Abstracts Archive - Page 1580 of 2607 - ACR Meeting Abstracts

Abstract Number: 2891 • 2017 ACR/ARHP Annual Meeting
Do Certain Dmards Increase Risk of New-Onset Type 2 Diabetes in RA Patients? a Disease Risk Score Analysis Using Administrative Databases
E Alemao, Z Guo and L Burns, Bristol-Myers Squibb, Princeton, NJ
Background/Purpose: Data on the association between RA and type 2 diabetes mellitus (T2DM) are inconsistent, suggesting RA treatments such as glucocorticoids (GCs) and hydroxychloroquine could…
Abstract Number: 2892 • 2017 ACR/ARHP Annual Meeting
Persistently Frequent Emergency Department (ED) Utilization Among Systemic Lupus Erythematosus (SLE) Patients
Jiha Lee¹, Lisa Gale Suter^1,2 and Liana Fraenkel^1,3, ¹Rheumatology, Rheumatology, Yale University School of Medicine, New Haven, CT, New Haven, CT, ²Medicine, Rheumatol., TAC S541, Rheumatology, VA Connecticut Healthcare System, West Haven, CT, New Haven, CT, ³Medicine, Section of Rheumatology, Rheumatology, VA Connecticut Healthcare System, West Haven, CT, New Haven, CT
Background/Purpose: SLE patients frequently utilize the ED irrespective of their access to care, which raises concern for inadequate quality of care in the outpatient setting.…
Abstract Number: 2893 • 2017 ACR/ARHP Annual Meeting
The Use of Natural Language Processing to Identify, Retrieve, Report, and Correct Observational Data on US Veterans Enrolled in the Veterans Affairs Rheumatoid Arthritis Registry
Grant Cannon¹, Jorge Rojas¹, Neill Bell², Andreas Reimold³, Ted R. Mikuls⁴, Namrata Singh⁵, Gail S. Kerr⁶, Pascale Schwab⁷, Jennifer Barton⁷, Liron Caplan⁸, Joshua Baker⁹, Angelo L. Gaffo¹⁰, J. Steuart Richards¹¹, Deana Lazaro¹², Vikas Majithia¹³ and Brian Sauer¹, ¹Salt Lake City VA Medical Center and University of Utah, Salt Lake City, UT, ²Salt Lake City VA Medical Center and University of Utah, Dallas VA Medical Center, Dallas, TX, ³Dallas VA Medical Center and University of Texas Southwestern, Dallas, TX, ⁴VA Nebraska-Western Iowa Health Care System and University of Nebraska Medical Center, Omaha, NE, ⁵VA Nebraska-Western Iowa Health Care System and University of Iowa, Omaha, IA, ⁶Washington DC VA Medical Center, Georgetown and Howard University Hospitals, Washington, DC, ⁷Portland VA Medical Center and University of Oregon, Portland, OR, ⁸Denver VA Medical Center and Univerity of Colorado, Denver, CO, ⁹Philadelphia VA Medical Center and University of Pennsylvania, Philadelphia, PR, ¹⁰Birmingham VA Medical Center and University of Alabama at Birmingham, Birmingham, AL, ¹¹Pittsburgh VA Medical Center and University Of Pittsburgh, Pittsburgh, PA, ¹²Brooklyn VA Medical Center and SUNY Downstate, Brooklyn, NY, ¹³Jackson VA Medical Center and University of Mississippi, Jackson, MS
Background/Purpose: The Veterans Affairs (VA) Rheumatoid Arthritis (RA) (VARA) registry is an observational cohort study at 12 VA medical centers that prospectively collects clinical…
Abstract Number: 2894 • 2017 ACR/ARHP Annual Meeting
Synchronous Telemedicine Care in Rheumatology for a Dispersed Veterans Affairs Health System
Patrick R. Wood¹ and Liron Caplan², ¹Rheumatology, University of Colorado School of Medicine, Aurora, CO, ²Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO
Background/Purpose: Rural Veterans with inflammatory arthritis (IA) lack access because of geographic and other barriers. A national shortage of rheumatologists exists, particularly in rural settings,…
Abstract Number: 2895 • 2017 ACR/ARHP Annual Meeting
Predictors of Hospitalization, Length of Stay and Costs of Care Among Children with Juvenile Dermatomyositis in the United States
Michael C. Kwa¹, Jonathan I. Silverberg² and Kaveh Ardalan^3,4, ¹Dermatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ²Dermatology, Preventive Medicine and Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, ³Departments of Pediatrics and Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁴Division of Rheumatology, Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL
Background/Purpose: Juvenile dermatomyositis (JDM) is a rare autoimmune disease that causes significant morbidity and quality of life impairment. Little is known about JDM inpatient burden…
Abstract Number: 2896 • 2017 ACR/ARHP Annual Meeting
Human Cartilage Influences the Crystallization of Monosodium Urate; Understanding the Link between Gout and Osteoarthritis
Ashika Chhana¹, Bregina Pool², Ally Choi¹, Ryan Gao¹, Mark Zhu¹, Jillian Cornish², Jacob Munro³ and Nicola Dalbeth⁴, ¹Medicine, University of Auckland, Auckland, New Zealand, ²Department of Medicine, University of Auckland, Auckland, New Zealand, ³Orthopaedics, Auckland City Hospital, Auckland, New Zealand, ⁴University of Auckland, Auckland, New Zealand
Background/Purpose: Monosodium urate (MSU) crystal deposition and gout flares frequently affect joints that have been damaged or are affected by osteoarthritis. The aim of…
Abstract Number: 2897 • 2017 ACR/ARHP Annual Meeting
A Non-Coding Genetic Variant Maximally Associated with Serum Urate Levels Is Functionally Linked to HNF4A-Dependent PDZK1 Expression
Tony R. Merriman¹, Sarada Ketharnathan², James Boocock³, Amanda Phipps-Green², Jisha Antony², Megan Leaask², Justin O'Sullivan⁴ and Julia Horsfield², ¹Biochemistry Dept, PO Box 56, University of Otago, Dunedin, New Zealand, ²University of Otago, Dunedin, New Zealand, ³University of California Los Angeles, Los Angeles, CA, ⁴University of Auckland, Auckland, New Zealand
A non-coding genetic variant maximally associated with serum urate levels is functionally linked to HNF4A-dependent PDZK1 expressionBackground/Purpose: Genome-wide association studies have revealed several dozen genetic…
Abstract Number: 2898 • 2017 ACR/ARHP Annual Meeting
New Mouse Model of Gout Risk Variant, ABCG2 Q141K, Reveals Unexpectedly Severe Molecular and Functional Defect in ABCG2 Mediated Intestinal Uric Acid Secretion
Kazi M. Hoque and Owen M. Woodward, Physiology, University of Maryland School of Medicine, Baltimore, MD
Background/Purpose: Gout is a common arthritic disease resulting from deposition of monosodium urate crystals in joints and is a consequence of having elevated circulating uric…
Abstract Number: 2899 • 2017 ACR/ARHP Annual Meeting
Trapped Crystals in Synovial Fluid: Neutrophil Extracellular Traps (NETs) from Bench to Bed-Side
Estrella Garcia Gonzalez, Orso Maria Luccherini, Alessandra Gamberucci, Alessandra Ali, Antonella Simpatico, Sauro Lorenzini, Marco Bardelli, Mauro Galeazzi and Enrico Selvi, Rheumatology Unit - Policlinico le Scotte, Siena, Italy
Background/Purpose: Recent data show that neutrophils are able to release chromatin and granular enzymes in web-like structures called neutrophil extracellular traps (NETs). The release of NETs has a physiological…
Abstract Number: 2900 • 2017 ACR/ARHP Annual Meeting
Osteoarthritis-Associated Calcium-Containing Crystals and Biomaterial Microparticles Both Drive M1 Macrophage Polarization in a Syk and MAP Kinase-Dependent Manner
Geraldine M. McCarthy¹, Olwyn Mahon², Sarah O'Hanlon³, Daniel Kelly⁴ and Aisling Dunne⁵, ¹Div of Rheumatology, Mater Misericordiae University Hospital, Dublin, Ireland, ²School of Biochemistry and Immunology,, ,Trinity College Dublin, Dublin, Ireland, ³School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland, ⁴Trinity Center for Bioengineering, ,Trinity College Dublin, Dublin, Ireland, ⁵School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland
Background/Purpose: Intra-articular basic calcium phosphate (BCP) crystals are associated with advanced osteoarthritis (OA) andsynovitis. OA-associated synovium exhibits increased numbers of macrophages compared with non-OA joints.…
Abstract Number: 2901 • 2017 ACR/ARHP Annual Meeting
Anti-Inflammatory Mechanism of Lubricin/Proteoglycan 4 (PRG4) in Monosodium Urate (MSU)-Crystal Induced Arthritis in THP-1 Macrophages Is Mediated By NALP3 Inflammasome.
Anthony M. Reginato¹, Changqi Sun², Tannin Schmidt³, Elsaid Khalid⁴ and Gregory Jay⁵, ¹Division of Rheumatology, The Warren Alpert School Of Medicine of Brown University, Providence, RI, ²Division of Rheumatology, Rhode Island Hosital/The Warren Alpert School of Medicine of Brown University, Providence, RI, ³Kinesiology and Schulich School of Engineering, University of Calgary, Calgary, AB, Canada, ⁴Department of Biomedical and Phramaceutical Science, Chapman University School of Pharmacy, Irvine, CA, ⁵Emergency Medicine and Engineering, The Warren Alpert Medical School Brown University, Providence, RI
Background/Purpose: Lubricin/proteoglycan-4 (PRG4) is a mucinous glycoprotein secreted by synovial fibroblast and superficial zone chondrocytes. PRG4 has a multifaceted homeostatic role in the joint including…
Abstract Number: 2902 • 2017 ACR/ARHP Annual Meeting
Inflammatory Arthritis Due to Immune Checkpoint Inhibitors: A Persistent Problem Requiring Immunosuppression
Laura Cappelli¹, Clifton O. Bingham III² and Ami A. Shah³, ¹Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ²Rheumatology, Johns Hopkins University, Baltimore, MD, ³Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD
Background/Purpose: Immune checkpoint inhibitors (ICIs) have emerged as an important treatment for advanced malignancies. ICIs are a form of immunotherapy which block negative co-stimulation of…
Abstract Number: 2903 • 2017 ACR/ARHP Annual Meeting
Serum CC-Chemokine Ligand 18 Level Is a Potential Biomarker of Disease Activity in IgG4-Related Disease
Mitsuhiro Akiyama¹, Hidekata Yasuoka², Keiko Yoshimoto² and Tsutomu Takeuchi², ¹Division of Rheumatology, Department of Internal Medicine,, Keio University School of Medicine, Tokyo, Japan, ²Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
Background/Purpose: IgG4-related disease (IgG4-RD) is a systemic disorder characterized by severe fibrosis in lesions. In previous reports, CC-chemokine ligand 18 (CCL18) level is a substantial…
Abstract Number: 2904 • 2017 ACR/ARHP Annual Meeting
Efficacy and Tolerance of TNF Alpha Inhibitor (TNFI) Treatment in Cardiac Sarcoidosis (CS)
Deborah Puyraimond-Zemmour¹, Catherine Chapelon-Abric², David Saadoun³, Diane Bouvry⁴, Marc Ruivard⁵, Marc Andre⁶, Laurent Perard⁷, Pascal Sève⁸ and Patrice Cacoub⁹, ¹Sorbonne Universités, UPMC Univ Paris 06, UMR 7211, and Inflammation-Immunopathology-Biotherapy Department (DHU i2B), F-75005, Paris, France, Paris, France, ²AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Internal Medicine and Clinical Immunology, F-75013, Paris, France, Paris, France, ³Department of Internal Medicine and clinical Immunology. French National Reference Center for Autoimmune Diseases. DHU I2B (Inflammation, Immunotherapy and Biotherapy), UPMC, Paris VI, Hôpital Pitié Salpétrière, AP-HP, UPMC, Univ Paris 06, Paris, France, ⁴Hopital Avicenne, Department of Pneumology, Bobigny, France, Bobigny, France, ⁵CHU Estaing, Department of Internal Medicine, Clermont-Ferrand, France, Clermont Ferrand, France, ⁶CHU Montpied, Department of Internal Medicine, Clermont-Ferrand, France, Clermont Ferrand, France, ⁷Department of Internal Medicine, Centre Hospitalier Saint Joseph-Saint Luc, Lyon, France, ⁸Internal medicine, Internal medicine department, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Lyon, France, ⁹Department of Internal Medicine and Clinical Immunology, Groupe Hospitalier Pitié-Salpêtrière, Paris, France
Background/Purpose: CS is a life-threatening condition that accounts for 85% of sarcoidosis-related deaths in Japan and 13-25% in America. The objective is to evaluate the…
Abstract Number: 2905 • 2017 ACR/ARHP Annual Meeting
TET2 Mutation Is Significantly Associated with the Development of Autoimmune Disorder in Patients with Myelodysplastic Syndrome
Yoon-Jeong Oh¹, Dong-Yeop Shin², Sang Mee Hwang³, Eun Young Lee⁴, Yeong Wook Song⁵, Dong-Soon Lee³ and Jin Kyun Park⁶, ¹Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea, Republic of (South), ²Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea, Republic of (South), ³Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea, Republic of (South), ⁴Seoul National University College of Medicine, Seoul, Korea, Republic of (South), ⁵Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Koer, Seoul, Korea, Republic of (South), ⁶Division of Rheumatology, Seoul National University Hospital, Seoul, Korea, Republic of (South)
Background/Purpose: Myelodysplastic syndrome (MDS) is characterized by ineffective hematopoiesis in bone marrow and peripheral cytopenia. Various genetic mutations contribute to MDS. Common mutations affect genes…

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