Abstracts Archive - Page 1571 of 2425 - ACR Meeting Abstracts

Abstract Number: 2308 • 2016 ACR/ARHP Annual Meeting
Thigh Muscle MRI Reveals Extensive Muscle Edema and Early Fatty Replacement in Patients with Immune-Mediated Necrotizing Myopathy
Iago Pinal-Fernandez¹, Maria Casal-Dominguez², John A. Carrino³, Arash Lahoutiharahdashti², Pari Basharat⁴, Jemima Albayda², Julie J. Paik², Shivani Ahlawat⁵, Sonye K. Danoff⁶, Thomas E. Lloyd⁷, Andrew Mammen⁸ and Lisa Christopher-Stine⁶, ¹Muscle Diseases Unit, National Institute of Arthritis and Musculoskeletal and Skin Diseases. National Institutes of Health, Bethesda, MD, ²Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ³Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, ⁴Rheumatology, University of Western Ontario, London, ON, Canada, ⁵Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, ⁶Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, ⁷Neurology, Johns Hopkins, Baltimore, MD, ⁸National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD
Background/Purpose: The aim of this study was to define the pattern of muscle involvement in patients with immune-mediated necrotizing myopathy (IMNM). Methods: All Johns Hopkins…
Abstract Number: 2309 • 2016 ACR/ARHP Annual Meeting
Focal Myositis: New Insights on Diagnosis and Pathology
Laure Gallay¹, Philippe Petiot², Arnaud Hot³, Francoise Thivolet-Bejui⁴ and Nathalie Streichenberger⁴, ¹Department of Internal Medicine, Edouard Heriot University Hospital, Hoscpices Civils de Lyon, Lyon cedex 03, France, ²Department of Neurology, Croix-Rousse Hospital, Hospices Civils de Lyon, Lyon, France, ³Department of Internal Medicine, Edouard Herriot University Hospital, Hospices Civils de Lyon, Lyon cedex 03, France, ⁴Department of Pathology, Neurology and Neurosurgery Pierre Wertheimer University Hospital, Hospices Civils de Lyon, Bron, France
Background/Purpose: Due to the rarity of the entity, the literature on focal myositis (FM) fails to address important questions on its nosology, associated disorders, clinical…
Abstract Number: 2310 • 2016 ACR/ARHP Annual Meeting
The Predictive Risk Factors for Complication of Infection during the Treatment for Inflammatory Myopathies Complicated with Interstitial Lung Disease
Yumiko SUGIYAMA^1,2, Maasa Tamura^1,2,3, Ryusuke Yoshimi^1,2, Naoki Hamada^1,2, Hideto Nagai^1,2, Yuko Tatekabe^1,2, Naomi Tsuchida^2,4, Yutaro Soejima^1,2, Yosuke Kunishita^2,4, Daiga Kishimoto^1,2, Hiroto Nakano^1,2, Reikou Kamiyama^1,2, Kaoru Minegishi^2,5, Yukiko Asami^1,2, Yohei Kirino^2,4, Shigeru Ohno^2,5 and Hideaki Nakajima¹, ¹Department of Stem Cell and Immune Regulation, Yokohama City University Graduate School of Medicine, Yokohama, Japan, ²Y-CURD Study Group, Yokohama, Japan, ³Nagaoka Red Cross Hospital, Nagaoka, Japan, ⁴Department of Hematology and Clinical Immunology, Yokohama City University School of Medicine, Yokohama, Japan, ⁵Center for Rheumatic Disease, Yokohama City University Medical Center, Yokohama, Japan
Background/Purpose: Interstitial lung disease (ILD) is one of the predominant causes of death in polymyositis/dermatomyositis (PM/DM). We have already reported that low PaCO2 and interstitial…
Abstract Number: 2311 • 2016 ACR/ARHP Annual Meeting
Initial Predictors of Short-Term Poor Survival Rates in Patients with Polymyositis/Dermatomyositis-Associated Interstitial Lung Disease
Shinji Sato¹, Kenichi Masui², Naoshi Nishina³, Yasushi Kawaguchi⁴, Atsushi Kawakami⁵, Maasa Tamura⁶, Kei Ikeda⁷, Takahiro Nunokawa⁸, Yoshinori Tanino⁹, Katsuaki Asakawa¹⁰, Yuko Kaneko¹¹, Takahisa Gono¹², Masataka Kuwana³ and JAMI investigators, ¹Division of Rheumatology, Department of Internal Medicine, Tokai University School of Medicine, Isehara, Japan, ²Department of Anesthesiology, National Defense Medical College School of Medicine, Tokorozawa, Japan, ³Department of Allergy and Rheumatology, Nippon Medical School Graduate School of Medicine, Tokyo, Japan, ⁴Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan, ⁵Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ⁶Department of Stem Cell and Immune Regulation, Yokohama City University Graduate School of Medicine, Yokohama, Japan, ⁷Department of Allergy and Clinical Immunology, Chiba University Hospital, Chiba, Japan, ⁸Department of Rheumatic Diseases, Tokyo Metropolitan Tama Medical Center, Tokyo, Japan, ⁹Department of Pulmonary Medicine, Fukushima Medical University School of Medicine, Fukushima, Japan, ¹⁰Division of Respiratory Medicine, Niigata University Medical and Dental Hospital, Niigata, Japan, ¹¹Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan, ¹²Department of Rheumatology, Jichi Medical University Saitama Medical Center, Saitama, Japan
Background/Purpose: Polymyositis (PM)/dermatomyositis (DM) is a chronic inflammatory disorder that affects muscle, skin and lung in various degree, and interstitial lung disease (ILD) is a…
Abstract Number: 2312 • 2016 ACR/ARHP Annual Meeting
Anti-TIF1-Gamma Antibodies Are Not Associated with Other Paraneoplastic Rheumatic Syndromes Than Dermatomyositis
Paulius Venalis¹, Sandra Selickaja^2,3, Karin Lundberg⁴, Rita Rugiene^5,6 and Ingrid E. Lundberg⁷, ¹Karolinska Institutet, Stockholm, Sweden, ²Vilnius University, Center of Rheumatology;, Vilnius, Lithuania, ³State Research Institute for Innovative Medicine, Vilnius, Lithuania, ⁴Rheumatology Unit, Department, Karolinska Institute, Stockholm, Sweden, ⁵Vilnius University Hospital Santariskiu Klinikos, Vilnius, Lithuania, ⁶State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania, ⁷Department of Medicine, Rheumatology Unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden
Background/Purpose: An association between cancer and dermatomyositis (DM), referred to as cancer-associated myositis, is well recognized and clinically important. The overall cancer risk is up…
Abstract Number: 2313 • 2016 ACR/ARHP Annual Meeting
Profile of Cardiovascular Burden in Myositis: A Case-Control Study
Alexander G.S. Oldroyd¹, Robert Cooper², Benjamin Parker³, Ian N. Bruce¹, Paul New⁴ and Hector Chinoy⁵, ¹Arthritis Research UK Centre for Epidemiology, The University of Manchester, Manchester, United Kingdom, ²Department of Musculoskeletal Biology, University of Liverpool, Liverpool, United Kingdom, ³Centre for Musculoskeletal Research, Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Sciences Centre, Manchester, United Kingdom, ⁴Institute of Ageing and Chronic Disease, The University of Liverpool, Liverpool, United Kingdom, ⁵Centre for Musculoskeletal Research, University of Manchester, Manchester, United Kingdom
Background/Purpose: Research has indicated that cardiovascular disease is the leading cause of death in the Idiopathic Inflammatory Myopathies (IIM). Only a small number of studies…
Abstract Number: 2314 • 2016 ACR/ARHP Annual Meeting
Anti-Mi2 Dermatomyositis Revisited: Pure DM Phenotype with Muscle Fiber Necrosis and High Risk of Malignancy
Océane Landon-Cardinal¹, Grégoire Monseau², Yoland Schoindre³, Aude Rigolet¹, Nicolas Champtiaux¹, Baptiste Hervier¹, Agathe Masseau⁴, Eric Hachulla⁵, Thomas Papo⁶, Benjamin Terrier⁷, Alain Meyer⁸, Jean-Emmanuel Kahn³, François Maurier⁹, Francis Gaches¹⁰, Emmanuelle Salort-Campana¹¹, Thierry Zenone¹², Nathalie Costedoat-Chalumeau⁷, Florian Perez¹³, Maxime Samson¹⁴, Anne-Marie Piette³, Guillaume Moulis¹⁰, Sylvain Audia¹⁵, Séverine Genot¹⁶, Nicolas Schleinitz¹⁷, Guillaume Lefevre⁵, Laurence Verneuil¹⁸, Olivier Benveniste¹⁹, Yves Allenbach¹ and Boris Bienvenu²⁰, ¹Internal Medicine, Pitié-Salpêtrière University Hospital, Paris, France, ²Internal Medicine, Caen University Hospital, Caen, France, ³Internal Medicine, Foch Hospital, Suresnes, France, ⁴Internal Medicine, Nantes University Hospital, Nantes, France, ⁵Internal Medicine, Lille University Hospital, Lille, France, ⁶Bichat University Hospital - Internal Medicine, Paris, France, ⁷Internal Medicine, Cochin University Hospital, Paris, France, ⁸Rheumatology, Strasbourg University Hospital, Strasbourg, France, ⁹Internal Medicine, Sainte-Blandine de Metz Hospital, Metz, France, ¹⁰Internal Medicine, Toulouse University Hospital, Toulouse, France, ¹¹Neurology, La Timone University Hospital, Marseille, France, ¹²Internal Medicine, Valence Hospital, Valence, France, ¹³Neurology, Albi Hospital, Albi, France, ¹⁴Dijon University Hospital, Dijon, France, ¹⁵Internal Medicine, Dijon University Hospital, Dijon, France, ¹⁶Internal Medicine, Martigues Hospital, Martigues, France, ¹⁷La Timone University Hospital, Marseille, France, ¹⁸Dermatology, Caen University Hospital, Caen, France, ¹⁹Pitié-Salpêtrière University Hospital, Paris, France, ²⁰Caen University Hospital, Caen, France
Background/Purpose: Anti-Mi2 autoantibodies (Aabs) have been proposed to be highly specific for dermatomyositis (DM) and to be associated with a DM classical phenotype consisting of…
Abstract Number: 2315 • 2016 ACR/ARHP Annual Meeting
The Effectiveness of Social Media in Recruiting for Rare Rheumatic Diseases
Adam Schiffenbauer¹, Lisa G. Rider², Sara Faghihi-Kashani³, Komal Patel⁴ and Frederick W. Miller⁵, ¹Environmental Autoimmunity Group, NIEHS, NIH, Bethesda, MD, ²Environmental Autoimmunity Group, National Institute of Environmental Health Sciences, National Institutes of Health, Bethesda, MD, ³Environmental Autoimmunity Group, National Institute of Environmental Health, Bethesda, MD, ⁴Social and Scientific Systems, Inc., Bethesda, MD, ⁵Environmental Autoimmunity Group, National Institute of Environmental Health Sciences, NIH, Bethesda, MD
Background/Purpose: Clinical research is dependent on being able to recruit and enroll appropriate patients in sufficient numbers to make robust conclusions. For many diseases it…
Abstract Number: 2316 • 2016 ACR/ARHP Annual Meeting
Successful Treatment of Statin-Induced Autoimmune Myopathy without Corticosteroids
Geneviève Oligny Longpré¹, Yves Troyanov¹, Marvin J. Fritzler², José Ferreira¹, Ira N. Targoff³, Hélène Couture⁴, Océane Landon-Cardinal¹, Eric Rich¹, Josiane Bourré-Tessier⁵, Anne-Marie Mansour¹, Julie Drouin¹, Sandra Chartrand¹, Edith Villeneuve¹, Jean-Richard Goulet¹, Benjamin Ellezam⁶, Ana Maria Tsanaclis¹, Vincent Morin¹, Marie-Pierre Fournier-Gosselin¹ and Jean-Luc Senécal¹, ¹Université de Montréal, Montréal, QC, Canada, ²Medicine, University of Calgary, Calgary, AB, Canada, ³University of Oklahoma, Oklahoma City, OK, ⁴Université Laval, Québec, QC, Canada, ⁵Université de Montréal, Montreal, QC, Canada, ⁶Centre hospitalier universitaire Ste-Justine, Montréal, QC, Canada
Methods: Our study included all patients from the Université de Montréal AIM cohort (comprising four academic hospitals) with a documented anti-3-hydroxy-3-methylglutaryl-CoA reductase (anti-HMGCR) autoantibody. We selected…
Abstract Number: 2317 • 2016 ACR/ARHP Annual Meeting
Preliminary Validation of a Magnetic Resonance Imaging-Based Inflammatory Scoring System in Adult Myositis
Nicolo Pipitone¹, Antonella Notarnicola^2,3, Arnaldo Scardapane⁴, Lucia Spaggiari⁵, Gabriele Levrini⁶, Florenzo Iannone⁷, Carlo Salvarani⁸, Giovanni Lapadula⁹, Ingrid E. Lundberg², Pierpaolo Pattacini¹⁰ and Giulio Zuccoli¹¹, ¹Rheumatology, Arcispedale S. M. Nuova, Reggio Emilia, Italy, ²Department of Medicine, Rheumatology Unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, ³Rheumatology, Bari University, Bari, Italy, ⁴Radiology, University of Bari, Bari, Italy, ⁵Radiology, Arcispedale S Maria Nuova, IRCCS, Reggio Emilia, Italy, ⁶Arcispedale S Maria Nuova, Reggio Emilia, Italy, ⁷Bari University, Rheumatology, Bari, Italy, ⁸Arcispedale Santa Maria Nuova-IRCCS, Reggio Emilia, Italy, ⁹Rheumatology Unit, University of Bari, Bari, Italy, ¹⁰Radiology, Arcispedale Santa Maria Nuova, Reggio Emilia, Italy, ¹¹Children's Hospital of Pittsburgh, Pittsburgh, PA
Background/Purpose: in patients with active myositis, magnetic resonance imaging (MRI) often demonstrates muscle edema thought to represent active inflammation. An MRI-based muscle inflammatory scoring system…
Abstract Number: 2318 • 2016 ACR/ARHP Annual Meeting
Real World Use of the Myositis Autoantibody Panel
Jason Weiner¹, Ryan Jessee², Robert T. Keenan³, Michael Datto⁴ and Lisa Criscione-Schreiber⁵, ¹Division of Rheumatology, Duke University, Durham, NC, ²Division of Internal Medicine, Duke University, Durham, NC, ³Rheumatology, Duke University, Durham, NC, ⁴Division of Pathology, Duke University, Durham, NC, ⁵Division of Rheumatology, Department of Medicine, Duke University, Durham, NC
Background/Purpose: The identification of myositis specific and associated autoantibodies occurring in idiopathic inflammatory myopathies (IIMs) has improved classification and prognosis determinations. With commercial availability, these…
Abstract Number: 2319 • 2016 ACR/ARHP Annual Meeting
High Prevalence of Asymptomatic Vertebral Fractures in Inflammatory Myositis
Latika Gupta, Sukesh Edavalath, Ramnath Misra and Able Lawrence, Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
Background/Purpose: Patients with inflammatory myositis have increased prevalence of symptomatic fractures. Early detection of asymptomatic vertebral fractures may help in their prevention. We studied the…
Abstract Number: 2320 • 2016 ACR/ARHP Annual Meeting
Oropharyngeal Dysphagia in Autoimmune Myositis
Jessica Nehme¹, Jean-Paul Makhzoum², Josiane Bourré-Tessier³, Yves Troyanov⁴, Marianne Landry¹, Océane Landon-Cardinal⁵, Marvin J. Fritzler⁶, Anne-Marie Mansour⁷, Eric Rich⁸, Jean-Richard Goulet⁹, Tamara Grodzicky¹⁰, Edith Villeneuve², Frédéric Massicotte¹¹, Florence Weber¹², Martial Koenig¹³, Sylvie Desmarais¹⁴, José Ferreira², Benjamin Ellezam¹⁵, Ira N. Targoff¹⁶ and Jean-Luc Senécal², ¹Université de Montréal, Montreal, QC, Canada, ²Université de Montréal, Montréal, QC, Canada, ³Rheumatology, Institut de Recherche en Rhumatologie de Montréal (IRRM), Montréal, QC, Canada, ⁴Rheumatology, Hôpital du Sacré-Coeur de Montréal, Montréal, QC, Canada, ⁵Internal Medicine, Pitié-Salpêtrière University Hospital, Paris, France, ⁶Medicine, University of Calgary, Calgary, AB, Canada, ⁷medicine, Hôpital du Sacré-Coeur de Montréal, Montréal, QC, Canada, ⁸Div of Rheumatology, C H Univ de Montreal, Montreal, QC, Canada, ⁹246 av Edison, CHUM - H, Saint-Lambert, QC, Canada, ¹⁰Rheumatology, Hôpital Notre-Dame du CHUM, Montreal, QC, Canada, ¹¹Hôpital Notre-Dame, Montr, QC, Canada, ¹²Hôpital St-Luc, Montreal, QC, Canada, ¹³Internal Medicine, Hôpital Notre-Dame du CHUM, Montréal, QC, Canada, ¹⁴Centre Hospitalier Pierre-Boucher, Longueuil, QC, Canada, ¹⁵Hôpital Ste-Justine, Montreal, QC, Canada, ¹⁶University of Oklahoma, Oklahoma City, OK
Background/Purpose: Oropharyngeal dysphagia (OPD) is an ominous finding in autoimmune myositis (AIM), yet few studies have evaluated the disease subsets at higher risk for this…
Abstract Number: 2321 • 2016 ACR/ARHP Annual Meeting
Early Damage and Mortality in a Cohort of Patients with Myositis Followed up to 20 Years
Sara Guerreiro Castro¹, Pedro Mota² and David A. Isenberg³, ¹Autoimmune Diseases Unit - Serviço Medicina 7.2, Hospital Curry Cabral, Centro Hospitalar Lisboa Central, Lisbon, Portugal, ²Internal Medicine, Hospital da Luz, Lisbon, Portugal, ³Centre for Rheumatology, Division of Medicine, University College London, London, United Kingdom
Background/Purpose: Idiopathic inflammatory myopathies (IIM) are a group of rare diseases, including dermatomyositis (DM), polymyositis (PM) and juvenile dermatomyositis (JDM). Patients often need long-term treatment…
Abstract Number: 2322 • 2016 ACR/ARHP Annual Meeting
The Clinical Significance of Curvilinear Bodies on Ultrastructural Examination of Muscle
Thomas Khoo¹, Sophia Otto², Barbara Koszyka², Caroline Smith², Peter Blumbergs³, Sue Lester⁴ and Vidya Limaye⁵, ¹Medical Student, University of Adelaide, Adelaide, Australia, ²Anatomical Pathology, SA Pathology, Adelaide, Australia, ³Pathology, University of Adelaide, Adelaide, Australia, ⁴Rheumatology, The Queen Elizabeth Hospital, Adelaide, Australia, ⁵Rheumatology, Royal Adelaide Hospital, Adelaide, Australia
Background/Purpose: The electronic database of muscle biopsies reported in the Anatomical Pathology Laboratory, SA Pathology was searched from 2006 to the present, to identify biopsies…

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