Abstracts Archive - Page 1534 of 2425 - ACR Meeting Abstracts

Abstract Number: 1748 • 2016 ACR/ARHP Annual Meeting
Effects of Anti-High Mobility Group Box 1 Antibody for MRL/Lpr lupus-Prone Mice
Haruki Watanabe¹, Katsue S. Watanabe¹, Keyue Liu², Minglu Yan¹, Sumie Hiramatsu¹, Sonia Zeggar¹, Keiji Ohashi¹, Eri Katsuyama¹, Yoshia Miyawaki¹, Michiko Morishiata³, Takayuki Katsuyama¹, Mariko Narazaki¹, Noriko Tatebe¹, Tomoko Kawabata¹, Ken-ei Sada¹, Masahiro Nishibori² and Jun Wada¹, ¹Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan, ²Department of Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan, ³Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
Background/Purpose: High mobility group box 1 (HMGB1) is a ubiquitous non-histone nuclear protein that exerts proinflammatory functions in the extracellular milieu. Here we evaluate the…
Abstract Number: 1749 • 2016 ACR/ARHP Annual Meeting
The Role of Mucosal-Associated Invariant T (MAIT) Cells in Lupus Dermatitis
Goh Murayama¹, Asako Chiba², Hirofumi Amano³, Ken Yamaji¹, Naoto Tamura¹ and Sachiko Miyake⁴, ¹Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan, ²Juntendo Univ Sch of Med, Juntendo University School of Medicine, Tokyo, Japan, ³Department of Rheumatology and Internal Medicine, Juntendo University School of Medicine, Tokyo, Japan, ⁴Immunology, Juntendo University School of Medicine, Tokyo, Japan
Background/Purpose: Mucosal-associated invariant T (MAIT) cells are innate T cells that are restricted by MHC-related molecule-1 (MR1) and express a semi-invariant TCRa chain: Va7.2-Ja33 in…
Abstract Number: 1750 • 2016 ACR/ARHP Annual Meeting
Down-Regulation of microRNA-200a-3p, Targeting C-Terminal Binding Protein-2 (CtBP2), Is Involved in Hypoproduction of IL-2 in SLE-Derived T Cells
Eri Katsuyama¹, Yan Minglu¹, Katsue Sunahori-Watanabe¹, Sonia Zeggar¹, Sumie Hiramatsu¹, Keiji Ohashi¹, Haruki Watanabe¹, Takayuki Katsuyama¹, Noriko Toyota-Tatebe², Ken-ei Sada¹ and Jun Wada¹, ¹Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan, ²Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science, Okayama, Japan
Background/Purpose: Systemic lupus erythematosus (SLE) is a complex autoimmune disease caused by genetic and epigenetic mechanisms. MicroRNAs (miRNAs) are small non-coding RNAs, post-transcriptionally regulate the…
Abstract Number: 1751 • 2016 ACR/ARHP Annual Meeting
Coagulation Pathway Function in Ischemia/Reperfusion Tissue Injury in Autoimmune Prone Mice
Rachel C. Robbins¹, Christopher Tracy², Jess Edison¹, Suzette Peng³ and Chantal Moratz⁴, ¹Rheumatology, Walter Reed National Military Medical Center, Bethesda, MD, ²Walter Reed National Military Medical Center, Bethesda, MD, ³Food and Drug Administration, Silver Spring, MD, ⁴Uniformed Services University, Bethesda, MD
Results: Tissue Factor Pathway Inhibitor (TFPI) and Anti-thrombin III (ATIII) resulted in reduction of tissue injury, as determined by histopathology scoring. However, TFPI was significantly…
Abstract Number: 1752 • 2016 ACR/ARHP Annual Meeting
IL-23 Promotes the Generation of DNT Cells and Shifts the Balance Between IL-2 and IL-17 Production in Murine and Human SLE
Hong Dai^1,2, Fan He^1,2, George C. Tsokos^1,2 and Vasileios C. Kyttaris^1,2, ¹Rheumatology, Beth Israel Deaconess Medical Center, Boston, MA, ²Harvard Medical School, Boston, MA
Background/Purpose: MRL/lpr mice develop a chronic inflammatory disease characterized by accumulation of CD4-CD8-B220+T cells mimicking human lupus; IL-23 driven IL-17 producing cell contribute to lupus…
Abstract Number: 1753 • 2016 ACR/ARHP Annual Meeting
Signal Transducer and Activator of Transcription (STAT) 3 Regulates Tcrαβ+CD4-CD8- T Cells in Systemic Lupus Erythematosus (SLE)
Fan He^1,2, Hao Li^1,2, George C. Tsokos^1,2 and Vasileios C. Kyttaris^1,2, ¹Rheumatology, Beth Israel Deaconess Medical Center, Boston, MA, ²Harvard Medical School, Boston, MA
Background/Purpose: TCRαβ+CD4-CD8-T cells (double negative T cells, DNT) have been reported to produce inflammatory cytokines such as IL-17, and infiltrate the kidneys of patients with…
Abstract Number: 1754 • 2016 ACR/ARHP Annual Meeting
Double-Negative T (DNT) Cell over-Expressing PD-1 and Helios Is Responsible for Lupus Tissue Injury in Systemic Lupus Erythematosus (SLE): Direct Proof That Increased Interferon Alpha (IFNα) Expression Is Sufficient to Induce SLE in Ifnα-Transgenic Mice
Ken Tsumiyama¹, Chieri Akiyama², Yumi Miyazaki¹, Yasushi Miura², Akira Hashiramoto² and Shunichi Shiozawa¹, ¹Department of Medicine, Rheumatic Diseases Unit, Kyushu University Beppu Hospital, Beppu, Japan, ²Department of Biophysics, Kobe University Graduate School of Health Science, Kobe, Japan
Background/Purpose: Previous studies strongly suggest that interferon α (IFNα) may be the principal driver of SLE, where increased IFNα and IFNα-regulated gene transcripts explain many of the immune…
Abstract Number: 1755 • 2016 ACR/ARHP Annual Meeting
Dendritic Cell-Specific Loss of Caspase 8 Incites Symptoms of Neuropsychiatric Systemic Lupus Erythematosus
Hadijat Makinde¹, Harris R. Perlman² and Carla Cuda¹, ¹Northwestern University, Chicago, IL, ²Department of Medicine, Division of Rheumatology, Northwestern University Feinberg School of Medicine, Northwestern University, Chicago, IL
Background/Purpose: Previous studies implicate dendritic cells (DCs) in the initiation and persistence of systemic lupus erythematosus (SLE), and although DCs from SLE patients exhibit elevated…
Abstract Number: 1756 • 2016 ACR/ARHP Annual Meeting
Novel Role of Rho Kinase in Neutrophil Netosis during UVB Induced-Skin Inflammation
Ming-Lin Liu^1,2, Meena Sharma^2,3 and Victoria P. Werth^4,5, ¹Department of Dermatology,, Philadelphia V.A. Medical Center, Philadelphia, PA, ²Department of Dermatology, University of Pennsylvania, Philadelphia, PA, ³Department of Dermatology, Philadelphia V.A. Medical Center, Philadelphia, PA, ⁴Dermatology, University of Pennsylvania, Philadelphia, PA, ⁵Philadelphia V.A. Medical Center, Philidelphia, PA
Background/Purpose: Skin inflammation appears in cutaneous or systemic lupus erythematosus. Ultraviolet B (UVB) is an important environmental trigger of skin inflammation in lupus. Mechanisms linking…
Abstract Number: 1757 • 2016 ACR/ARHP Annual Meeting
Association of the Lupus Low Disease Activity State (LLDAS) with Health-Related Quality of Life
Vera Golder¹, Rangi Kandane-Rathnayake², Alberta Y. Hoi³, Molla Huq⁴, Worawit Louthrenoo⁵, Yuan An⁶, Zhanguo Li⁶, Shue Fen Luo⁷, Sargunan Sockalingam⁸, Chak Sing Lau⁹, Mo Yin Mok¹⁰, Aisha Lateef¹¹, Kate Franklyn³, Susan Morton¹², Sandra V. Navarra¹³, Leonid Zamora¹³, Yeong-Jian Wu⁷, Laniyati Hamijoyo¹⁴, Madelynn Chan¹⁵, Sean O'Neill¹⁶, Fiona Goldblatt¹⁷, Mandana Nikpour¹⁸, Eric F Morand³ and Asia Pacific Lupus Collaboration, ¹Southern Clinical School, Centre for Inflammatory Diseases, Monash University, Melbourne, Australia, ²Rheumatology, Monash University, Melbourne, Australia, ³Centre for Inflammatory Diseases, Monash University, Melbourne, Australia, ⁴Department of Medicine (Rheumatology), Melbourne University, Melbourne, Australia, ⁵Division of Rheumatology, Department of Internal Medicine, Chiang Mai University, Chiang Mai, Thailand, ⁶Peking University People's Hospital, Beijing, China, ⁷Chang Gung University, Taoyuan County, Taiwan, ⁸University of Malaya, Kuala Lumpur, Malaysia, ⁹Univ Dept of Medicine, Queen Mary Hospital, Hong Kong, Hong Kong, ¹⁰Queen Mary Hospital, Hong Kong, Hong Kong, ¹¹Medicine/Rheumatology, National University Health System, Singapore, Singapore, ¹²Monash Health, Melbourne, Australia, ¹³Rheumatology, University of Santo Tomas Hospital, Manila, Philippines, ¹⁴University of Padjadjaran, Bandung, Indonesia, ¹⁵Tan Tock Seng Hospital, Singapore, Singapore, ¹⁶University of New South Wales, Sydney, Australia, ¹⁷Royal Adelaide Hospital, Adelaide, Australia, ¹⁸Melbourne University, Melbourne, Australia
Background/Purpose: Systemic lupus erythematosus (SLE) is associated with significant impairment of health-related quality of life (HR-QoL). Recently, meeting a definition of a Lupus Low Disease…
Abstract Number: 1758 • 2016 ACR/ARHP Annual Meeting
Physical Activity and Sedentary Behaviour in Patients with Systemic Lupus Erythematosus and Rheumatoid Arthritis
Alexandra Legge¹, John Hanly² and Chris Blanchard¹, ¹Department of Medicine, Dalhousie University, Halifax, NS, Canada, ²Division of Rheumatology, Department of Medicine and Department of Pathology, Queen Elizabeth II Health Sciences Centre and Dalhousie University, Halifax, NS, Canada
Background/Purpose: Patients with systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) are at increased risk for premature cardiovascular disease. As sedentary behaviour and lack of…
Abstract Number: 1759 • 2016 ACR/ARHP Annual Meeting
Sleep Disturbance Is Associated with Worsening Patient-Reported Outcomes over Two Years in Systemic Lupus Erythematosus (SLE)
Patricia P. Katz¹, Laura Trupin¹, Gabriela Schmajuk², Jinoos Yazdany¹, Edward H. Yelin¹ and Lindsey A. Criswell³, ¹Medicine/Rheumatology, University of California, San Francisco, San Francisco, CA, ²San Francisco VA Medical Center, University of California, San Francisco, San Francisco, CA, ³Division of Rheumatology, UCSF, San Francisco, CA
Background/Purpose: Although studies to date have suggested sleep disturbance among individuals with SLE, prior studies have been small and have examined a limited number of…
Abstract Number: 1760 • 2016 ACR/ARHP Annual Meeting
Systemic Lupus Erythematosus in Immigrants: Results from the 1000 Canadian Faces of Lupus Study
Amber Cogar¹, Janet E. Pope², Earl Silverman³, Paul R. Fortin⁴, Carol Hitchon⁵, Ann E. Clarke⁶, Christian Pineau⁷, Sasha Bernatsky^8,9, C Douglas Smith¹⁰, Marie Hudson¹¹, Adam Huber¹², Lori B. Tucker¹³, Michel Zummer¹⁴, Gaëlle Chédeville¹⁵, Hector Arbillaga¹⁶, Deborah M. Levy¹⁷, Christine A. Peschken¹⁸ and Canadian Network for Improved Outcomes in Systemic Lupus Erythematosus, ¹Medicine, University of Manitoba, Winnipeg, MB, Canada, ²University of Western Ontario, St Joseph's Health Care, London, ON, Canada, ³University of Toronto, Toronto, ON, Canada, ⁴Medicine, CHU de Québec - Université Laval, Québec, QC, Canada, ⁵University of Manitoba, Winnipeg, MB, Canada, ⁶Division of Rheumatology, University of Calgary, Calgary, AB, Canada, ⁷Rheumatology, MUHC, Montreal, QC, Canada, ⁸Division of Rheumatolog, McGill University Health Center, Montreal, QC, Canada, ⁹Division of Rheumatology and Clinical Epidemiology, McGill University, Montreal, Quebec, QC, Canada, ¹⁰The Arthritis Centre, TOH Riverside Campus, Ottawa, ON, Canada, ¹¹Medicine/Rheumatology, Jewish General Hospital, Lady Davis Research Institute, Montreal, QC, Canada, ¹²IWK Health Centre, Halifax, NS, Canada, ¹³Pediatric Rheum/Rm K4-120, BC Childrens Hospital, Vancouver, BC, Canada, ¹⁴Rheumatology, Ch Maisonneuve-Rosemont, Montreal, QC, Canada, ¹⁵Rheumatology, McGill University, Montreal, QC, Canada, ¹⁶Calgary Rheumatology, Calgary, AB, Canada, ¹⁷Division of Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada, ¹⁸Arthritis Center, University of Manitoba, Winnipeg, MB, Canada
Background/Purpose: Ethnic differences in SLE are well known, but little is known about SLE in patients who have immigrated to North America from elsewhere in…
Abstract Number: 1761 • 2016 ACR/ARHP Annual Meeting
Fatigue in Patients with Systemic Lupus Erythematosus Is Independent of Their Disease Activity but Dependent on Their Damage Accrual and Body Mass Index
Adam Munday¹, Zerai G. Manna¹, Sarfaraz Hasni¹, Randall Keyser², Liana Wooten² and Ann Biehl³, ¹National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ²George Mason University Department of Rehabilitation Science, Fairfax, VA, ³Department of Pharmacy, National Institutes of Health Clinical Center, Bethesda, MD
Background/Purpose: Fatigue is omnipresent in patients with SLE. According to one study 80-90 % of the subjects report some degree of fatigue. This has huge…
Abstract Number: 1762 • 2016 ACR/ARHP Annual Meeting
Systemic Lupus Erythematosus and the Evaluation of Poor Sleep
Philip Chu¹, Alicia Hinze², Nancy Mathis³, Lacey Feigl⁴, Noor Al-Hammadi⁵, Seth Eisen⁶, Yo-El Ju⁷ and Alfred Kim⁸, ¹Internal Medicine, Washington University School of Medicine, St Louis, MO, ²Johns Hopkins University, Baltimore, MD, ³Rheumatology, Washington University School of Medicine, Saint Louis, MO, ⁴Washington University School of Medicine, St Louis, MO, ⁵Division of Biostatistics, Washington University School of Medicine, St Louis, MO, ⁶Division of Rheumatology, Washington University School of Medicine, St Louis, MO, ⁷Neurology, Washington University School of Medicine, Saint Louis, MO, ⁸IM/Div of Rheumatology, Washington University School of Medicine, St. Louis, MO
Background/Purpose: Poor sleep quality is an underappreciated complaint commonly observed in patients with SLE. We hypothesize that poor sleep quality contributes to worsening lupus disease…

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