ACR Meeting Abstracts

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  • Abstract Number: 1688 • 2016 ACR/ARHP Annual Meeting

    Ixekizumab Provides Sustained Improvement up to 52 Weeks of Disease Activity As Assessed By Composite Measure Scores in Biologic Disease-Modifying Antirheumatic Drug-Naive Patients with Active Psoriatic Arthritis

    Laura C. Coates1, M. Elaine Husni2, Catherine L. Shuler3, Hilde Carlier3, Chen-Yen Lin3, Jiani Mou3, Chin H. Lee3 and Philip J Mease4, 1University of Leeds, Leeds, United Kingdom, 2Rheumatology, Cleveland Clinic Foundation, Cleveland, OH, 3Eli Lilly and Company, Indianapolis, IN, 4Rheumatology Research, Swedish Medical Center and University of Washington, Seattle, WA

    Background/Purpose: PsA, a chronic immune-mediated inflammatory disease, can be progressive and destructive, resulting in physical deformities, impaired function, decreased quality of life, and increased mortality.…
  • Abstract Number: 1689 • 2016 ACR/ARHP Annual Meeting

    Ixekizumab Provides Improvements through 52 Weeks in Physical Function, Quality of Life, and Work Productivity in Biologic Disease-Modifying Antirheumatic Drug-Naive Patients with Active Psoriatic Arthritis

    Alice B. Gottlieb1, M. Elaine Husni2, Catherine L. Shuler3, Russel T. Burge3, Chen-Yen Lin3, Chin H. Lee3 and D Gladman4, 1Tufts University School of Medicine, Boston, MA, 2Rheumatology, Cleveland Clinic Foundation, Cleveland, OH, 3Eli Lilly and Company, Indianapolis, IN, 4University of Toronto, Toronto, ON, Canada

    Background/Purpose: PsA has a negative impact on patients’ quality of life, physical function, and work productivity. Ixekizumab (IXE) is an IgG4 mAb that binds with…
  • Abstract Number: 1690 • 2016 ACR/ARHP Annual Meeting

    Efficacy and Safety of Apremilast and Switch from Etanercept in Patients with Moderate to Severe Psoriasis: 52-Week Results

    Kristian Reich1, Jennifer Soung2, Melinda Gooderham3, Zuoshun Zhang4, Kristine Nograles4, Robert M. Day4, Laura Ferris5 and Mark Goodfield6, 1SCIderm Research Institute and Dermatologikum Hamburg, Hamburg, Germany, 2Southern California Dermatology, Santa Ana, CA, 3SKiN Centre for Dermatology and Probity Medical Research, Peterborough, ON, Canada, 4Celgene Corporation, Summit, NJ, 5University of Pittsburgh, Pittsburgh, PA, 6Department of Dermatology, Leeds Centre for Dermatology, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom

    Background/Purpose: Psoriasis is a chronic systemic inflammatory disease often treated with conventional systemic and biologic drugs that may variously be ineffective, be inaccessible, or pose…
  • Abstract Number: 1691 • 2016 ACR/ARHP Annual Meeting

    The Comparative Immunogenicity of Biologic Therapy and Its Clinical Relevance in Psoriatic Arthritis: A Systematic Review of the Literature

    Alejandro Balsa1, Sadiq Lula2, Lisa Marshall3, Piotr Szczypa4 and Laraine Aikman5, 1Rheumatology, IdiPAZ, Hospital Universitario La Paz, Madrid, Spain, 2Envision Pharma Group, London, United Kingdom, 3Inflammation Global Medical Affairs, Pfizer, Collegeville, PA, 4Pfizer Ltd, Sandwich, United Kingdom, 5Pfizer Ltd, Walton Oaks, United Kingdom

    Background/Purpose: Anti-inflammatory biologic agents have been shown to provide significant benefit in controlling disease activity in psoriatic arthritis (PsA) and inhibiting progression of joint damage.…
  • Abstract Number: 1692 • 2016 ACR/ARHP Annual Meeting

    Validation of a Two-Question Patient Reported Outcome Measure for Psoriasis

    Jessica Mounessa1, Darren Lynn1, Jessica Walsh2, Mena Hashim1, Ryan Duong3, Robert Dellavalle1 and Liron Caplan1, 1Denver Veterans Affairs Medical Center and UC Denver SOM, Denver, CO, 2Division of Rheumatology, Salt Lake City Veteran Affairs and University of Utah Medical Centers, Salt Lake City, UT, 3Rheumatology, Denver Veterans Affairs Medical Center and UC Denver SOM, Denver, CO

    Background/Purpose: While the psoriasis area and severity index (PASI) is the most commonly used assessment tool for psoriasis severity, it has been criticized for its…
  • Abstract Number: 1693 • 2016 ACR/ARHP Annual Meeting

    Chronic Back Pain in Early Psoriatic Arthritis

    Kim Wervers1, Jolanda J. Luime2, Ilja Tchetverikov3, Andreas H. Gerards4, Marc R. Kok5, Cathelijne W. Y. Appels6, Wiebo L. van der Graaff7, Hans L. M. van Groenendael8, Lindy-Anne Korswagen9, Jozien Veris10, Johanna M.W. Hazes11 and Marijn Vis2, 1Erasmus Medical Centre, Rotterdam, Netherlands, 2Rheumatology, Erasmus Medical Centre, Rotterdam, Netherlands, 3Albert Schweitzer Hospital, Dordrecht, Netherlands, 4Rheumatology, Vlietland Hospital, Schiedam, Netherlands, 5Rheumatology, Maasstad Hospital, Rotterdam, Netherlands, 6Rheumatology, Amphia Hospital, Breda, Netherlands, 7Rheumatology, Rivas hospital, Gorinchem, Netherlands, 8Rheumatology, Reumazorg Zuid West Nederland, Roosendaal, Netherlands, 9Sint Franciscus Gasthuis, Rotterdam, Netherlands, 10Rheumatology, Reumazorg Zuid West Nederland, Goes, Netherlands, 11Department of Rheumatology, Erasmus Medical Center, Rotterdam, Netherlands

    Background/Purpose: Axial involvement is less well studied in peripheral spondyloarthritis where chronic back pain is not the predominant symptom, such as in psoriatic arthritis (PsA).…
  • Abstract Number: 1694 • 2016 ACR/ARHP Annual Meeting

    Does Treat to Target or Achieving Remission Improve Radiographic Outcome in Psa?

    Laura C. Coates1,2, Elizabeth M.A. Hensor1,3, Paul Emery4, Philip G. Conaghan1 and Philip S. Helliwell5, 1Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, 2NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds, United Kingdom, 3NIHR-Leeds Musculoskeletal Biomedical Research Unit, Leeds, United Kingdom, 4NIHR-Leeds Musculoskeletal Biomedical Research Unit and Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, 5NIHR-Leeds Musculoskeletal Biomedical Research Unit, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom

    Background/Purpose:   The Tight Control of PsA (TICOPA) study was the first to address treat to target in PsA using the minimal disease activity (MDA)…
  • Abstract Number: 1695 • 2016 ACR/ARHP Annual Meeting

    Pharmacological Monitoring of Adalimumab and Etanercept-Treated Psoriatic Arthritis Patients in Predicting Future Treatment Response

    Meghna Jani1, Hector Chinoy2, Anne Barton2 and on behalf of OUTPASS, 1Centre for Musculoskeletal Research, The University of Manchester, Manchester, United Kingdom, 2Centre for Musculoskeletal Research, University of Manchester, Manchester, United Kingdom

    Background/Purpose: Up to 40% of patients with inflammatory arthritis on TNF-α inhibitor (TNFi) treatment fail to respond either due to primary inefficacy or loss of…
  • Abstract Number: 1696 • 2016 ACR/ARHP Annual Meeting

    Minimal Disease Activity Is a Stable Measure of Therapeutic Response in Psoriatic Arthritis Patients Receiving Treatment with Adalimumab

    Frank Behrens1, Michaela Koehm2, Eva Christina Schwaneck3, Marc Schmalzing4, Holger Gnann5, Gerd Greger6, Hans-Peter Tony7 and Harald Burkhardt1, 1Division of Rheumatology and Fraunhofer IME-Project-Group Translational Medicine and Pharmacology, Goethe University, Frankfurt, Germany, 2Division of Rheumatology and Fraunhofer IME-Project-Group Translational Medicine and Pharmacology, Goethe University, Frankfurt/Main, Germany, 3Rheumatology/Immunology, Medical Clinic II, University Clinic Wuerzburg, Wuerzburg, Germany, 4Rheumatology/Clinical Immunology, Medical Clinic II, University Clinic Wuerzburg, Würzburg, Germany, 5Abteilung Biostatistik, GKM Gesellschaft für Therapieforschung mbH, München, Germany, 6AbbVie Deutschland GmbH & Co.KG, Wiesbaden, Germany, 7Rheumatology/Immunology, Medical Clinic II, University Clinic Wuerzburg, Würzburg, Germany

    Background/Purpose: Minimal disease activity (MDA) is an important goal for patients with rheumatologic disorders, including psoriatic arthritis (PsA). The assessment of MDA could potentially help…
  • Abstract Number: 1697 • 2016 ACR/ARHP Annual Meeting

    Validity of Diagnostic Codes and Point Prevalence of Psoriatic Arthritis in Israel – a Population-Based Study

    Lihi Eder1, Arnon Dov Cohen2,3, Ilan Feldhamer3, Sari Greenberg-Dotan3, Erez Batat3 and Devy Zisman4,5, 1Medicine, University of Toronto, Women's College Hospital, Toronto, ON, Canada, 2Siaal Research Center for Family Medicine and Primary Care, Ben-Gurion University of the Negev, Beer-Sheba, Israel, 3Chief Physician's Office, Clalit Health Services, Tel Aviv, Israel, 4The Ruth and Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel, 5Department of Rheumatology, Carmel Medical Center, Haifa, Israel

    Background/Purpose:  The information on the population-based prevalence of Psoriatic Arthritis (PsA) is limited. Large population-based databases provide an opportunity to study the epidemiology of PsA,…
  • Abstract Number: 1698 • 2016 ACR/ARHP Annual Meeting

    Late Onset Psoriatic Arthritis in a Longitudinal Cohort: Disease Presentation, Activity over Time and Prognosis

    Ari Polachek1, Roa'a Al Johani2, Suzanne Li1, Vinod Chandran1 and Dafna D Gladman3, 1Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, 2Medicine, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, 3University of Toronto, Toronto, ON, Canada

    Background/Purpose: Psoriatic arthritis (PsA) often develops between the 3rd to 5th decades of life. However, little is known about PsA activity and prognosis among patients…
  • Abstract Number: 1699 • 2016 ACR/ARHP Annual Meeting

    RAPID3 Near Remission Shows Good Agreement with Minimal Disease Activity Criteria in Psoriatic Arthritis

    Laura C. Coates1,2, William Tillett3,4, Theodore Pincus5, Arthur Kavanaugh6 and Philip S. Helliwell7, 1Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, 2NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds, United Kingdom, 3Pharmacy and Pharmacology, University of Bath, Bath, United Kingdom, 4Rheumatology, Royal National Hospital for Rheumatic Diseases, Bath, United Kingdom, 5Rheumatology, Rush University Medical Center, Chicago, IL, 6Division of Rheumatology, Allergy, and Immunology, University of California San Diego, La Jolla, CA, 7NIHR-Leeds Musculoskeletal Biomedical Research Unit, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom

    Background/Purpose:  RAPID3 (routine assessment of patient index data) is a patient self-report index which is feasible in busy clinical settings to assess severity and change…
  • Abstract Number: 1700 • 2016 ACR/ARHP Annual Meeting

    Treating Psoriatic Arthritis (PsA) to Target: Defining Psoriatic Arthritis Disease Activity Score (PASDAS) That Reflects Disease Activity in Psa

    Matthew Got1, Suzanne Li2, Anthony V. Perruccio3,4, Dafna D Gladman1 and Vinod Chandran5, 1University of Toronto, Toronto, ON, Canada, 2University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, 3Krembil Research Institute, Toronto Western Hospital, University Health Network, Toronto, ON, Canada, 4Arthritis Program, Toronto Western Hospital, University Health Network, Toronto, ON, Canada, 5Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada

    Background/Purpose: PASDAS is a composite disease activity measure (range 0–10) for psoriatic arthritis (PsA). Recently, PASDAS disease activity cutoffs were proposed and a minimal disease…
  • Abstract Number: 1701 • 2016 ACR/ARHP Annual Meeting

    The Presence of Depression Might be an Important Determinant of Achieving Minimal Disease Activity State in Psoriatic Arthritis

    Agnes Szentpetery1, Natsumi Ikumi1, Brian Kirby2 and Oliver FitzGerald3, 1St. Vincent's University Hospital, Department of Rheumatology, Dublin, Ireland, 2St. Vincent's University Hospital, Department of Dermatology, Dublin, Ireland, 3St. Vincent's University Hospital, Department of Rheumatology. UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland

    Background/Purpose:   Depression and anxiety are well known comorbidities in psoriasis (PsO) and psoriatic arthritis (PsA) with higher prevalence in PsA. Patients with PsA have…
  • Abstract Number: 1702 • 2016 ACR/ARHP Annual Meeting

    Baseline Patient Characteristics Associated with Response to Biologic Therapy in Patients with Psoriatic Arthritis Enrolled in the Corrona Psoriatic Arthritis/Spondyloarthritis (PsA/SpA) Registry

    Philip J Mease1, Chitra Karki2, Mei Liu2, Arthur Kavanaugh3, Christopher T. Ritchlin4, Doquyen H. Huynh3, Renganayaki Pandurengan2, Jacqueline B. Palmer5 and Jeffrey D. Greenberg2,6, 1Swedish Medical Center and University of Washington, Seattle, WA, 2Corrona, LLC, Southborough, MA, 3University of California San Diego, La Jolla, CA, 4Allergy, Immunology and Rheumatololgy Division, University of Rochester Medical Center, Rochester, NY, 5Novartis Pharmaceuticals Corporation, East Hanover, NJ, 6New York University School of Medicine, New York, NY

    Background/Purpose: The objective of this analysis was to investigate differences in baseline demographic and clinical characteristics of patients with psoriatic arthritis (PsA) who responded to…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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