpose: Regulatory T cells (Tregs) represent the fundamental T-cell capable of promoting self-tolerance and balancing excessive inflammation. Quantitative and qualitative Treg deficiencies have been characterized…Abstract Number: 3110 • 2016 ACR/ARHP Annual Meeting
Rab4A Is Required for Development of Tregs, Restricts Antiphospholipid Antibody Production and Pro-Inflammatory Expansion of Macrophages and Neutrophils, and Blocks Pristane-Induced Intra-Alveolar Hemorrhage in a Mouse Model of SLE
Background/Purpose: Polymorphic haplotypes of the HRES-1 endogenous retrovirus at the 1q42 chromosomal locus have been associated with lupus susceptibility, in particular, with predisposition to antiphospholipid…Abstract Number: 3111 • 2016 ACR/ARHP Annual Meeting
Pathogenic T Cell Responses in Systemic Sclerosis Is Shaped By Novel Cytokine Axis in the Microenvironment: A Multidimensional, High Throughput Analysis
Background/Purpose: Pathogenic immune responses can be profoundly shaped by the interplay between the periphery and the microenvironment. In this work we aimed at defining the…Abstract Number: 3112 • 2016 ACR/ARHP Annual Meeting
DOCK8 Associates with STAT5 and Promotes Regulatory T Cell Function
Background/Purpose: DOCK8 deficiency leads to autosomal recessive Hyper-IgE syndrome (AR-HIES). DOCK8 deficient patients develop recurrent sinopulmonary infections, chronic mucocutaneous viral infections, hyper-IgE, eosinophilia, food allergies,…Abstract Number: 3113 • 2016 ACR/ARHP Annual Meeting
Evaluation of a Clinical Transition Pathway for Adolescents with Autoimmune Diseases
Background/Purpose: It is clear that young people (YP) with an autoimmune disease need a transitional process before they are transferred to the adult clinic. Therefore,…Abstract Number: 3114 • 2016 ACR/ARHP Annual Meeting
Cardiorespiratory Fitness in Children with Juvenile Idiopathic Arthritis Treated in the Biological Era Is Comparable with Controls- a Cross-Sectional Study
Cardiorespiratory Fitness in Children with Juvenile Idiopathic Arthritis Treated in the Biological Era is Comparable with Controls- a Cross-Sectional Study Background/Purpose: Reduced cardiorespiratory fitness (CRF)…Abstract Number: 3115 • 2016 ACR/ARHP Annual Meeting
Reconsidering the Juvenile Idiopathic Arthritis Core Set: How Patients and Caregivers Define Disease Activity
Background/Purpose: The current JIA Core Set (ACR Pediatric 30) contains items that should be assessed in clinical trials for children with JIA. It was developed…Abstract Number: 3116 • 2016 ACR/ARHP Annual Meeting
Risk of Infections in Juvenile Idiopathic Arthritis Patients Treated with Biologic Agentsand/or Methotrexate: Results from Pharmachild Registry
Background/Purpose: Pharmachild is an international registry involving over 100 the Paediatric Rheumatology INternational Trials Organisation (PRINTO)/ the Paediatric Rheumatology European Society (PRES) centres in 38 countries. The registry was set up to evaluate long term safety and efficacy…Abstract Number: 3117 • 2016 ACR/ARHP Annual Meeting
Development of Autoimmune Diseases and Genetic Predisposition in Children with Neonatal Lupus and Their Unaffected Siblings
Background/Purpose: Neonatal Lupus (NL) is a model of passively acquired autoimmunity conferred by exposure to maternal anti-Ro antibodies. This study was initiated to address the…Abstract Number: 3118 • 2016 ACR/ARHP Annual Meeting
Differences in Disease Phenotype, Management and Outcomes of Children with Juvenile Idiopathic Arthritis throughout the World – Analysis of 8,325 Patients Enrolled in the Epoca Study
Background/Purpose: Several epidemiologic surveys have documented a remarkable, yet unexplained, disparity in the prevalence of juvenile idiopathic arthritis (JIA) subtypes among different geographic areas or…Abstract Number: 3119 • 2016 ACR/ARHP Annual Meeting
Complete Whole Genome Transcriptome, DNA Methylation, and Histone Mark Analysis of Rheumatoid Arthritis (RA) Fibroblast-like Synoviocytes (FLS) Reveals a Distinctive Epigenetic Landscape and Critical Pathogenic Pathways
Background/Purpose: RA FLS display a unique aggressive phenotype with a distinctive DNA methylation profile that marks genes involved with cytokine signaling, cell recruitment, and matrix…
ACR Meeting Abstracts