Abstract Number: 2985 • 2016 ACR/ARHP Annual Meeting
Practice-Level Variation in Quality of Care in the Acr’s Rheumatology Informatics System for Effectiveness (RISE) Registry
Background/Purpose: The Medicare Access and CHIP Reauthorization Act (MACRA) of 2015 has put into place an aggressive timeline for a Merit-Based Incentive Payment System (MIPS)…Abstract Number: 2986 • 2016 ACR/ARHP Annual Meeting
Trends and Determinants of Osteoporosis Prevention and Management in Patients with Rheumatoid Arthritis Compared to Osteoarthritis
Background/Purpose: Despite more aggressive treatment strategies and new biologic DMARDs, the prevalence of osteoporosis (OP) leading to fracture in RA remains high. It is unknown…Abstract Number: 2987 • 2016 ACR/ARHP Annual Meeting
Comparison of Certolizumab Pegol Versus Adalimumab: 2 Year Efficacy and Safety Results from a Superiority, Investigator-Blind, Head-to-Head Study
Background/Purpose: Head-to-head comparisons of biological (b)DMARDs in the treatment of RA should provide rigorous evidence on the comparative efficacy of different treatments. Although there are…Abstract Number: 2988 • 2016 ACR/ARHP Annual Meeting
Cigarette Smoking Increases the Risk of Anti-Double-Stranded DNA Positive SLE Among Women in the Nurses’ Health Studies
Background/Purpose: SLE is heterogeneous with subtypes characterized by different systemic manifestations and autoantibodies. Past studies suggest that smoking may be a risk factor for SLE,…Abstract Number: 2989 • 2016 ACR/ARHP Annual Meeting
Risk of Cardiovascular Disease Events Among Patients with Systemic Lupus Erythematosus Compared to Those with Diabetes Mellitus in a Nationwide Medicaid Cohort
Background/Purpose: Cardiovascular disease (CVD) risk is elevated in SLE patients compared to non-SLE patients. However, how CVD rates differ in SLE patients compared with other…Abstract Number: 2990 • 2016 ACR/ARHP Annual Meeting
Cancer in Systemic Lupus Erythematosus: Results from the Systemic Lupus International Collaborating Clinics Inception Cohort
Background/Purpose: Published studies of cancer risk in SLE to date have never focussed solely on clinically confirmed, incident patients. Prior studies thus may not reflect the cancer…Abstract Number: 2991 • 2016 ACR/ARHP Annual Meeting
A Molecular Signature Based on IFN Gene Signature and Serology Defines Two Populations of Patients with Different Baseline Disease Activity in a Large Multinational Phase 3 SLE Trial Population
Background/Purpose: Registration trials for SLE therapeutics require large numbers of patients with active disease, which in turn necessitates the trials be multinational with many participating…Abstract Number: 2992 • 2016 ACR/ARHP Annual Meeting
In Systemic Lupus Erythematosus with Antiphospholipid Antibodies, Hypocomplementemia Associates with Thrombosis
Background/Purpose: Hypocomplementemia is a common phenomenon in systemic lupus erythematosus (SLE) and antiphospholipid antibody syndrome (APS). Robust mechanistic data implicate complement activation in antiphospholipid antibody…Abstract Number: 2993 • 2016 ACR/ARHP Annual Meeting
Membrane-Type 1 Matrix Metalloproteinase Controls Osteo- and Chondrogenesis By a Proteolysis-Independent Mechanism Mediated By Its Cytoplasmic Tail
Background/Purpose: We aimed to understand the mechanism by which membrane-type 1 matrix metalloproteinase (MT1-MMP, MMP-14) controls bone and cartilage homeostasis. MT1-MMP, a cell-membrane-bound proteinase with…Abstract Number: 2994 • 2016 ACR/ARHP Annual Meeting
Binding of Periostin to Discoidin Domain Receptor-1 (DDR1) Promotes Cartilage Degeneration By Inducing MMP-13 Expression
Background/Purpose: We and others have previously shown that periostin (Postn) expression is dramatically elevated in cartilage and sub-chondral bone in OA patients and surgical models…Abstract Number: 2995 • 2016 ACR/ARHP Annual Meeting
WISP1/CCN4 Aggravates Experimental Osteoarthritis and Is Associated with Disease Progression in Early Osteoarthritis Patients
Background/Purpose: Many osteoarthritis (OA) patients show synovial activation, which is thought to be involved in joint destruction. Previously, we described strongly increased expression of Wnt2b…Abstract Number: 2996 • 2016 ACR/ARHP Annual Meeting
High Fat Diet-Induced Osteoarthritis Progression Is Dependent on Toll-like Receptor 4
Background/Purpose: Obesity is considered the primary preventable risk factor for OA, increasing the risk of developing OA in weight-bearing joints, especially the knee, as…Abstract Number: 2997 • 2016 ACR/ARHP Annual Meeting
Microrna-29a Curtails Synovitis in the Development of Knee Osteoarthritis By Disrupting VEGF
Background/Purpose: Intensive synovitis is a prominent feature that progressively aggravated excessive fibrosis reactions relative to joint stiffness in the pathogenesis of osteoarthritis (OA). MicroRNA-29a (miR-29a)…Abstract Number: 2998 • 2016 ACR/ARHP Annual Meeting
Gut Microbiota Induce IGF-1 and Promote Bone Formation and Growth
Background/Purpose: Appreciation of the role of the gut microbiome in regulating vertebrate metabolism has exploded recently. However, the effects of gut microbiota on skeletal growth…Abstract Number: 2999 • 2016 ACR/ARHP Annual Meeting
Autologous Osteoblastic Cells Versus Concentrated Bone Marrow Implantation in Osteonecrosis of the Femoral Head: A Randomized Controlled Single Blind Study
Background/Purpose: Non traumatic osteonecrosis (ON) of the femoral head is characterized by epiphyseal necrosis leading to femoral head collapse and eventually hip replacement. The physiopathology…
ACR Meeting Abstracts