ACR Meeting Abstracts

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  • Abstract Number: 2940 • 2016 ACR/ARHP Annual Meeting

    Bechet’s Disease and Sleep Quality in Korean Patients

    Chang-Nam Son1, Ji Min Lee1, Hye-Jin Jeong2, Ji-Min Kim1, Sang-Hyon Kim1, Sung Soo Kim3 and Seung-Hyeon Bae4, 1Division of Rheumatology, Department of Internal Medicine, Dongsan Medical Center, Keimyung University School of Medicine, Daegu, Korea, The Republic of, 2Division of Rheumatology, Department of Internal Medicine, Dongsan Medical Center, Keimyung University School of Medicine, Daegu, South Korea, 3Division of Rheumatology, Department of Internal Medicine, Ulsan University School of Medicine, GangNeung Asan Hospital, Gangneung, South Korea, 4Division of Rheumatology, Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea

    Background/Purpose:  The purpose of this study was to find out the effects of sleep quality on Behcet’s disease in Korean population. We also investigated the…
  • Abstract Number: 2941 • 2016 ACR/ARHP Annual Meeting

    Optimization of Adalimumab on Refractory Uveitis of Behcet’s Syndrome. Multicenter Study of 23 Patients

    Carlos Fernández-Díaz1, Ricardo Blanco1, Vanesa Calvo-Río1, Javier Loricera1, J. Sanchez-bursón2, Norberto Ortego Centeno3, Jose L. García Serrano4, Miguel Cordero5, J. Vazquez6, Emma Beltran7, Elia Valls8, O. Maiz Alonso9, Ana Blanco10, Ignacio Torre11, Angel García-Aparicio12, F.j Toyos-saénz13, L. Martinez-Costa14, Lucia C. Domínguez-Casas1, Natalia Palmou1 and Miguel Angel Gonzalez-Gay1, 1Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL, Santander, Spain, 2Rheumatology, Hospital Valme, Hospital Valme, Sevilla, Spain, 3Medicine Department, Hospital Universitario San Cecilio, Granada, Spain, 4Ophthalmology, Hospital Universitario San Cecilio, Granada, Spain, 5Ophthalmology, Hospital de León, León, Spain, 6Rheumatology, Hospital de Ferrol, Ferrol, Spain, 7Rheumatology, Hospital General Universitario de Valencia, Valencia, Spain, 8Rheumatology, Hospital Dr. Peset., Valencia, Spain, 9Rheumatology, Hospital Donostia, San Sebastian, Spain, 10Ophthalmology Department. Donostia University Hospital, Donostia, Spain, 11Rheumatology, Hospital de Basurto, Bilbao, Spain, 12Rheumatology, Ophthalmology and rheumatology, Hospital de Ferrol, Ferrol, Ferrol, Spain, 13Rheumatology,, Hospital Virgen de la Macarena, Sevilla, Spain, 14Hospital Dr. Peset., Valencia, Spain

    Background/Purpose:   In non-infectious no anterior uveitis, adalimumab (ADA) is the only biologic drug that has shown efficacy in phase III randomized, double blind studies,…
  • Abstract Number: 2942 • 2016 ACR/ARHP Annual Meeting

    Sequencing of 16S rRNA Reveals a Distinct Salivary Microbiome Signature in Behcet’s Disease

    Patrick Coit1, Gonca Mumcu2, Filiz Ture Ozdemir3, Ali Ugur Unal4, Ugur Alpar5, Nagihan Bostanci6, Tulin Ergun7, Haner Direskeneli4 and Amr Sawalha1, 1Division of Rheumatology, University of Michigan, Ann Arbor, MI, 2Department of Health Management, Marmara University, Faculty of Health Sciences, Istanbul, Turkey, 3Marmara University, School of Medicine, Department of Immunology, Istanbul, Turkey, 4Department of Rheumatology, Marmara University Faculty of Medicine, Istanbul, Turkey, 5Faculty of Dentistry, Marmara University, Istanbul, Turkey, 6Division of Periodontology, Department of Dental Medicine, Karolinska Institute, Stockholm, Sweden, 7Department of Dermatology, Faculty of Medicine, Marmara University, Istanbul, Turkey

    Background/Purpose:   Results:  This is the first high-throughput sequencing-based evaluation of the salivary microbiome in BD. Salivary microbiome of BD patients has a specific signature…
  • Abstract Number: 2943 • 2016 ACR/ARHP Annual Meeting

    Relationship Between  Menstruation and Symptoms of Behcet’s Syndrome

    Gul Guzelant1, Yesim Ozguler2, Sinem Nihal Esatoglu3, Guzin Karatemiz2, Huri Ozdogan2, Sebahattin Yurdakul1, Hasan Yazici1 and Emire Seyahi1, 1Istanbul University, Cerrahpasa Medical Faculty, Department of Internal Medicine, Division of Rheumatology, Istanbul, Turkey, 2Rheumatology, Istanbul University, Cerrahpasa Medical Faculty, Division of Rheumatology, Istanbul, Turkey, 3Rheumatology, Istanbul University, Cerrahpasa Medical Faculty, Department of Internal Medicine, Division of Rheumatology, Istanbul, Turkey

    Background/Purpose: It is well known that menstruation triggers several conditions such as migraine, recurrent aphtous stomatitis and acne vulgaris in otherwise healthy individuals (1). It…
  • Abstract Number: 2944 • 2016 ACR/ARHP Annual Meeting

    Use of Muscle Biopsies for the Diagnosis of Systemic Vasculitis in a Rheumatology Service

    Samantha Rodriguez-Muguruza1,2, Juana Sanint3, Xavier Saenz-Sarda4, Agueda Prior2, Yaiza Garcia5, Maria Lourdes Mateo6, Susana Holgado6, Jeronima Cañellas2, Melania Martínez-Morillo7, Xavier Tena6 and Alejandro Olivé1, 1Rheumatology, Hospital Universitario Germans Trias i Pujol, Barcelona, Spain, 2Rheumatology, Hospital Universitari Germans Trias i Pujol, Barcelona, Spain, 3Rheumatology, Hospital Universitario Germans Trias i Pujol, Badalona, Spain, 4Anathomy Pathology, Germans Trias i Pujol Hospital, Barcelona, Spain, 5Rheumatology, Germans Trias i Pujol Hospital, Barcelona, Spain, 6Rheumatology, Hospital Germans Trias i Pujol, Badalona, Spain, 7Rheumatology, Germans Trias i Pujol University Hospital, Barcelona, Spain

    Background/Purpose: Systemic vasculitis comprises a group of diseases characterized by non-infectious inflammation of vessels in various organs. Histopathological confirmation of systemic vasculitis is required for…
  • Abstract Number: 2945 • 2016 ACR/ARHP Annual Meeting

    Systematic Review: “Efficacy and Safety of Biological Versus Immunosuppressive Therapy Compared to Placebo in the Treatment of Uveitis Associated with BehçEt’s Disease.”

    Ana Urruticoechea-Arana1, Tatiana Cobo-Ibáñez2, Virginia Villaverde García3, Montserrat Santos-Gómez4, Kelly Vargas Osorio5, Federico Díaz-González6, Leslie Fariñas Padrón5, Vanesa Calvo-Río7 and Ricardo Blanco Alonso7, 1Hospital Can Misses, Ibiza, Spain, 2Hospital Universitario Reina Sofía, Universidad Europea de Madrid, Madrid, Spain, 3Rheumatology, Hospital Universitario de Móstoles, Móstoles, Spain, 4Rheumatology, Hospital Can Misses, Ibiza, Spain, 5Family and Community Medicine, Hospital Can Misses, Ibiza, Spain, 6Rheumatology, Hospital Universitario de Canarias, S/C Tenerife, Spain, 7Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL, Santander, Spain

    Background/Purpose:
  • Abstract Number: 2946 • 2016 ACR/ARHP Annual Meeting

    Large Scale Genetic Analysis in BehçEt Disease. Identification of Residues Associated in the HLA Class I Region and New Susceptibility Loci

    Lourdes Ortiz Fernández1, Francisco David Carmona2, Marco Antonio Montes Cano3, José Raúl García Lozano3, Marta Conde Jaldón4, Norberto Ortego Centeno5, María Jesús Castillo Palma6, Gerard Espinosa7, Genaro Graña Gil8, Juan Sánchez Bursón Sr.9, María Rosa Juliá10, Roser Solans11, Ricardo Blanco Alonso12, Ana Celia Barnosi Marín13, Ricardo Gómez de la Torre14, Patricia Fanlo Mateo15, Mónica Rodriguez Carballeira16, Luis Rodriguez-Rodriguez17, Teresa Camps18, Santos Castañeda19, Juanjo J Alegre Sancho20, Javier Martín2 and María Francisca Gonzalez Escribano21, 1Instituto de Parasitología y Biomedicina "López-Neyra", CSIC, Granada, Spain, 2Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, PTS-Granada, Granada, Spain, 3Departament of Immunology, Hospital Universitario Virgen del Rocío (IBiS,CSIC,US), Sevilla, Spain, 4Immunology, Hospital Universitario Virgen del Rocío, Sevilla, Spain, 5Systemic Autoimmune Diseases Unit, Hospital Universitario San Cecilio, Granada, Spain, 6Department of Internal Medicine, Hospital Universitario Virgen del Rocío, Sevilla, Spain, 7Department of Autoimmune Diseases, Hospital Clinic, Barcelona, Spain, 8Rheumatology Division, INIBIC-Complejo Hospitalario Universitario A Coruña (CHUAC), A Coruna, Spain, 9Rheumatology, Hospital de Valme., Sevilla, Spain, 108Department of Immunology, Hospital Universitari Son Espases, Palma de Mallorca, Spain, 11Autoimmune Systemic Diseases Unit, Department of Internal Medicine, Hospital Vall d'Hebron, Autonomous University of Barcelona, Spain, Barcelona, Spain, 12Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL, Santander, Spain, 13Department of Internal Medicine, Complejo Hospitalario Torrecárdenas, Almeria, Spain, 14Departament of Internal Medicine, Hospital Universitario Central de Asturias, Asturias, Spain, 15Department of Internal Medicine, Hospital Virgen del Camino, Pamplona, Spain, 16Departament of Internal Medicine, Hospital Universitari Mútua Terrassa, Terrasa, Spain, 17Rheumatology Service, Hospital Clínico San Carlos, Madrid, Spain, 18Departament of Internal Medicine, Hospital Regional Universitario de Málaga, Málaga, Spain, 19Rheumatology, Hospital de la Princesa, IIS-IP, Madrid, Spain, 20Department of Rheumatology, Hospital Universitario Doctor Peset, Valencia, Spain, 21Hospital Universitario Virgen del Rocío (IBiS,CSIC,US), Sevilla, Spain

    Background/Purpose: Behçet’s disease (BD) is a complex immune-mediated vasculitis which aetiology remains unknown although some evidences suggest that certain infectious agents and environmental factors may…
  • Abstract Number: 2947 • 2016 ACR/ARHP Annual Meeting

    Adalimumab Versus Infliximab in Cystoid Macular Edema of Uveitis Associated to BehçEt Disease. Multicenter Study of 34 Patients

    Lucia Cristina Domínguez-Casas1, Vanesa Calvo-Río1, Ricardo Blanco2, Carlos Fernández-Díaz1, Paz Rodríguez-Cundín3, Emma Beltran4, Marisa Hernández-Garfella5, Jose M Herreras6, Miguel Cordero-Coma7, Marina Mesquida8, Alfredo Adan9, M. Victoria Hernández10, David Diaz-Valle11, Ignacio Torre-Salaberri12, Manuel Díaz-Llopis13, Roberto Gallego14, Olga Maiz-Alonso15, Santos Insua16, Félix Francisco17, Raquel Almodóvar González18, Oscar Ruiz Moreno19, Fernando Jiménez-Zorzo20, Javier Manero21, Myriam Gandía22, Joan Miquel Nolla23, Nuria Vegas-Revenga24, Natalia Palmou-Fontana1 and Miguel Angel Gonzalez-Gay1, 1Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL, Santander, Spain, 2Rheumatology Department. Hospital Universitario Marqués de Valdecilla, Santander, Spain, 3Preventive Medicine, Hospital Universitario Marqués de Valdecilla. IDIVAL, Santander, Spain, 4Rheumatology, Hospital General Universitario de Valencia, Valencia, Spain, 5Ophtamology, Hospital General Universitario de Valencia, Valencia, Spain, 6Ophthalmology, Hospital Universitario, IOBA, Valladolid, Spain, 7Ophthalmology, Hospital de León, León, Spain, 8Ophthalmology, Hospital Clinic. Barcelona. Spain, Barcelona, Spain, 9Ophthalmology, Hospital Clinic de Barcelona,, Barcelona, Spain, 10Rheumatology, Hospital Clinic. Barcelona. Spain, Barcelona, Spain, 11Ophthalmology Department, Hospital Clínico San Carlos, Madrid, Spain, 12Rheumatology, Hospital de Basurto, Bilbao, Spain, 13Hospital Universitario La Fe, Valencia, Spain, 14Ophtalmology, Hospital Universitario La Fe, Valencia, Spain, 15Hospital Universitario Donostia, Donostia, Spain, 16Rheumatology, Hospital Universitario Santiago de Compostela, La Coruña, Spain, 17Rheumatology, Hospital Doctor Negrín, Las Palmas de Gran Canaria, Spain, 18Rheumatology Unit, Hospital Universitario Fundación Alcorcón, Madrid, Spain, 19Ophthalmology and Rheumatology., Hospital Miguel Servet, Zaragoza, Spain, 20Hospital Miguel Servet, Zaragoza, Spain, 21Rheumatology, Hospital Miguel Servet, Zaragoza, Spain, 22Rheumatology, Hospital Puerta del Mar, Cadiz, Spain, 23Rheumatology, Department of Rheumatology, Hospital Universitario de Bellvitge, Barcelona, Spain, 24Hospital Universitario Marqués de Valdecilla. IDIVAL, Santander, Spain

    Background/Purpose:   Cystoid macular edema (CME) is the most serious complication of uveitis and the most common cause of blindness in uveitis. Our aim was…
  • Abstract Number: 2948 • 2016 ACR/ARHP Annual Meeting

    Fecal Calprotectin Level Is Useful in Identifying Active Disease in Behçet’s Syndrome Patients with Gastrointestinal Involvement: A Controlled Study

    Sinem Nihal Esatoglu1, Ibrahim Hatemi2, Yesim Ozguler3, Gulen Hatemi3, Hafize Uzun4, Aykut Ferhat Celik5 and Hasan Yazici3, 1Rheumatology, Istanbul University, Cerrahpasa Medical Faculty, Department of Internal Medicine, Division of Rheumatology, Istanbul, Turkey, 2Istanbul University, Cerrahpasa Medical School, Istanbul University, Cerrahpasa Medical Faculty, Department of Internal Medicine, Division of Gastroenterology, Istanbul, Turkey, 3Istanbul University, Cerrahpasa Medical Faculty, Department of Internal Medicine, Division of Rheumatology, Istanbul, Turkey, 4Biochemistry, Istanbul University, Cerrahpasa Medical School, Department of Biochemistry, Istanbul, Turkey, 5Istanbul University, Cerrahpasa Medical Faculty, Department of Internal Medicine, Division of Gastroenterology, Istanbul, Turkey

    Background/Purpose: The fecal calprotectin (FC) is widely used as a non-invasive method for identifying patients with active Crohn’s disease (CD) and ulcerative colitis. Gastrointestinal involvement…
  • Abstract Number: 2949 • 2016 ACR/ARHP Annual Meeting

    Surgical Method for Aortic Root Involvement of Behcet Disease

    Byeongzu Ghang1, Suk Jung Choo2, Oh Chan Kwon3, Seokchan Hong4, Yong-Gil Kim5, Chang-Keun Lee5 and Bin Yoo5, 1Division of Rheumatology, Department of Internal Medicine, Univerisy of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea, 2Division of Thoracic and Cardiovascular Surgery, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea, The Republic of, 3Division of Rheumatology, Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea, The Republic of, 4Division of Rheumatology, Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea, 5Division of Rheumatology, Department of Internal Medicine, Department of Rheumatology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea

    Background/Purpose:  Aortic regurgitation (AR) in Behcet disease is a rare but very fatal condition. Many patients require a second or third operation after simple aortic…
  • Abstract Number: 2950 • 2016 ACR/ARHP Annual Meeting

    Cogan Syndrome: Treatment and Outcome from French Nationwide Retrospective Study and Literature Review of 62 Patients

    CHARLOTTE DURTETTE1, Mathieu Resche Regon2, eric hachulla3, anne Graslands4, Thomas Papo5,6, Jacques Pouchot7, jean Emmanuel kahn8, Thierry Zenone9, cedric landron10, benoit de Wazieres11, Robin Dhote12, Christophe Deligny13, Guillaume Gondran14, Edouard Pertuiset15, thomas quemeneur16, Bertrand Lioger17, Pascal Sève18, Christian Lavigne19, thomas le Galllou20, Mohamed Hamidou21, claire delaunay22, Olivier Fain23 and Arsene Mekinian24, 1SAINT ANTOINE HOSPITAL, PARIS, France, 2biostatistics Saint Louis Hospital, paris, France, 3chru lille hospital, lille, France, 4Service de Médecine interne, Hôpital Louis-Mourier, colombes, France, 5Department of Internal Medicine, AP-HP Bichat Hospital, Paris, France, 6Internal Medicine, Hôpital Bichat, Université Paris-Diderot, Paris, France, 7Paris University, Internal medicine, Paris, France, 8foch hospital, foch, France, 9Internal Medicine, Valence Hospital, Valence, France, 10service de médecine interne, CH Poitiers, CHU Poitiers, poitiers, France, 11CHU de Nîmes, nimes, France, 12Internal Medicine, Hospital Avicenne, Bobigny, France, 13Zobda Quitman Hospital, Rheumatology and Internal Medicine, Fort de France, Martinique, 14Internal Medicine Department, Limoges, France, 15CH René Dubos, Pontoise, France, 16valenciennes hospital, valenciennes, France, 17INTERNAL MEDICINE, tours, France, 18Internal medicine, Internal medicine department, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Lyon, France, 19CHU Angers, department of Internal Medicine, Angers, France, 20rennes CHU hospital, rennes, France, 21Internal Medicine Department, Internal Medicine Department, Nantes University Hospital, Nantes, France, 22Centre hospitalier niort, niort, France, 23Service de médecine interne. Hôpital Saint-Antoine., Paris, France, 24DHU2iB, Internal Medicine Saint Antoine Hospital, PARIS, France

    Background/Purpose: Methods:   Sixty two patients were included with median age 37 [2-76] and 31/62 (50%) women. At the diagnosis, 61 (98%) had audiovestibular involvement,…
  • Abstract Number: 2951 • 2016 ACR/ARHP Annual Meeting

    Patient Outcomes in Primary Angiitis of the Central Nervous System

    Elisabeth Ray1, Didem Saygin2, Anabelle Morales-Mena3, William Messner4, Leonard H. Calabrese5 and Rula A Hajj-Ali6, 1Rheumatology, Cleveland Clinic, Cleveland, OH, 2Cleveland Clinic, Cleveland, OH, 3Rheumatology, Hillcrest Hospital, Mayfield Heights, OH, 4Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH, 5Rheumatic & Immunologic Disease, Cleveland Clinic, Cleveland, OH, 6Rheumatic and Immunologic Dis, Cleveland Clinic, Cleveland, OH

    Results: 1855 patient records were identified using the ICD-9 code for cerebral angiitis. 78 patients met inclusion criteria, of which 27 responded to the questionnaires…
  • Abstract Number: 2952 • 2016 ACR/ARHP Annual Meeting

    Differentiation Between Neurosarcoidosis and Primary CNS Vasculitis Based on Clinical and Cerebrospinal Fluid Parameters

    Didem Saygin1, Leonard H. Calabrese2, Elisabeth Ray1, William Messner3, Jinny Tavee4 and Rula A Hajj-Ali5, 1Rheumatology, Cleveland Clinic, Cleveland, OH, 2Rheumatic & Immunologic Disease, Cleveland Clinic, Cleveland, OH, 3Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH, 4Neuromuscular diseases, Cleveland Clinic, Cleveland, OH, 5Rheumatic and Immunologic Dis, Cleveland Clinic, Cleveland, OH

    Background/Purpose: Neurosarcoidosis is one of the great mimickers of primary angiitis of central nervous system (PACNS) in terms of disease presentation, imaging and pathologic findings.…
  • Abstract Number: 2953 • 2016 ACR/ARHP Annual Meeting

    Comparison of Patient Outcomes in Primary Angiitis of the Central Nervous System and Reversible Cerebral Vasoconstriction Syndrome

    Elisabeth Ray1, Didem Saygin1, Seby John2, William Messner3, Ken Uchino4, Leonard H. Calabrese5 and Rula A Hajj-Ali6, 1Rheumatology, Cleveland Clinic, Cleveland, OH, 2Cleveland Clinic, Cleveland, OH, 3Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH, 4Cerebrovascular Center, Cleveland Clinic Foundation, Cleveland, OH, 5Rheumatic & Immunologic Disease, Cleveland Clinic, Cleveland, OH, 6Rheumatic and Immunologic Dis, Cleveland Clinic, Cleveland, OH

    Background/Purpose: Reversible Cerebral Vasoconstriction Syndrome (RCVS) is an important mimic of Primary Angiitis of the Central Nervous System (PACNS). Distinct clinical and diagnostic features differentiate…
  • Abstract Number: 2954 • 2016 ACR/ARHP Annual Meeting

    Anti-IL6-R Tocilizumab in Refractory Uveitis Associated with BehçEt’s Disease. Multicenter Study of 11 Patients

    Lucia C. Domínguez-Casas1, Vanesa Calvo-Río1, Ricardo Blanco1, Emma Beltran2, L. Martinez-Costa3, Elia Valls-Pascual4, Marisa Hernández-Garfella5, Antonio Atanes6, Miguel Cordero-Coma7, Joan Miquel Nolla8, Carmen Carrasco-Cubero9, Javier Loricera1, MC Gonzalez-Vela10, Nuria Vegas-Revenga11, Carlos Fernández-Díaz1, Natalia Palmou-Fontana1 and Miguel Angel Gonzalez-Gay1, 1Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL, Santander, Spain, 2Rheumatology, Hospital General Universitario de Valencia, Valencia, Spain, 3Hospital Dr. Peset., Valencia, Spain, 4Rheumatology, Hospital Dr. Peset., Valencia, Spain, 5Ophtamology, Hospital General Universitario de Valencia, Valencia, Spain, 6Rheumatology Division, INIBIC-Complejo Hospitalario Universitario A Coruña (CHUAC), A Coruna, Spain, 7Ophthalmology, Hospital de León, León, Spain, 8Rheumatology, Department of Rheumatology, Hospital Universitario de Bellvitge, Barcelona, Spain, 9Rheumatology, Complejo Universitario de Badajoz, Badajoz, Spain, 10Pathology, Hospital Universitario Marqués de Valdecilla. IDIVAL, Santander, Spain, 11Hospital Universitario Marqués de Valdecilla. IDIVAL, Santander, Spain

    Background/Purpose:   Treatment recommended in severe and/or refractory uveitis of Behçet disease is anti-TNFα therapy, usually infliximab (IFX) or adalimumab (ADA) (Levy-Clarke et al Ophthalmology…
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