Abstracts Archive - Page 1533 of 2607 - ACR Meeting Abstracts

Abstract Number: 2186 • 2017 ACR/ARHP Annual Meeting
The Role of Hip Injury in Pain Exacerbation in Hip Osteoarthritis: an Internet-Based Case-Crossover Study
Kai Fu¹, Joanna Makovey², Ben Metcalf³, Kim Bennell³, Yuqing Zhang⁴, Rebecca Asher⁵, Sarah Meneses², Leticia Deveza² and David Hunter², ¹Rheumatology, Institute of Bone and Joint Research, Kolling Institute, University of Sydney, Syndey, Australia, ²Rheumatology, Institute of Bone and Joint Research, Kolling Institute, University of Sydney, Sydney, Australia, ³Centre for Health, Exercise and Sports Medicine, Department of Physiotherapy, University of Melbourne, Melbourne, Australia, ⁴School Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ⁵NHMRC Clinical Trials Centre, University of Sydney, Sydney, Australia
Background/Purpose: Pain is the main symptom in hip osteoarthritis (OA) and many patients experience recurrent pain exacerbations. The purpose of this study is to evaluate…
Abstract Number: 2187 • 2017 ACR/ARHP Annual Meeting
Association of Circulating microRNAs with Prevalent and Incident Osteoarthritis in Women: The Ofely Study
Jean-Charles Rousseau¹, Marjorie Millet¹, Martine Croset¹, Elisabeth Sornay-Rendu², Olivier Borel² and Roland Chapurlat³, ¹INSERM 1033, Lyon, France, ²INSERM 1033, E. Herriot Hospital, Hospices Civils de Lyon, Lyon, France, ³INSERM 1033, University of Lyon, E. Herriot Hospital, Hospices Civils de Lyon, Lyon, France
Background/Purpose: Sensitive and specific blood biomarkers to detect the initial stages of osteoarthritis (OA) and to predict the future development of the disease are not…
Abstract Number: 2188 • 2017 ACR/ARHP Annual Meeting
Risk of Disability in Underweight Persons with or at Increased Risk of Knee Osteoarthritis
Nilasha Ghosh, Joan S. Chmiel, Orit Almagor, Karen W. Hayes, Kirsten C. Moisio, Alison H. Chang, Julie Szymaszek and Leena Sharma, Northwestern University, Chicago, IL
Background/Purpose: US studies have revealed a U-shaped relationship between BMI and poor outcomes (function, mortality); both underweight and overweight/obese persons have greater risk. In knee…
Abstract Number: 2189 • 2017 ACR/ARHP Annual Meeting
Metabolic Syndrome Influences the Radiographic Progression of Knee Osteoarthritis and Condition the Risk of Erosive Hand OA
Natividad Oreiro¹, Mercedes Fernandez Moreno², Estefanía Cortés-Pereira², Maria Eugenia Vazquez Mosquera³, Sonia Pertega⁴, Sara Relaño-Fernandez⁵, Ana Cecilia Raga⁶, Carlos Fernandez-Lopez⁶, Ignacio Rego-Pérez⁶ and Francisco J Blanco⁶, ¹Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña. España, A Coruna, Spain, ²Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña, España, A Coruna, Spain, ³Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña, España, A Coruña, Spain, ⁴Unidad de Epidemiología Clínica y Bioestadística. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña, España, A Coruña, Spain, ⁵Plataforma de Genómica. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña, España, A Coruña, Spain, ⁶Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña. España, A Coruña, Spain
Background/Purpose: The contribution of metabolic factors in the development of OA has not been fully elucidated. The aim of this work is to analyze the…
Abstract Number: 2190 • 2017 ACR/ARHP Annual Meeting
War and Arthritis
Rohan Sharma¹, Casey Cooper², Kaustubh Chaudhari³, Sixia Chen⁴ and R. Hal Scofield⁵, ¹Medicine and Public Health, Univeristy of Oklahoma Health Sciences Center, Oklahoma City, OK, ²Public Health, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ³Medicine, Departhment of Veterans Affairs Medical Center, Oklahoma City, OK, ⁴Biostatistics and Epidemiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ⁵Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation; Department of Medicine, University of Oklahoma Health Sciences Center; US Department of Veterans Affairs Medical Center, Oklahoma City, OK
Background/Purpose: Veterans have increased predilection for multiple health conditions. We undertook this study to investigate the possible association of participation in active military duty in…
Abstract Number: 2191 • 2017 ACR/ARHP Annual Meeting
Widespread Regulation of Gene Expression By Glucocorticoids in Chondrocytes from OA Patients As Determined By NGS-Based Genome Wide Expression Analysis
Antti Pemmari, Erja-Leena Paukkeri, Mari Hämäläinen, Tiina Leppänen and Eeva Moilanen, The Immunopharmacology Research Group, Faculty of Medicine and Life Sciences, University of Tampere and Tampere University Hospital, Tampere, Finland, Tampere, Finland
Background/Purpose: In osteoarthritis (OA), chondrocytes display marked changes in their gene expression profile. Some of these are thought to be protective [e.g. increased synthesis of…
Abstract Number: 2192 • 2017 ACR/ARHP Annual Meeting
Association between Mitochondrial DNA (mtDNA) Haplogroups and Bone Marrow Lesions at 24 Months in Osteoarthritis Subjects: Subjets from the Osteoarthritis Initiative
Ignacio Rego-Pérez¹, Jean-Pierre Pelletier², François Abram³, Natividad Oreiro⁴, Carlos Fernandez-Lopez¹, Ana Cecilia Raga¹, Francisco J Blanco¹ and Johanne Martel-Pelletier², ¹Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña. España, A Coruña, Spain, ²Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Montreal, QC, Canada, ³Medical Imaging Research & Development, ArthroLab Inc., Montreal, QC, Canada, ⁴Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña. España, A Coruna, Spain
Background/Purpose: Bone marrow lesions (BMLs) have been consistently associated with the development of osteoarthritis (OA); however the extent to which they are genetically driven by…
Abstract Number: 2193 • 2017 ACR/ARHP Annual Meeting
Physical Activity and Disease Progression in Persons with or at Higher Risk for Knee Osteoarthritis
Prakash Jayabalan^1,2, Gerald W. Rouleau¹, Masha Kocherginsky¹, Dorothy D. Dunlop¹, Julia (Jungwha) Lee¹, Rowland W. Chang¹ and Leena Sharma¹, ¹Northwestern University, Chicago, IL, ²Shirley Ryan AbilityLab, Chicago, IL
Background/Purpose: The benefits of physical activity in the general population and among persons with knee osteoarthritis (OA) are well-established. However, it remains unclear if inactivity…
Abstract Number: 2194 • 2017 ACR/ARHP Annual Meeting
The Relationship between the Number of Prescription Medications and Physical Activity Amongst Patients with or at High Risk for Knee Osteoarthritis
Nivaas Thanoo¹, Abigail Gilbert², Jing Song³, Dorothy D. Dunlop⁴ and Rowland W. Chang⁵, ¹Feinberg School of Medicine, Chicago, IL, ²Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ³Center for Healthcare Studies, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁴Inst Hlthcare Studies, Northwestern Univ/ Feinberg, Chicago, IL, ⁵Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose: Physical activity amongst individuals with knee osteoarthritis (KOA) has been linked to improved pain, functional status, and less disability. It is important to understand…
Abstract Number: 2195 • 2017 ACR/ARHP Annual Meeting
The Relationship between Self-Reported Restless Sleep and Objectively Measured Physical Activity
Abigail Gilbert¹, Julia (Jungwha) Lee², Jing Song³, Pamela Semanik⁴, Linda S. Ehrlich-Jones⁵, C. Kent Kwoh⁶, Dorothy D. Dunlop³ and Rowland W. Chang^7,8, ¹Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ²Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, ³Center for Healthcare Studies, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁴College of Nursing, Rush University, Chicago, IL, ⁵Research CROR, Shirley Ryan AbilityLab, Chicago, IL, ⁶University of Arizona, Tucson, AZ, ⁷Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁸Preventive Medicine, Medicine, and Physical Medicine & Rehabilitation, Northwestern University Feinberg School of Medicine, Chicago, IL
Title: The Relationship between Self-reported Restless Sleep and Objectively Measured Physical ActivityBackground/Purpose: Despite many health benefits of physical activity, inactivity is endemic among adults, especially…
Abstract Number: 2196 • 2017 ACR/ARHP Annual Meeting
An Exploratory Analysis of Physical Activity Levels and the Presence of Bone Marrow Lesions in Adults with Knee Osteoarthritis: Data from the Osteoarthritis Initiative
Amanda R. Canavatchel¹, Lori Lyn Price², Jeffrey B. Driban³, Ming Zhang¹, Grace H. Lo⁴ and Timothy E. McAlindon⁵, ¹Tufts Medical Center, Boston, MA, ²Tufts Clinical and Translational Science Institute, Tufts University, Boston, MA, ³Rheumatology, Tufts Medical Center, Boston, MA, ⁴Immunology, Allergy, Rheumatology, Baylor College of Medicine, Houston, TX, ⁵Division of Rheumatology, Tufts Medical Center, Boston, MA
Background/Purpose: Many people with knee OA have bone marrow lesions (BMLs). BMLs are related with structural pathology and pain. Some investigators have found an association…
Abstract Number: 2197 • 2017 ACR/ARHP Annual Meeting
Systemic Inflammation and Physical Function in Knee Osteoarthritis
Devyani Misra¹, Carrie Brown², Roger A. Fielding³, Tuhina Neogi⁴, Michael C. Nevitt⁵, Cora E. Lewis⁶, James Torner⁷ and David T. Felson⁴, ¹Medicine, Section of, Boston University School of Medicine, Boston, MA, ²Boston University School of Public Health, Boston, MA, ³Nutrition, Exercise Physiology and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, ⁴Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, ⁵Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, ⁶University of Alabama Birmingham, Birmingham, AL, ⁷University of Iowa, Iowa City, IA
Background/Purpose: Knee osteoarthritis (OA) is a leading cause of functional limitation and disability in older adults. But why some knee OA patients develop functional limitation…
Abstract Number: 2198 • 2017 ACR/ARHP Annual Meeting
Combinatorial Peripheral Blood Inflammatory and MRI-Based Biomarkers Predict Radiographic Joint Space Narrowing in Knee OA
Svetlana Krasnokutsky Samuels¹, Hua Zhou², Mukundan Attur¹, Jonathan Samuels¹, Gregory Chang³, Jenny Bencardino⁴, Sisi Ma², Leon Rybak³ and Steven B. Abramson⁵, ¹Rheumatology, NYU Langone Medical Center, New York, NY, ²Bioinformatics, New York University, New York, NY, ³Department of Radiology, NYU Langone Medical Center, New York, NY, ⁴Radiology, NYU Langone Medical Center, New York, NY, ⁵Dept of Medicine, NYU Langone Medical Center, New York, NY
Background/Purpose: Inflammation contributes to OA disease pathogenesis. Subsets of knee OA patients with peripheral blood leukocyte (PBL) detected inflammatory gene expression profiles exhibit more rapid…
Abstract Number: 2199 • 2017 ACR/ARHP Annual Meeting
Feasibility of a Novel Approach to Studying Early Knee Osteoarthritis: An Offspring Study
Grace H. Lo¹, Jane A. Cauley², Michael T. Strayhorn³, Mary Jansen⁴, Michael J Hannon⁵, Donna White⁶, Stephanie Green⁷ and C. Kent Kwoh^8,9, ¹Immunology, Allergy, Rheumatology, Baylor College of Medicine, Houston, TX, ²Department of Epidemiology, Univ of Pittsburgh, Pittsburgh, PA, ³VA HSR&D Center for Innovations in Quality, Effectiveness and Safety; Department of Medicine, Michael E. DeBakey VA Medical Center, Baylor College of Medicine, Houston, TX, ⁴University of Pittsburgh, Pittsburgh, PA, ⁵Medicine, University of Pittsburgh, Pittsburgh, PA, ⁶Baylor College of Medicine, Houston, TX, ⁷Univeristy of Pittsburgh, Houston, PA, ⁸University of Arizona, Tucson, AZ, ⁹1501 N. Campbell Avenue, Room 8303, The University of Arizona Arthritis Center, Tucson, AZ
Background/Purpose: Much of osteoarthritis (OA) research has focused on identifying treatments for late stage disease. However, interventions in early disease may be most effective. Capitalizing…
Abstract Number: 2200 • 2017 ACR/ARHP Annual Meeting
History of Walking for Exercise Is Not Associated with More Symptomatic Knee Osteoarthritis: Data from the Osteoarthritis Initiative
Grace H. Lo¹, Jeffrey B. Driban², Andrea Kriska³, Timothy E. McAlindon⁴, Richard Souza⁵, Nancy J. Petersen⁶, Bonny Jane Rockette-Wagner⁷, Charles Eaton⁸, Marc Hochberg⁹, Rebecca D. Jackson¹⁰, C. Kent Kwoh¹¹, Michael C. Nevitt¹² and Maria Suarez-Almazor¹³, ¹Immunology, Allergy, Rheumatology, Baylor College of Medicine, Houston, TX, ²Rheumatology, Tufts Medical Center, Boston, MA, ³University of Pittsburgh, Pittsburgh, PA, ⁴Division of Rheumatology, Tufts Medical Center, Boston, MA, ⁵University of California, San Francisco, San Francisco, CA, ⁶Medicine, Baylor College of Medicine, Houston, TX, ⁷University of Pittsburgh Medical Center, Pittsburgh, PA, ⁸Family Medicine and Epidemiology, Warren Alpert Medical School, School of Public Health, Brown University, Providence, RI, ⁹Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, ¹⁰Ohio State University, Columbus, OH, ¹¹University of Arizona, Tucson, AZ, ¹²Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, ¹³Section of Rheumatology and Clinical Immunology, Department of General Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA, Houston, TX
Background/Purpose: Walking is recommended for those with knee OA (KOA). However, few studies have explored the association between walking and symptomatic OA, and conflicting data…

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