Abstracts Archive - Page 1579 of 2425 - ACR Meeting Abstracts

Abstract Number: 2428 • 2016 ACR/ARHP Annual Meeting
Autoantibody Diversity in Pediatric Patients Undergoing Evaluation for Autoimmune Encephalitis: A Retrospective Investigation
Anne E Tebo¹, Thomas Haven², Aimee O. Hersh³ and Eyal Muscal⁴, ¹Pathology, University of Utah School of Medicine and ARUP Laboratories, Salt Lake City, UT, ²Department of Pathology, University of Utah, ARUP Institute of Clinical and Experimental Pathology, Salt Lake City, UT, ³Pediatrics/Rheumatology, University of Utah, Salt Lake City, UT, ⁴Immunology, allergy and Rheumatology, Baylor College of Medicine, Texas Children's Hospital, Houston, TX
Background/Purpose: Antibodies directed against N-methyl-D-aspartate type glutamate receptor (NMDAR), voltage-gated potassium channel (VGKC) or glutamic acid decarboxylase (GAD65) are frequently associated with autoimmune encephalitis (AE)…
Abstract Number: 2429 • 2016 ACR/ARHP Annual Meeting
Mechanisms for the Development of Lung Fibrosis in Sting-Associated Vasculopathy with Onset in Infancy (SAVI)
Adriana Almeida de Jesus¹, Louise Malle¹, Dan Yang², Bernadette Marrero¹, Yin Liu³, Gina A. Montealegre Sanchez¹, Dawn C. Chapelle⁴, Hanna Kim⁴, Michelle O'Brien⁴, Gregor Dueckers⁵, Suzanne Ramsey⁶, Joseph R. Fontana⁷, Steven M. Holland⁸, Yan Huang¹, Suvimol Hill⁹, Laisa Santiago¹⁰, Benito Gonzalez¹¹, Paul Brogan¹², Juergen Brunner¹³, Ebun Omoyinmi¹⁴, Athimalaipet V Ramanan¹⁵, Amy Paller¹⁶, Olcay Y. Jones¹⁷, Seza Ozen¹⁸, Stephen Brooks⁴, Zuoming Deng⁴, Manfred Boehm¹⁹, Raphaela Goldbach-Mansky²⁰ and Helmut Wittkowski²¹, ¹National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, MD, ²National Heart, Lung, and Blood Institute (NHLBI), NIH, Bethesda, MD, ³Scientific Review Branch, NIAMS, NIH, Bethesda, MD, ⁴NIAMS/NIH, Bethesda, MD, ⁵Helios Kliniken - Kinderklinik, HELIOS Klinikum Krefeld, Krefeld, Germany, ⁶Pediatric Rheumatology, IWK Health Centre, Halifax, NS, Canada, ⁷Cardiovascular and Pulmonary Branch, NHLBI, NIH, Bethesda, MD, ⁸Laboratory of Clinical Infectious Disease, NIAID, NIH, Bethesda, MD, ⁹Radiology Department, Clinical Center, NIH, Bethesda, MD, ¹⁰Johns Hopkins All Children's Hospital Rheumatology, Saint Petersburg, FL, ¹¹Luis Calvo Mackenna Hospital, Santiago, Chile, ¹²UCL Institute of Child Health and Great Ormond Street Hospital NHS Foundation Trust, London, United Kingdom, ¹³Department of Pediatrics, Medical University Innsbruck, Innsbruck, Austria, ¹⁴University College London Institute of Child Health, London, United Kingdom, ¹⁵University Hospitals Bristol NHS Foundation Trust, Bristol, United Kingdom, ¹⁶Departments of Dermatology and Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA;, Chicago, IL, ¹⁷Pediatrics, Walter Reed National Military Medical Center, Bethesda, MD, ¹⁸Department of Pediatrics, Division of Rheumatology, Hacettepe University Faculty of Medicine, ANKARA, Turkey, ¹⁹Laboratory of Cardiovascular Regenerative Medicine, National Heart, Lung, and Blood Institute (NHLBI), NIH, Bethesda, MD, ²⁰Translational Autoinflammatory Disease Studies, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, MD, ²¹Department of Pediatric Rheumatology and Immunology, University Hospital of Muenster, Münster, Germany
Background/Purpose: STING-Associated Vasculopathy with Onset in Infancy (SAVI) is a monogenic autoinflammatory interferonopathy caused by gain-of-function mutations in TMEM173/STING, a nucleic acid sensor adaptor linked…
Abstract Number: 2430 • 2016 ACR/ARHP Annual Meeting
Mutations in the Tyrosine-Protein Kinase Lyn Cause an Early-Onset Neutrophilic Vasculitis Syndrome
Adriana Almeida de Jesus¹, Gina A. Montealegre¹, Helen Freeman², Neil Martin³, Ebun Omoyinmi⁴, Bernadette Marrero¹, Katherine R. Calvo⁵, Chyi-Chia Richard Lee⁶, April D. Brundidge⁷, David Kleiner⁸, Stephen Hewitt⁸, Dawn C. Chapelle⁷, Yan Huang¹, Nirali Shah⁸, Stephen Brooks⁷, Eric Meffre⁹, Paul Brogan¹⁰, Hyesun Kuehn¹¹, Sergio Rosenzweig¹², Melinda Merchant⁸, Zuoming Deng⁷, Susan Moir¹³ and Raphaela Goldbach-Mansky¹⁴, ¹National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, MD, ²Raigmore Hospital, Inverness, United Kingdom, ³Royal Hospital for Children, Glasgow, United Kingdom, ⁴University College London Institute of Child Health, London, United Kingdom, ⁵Department of Laboratory Medicine, Hematology Section, National Institutes of Health Clinical Center, Bethesda, MD, ⁶Dermatopathology Section, Laboratory of Pathology, National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD, ⁷NIAMS/NIH, Bethesda, MD, ⁸National Cancer Institute, NIH, Bethesda, MD, ⁹Department of Immunobiology, Yale University School of Medicine, New Haven, CT, ¹⁰UCL Institute of Child Health and Great Ormond Street Hospital NHS Foundation Trust, London, United Kingdom, ¹¹Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, MD, ¹²Department of Laboratory Medicine/NIH, Bethesda, MD, ¹³National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, ¹⁴Translational Autoinflammatory Disease Studies, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, MD
Background/Purpose: Tyrosine-protein kinase Lyn is a Src-family tyrosine kinase expressed by hematopoietic and non-hematopoietic cell types. Phosphorylation of a tyrosine residue at position 508 renders…
Abstract Number: 2431 • 2016 ACR/ARHP Annual Meeting
Characterization of Innate Immune Cells in Patients with the Interferon-Mediated Autoinflammatory Diseases Sting Associated Vasculopathy with Onset in Infancy (SAVI) and Chronic Atypical Neutrophilic Dermatosis with Lipodystrophy and Elevated Temperature (CANDLE)
Bernadette Marrero¹, Yin Liu², Katherine R. Calvo³, Angelique Biancotto⁴, Yan Huang¹, Adriana Almeida de Jesus¹, Gina A. Montealegre Sanchez¹ and Raphaela Goldbach-Mansky⁵, ¹National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, MD, ²Scientific Review Branch, NIAMS, NIH, Bethesda, MD, ³Department of Laboratory Medicine, Hematology Section, National Institutes of Health Clinical Center, Bethesda, MD, ⁴Center for Human Immunology, Autoimmunity and Inflammation, NHLBI/NIH, Bethesda, MD, ⁵Translational Autoinflammatory Disease Studies, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, MD
Background/Purpose: We recently described two rare autoinflammatory interferonopathies, STING Associated Vasculopathy with Onset in Infancy (SAVI) and Chronic Atypical Neutrophilic Dermatosis with Lipodystrophy and…
Abstract Number: 2432 • 2016 ACR/ARHP Annual Meeting
Immune Abnormalities Leading to Exaggerated Production of IFN-Gamma (IFNγ) and the Therapeutic Response to an Anti-IFNγ Antibody in a Patient with NRLC4 Mediated Disease
Claudia Bracaglia¹, Giusi Prencipe², Manuela Pardeo¹, Geneviève Lapeyre³, Emiliano Marasco², Antonella Insalaco¹, Walter Ferlin³, Robert Nelson³, Cristina de Min³ and Fabrizio De Benedetti¹, ¹Division of Rheumatology, Ospedale Pediatrico Bambino Gesù IRCCS, Roma, Italy, Rome, Italy, ²Division of Rheumatology, Ospedale Pediatrico Bambino Gesù IRCCS, Rome, Italy, ³NovImmune S.A., Geneva, Switzerland
Background/Purpose: Animal and human data suggest that IFNγ plays a pathogenic role in HLH. A phase 2 trial with the anti-IFNγ monoclonal antibody NI-0501 in…
Abstract Number: 2433 • 2016 ACR/ARHP Annual Meeting
Trends in Use of Hydroxychloroquine during Pregnancy in SLE Patients from 2001 to 2012
Bonnie L. Bermas¹, Seoyoung Kim^2,3, Krista Huybrechts⁴, Sonia Hernandez-diaz⁵, Brian T. Bateman⁶ and Rishi J. Desai⁷, ¹Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ²Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, ³Division of Pharmacoepidemiology and Pharmocoeconomics, Brigham and Women's Hospital, Boston, MA, ⁴Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women’s Hospital, Boston, MA, ⁵Harvard School of Public Health, Boston, MA, ⁶Division of Pharmacoepidemiology and Pharocoeconomics, Brigham and Women's Hospital, Boston, MA, ⁷PharmacoEpidemiology & PharmacoEconomics, Brigham & Women's Hospital, Boston, MA
Background/Purpose : Data suggest that hydroxychloroquine (HCQ) use during systemic lupus erythematosus (SLE) pregnancies improves outcomes. In the past decade, single-center studies report that a…
Abstract Number: 2435 • 2016 ACR/ARHP Annual Meeting
Counseling on Family Planning and Contraception, and Pregnancy Outcome in Women with Rheumatic Diseases: Analysis of 398 Patient-Reported Questionnaires from a Multicenter Italian Study
Francesca Dall'Ara¹, Maria Grazia Lazzaroni¹, Laura Andreoli¹, Marilia Rodrigues², Carolina Benigno³, Elena Bartoloni-Bocci⁴, Corrado Capochiaro⁵, Cecilia B. Chighizola⁶, Paola Conigliaro⁷, ADA Corrado⁸, Salvatore D'Angelo⁹, maria favaro¹⁰, Elena Generali¹¹, Maria Gerosa¹², M larosa¹³, Marianna Meroni¹⁴, Melissa Padovan¹⁵, Giulia Pazzola¹⁶, Susanna Peccatori¹⁷, Imma Prevete¹⁸, Véronique Ramoni¹⁹, G Sebastiani²⁰, Chiara Tani²¹, Marica Trevisani²², M Vadacca²³, Ester Vivaldelli²⁴, E Visalli²⁵, L Zuliani²⁶, A Afeltra²³, Elena Baldissera²⁷, Antonio Brucato²⁸, Francesco Paolo Cantore²⁹, Roberto Caporali³⁰, Maurizio Cutolo³¹, Andrea Doria³², Rosario Foti³³, Armando Gabrielli³⁴, Roberto Gerli³⁵, Marcello Govoni³⁶, Armin Maier²⁴, Nazzarena Malavolta³⁷, Pier Luigi Meroni³⁸, Giovanni Minisola¹⁸, Carlo Maurizio Montecucco³⁹, Marta Mosca⁴⁰, Ignazio Olivieri⁴¹, Giuseppe Paolazzi⁴², Roberto Perricone⁴³, N Romeo⁴⁴, Amelia Ruffatti⁴⁵, Maria Grazia Sabbadini⁵, Carlo Salvarani⁴⁶, Carlo Selmi⁴⁷, Luigi Sinigaglia⁴⁸ and Angela Tincani¹, ¹Rheumatology and Clinical Immunology, Spedali Civili and University of Brescia, Brescia, Italy, ²Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal, Coimbra, Portugal, ³University Federico II, Napoli, Italy, Napoli, Jamaica, ⁴Department of Medicine, Rheumatology Unit, University of Perugia, Perugia, Italy, ⁵Ospedale San Raffaele, Milano, Italy, milano, Italy, ⁶Department of Clinical Sciences and Community Health, University of Milan, IRCCS Istituto Auxologico Italiano, Milano, Italy, ⁷Policlinico and University of Tor Vergata, Roma, Italy, roma, Italy, ⁸Ospedali Riuniti of Foggia, Foggia, Italy, foggia, Italy, ⁹Rheumatology Department of Lucania, San Carlo Hospital of Potenza and Madonna delle Grazie Hospital of Matera, matera, Italy, ¹⁰Rheumatology Unit, University and Azienda Ospedaliera of Padova, Padova, Italy, padova, Italy, ¹¹Rheumatology and Clinical Immunology, Humanitas Research Hospital, Rozzano (MI), Italy, ¹²University of Milan, Istituto Ortopedico Gaetano Pini, Milano, Italy, ¹³University and Azienda Ospedaliera of Padova, Padova, Italy, padova, Italy, ¹⁴University of Genova-IRCCS San Martino Genova, Genova, Italy and ASST Papa Giovanni XXIII, Bergamo, Italy, genova, Italy, ¹⁵Department if Clinical and Experimental Medicine, University of Ferrara, Section of Rheumatology, Ferrara, Italy, ¹⁶Rheumatology Unit, Internal Medicine Department, Arcispedale Santa Maria Nuova - IRCCS, Reggio Emilia, Italy, ¹⁷Azienda Provinciale Servizi Sanitari, Trento, Italy, trento, Italy, ¹⁸Azienda Ospedaliera San Camillo, Roma, Italy, Roma, Italy, ¹⁹Rheumatology, Policlinico San Matteo, Pavia, Italy, ²⁰15 Azienda Ospedaliera San Camillo, Roma, Italy, roma, Italy, ²¹Clinical and Experimental Medicine, University of Pisa, Rheumatology Unit, Pisa, Italy, ²²Rheumatology Unit, Internal Medicine, Policlinico S.Orsola-Malpighi, Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy, ²³University Campus Biomedico, Roma, Italy, roma, Italy, ²⁴Ospedale of Bolzano, Bolzano, Italy, bolzano, Italy, ²⁵A.O.U. Policlinico Vittorio Emanuele, Catania, Italy, catania, Italy, ²⁶Ospedali Riuniti and University of Ancona, Ancona, Italy, ancona, Italy, ²⁷Internal Medicine and Clinical Immunology, Vita-Salute San Raffaele University, Milan, Italy, ²⁸Internal Medicine, Hospital Papa Giovanni XXIII, Bergamo, Italy, ²⁹Ospedali Riuniti of Foggia, Foggia, Italy, Foggia, Italy, ³⁰Università di Pavia, Pavia, Italy, ³¹Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genoa, Italy, Genova, Italy, ³²Rheumatology Unit, Department of Medicine - DIMED, Department of Medicine-DIMED, University of Padova, Padova, Italy, ³³Rheumatology Unit, Vittorio-Emanuele University Hospital of Catania, Catania, Italy, ³⁴Medical Clinic Unit, Department of Internal Medicine, Ospedali Riuniti, Ancona, Italy, ³⁵Clinical and Experimental Medicine, Rheumatology Unit, University of Perugia, Italy, Perugia, Italy, ³⁶Department of Clinical and Experimental Medicine, Rheumatology Unit-Azienda Ospedaliera-Universitaria Sant'Anna, Ferrara, Italy, ³⁷Internal medicine Unit, Policlinico S. Orsola Malpighi, Bologna, Italy, ³⁸Rheumatology Department, University of Milan, Istituto Ortopedico Gaetano Pini, Milano, Italy, ³⁹Division of Rheumatology, University of Pavia School of Medicine, IRCCS Policlinico San Matteo Foundation, Pavia, Italy, ⁴⁰Rheumatology Unit, University of Pisa, Pisa, Italy, ⁴¹U.O. Reumatologia, A.O. Ospedale San Carlo, Potenza, Italy, ⁴²Rheumatology Unit, Santa Chiara Hospital, Trento, Italy, ⁴³Rheumatology, allergology and clinical immunology, University of Rome Tor Vergata, Rome, Italy, ⁴⁴Ospedale S.Croce e Carle, Cuneo, Italy, cuneo, Italy, ⁴⁵Azienda Ospedaliera of Padova, University of Padova, Padova, Italy, ⁴⁶Rheumatology Unit, Arcispedale S Maria Nuova, IRCCS, Reggio Emilia, Italy, ⁴⁷Internal Medicine- Unit of Rheumatology and Clinical Immunology, Humanitas Clinical and Research Center, Rozzano, Italy, ⁴⁸University of Milan, Milan, Italy, milano, Italy
COUNSELING ON FAMILY PLANNING AND CONTRACEPTION, AND PREGNANCY OUTCOME IN WOMEN WITH RHEUMATIC DISEASES: ANALYSIS OF 398 PATIENT-REPORTED QUESTIONNAIRES FROM A MULTICENTER ITALIAN STUDYBackground/Purpose: Rheumatic…
Abstract Number: 2436 • 2016 ACR/ARHP Annual Meeting
Birth Outcomes Significantly Worsen after the Development of Systemic Lupus Erythematosus in a Population-Based Registry
Mary Abraham¹, Lexi Rene¹, Cristina Drenkard² and S. Sam Lim³, ¹Department of Medicine, Emory University, Atlanta, GA, ²Emory University School of Medicine, Atlanta, GA, ³Medicine, Emory University School of Medicine, Atlanta, GA
Background/Purpose: SLE mothers are known to have higher rates of pre-term birth and low birth weight compared to women in the general population. We evaluated…
Abstract Number: 2437 • 2016 ACR/ARHP Annual Meeting
Causes of Cesarean Section and Labor Induction in Systemic Lupus Erythematosus and Rheumatoid Arthritis Pregnancies
Amanda M. Eudy, Laura Neil and Megan E. B. Clowse, Rheumatology, Duke University Medical Center, Durham, NC
Background/Purpose: Women with SLE and RA have an increased risk of delivering a preterm infant. However, the causes of these preterm births remain unknown. Some…
Abstract Number: 2438 • 2016 ACR/ARHP Annual Meeting
Increased Risk of Postpartum Depression in SLE Pregnancies
Evelyne Vinet¹, Susan Scott², Debbie Ehrmann Feldman³, Christian A. Pineau⁴ and Sasha Bernatsky², ¹Divisions of Rheumatology and Clinical Epidemiology, McGill University Health Centre, Montreal, QC, Canada, ²Clinical Epidemiology, Research Institute of the McGill University Health Centre, Montreal, QC, Canada, ³School of Rehabilitation, Université de Montréal, Montreal, QC, Canada, ⁴McGill University Health Centre, Montreal, QC, Canada
Background/Purpose: Chronic diseases have been shown to be a strong risk factor for postpartum depression. Although there is a 2-fold increased risk of major depression…
Abstract Number: 2439 • 2016 ACR/ARHP Annual Meeting
Effect of Pregnancy Counseling on the Outcome of Pregnancies in Women with Systemic Lupus Erythematosus: A Prospective Observational Study
Rebecca Fischer-Betz¹, Lisa Kueppers², Ralph Brinks², Oliver Sander³, Christof Specker⁴ and Matthias Schneider³, ¹Policlinic of Rheumatology and Hiller Research Unit Rheumatology, Heinrich-Heine University, Duesseldorf, Duesseldorf, Germany, ²Department of Rheumatology&Hiller Research Unit, Heinrich-Heine-University, Duesseldorf, Germany, ³Department of Rheumatology & Hiller Research Unit, Heinrich-Heine-University, Duesseldorf, Germany, ⁴Rheumatology and Clinical Immunology, Kliniken Essen Sued, Essen, Germany
Background/Purpose: Pregnancies in women with systemic lupus erythematosus (SLE) are associated with increased frequencies of adverse pregnancy outcomes (APOs). Preconception counseling including risk stratification and…
Abstract Number: 2440 • 2016 ACR/ARHP Annual Meeting
First Results from the Prospective German Pregnancy Register
Rebecca Fischer-Betz¹, Christina Bungartz², Jutta Richter¹, Angela Zink³, Matthias Schneider¹, Anja Weiss², Joachim Listing⁴ and Anja Strangfeld⁵, ¹Department of Rheumatology & Hiller Research Unit, Heinrich-Heine-University, Duesseldorf, Germany, ²German Rheumatism Research Centre, Berlin, Germany, ³Epidemiology Unit, German Rheumatism Research Center and Charité University Medicine, Berlin, Germany, ⁴German Rheumatism Research Center, Berlin, Germany, ⁵Epidemiology, German Rheumatism Research Center, Berlin, Germany
Background/Purpose: There is limited evidence on the safety of treatment during pregnancy and lactation. With the increasing number of new therapeutic options for inflammatory rheumatic…
Abstract Number: 2441 • 2016 ACR/ARHP Annual Meeting
Rheumatoid Arthritis Flares and Pregnancy Outcomes Among Women in a Longitudinal Registry
Sara K. Tedeschi, Michelle Frits, Christine Iannaccone, Michael Weinblatt, Nancy A. Shadick and Bonnie L. Bermas, Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA
Background/Purpose: Rheumatoid arthritis (RA) has been reported to improve during 50-60% of pregnancies. In this study, we evaluated RA disease activity during pregnancy and pregnancy…
Abstract Number: 2442 • 2016 ACR/ARHP Annual Meeting
Use of Nonsteroidal Anti-Inflammatory Drugs in Pregnant Women with Inflammatory Arthritis
Neda Amiri¹, Gretchen Bandoli², Diana L Johnson² and Christina D. Chambers², ¹Division of Rheumatology, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada, ²Pediatrics, University of California, San Diego, La Jolla, CA
Use of Nonsteroidal Anti-inflammatory Drugs in Pregnant Women with Inflammatory Arthritis Background/Purpose: Nonsteroidal anti-inflammatory drugs (NSAIDs) are generally contraindicated in the third trimester of pregnancy…
Abstract Number: 2443 • 2016 ACR/ARHP Annual Meeting
Pregnancy Comorbidities and Outcomes in Psoriasis and Psoriatic Arthritis: A Prospective Cohort Study
Neda Amiri¹, Gretchen Bandoli² and Christina Chambers², ¹Division of Rheumatology, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada, ²Pediatrics, University of California, San Diego, La Jolla, CA
Pregnancy Comorbidities and Outcomes in Psoriasis and Psoriatic Arthritis: A Prospective Cohort Study Background/Purpose: While there is some evidence that women with psoriasis (Pso) and…

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