ACR Meeting Abstracts

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  • Abstract Number: 1990 • 2016 ACR/ARHP Annual Meeting

    Increased Risk of Cardiovascular Events in Patients with Rheumatoid Arthritis over a 15 Year Time Period That Is Comparable to Type 2 Diabetes

    Rabia Agca1,2, Luuk H.G.A. Hopman2, Vokko P. van Halm3, Mike J.L. Peters4, Jacqueline M. Dekker5, Giel Nijpels5, Coen D.A. Stehouwer6, Yvo M. Smulders4, Alexandre E. Voskuyl1, Maarten Boers1, Willem F. Lems7 and Mike T. Nurmohamed2,8, 1Rheumatology, Amsterdam Rheumatology and immunology Center, Location VU University Medical Center, Amsterdam, Netherlands, 2Rheumatology, Amsterdam Rheumatology and immunology Center, Location Reade, Amsterdam, Netherlands, 3Cardiology, VU University Medical Center, Amsterdam, Netherlands, 4Internal Medicine, VU University Medical Center, Amsterdam, Netherlands, 5EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, Netherlands, 6Internal Medicine, Department of Internal Medicine, Maastricht University Medical Centre, Maastricht, Netherlands, 7Rheumatology, Amsterdam Rheumatology and immunology Center, location VU University Medical Center, Amsterdam, Netherlands, Amsterdam, Netherlands, 8Rheumatology, Amsterdam Rheumatology and immunology Center, Location VU University Medical Center, Amsterdam, Netherlands, Amsterdam, Netherlands

    Background/Purpose:  recent cohort studies with long term follow up studying this risk are scarce.We report the results of a 15 year observational cohort study comparing…
  • Abstract Number: 1991 • 2016 ACR/ARHP Annual Meeting

    Risk of Incident Diabetes Mellitus and Its Association with Disease-Modifying Antirheumatic Drugs and Statins in Rheumatoid Arthritis

    Gulsen Ozen1,2, Sofia Pedro3, Marie Holmqvist4, Frederick Wolfe3 and Kaleb Michaud2,3, 1Rheumatology, Marmara University Faculty of Medicine, Istanbul, Turkey, 2Rheumatology, University of Nebraska Medical Center, Omaha, NE, 3National Data Bank for Rheumatic Diseases, Wichita, KS, 4Dept of Medicine, Clinical Epidemiology Unit, Dept of Medicine, Karolinska Institutet, Stockholm, Sweden

    Background/Purpose: Diabetes mellitus (DM) is an important cardiovascular risk factor in RA. Although a few prior studies reported DM risk reduction with hydroxychloroquine (HCQ) and…
  • Abstract Number: 1992 • 2016 ACR/ARHP Annual Meeting

    Rheumatoid Arthritis Is an Independent Risk Factor for Increased Insulin Resistance and Impaired Beta-Cell Function: Impact of Disease Activity

    Gorica Ristic1, Vesna Subota2, Dejana Stanisavljevic3, Branislava Glisic1, Milan Petronijevic1 and Dusan Stefanovic1, 1Department of Rheumatology and Clinical Immunology, Military Medical Academy, Belgrade, Serbia, 2Institute of Medical Biochemistry, Military Medical Academy, Belgrade, Serbia, 3Institute of Medical Statistics, Belgrade University School of Medicine, Belgrade, Serbia

    Background/Purpose: Increased insulin resistance and impaired β-cell function have been demonstrated in pts with rheumatoid arthritis (RA). The aim of our study was to investigate…
  • Abstract Number: 1993 • 2016 ACR/ARHP Annual Meeting

    The Risk of Stroke in Patients with Rheumatoid Arthritis and the Association with Competing Adverse Events

    Yvette Meißner1, Adrian Richter2, Joern Kekow3, Hans Peter Tony4, Elke Wilden5, Angela Zink6,7, Joachim Listing2 and Anja Strangfeld7, 1Programme Area Epidemiology, German Rheumatism Research Center, Berlin, Germany, 2German Rheumatism Research Center, Berlin, Germany, 3University of Magdeburg, Clinic of Rheumatology, Magdeburg, Germany, 4Rheumatology / Clinical Immunology, University Hospital Würzburg, Würzburg, Germany, 5Rheumatologist, Köln, Germany, 6Rheumatology and Clinical Immunology, Charité - University Medicine Berlin, Berlin, Germany, 7Epidemiology, German Rheumatism Research Center, Berlin, Germany

    Background/Purpose: Patients with rheumatoid arthritis (RA) are at increased risk for infections, hospitalizations and cardiovascular (CV) events. The association of serious adverse events (SAE) with…
  • Abstract Number: 1994 • 2016 ACR/ARHP Annual Meeting

    Associations of Chronic Lung Comorbidity with Medications, Disease Activity, and All-Cause Mortality in Rheumatoid Arthritis

    Bryant R. England1,2, Harlan Sayles3, Kaleb Michaud3,4, Liron Caplan5, Lisa A. Davis6,7, Grant W. Cannon8, Brian Sauer9, E. Blair Solow10, Andreas Reimold11, Gail S. Kerr12, Pascale Schwab13, Joshua F. Baker14, Namrata Singh15 and Ted R. Mikuls16, 1VA Nebraska-Western Iowa, Omaha, NE, 2Division of Rheumatology, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, 3University of Nebraska Medical Center, Omaha, NE, 4National Data Bank for Rheumatic Diseases, Wichita, KS, 5Div of Rheumatology, Denver VAMC and Univ of Colorado School of Medicine, Aurora, CO, 6Denver VAMC and Univ of Colorado School of Medicine, Aurora, CO, 7Medicine, Division of Rheumatology, Denver Health and Hospital Authority, Denver, CO, 8Internal Medicine, Veterans Affairs Salt Lake City Health Care System and University of Utah School of Medicine, Salt Lake City, UT, 9IDEAS Center and Division of Epidemiology, HSR&D SLC VA Medical Center and University of Utah, Salt Lake City, UT, 10Rheumatology, UT Southwestern Medical Center, Dallas, TX, 11Dallas VA Medical Center and University of Texas Southwestern Medical Center, Dallas, TX, 12Washington DC VAMC, Georgetown University Hospital, Howard University Hospital, Washington, DC, 13Div Arth & Rheum Dis, Portland VA and Oregon Health & Science University, Portland, OR, 14Medicine/Rheumatology, University of Pennsylvania and Philadelphia VAMC, Philadelphia, PA, 15Internal Medicine, University of Iowa Hospitals and Clinics and Iowa City VA, Iowa City, IA, 16Veteran Affairs Nebraska-Western Iowa Health Care System and University of Nebraska Medical Center, Omaha, NE

    Background/Purpose: While the impact of interstitial lung disease (ILD) on mortality in RA has been demonstrated, less is known about the influence of other lung…
  • Abstract Number: 1995 • 2016 ACR/ARHP Annual Meeting

    Smoking Is Associated with Unfavorable Flare/ Remission Pattern in Patients with Rheumatoid Arthritis

    Shafay Raheel1, Cynthia S. Crowson2, Eric L. Matteson1 and Elena Myasoedova1, 1Rheumatology, Mayo Clinic, Rochester, MN, 2Health Sciences Research, Mayo Clinic, Rochester, MN

    Background/Purpose: Smoking is well recognized as a risk factor for rheumatoid arthritis (RA), and determinant of RA disease activity, severity, response to therapy, and possibly…
  • Abstract Number: 1997 • 2016 ACR/ARHP Annual Meeting

    Non-Medical Switch from Originator to Biosimilar Infliximab in Patients with Inflammatory Arthritis – Impact on s-Infliximab and Antidrug-Antibodies. Results from the Danish Rheumatologic Biobank and the Danbio Registry

    Bente Glintborg1, Tina Marie Kringelbach1, Estrid Høgdall1, Inge Juul Sørensen2, Dorte Vendelbo Jensen2, Anne Gitte Loft3, Oliver Hendricks4, Inger Marie Jensen Hansen2, Asta Linauskas2, Salome Kristensen2, Hanne Lindegaard5, Henrik Nordin2, Nils Bolstad6, David Warren6, Johanna Gehin6, Guro Løvik Goll6, Kathrine Lederballe Grøn2, Grith Eng2, Christian Enevold1, Claus Henrik Nielsen1, Julia Sidenius Johansen1 and Merete Lund Hetland1, 1Danish Rheumatologic Biobank and DANBIO registry, Rigshospitalet, Glostrup, Gentofte and Herlev University Hospital, Copenhagen, Denmark, 2The DANBIO registry and the Danish Departments of Rheumatology, Copenhagen, Denmark, 3Departments of Rheumatology at Vejle and Aarhus Hospitals, Vejle and Aarhus, Denmark, 4Dep. of Rheumatology, King Christians Hospital for Rheumatic Diseases, Copenhagen, Denmark, 5The DANBIO registry and the Danish Departments of Rheumatology, Odense, Denmark, 6Department of Medical Biochemistry, OUS-Radiumhospitalet and Diakonhjemmet Sykehus, Oslo, Norway

    Background/Purpose: According to national guidelines issued in 2015, a non-medical switch from originator infliximab (IFX) (Remicade) to biosimilar Remsima was conducted in all Danish patients…
  • Abstract Number: 1998 • 2016 ACR/ARHP Annual Meeting

    Long-Term Registry Data in 4498 Patients with Rheumatoid Arthritis Indicate a Similar Safety but a Different Drug Retention Between Abatacept, Rituximab and Tocilizumab

    Jacques-Eric Gottenberg1, Jacques Morel2, Arnaud Constantin3, Thomas Bardin4, Alain G. Cantagrel5, Bernard Combe6, Maxime Dougados7, Rene-Marc Flipo8, Alain Saraux9, Thierry Schaeverbeke10, Jean Sibilia11, Martin Soubrier12, Olivier Vittecoq13,14, Elodie Perrodeau15, Philippe Ravaud16, Xavier Mariette17 and on behalf of the French Society of Rheumatology and of all the investigators participating to the AIR, ORA and REGATE registries, 1Department of Rheumatology, Strasbourg University Hospital, Strasbourg, France, 2Rheumatology, Department of Rheumatology, Montpellier University Hospital, Montpellier, France, 3Rheumatology, CHU Purpan - Hopital Pierre-Paul Riquet, Toulouse, France, 4Clinique de Rhumatologie, Hopital Lariboisiere, Paris Cedex 10, France, 5Rheumatology, Centre Hospitalier Universitaire, Toulouse Purpan, Toulouse, France, 6Département Rhumatologie, Hôpital Lapeyronie, Montpellier, France, 7Rheumatology, Paris Descartes University, Paris, France, 8Rheumatology, University Hospital, Lille, France, 9Rheumatology, Brest University Hospital, Brest, France, 10Rheumatology, CHU Bordeaux, Bordeaux, France, 11Department of Rheumatology, Strasbourg University Hospital, Strasbourg, France, 12Rheumatology, Department of Rheumatology, CHU Gabriel Montpied, Clermont-Ferrand, France, 13Rheumatology, Rouen University Hospital &INSERM U905, Rouen, France, 14Rheumatology, Rouen University Hospital, Rouen, France, 15Epidemiology, Hopital Hotel Dieu, Paris Descartes University, Paris, France, 16Epidemiologist, PARIS, France, 17Rheumatology, Rheumatology department, Bicetre Hospital, Paris-Sud University, Le Kremlin Bicetre, France

    Three non-TNF targeted biologics – rituximab, abatacept, and tocilizumab – are widely used, notably in TNF-IR patients. We aimed to compare the efficacy and safety…
  • Abstract Number: 1999 • 2016 ACR/ARHP Annual Meeting

    Claims-Based Analysis of Cost-Effectiveness Among Patients with Rheumatoid Arthritis Who Switched from a Tumor Necrosis Factor Inhibitor to Another Targeted Disease-Modifying Antirheumatic Drug

    Machaon Bonafede1, Wenhui Wei2, Chieh-I Chen3, Donna McMorrow1, Stefano Fiore4, Jonathan Fay3, Toshio Kimura3 and Jeffrey R. Curtis5, 1Truven Health Analytics, Cambridge, MA, 2Sanofi US, Inc., Bridgewater, NJ, 3Regeneron Pharmaceuticals, Inc., Tarrytown, NY, 4Sanofi Genzyme, Bridgwater, NJ, 5Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL

    Background/Purpose: Patients with rheumatoid arthritis (RA) who have an inadequate response to a tumor necrosis factor inhibitor (TNFi) can switch to another targeted disease-modifying antirheumatic…
  • Abstract Number: 2000 • 2016 ACR/ARHP Annual Meeting

    Incidence of Cancer in Patients with Rheumatoid Arthritis and a History of Cancer Treated with Rituximab or Abatacept

    Jacques-Eric Gottenberg1, Philippe Ravaud2, Thomas Bardin3, Alain Cantagrel4, Bernard Combe5, Maxime Dougados6, RENE MARC FLIPO7, Olivier Vittecoq8, Thierry Schaeverbeke9, Isabelle Pane10, Jean Sibilia11, Xavier Mariette12 and on behaf of all of the investigators of the AIR registry and of the French Society of Rheumatology , 1Department of Rheumatology, Strasbourg University Hospital, Strasbourg, France, 2Epidemiology, Hotel Dieu, PARIS, France, 3Clinique de Rhumatologie, Hopital Lariboisiere, Paris Cedex 10, France, 4Rheumatology, INSERM CNRS UMR 1043, Paul Sabatier University Toulouse, Purpan Teaching Hospital, Toulouse, France, 5Département Rhumatologie, Hôpital Lapeyronie, Montpellier, France, 6Rheumatology, Paris Descartes University, Paris, France, 7Rheumatology, Department of Rheumatology, CHU Teaching Hospital Lille, France., Lille, France, 8INSERM U905 & Normandy University, Institute for Research and Innovation in Biomedicine, Rouen, France, 9Rheumatology, CHU Bordeaux, Bordeaux, France, 10Epidemiology, Hotel Dieu, Paris, France, 11Department of Rheumatology, Strasbourg University Hospital, Strasbourg, France, 12Institut National de la Santé et de la Recherche Médicale, Université Paris-Sud, AP-HP, Hôpitaux Universitaires Paris-Sud, Paris, France

    Background/Purpose: Patients with a history of cancer were excluded from pivotal clinical trials evaluating biologics. Therefore, only registries can inform us on the incidence of…
  • Abstract Number: 2001 • 2016 ACR/ARHP Annual Meeting

    Perioperative Use of Synthetic Disease-Modifying Anti-Rheumatic Drugs or Tumor Necrosis Factor α Inhibitors Does Not Associate with Increased Rates of Post-Operative Infections

    Hsin-Hsuan Juo1,2, Anders Peck3,4, Nancy Gove5 and Bernard Ng1,2, 1Division of Rheumatology, Department of Medicine, University of Washington, Seattle, WA, 2Rheumatology, VA Puget Sound Healthcare System, Seattle, WA, 3Medicine / Rheumatology, University of Washington, Seattle, WA, 4The Seattle Arthritis Clinic, Seattle, WA, 5Biostatistics, Seattle Children's Research Institute, Seattle, WA

    Background/Purpose: The aim of the study is to assess whether the risk of post-operative infectious complications in rheumatoid arthritis (RA) patients undergoing surgical procedures is…
  • Abstract Number: 2002 • 2016 ACR/ARHP Annual Meeting

    Differences in Features of Chronic Back Pain in First Degree Relatives of Patients with Ankylosing Spondylitis (AS) Compared to the U.S. Population

    David Kung1, Michael Weisman2, MinJae Lee3, Lianne S. Gensler4, Michael Ward5, Amirali Tahanan3, Laura A. Diekman1, Shervin Assassi6, Mohammad H. Rahbar3 and John D. Reveille1, 1Rheumatology, University of Texas-McGovern Medical School, Houston, TX, 2Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, 3Biostatistics/Epidemiology/Research Design (BERD) Core | Center for Clinical and Translational Sciences, University of Texas-McGovern Medical School, Houston, TX, 4Medicine/Rheumatology, UCSF, San Francisco, CA, 5NIH/NIAMS, Bethesda, MD, 6Department of Internal Medicine - Rheumatology, University of Texas-McGovern Medical School, Houston, TX

    Background/Purpose:  To compare the clinical features of spondyloarthritis in first degree relatives (FDRs) of patients with ankylosing spondylitis (AS) with chronic back pain (CBP) with…
  • Abstract Number: 2003 • 2016 ACR/ARHP Annual Meeting

    Validation of the ASAS Health Index: Results of a Multicenter International Study in 23 Countries

    Uta Kiltz1, Désirée van der Heijde2, Annelies Boonen3, Jürgen Braun1 and ASAS HI international validation study, 1Rheumazentrum Ruhrgebiet, Herne, Germany, 2Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 3Department of Internal Medicine, Division of Rheumatology, Maastricht University Medical Center, Maastricht, Netherlands

    Background/Purpose:  The ASAS Health Index (ASAS HI) was developed to measure functioning and health in patients with spondyloarthritis (SpA) aiming to better define the impact…
  • Abstract Number: 2004 • 2016 ACR/ARHP Annual Meeting

    Is Disease Activity Associated with Work Productivity Loss, Presenteeism and Absenteeism in Patients with Early Axial Spondyloarthritis? Results from the Spondyloarthritis Caught Early (SPACE)-Cohort

    Miranda van Lunteren1, Pauline Bakker1, Zineb Ez-Zaitouni1, Camilla Fongen2, Robert Landewé3, Maikel van Oosterhout4, Roberta Ramonda5, Floris van Gaalen1 and Désirée van der Heijde1, 1Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 2Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, 3Rheumatology, Academic Medical Center, Amsterdam, Netherlands, 4Rheumatology, Groene Hart Hospital, Gouda, Netherlands, 5Rheumatology Unit, University of Padova, Padova, Italy

    Background/Purpose: Disease activity has an important impact on work productivity in patients with Ankylosing Spondylitis (AS). However, if and to what extent this is the…
  • Abstract Number: 2005 • 2016 ACR/ARHP Annual Meeting

    Exploring the Window of Opportunity for Drug-Free Clinical Remission in Patients with Active, Very Early Peripheral Spondyloarthritis

    Philippe Carron1, Gaëlle Varkas2, Heleen Cypers2, Liesbet Van Praet1, Dirk Elewaut2 and Filip van Den Bosch1, 1Department of Rheumatology, Ghent University Hospital, Ghent, Belgium, 2Laboratory for Molecular Immunology and Inflammation, Department of Rheumatology, VIB, Ghent University and Ghent University Hospital, Ghent, Belgium

    Background/Purpose: To evaluate drug-free sustained clinical remission and clinical relapse after induction therapy with golimumab in patients with active peripheral Spondyloarthritis (pSpA) in a very…
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