Abstracts Archive - Page 1575 of 2607 - ACR Meeting Abstracts

Abstract Number: 2816 • 2017 ACR/ARHP Annual Meeting
Prediction of Connective Tissue Disease in an at-Risk Cohort Using a Novel Interferon Stimulated Gene Expression Score
Md Yuzaiful Md Yusof^1,2, Yasser M El-Sherbiny^1,3, Antonios Psarras¹, Elizabeth M.A. Hensor^1,4, Adewonuola Alase¹, Alaa Mohamed¹, Miriam Wittmann^1,4, Paul Emery^1,4 and Edward M Vital^1,4, ¹Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ²NIHR Leeds Biomedical Research Unit, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom, ³Clinical Pathology dept., School of Medicine, Mansoura University, Mansoura, Egypt, ⁴NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom
Prediction of connective tissue disease in an at-risk cohort using a novel interferon stimulated gene expression scoreBackground/Purpose: A period of ANA positivity and other immune…
Abstract Number: 2817 • 2017 ACR/ARHP Annual Meeting
Expression Patterns of Interferon Induced Genes in Newborns Exposed to Ro/SSA Autoantibodies in Utero
Gudny Ella Thorlacius¹, Malin Hedlund¹, Margarita Ivanchenko¹, Vijole Ottosson¹, Amina Ossoinak¹, Linda Lagnefeldt¹, Lars Rönnblom², Sven-Erik Sonesson³, Maija-Leena Eloranta⁴ and Marie Wahren-Herlenius¹, ¹Unit of Experimental Rheumatology, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, Stockholm, Sweden, ²Department of Medical Sciences, Section of Rheumatology, Uppsala University, Uppsala, Sweden, Uppsala, Sweden, ³Pediatric Cardiology Unit, Department of Women´s and Children´s Health, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, Stockholm, Sweden, ⁴Rheumatology and Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Sweden, Uppsala, Sweden
Background/Purpose: Women with Sjögren’s syndrome and autoantibodies against Ro/SSA are at risk for pregnancy complications, including neonatal lupus erythematosus (NLE) and a congenital heart block…
Abstract Number: 2818 • 2017 ACR/ARHP Annual Meeting
Gene Expression Analysis Demonstrates That Multiple Type 1 Interferons Are Involved in Lupus Pathogenesis
Michelle Catalina¹, Prathyusha Bachali², Sushma Madamanchi¹, Amrie Grammer¹ and Peter Lipsky¹, ¹Ampel BioSolutions LLC, Charlottesville, VA, ²Ampel BioSolutions LLC, Charlottesville, MA
Background/Purpose: A role for interferon (IFN) in lupus pathogenesis has been inferred from the prominent IFN gene signature (IGS) found in lupus peripheral blood. However,…
Abstract Number: 2819 • 2017 ACR/ARHP Annual Meeting
Association of Socioeconomic Status with Osteoarthritis-Induced Disability Progression
Divya Narayanan¹, Rebecca J. Cleveland², Joanne M. Jordan³, Eric Seaberg⁴ and Leigh F. Callahan¹, ¹Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, ²Thurston Arthritis Research Center, University of North Carolina School of Medicine, Chapel Hill, NC, ³Thurston Arthritis Research Center, University of North CArolina at Chapel Hill, Chapel Hill, NC, ⁴Bloomberg School of Public Health, Johns Hopkins Unviersity, Baltimore, MD
Background/Purpose: Osteoarthritis (OA) is the number one chronic condition of the joints. Social determinants associated with disability progression due to OA are largely unknown. Efforts…
Abstract Number: 2820 • 2017 ACR/ARHP Annual Meeting
Disease Activity By the Sledai in Lupus Patients Who Self Report Sleep Disturbance and Sleep Impairment Using the Patient-Reported Outcomes Measurement Information System Instruments
Teresa Aberle¹, Rufei Lu², Sarah Cioli³, Stan Kamp¹, Wade DeJager¹, Stephen Apel⁴, Cristina Arriens⁵, Eliza Chakravarty⁶, Aikaterini Thanou¹, Joel M. Guthridge⁷, Joan T. Merrill⁸ and Judith A. James⁹, ¹Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ³Arthritis and Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁴Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁵Arthritis & Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁶Oklahoma Medical research af, Edmond, OK, ⁷Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, OKC, OK, ⁸Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁹Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK
Background/Purpose: Lupus patients commonly report sleep dysfunction, which is associated with upregulation of inflammatory cytokines in healthy people. Studies exploring relationships between self-reported sleep dysfunction…
Abstract Number: 2821 • 2017 ACR/ARHP Annual Meeting
A Multidisciplinary Telemedicine Program for Identification of Spondyloarthritis in Medically Underserviced Communities
Christopher Hawke¹, Laura Passalent¹, Nigil Haroon², Robert D Inman³ and Y. Raja Rampersaud⁴, ¹Allied Health, Toronto Western Hospital, Toronto, ON, Canada, ²Rheumatology, Toronto Western Hospital, University of Toronto, Spondylitis Clinic, Toronto, ON, Canada, ³Department of Immunology, University of Toronto, Toronto, ON, Canada, ⁴Arthritis Program, Krembil Research Institute, University Health Network, Torotno, ON, Canada
Background/Purpose: Early diagnosis is critical for optimal management of patients with inflammatory arthritis. Axial spondyloarthritis (AxSpA) has the longest delay in diagnosis among inflammatory joint…
Abstract Number: 2822 • 2017 ACR/ARHP Annual Meeting
A Randomized Controlled Effectiveness Trial of the Enhance-Fitness® Physical Activity Program in People with Arthritis
Dina L. Jones¹, Jennifer L. Eicher¹, Hannah M. Ludwick² and Kayéromi D. Gomez³, ¹Orthopaedics, West Virginia University, Morgantown, WV, ²Biostatistics, West Virginia University, Morgantown, WV, ³Office of Research, University of Illinois College of Medicine at Rockford, Rockford, IL
Background/Purpose: EnhanceFitness® (EF) is an evidence-based, community-delivered intervention for older adults; however, its effectiveness in people with arthritis is unknown. The purpose of this pragmatic,…
Abstract Number: 2823 • 2017 ACR/ARHP Annual Meeting
Preliminary Comparison of Patient-Centered Weight Loss Programs Starting before Versus after Knee Replacement
Christine Pellegrini^1,2, Rowland W. Chang³, Dorothy D. Dunlop⁴, David Conroy^1,5, Julia (Jungwha) Lee⁶, Linda VanHorn⁶, Bonnie Spring¹ and Kenzie Cameron⁷, ¹Northwestern University Feinberg School of Medicine, Chicago, IL, ²Exercise Science, University of South Carolina's Arnold School of Public Health, Columbia, SC, ³Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁴Center for Healthcare Studies, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁵Kinesiology, The Pennsylvania State University, University Park, PA, ⁶Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁷General Internal Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose: Most patients risk gaining weight in the years after knee replacement, adding further concern to a population that is mostly overweight/obese prior to surgery.…
Abstract Number: 2824 • 2017 ACR/ARHP Annual Meeting
Sleep and Depression Mediate the Relationship between Pain and Cognitive Dysfunction in Lupus Patients
Teresa A. Lillis¹, Vanessa Tirone¹, Stacy Weinberg², Nisarg Gandhi³, Ailda Nika⁴, Winston Sequeira⁴, Stevan E. Hobfoll¹, Joel A. Block² and Meenakshi Jolly⁴, ¹Behavioral Sciences, Rush University Medical Center, Chicago, IL, ²Division of Rheumatology, Rush University Medical Center, Chicago, IL, ³Rush University Medical Center, Chicago, IL, ⁴Rheumatology, Rush University Medical Center, Chicago, IL
Background/Purpose: Cognitive Dysfunction (CD) is seen among 20-80% of patients with Systemic Lupus Erythematosus (SLE) and adversely affects their quality of life and productivity. Pain,…
Abstract Number: 2825 • 2017 ACR/ARHP Annual Meeting
A Possible Environmental Origin for a Proportion of the Genetic Risk of Rheumatoid Arthritis and Systemic Lupus Erythematosus
John B. Harley¹, Xiaoting Chen¹, Mario Pujato², Daniel Miller¹, Avery Maddox¹, Carmy Forney³, Albert Magnusen³, Arthur Lynch¹, Kashish Chetal⁴, Masashi Yukawa⁵, Artem Barski⁶, Nathan Salomonis⁴, Kenneth Kaufman⁷, Leah C. Kottyan⁸ and Matthew Weirauch⁹, ¹Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ²Center of Autoimmune Genomics and Etiology (CAGE), Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, ³Center of Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁴Division of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁵Divisions of Allergy and Immunology and Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁶Divisions of Allergy and Immunology and Bioinformatics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁷Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center; US Department of Veterans Affairs Medical Center, Cincinnati, OH, ⁸Center for Autoimmune Genomics and Etiology (CAGE), Division of Allergy and Immunology, Cincinnati Children's Hospital, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁹Center for Autoimmune Genomics and Etiology (CAGE) and Divisions of Biomedical Informatics and Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
Background/Purpose: Nearly 150 genetic loci are convincingly associated with lupus (SLE) or rheumatoid arthritis (RA) and underlie their incompletely understood mechanisms of pathogenesis. Since 90%…
Abstract Number: 2826 • 2017 ACR/ARHP Annual Meeting
Fine-Mapping Identifies Causal Variants for RA and T1D in DNASE1L3, Sirpg, MEG3, TNFAIP3 and CD28/CTLA4 Loc
Harm-Jan Westra¹, Marta Martinez-Bonet², Suna Onengut³, Annette Lee⁴, Yang Luo¹, Nikola Teslovich¹, Jane Worthington⁵, Javier Martín⁶, TWJ Huizinga⁷, Lars Klareskog⁸, Solbritt Rantapää Dahlqvist⁹, Wei-Min Chen³, Aaron Quinlan¹⁰, John Todd¹¹, Stephen Eyre⁵, Peter Nigrovic², Peter Gregersen⁴, Stephen Rich³ and Soumya Raychaudhuri¹², ¹Division of Genetics and Rheumatology, Department of Medicine, Harvard Medical School, Boston, MA, ²Division of Rheumatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ³Department of Public Health Sciences, University of Virginia, Charlottesville, VA, ⁴The Feinstein Institute for Medical Research, Northwell Health, Manhasset, NY, ⁵Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, Manchester, United Kingdom, ⁶Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, PTS-Granada, Granada, Spain, ⁷Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁸Dept. of Medicine, Rheumatology Unit, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, ⁹University of Umeå, Umeå, Sweden, ¹⁰Department of Human Genetics, University of Utah, Salt Lake City, UT, ¹¹JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom, ¹²Division of Medicine and Rheumatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
Background/Purpose: While genome-wide association studies have identified risk loci for rheumatoid arthritis and other autoimmune diseases, in very few instances have causal variants driving risk…
Abstract Number: 2827 • 2017 ACR/ARHP Annual Meeting
A Novel Statistical Method to Resolve Cellular Heterogeneity in Disease Tissues: Integrating Transcriptomic Data in Accelerating Medicines Partnership (AMP) – RA Network Phase 1 Data
Fan Zhang¹, Kamil Slowikowski², Chamith Fonseka¹, Kevin Wei³, Maria Gutierrez-Arcelus⁴, James Lederer⁵, Nir Hacohen⁶, Vivian P. Bykerk⁷, Michael Holers⁸, Peter Gregersen⁹, Mandy J. McGeachy¹⁰, Larry W. Moreland¹¹, Andrew Filer¹², Costantino Pitzalis¹³, Yvonne C. Lee¹⁴, Jennifer H. Anolik¹⁵, Michael Brenner⁴ and Soumya Raychaudhuri¹⁶, ¹Divisions of Genetics and Rheumatology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ²Division of Medicine and Rheumatology, Brigham and Women's Hospital, Harvard Medical Schoo, Boston, MA, ³Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ⁴Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ⁵Department of Surgery, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ⁶Harvard Medical School, Boston, MA, ⁷2-005, Mt Sinai Hospital, Toronto, ON, Canada, ⁸Medicine, Division of Rheumatology, University of Colorado Denver, Aurora, CO, ⁹The Feinstein Institute for Medical Research, Northwell Health, Manhasset, NY, ¹⁰Medicine, University of Pittsburgh, Pittsburgh, PA, ¹¹Rheumatology & Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ¹²Institute of Inflammation and Ageing (IIA), University of Birmingham, Birmingham, United Kingdom, ¹³Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Barts and The London, School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom, ¹⁴Rheumatology Immunology & Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ¹⁵Medicine- Allergy, Immunology and Rheumatology, University of Rochester Medical Center, Rochester, NY, ¹⁶Division of Medicine and Rheumatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
Background/Purpose: Detecting distinct cellular subsets in disease tissues is key to understanding the pathogenesis of immune diseases, for example in synovial tissues in rheumatoid arthritis…
Abstract Number: 2828 • 2017 ACR/ARHP Annual Meeting
A Graph-Theoretic-Approach Applied to Modular-Repertoire-Analysis Identifies Shared Gradual Whole Blood Interferon Signatures in Systemic Lupus Erythematosus and Primary Sjögren’s Syndrome Patients and Reveals New Interferon-Related Modules in Disease Progression
Ilya Korsunski¹, Noémie Jourde-Chiche², Peter Gregersen³, Damien Chaussabel⁴, Laurent Chiche⁵ and Naomi I. Maria⁶, ¹Center for Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, NY, ²Nephrology, AP-HM, Department of Nephrology, CHU Conception, Marseille, France, ³Robert S. Boas Center for Genomics and Human Genetics, Feinstein Institute for Med Res, Manhasset, NY, ⁴Translational Medicine, Sidra Medical and Research Center, Doha, Qatar, ⁵Internal medicine, Hopital europeen, Marseille, France, ⁶Center for Autoimmune and Musculoskeletal Diseases, Feinstein Institute for Medical Research, Manhasset, NY
Background/Purpose: There is significant clinical and molecular heterogeneity among patients suffering from systemic autoimmune diseases, such as systemic lupus erythematosus (SLE) and primary Sjögren’s Syndrome…
Abstract Number: 2829 • 2017 ACR/ARHP Annual Meeting
Complete Epigenetic Landscape of Rheumatoid Arthritis Fibroblast-like Synoviocytes Reveals Unanticipated Critical Pathogenic Pathways
Rizi Ai¹, Teresina Laragione², Deepa Hammaker³, David L. Boyle⁴, Andre ‎ Wildberg⁵, Keisuke Maeshima³, Emmanuele Palescandolo⁶, Vinod Krishna⁶, Bryan Linggi⁷, David Pocalyko⁸, John W. Whitaker⁹, Percio S. Gulko², Wei Wang¹⁰ and Gary S. Firestein¹¹, ¹UC San Diego, La Jolla, CA, ²Medicine/Rheumatology, Icahn School of Medicine at Mount Sinai, New York, NY, ³Division of Rheumatology, Allergy and Immunology, UCSD School of Medicine, La Jolla, CA, ⁴University of California San Diego, La Jolla, CA, ⁵Chemistry and Biochemistry, UNIVERSITY OF CALIFORNIA SAN DIEGO, LA JOLLA, CA, ⁶Janssen Pharmaceuticals, Spring House, PA, ⁷janssen Pharmaceuticals, Spring House, PA, ⁸Janssen Research, Spring House, PA, ⁹Janssen Pharmaceuticals, La Jolla, CA, ¹⁰Chemistry and Biochemistry, UC San Diego, La Jolla, CA, ¹¹Medicine, University of California San Diego, La Jolla, CA
Background/Purpose: Epigenetics participates in the pathogenesis of rheumatoid arthritis (RA). Epigenetic marks, gene expression and DNA polymorphisms have been investigated but the analyses are limited…
Abstract Number: 2830 • 2017 ACR/ARHP Annual Meeting
Epigenetic Cell Counting: A Novel Tool to Quantify Immune Cells in Salivary Glands Detects Robust Correlations of T Follicular Helper Cells with Immunopathology
Joel A.G. van Roon¹, Frederique M. Moret¹, Sofie L.M. Blokland¹, Aike A. Kruize², Gerben Bouma³, Andre van Maurik³, Sven Olek⁴, Ulrich Hoffmueller⁴ and Timothy R.D.J. Radstake⁵, ¹Rheumatology & Clinical Immunology/ Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ²Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ³Immunoinflammation TAU, GlaxoSmithKline, Stevenage, United Kingdom, ⁴Epiontis GmbH, Berlin, Germany, ⁵Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands
Background/Purpose: Histological analysis of salivary glands for decades has been a valuable tool in the characterization of patients with primary Sjögren’s syndrome (pSS) and non-Sjögren’s…

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