Abstract Number: 2564 • 2016 ACR/ARHP Annual Meeting
Autophagy Alteration Affects Migration and Proliferation of Rheumatoid Arthritis Fibroblast-like Synoviocytes Stimulated By IL-17A
Background/Purpose: Autophagy is required to ensure cellular homeostasis. Perturbations in autophagy have been reported to be involved in the pathogenesis of several diseases such as…Abstract Number: 2565 • 2016 ACR/ARHP Annual Meeting
Common Biomarker Elevations in Idiopathic Pulmonary Fibrosis and Rheumatoid Arthritis-Associated Interstitial Lung Disease
Background/Purpose: Interstitial lung disease (ILD) is an extra-articular manifestation of rheumatoid arthritis (RA) which contributes to increased morbidity and mortality. Clinico-epidemiological data indicate some overlap…Abstract Number: 2566 • 2016 ACR/ARHP Annual Meeting
Hexokinase 2 As a Novel Metabolic Target for Rheumatoid Arthritis
Background/Purpose: Hexokinases (HKs) catalyze the first step in glucose metabolism. HK2 constitutes the principal inducible isoform with a restricted distribution in normal adult tissues. Up-regulated…Abstract Number: 2567 • 2016 ACR/ARHP Annual Meeting
The Effect of Fibroblast Growth Factor 4 on the Proliferation of Fibroblast-like Synoviocytes in Rheumatoid Arthritis
Background/Purpose: Fibroblast-like synoviocytes (FLSs) contribute to synovial hyperplasia in rheumatoid arthritis (RA). Fibroblast growth factor 4 (FGF4) is a potent mitogen for tumor cells. The…Abstract Number: 2568 • 2016 ACR/ARHP Annual Meeting
ARL15 expressed By Rheumatoid Arthritis Synovial Fibroblasts Regulates IL6 and Plays a Role in Apoptosis and Hypoxia
Background/Purpose: Rheumatoid Arthritis (RA) is a chronic, inflammatory condition that affects more than 1% population globally. Several studies suggest RA to be controlled by a…Abstract Number: 2569 • 2016 ACR/ARHP Annual Meeting
Restoration of Decreased Lymphocyte Counts and the Shift to Th1 and Effector Memory CD8+T Cell Subsets Associate with Spontaneous Regression of Lympho-Proliferative Disorders Developed in RA Patients Treated with Methotrexate
Background/Purpose: Methods: Forty-three RA patients complicated with LPD were identified and 76 control patients were selected. Among the 43 LPD patients, 28 were regressive and…Abstract Number: 2570 • 2016 ACR/ARHP Annual Meeting
Pyruvate Regulates Reactive Oxygen Species (ROS) Production, Dysfunction and Aberrant Metabolism of Mitochondria in Fibroblast-like Synoviocytes of Rheumatoid Arthritis
Background/Purpose: In rheumatoid arthritis (RA), fibroblast-like synoviocyte (FLS) is a key component of invasive synovium and mediates inflammation and destruction of joint. Recently, change of…Abstract Number: 2571 • 2016 ACR/ARHP Annual Meeting
Distinct Oral and Fecal Community Profiles Enriched in Opportunistic Pathogens in RA Patients and First Degree Relatives Are Influenced By Environmental Risk Factors, Including Smoking, Dental History and Lung Infection
Background/Purpose: In the Rheumatoid Arthritis (RA) prodrome, genetic predisposition intersects with environmental risk factors, such as smoking, periodontal disease and respiratory infection, however no studies…Abstract Number: 2572 • 2016 ACR/ARHP Annual Meeting
Study of Two Biomarkers of Biological Age in the Blood of Patients with Rheumatoid Arthritis
Background/Purpose: Accelerated biological aging of blood cells could contribute to the pathogenesis of RA. However, biological age has multiple facets, some as epigenetic aging not…Abstract Number: 2573 • 2016 ACR/ARHP Annual Meeting
Galectin 1 As Potential Prognostic Biomarker in Rheumatoid Arthritis
Background/Purpose: Galectin 1 (Gal1) is a type of lectin expressed in a wide variety of tissues and organs. In the immune context, is broadly described…Abstract Number: 2574 • 2016 ACR/ARHP Annual Meeting
IL-22 As a Biomarker for Erosive Disease in Rheumatoid Arthritis
Background/Purpose: Consistent with models of experimental arthritis implicating IL-22 – in the development of joint destruction could previously demonstrate that elevated IL-22 serum levels were…Abstract Number: 2575 • 2016 ACR/ARHP Annual Meeting
The Presence of Staphylococcal Toxins in the Urine of Patients with Rheumatoid Arthritis
Background/Purpose: Rheumatoid arthritis (RA) is a disease of unknown etiology;with a pathogenesis that is due to a mixture of genetic, immunological and environmental factors. A…Abstract Number: 2576 • 2016 ACR/ARHP Annual Meeting
uPAR Promotes Tumor-like Biologic Role of Fibroblast-like Synoviocytes through PI3K/Akt Signaling Pathway in Patients with Rheumatoid Arthritis
Background/Purpose: Urokinase-type plasminogen activator receptor (uPAR), is a multi-functional receptor on cell surface, widely present in endothelial cells, fibroblasts, and a variety of malignant cells.…Abstract Number: 2577 • 2016 ACR/ARHP Annual Meeting
Elevated Matrix Metalloproteinases Levels in Oral Fluids of Most Rheumatoid Arthritis Patients, Even without Frank Periodontitis
Background/Purpose: Periodontitis shares pathogenic mechanisms with rheumatoid arthritis (RA) and may trigger its onset. However, little information is available about inflammatory responses in oral fluids…Abstract Number: 2578 • 2016 ACR/ARHP Annual Meeting
Plasma Levels of Bone Morphogenetic Protein (BMP) Subgroups and Their Inhibitors (noggin, sclerostin) in Rheumatoid Arthritis Patients and Correlation with Disease Activity, Clinical and Radiographic Progression
Background/Purpose: Progressive bone destruction occurs in rheumatoid arthritis (RA) due to imbalance of osteoblast/osteoclast activity. Bone morphogenetic proteins (BMPs) regenerate bone damage by stimulating the…
ACR Meeting Abstracts