Abstracts Archive - Page 1613 of 2607 - ACR Meeting Abstracts

Abstract Number: 200 • 2016 ACR/ARHP Annual Meeting
The Safety and Efficacy of Benzbromarone in Gout in Aotearoa New Zealand
Lisa K. Stamp¹, Janine Haslett¹, Christopher Frampton¹, Doug White², David Gardner³, Simon Stebbings⁴, Guy Taylor⁵, Rebecca Grainger⁶, Rajesh Kumar⁷, Sunil Kumar⁸, Tracey Kain⁹, David Porter¹⁰, Michael Corkill¹¹, Angela Cathro¹², Scott Metcalfe¹², John Wyeth¹² and Nicola Dalbeth¹³, ¹University of Otago, Christchurch, New Zealand, ²Waikato Hospital, Hamilton, New Zealand, ³Hawkes Bay DHB, Napier, New Zealand, ⁴Department of Medicine, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand, ⁵Whanganui Hospital, Whanganui, New Zealand, ⁶Wellington Regional Rheumatology Unit, Hutt Valley District Health Board, Lower Hutt, New Zealand, ⁷Taranaki Hospital, New Plymouth, New Zealand, ⁸Middlemore Hospital, Auckland, New Zealand, ⁹Tauranga Hospital, Tauranga Hospital, Tauranga, New Zealand, ¹⁰Porter Rheumatology Ltd, The Collingwood Centre, Nelson, New Zealand, ¹¹North Shore Hospital, Auckland, New Zealand, ¹²Pharmaceutical Management Agency, Wellington, New Zealand, ¹³Department of Medicine, University of Auckland, Auckland, New Zealand
Background/Purpose: Benzbromarone is a potent uricosuric, but is not widely available due to concerns about hepatotoxicity. In Aotearoa New Zealand benzbromarone has been available since…
Abstract Number: 201 • 2016 ACR/ARHP Annual Meeting
Allopurinol Reduces the Risk of Myocardial Infarction (MI) in the Elderly: A Study of Medicare Claims
Jasvinder A. Singh¹ and Shaohua Yu², ¹Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ²University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: To assess whether allopurinol use reduces the risk of myocardial infarction (MI) in the elderly. Methods: We used the 2006-2012 5% random sample of…
Abstract Number: 202 • 2016 ACR/ARHP Annual Meeting
Allopurinol Use and the Risk of Ventricular Tachycardia in the US Elderly: A Study of Medicare Claims Data
Jasvinder A. Singh¹ and John Cleveland², ¹Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ²Rheumatology, University of Alabama at Birmingham (UAB), Birmingham, AL
Background/Purpose: To assess whether allopurinol use reduces the risk of ventricular tachycardia in the elderly. Methods: We used the 2006-2012 5% random sample of Medicare…
Abstract Number: 203 • 2016 ACR/ARHP Annual Meeting
Allopurinol Dose Escalation and Mortality Among Patients with Gout: A National Propensity-Matched Cohort Study
Brian W Coburn^1,2, Kaleb Michaud³, Debra A Bergman² and Ted R Mikuls^4,5, ¹Research Service, Veterans Affairs Nebraska-Western Iowa Health Care System, Omaha, NE, ²Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, ³Internal Medicine, University of Nebraska Medical Center, Omaha, NE, ⁴Veteran Affairs Nebraska-Western Iowa Health Care System and University of Nebraska Medical Center, Omaha, NE, ⁵Internal Medicine, Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE

Allopurinol Dose Escalation and Mortality among Patients with Gout: A National Propensity-Matched Cohort Study Background/Purpose: Numerous epidemiologic studies show that hyperuricemia and gout are associated…
Abstract Number: 204 • 2016 ACR/ARHP Annual Meeting
The Safety and Efficacy of Allopurinol Dose Escalation in People with Gout, a Randomised Controlled Trial
Lisa K. Stamp¹, Peter T. Chapman², Murray Barclay³, Anne Horne⁴, Christopher Frampton¹, Paul Tan⁵, Jill Drake⁶ and Nicola Dalbeth⁵, ¹University of Otago, Christchurch, New Zealand, ²Christchurch Hospital, Christchurch, New Zealand, ³Medicine, University of Otago, Christchurch, New Zealand, ⁴Department of Medicine, University of Auckland, Auckland, New Zealand, ⁵University of Auckland, Auckland, New Zealand, ⁶Rheumatology, Immunology and Allergy, Christchurch Hospital, Christchurch, New Zealand
Background/Purpose: Allopurinol is the most widely used urate lowering therapy. Many patients on allopurinol fail to achieve target serum urate (SU), in part due to…
Abstract Number: 205 • 2016 ACR/ARHP Annual Meeting
Serum Uric Acid Lowering Treatment Appears Unnecessary during Hemodialysis
Raquel Soriano¹, Mariano Andrés¹, Eloy Oliveira², Celia Trigo², Eliseo Pascual³ and María Dolores Arenas⁴, ¹Departamento de Medicina Clínica, Universidad Miguel Hernández, Alicante, Spain, ²Servicio de Análisis Clínicos, Hospital General Universitario de Alicante, Alicante, Spain, ³Departamento de Medicina Clínica, Emeritus Professor, Universidad Miguel Hernández, Alicante, Spain, ⁴Unidad de Nefrología, Hospital Vithas Perpetuo Socorro, Alicante, Spain
Background/Purpose: Gout patients often suffer from renal disease, some ultimately developing end-stage renal disease (ESRD) and requiring hemodialysis (HD) replacement therapy. Though some reports suggested…
Abstract Number: 206 • 2016 ACR/ARHP Annual Meeting
Renal Safety of Lesinurad: A Pooled Analysis of Phase III and Extension Studies
Robert Terkeltaub¹, Raymond Malamet², Kathleen Bos², Jingyi Li², David Goldfarb³, Michael Pillinger⁴, Diana Jalal⁵, Jia Hu⁶ and Kenneth Saag⁷, ¹Rheumatology, VA Medical Center, San Diego, CA, ²AstraZeneca Pharmaceuticals, Wilmington, DE, ³New York University School of Medicine, New York, NY, USA, New York, NY, ⁴Medicine/Rheumatology, NYU School of Medicine/NYU Hospital for Joint Diseases, New York, NY, ⁵University of Colorado Anschutz Medical Center, Aurora, CO, USA, Aurora, CO, ⁶Ardea Biosciences, Inc., San Diego, CA, ⁷University of Alabama at Birmingham, Birmingham, AL, USA, Birmingham, AL
Background/Purpose: Lesinurad is a selective uric acid reabsorption inhibitor approved in the United States and European Union at 200 mg daily dose in combination with…
Abstract Number: 207 • 2016 ACR/ARHP Annual Meeting
Integrated Safety of Lesinurad, a Novel Uric Acid Reabsorption Inhibitor for the Treatment of Gout
Michael A. Becker¹, Robert T. Keenan², Puja Khanna³, Raymond Malamet⁴, Kathleen Bos⁴, Jingyi Li⁴, Jia Hu⁵ and William White⁶, ¹University of Chicago, Chicago, IL, ²Rheumatology, Duke University, Durham, NC, ³Rheumatology, University of Michigan, Ann Arbor, MI, ⁴AstraZeneca Pharmaceuticals, Wilmington, DE, ⁵Ardea Biosciences, Inc., San Diego, CA, ⁶University of Connecticut School of Medicine, Farmington, CT
Background/Purpose: Lesinurad is a selective uric acid reabsorption inhibitor recently approved at 200 mg daily in combination with a xanthine oxidase inhibitor (XOI) for treatment…
Abstract Number: 208 • 2016 ACR/ARHP Annual Meeting
Examination of Serum Uric Acid (sUA) Lowering and Safety with Extended Lesinurad + Allopurinol Treatment in Subjects with Gout
Kenneth Saag¹, Michael A. Becker², Chris Storgard³, Maple Fung³, Jia Hu³ and Thomas Bardin⁴, ¹University of Alabama at Birmingham, Birmingham, AL, ²University of Chicago, Chicago, IL, ³Ardea Biosciences, Inc., San Diego, CA, ⁴Hôpital Lariboisière, Paris, France
Background/Purpose: Two replicate, randomized, core Phase III trials (CLEAR 1 & 2) reported significantly more subjects treated with lesinurad 200 mg (LESU200) or 400 mg…
Abstract Number: 209 • 2016 ACR/ARHP Annual Meeting
Clinical Response of Tophus and Flares to Extended Use of Lesinurad in Combination with a Xanthine Oxidase Inhibitor in Patients with Gout
Thomas Bardin¹, Nicola Dalbeth², Robert Terkeltaub³, Chris Storgard⁴, Maple Fung⁴, Jia Hu⁴ and Fernando Perez-Ruiz⁵, ¹Hôpital Lariboisière, Paris, France, ²University of Auckland, Auckland, New Zealand, ³Medicine-Rheumatology, VA Medical Ctr/University of California San Diego, San Diego, CA, ⁴Ardea Biosciences, Inc., San Diego, CA, ⁵Hospital de Cruces and Biocruces Health Research Institute, Vizcaya, Spain
Background/Purpose: Three randomized, double-blind, Phase III trials reported that greater proportions of patients treated with lesinurad 200 mg (LESU200) or 400 mg (LESU400), combined with…
Abstract Number: 210 • 2016 ACR/ARHP Annual Meeting
Skin Events with Febuxostat in Gout Patients and Previous Skin Reactions to Allopurinol. a Retrospective Review
Neus Quilis¹, Mariano Andrés^1,2, Carlos Muñoz³, Paloma Vela^1,2 and Eliseo Pascual⁴, ¹Sección de Reumatología, Hospital General Universitario de Alicante, Alicante, Spain, ²Departamento de Medicina Clínica, Universidad Miguel Hernández, Alicante, Spain, ³Sección de Inmunología, Hospital General Universitario de Alicante, Alicante, Spain, ⁴Departamento de Medicina Clínica, Emeritus Professor, Universidad Miguel Hernández, Alicante, Spain
Background/Purpose: Allopurinol is the most used urate-lowering agent for patients with gout, but around 10% of patients show intolerance to this drug, often at skin,…
Abstract Number: 211 • 2016 ACR/ARHP Annual Meeting
Safety and Efficacy of Febuxostat in Advanced CKD Patients with Hyperuricemia
Yoon-Jeong Oh¹, Seung Min Jung¹, Sang-Won Lee², Yong-Beom Park² and Jason Jungsik Song², ¹Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea, The Republic of, ²Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea
Background/Purpose: Dosing adjustments and increased risk of serious side effects of uric acid lowering agents in patients with reduced renal function lead to undercorrection of…
Abstract Number: 212 • 2016 ACR/ARHP Annual Meeting
Pegloticase Provides Clinical Benefit in Patients with Chronic Refractory Gout Who Did Not Meet the Clinical Trial Biochemical Definition of Response
Brian F. Mandell¹, Michael Weisman², Anthony Yeo³ and Peter E. Lipsky⁴, ¹Rheumatology, Cleveland Clinic, Cleveland, OH, ²Rheumatology, Cedars-Sinai Medical Center, West Hollywood, CA, ³Horizon Pharma, Lake Forest, IL, ⁴AMPEL BioSolutions, Charlottesville, VA
Background/Purpose: Pegloticase is a recombinant uricase conjugated to polyethylene glycol approved for the treatment of chronic refractory gout refractory. The pivotal clinical trials for pegloticase…
Abstract Number: 213 • 2016 ACR/ARHP Annual Meeting
Prophylaxis for Infusion Reactions to Pegloticase: An Analyis of Two Different Corticosteroid Pre-Infusion Regimens in US Community Rheumatology Practices
Amar Majjhoo¹, Kome Okposo² and Michael Zdanis³, ¹Shores Rheumatology, St. Clair Shores, MI, ²Horizon Pharma, Lake Forest, IL, ³Cetus Group, LLC, Towson, MD
Background/Purpose: Corticosteroids are commonly utilized, along with other agents in clinical practice for pre-infusion prophylaxis prior to the administration of therapeutic biologic proteins. Two steroids,…
Abstract Number: 214 • 2016 ACR/ARHP Annual Meeting
Anakinra Compared to Prednisone on the Treatment of Acute CPPD Crystal Arthritis, a Randomized, Controlled, Double-Blind Study
Alexandre Dumusc¹, Borbala Pazar Maldonado¹, Charles Benaim², Isabelle Fabreguet¹, Pascal Zufferey¹, Bérengère Aubry-Rozier¹ and Alexander So¹, ¹Rheumatology Department, Lausanne University Hospital, Switzerland, Lausanne, Switzerland, ²Physical Medicine and Rehabilitation Department, Lausanne University Hospital, Switzerland, Lausanne, Switzerland
Background/Purpose: Calcium pyrophosphate crystal-induced arthritis (CPPD) is an acute crystal arthritis, frequently involving the wrist or the knee. Monosodium urate in gout or CPPD…

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