Abstracts Archive - Page 1510 of 2607 - ACR Meeting Abstracts

Abstract Number: 1841 • 2017 ACR/ARHP Annual Meeting
Can Systemic Lupus (SLE) Disease Activity be Consistently Scored and Interpreted with Simple, Rapid Outcome Measures?
Aikaterini Thanou¹, Stan Kamp², Stavros Stavrakis³, Cristina Arriens⁴, Teresa Aberle², Eliza Chakravarty⁵, Joe Rawdon², Judith A. James⁶, Joan T. Merrill⁵ and Anca Askanase⁷, ¹Arthritis and Clinical Immmunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ³University of Oklahoma Health Sciences Center, Ok, OK, ⁴Arthritis & Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁵Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁶Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁷Rheumatology, Columbia University College of Physicians & Surgeons, New York, NY
Background/Purpose: Clinical trial evaluations in SLE have been problematic, in part due to glossary-based outcome measures that provide imperfect thresholds for grading flares or improvement.…
Abstract Number: 1842 • 2017 ACR/ARHP Annual Meeting
Subsetting Systemic Lupus Erythematosus By Interferon Gene Signatures and Serologies (anti-dsDNA and Low Complement) Uncovers Significant Clinical Diversity
Michelle Petri¹, Steven Watts², Richard Higgs², MaryAnn Morgan-Cox² and Matthew D Linnik³, ¹Medicine (Rheumatology), Division of Rheumatology, Johns Hopkins University School of Medicine, MD, USA, Baltimore, MD, ²Eli Lilly and Company, Indianapolis, IN, ³Immunology, Lilly Biotechnology Center, San Diego, CA
Background/Purpose: Personalized therapy in systemic lupus erythematosus (SLE) will require identifying SLE subsets that will benefit from different targeted therapies. Belimumab, for example, has…
Abstract Number: 1843 • 2017 ACR/ARHP Annual Meeting
Serum Albumin at 12 Months Post Biopsy Has Excellent Sensitivity and Specificity for Favorable 4 Year Renal Outcome in Lupus Nephritis (LN)
Vinicius Domingues¹, Nicole Bornkamp¹, Benjamin A. Levinson², Judith D. Goldberg², Jill P. Buyon¹ and H. Michael Belmont¹, ¹Medicine, New York University School of Medicine, New York, NY, ²Population Health, New York University School of Medicine, New York, NY
Background/Purpose: LN is a common, deleterious manifestation of systemic lupus erythematosus (SLE) and despite recent advances in treatment remains the most significant end organ injury…
Abstract Number: 1844 • 2017 ACR/ARHP Annual Meeting
Circulating Cytokine Profiles Reflect ANCA Specificity in Patients with ANCA-Associated Vasculitis
Alvise Berti¹, Roscoe Warner², Kent Johnson³, Divi Cornec⁴, Darrell Schroder⁵, Brian Kabat⁵, Peter A. Merkel⁶, Carol A. Langford⁷, Gary S. Hoffman⁸, Cees G.M. Kallenberg⁹, Philip Seo¹⁰, Robert F. Spiera¹¹, Eugene St. Clair¹², John H. Stone¹³, Ulrich Specks¹⁴ and Paul A. Monach¹⁵, ¹Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN, ²University of Michigan Medical School, Ann Arbor,, MI, ³University of Michigan Medical School, Ann Arbor, MI, ⁴Pulmonary and Critical Care Medicine, Mayo Clinic College of Medicine and Science, Rochester, MN, ⁵Mayo Clinic, Rochester, MN, ⁶Division of Rheumatology, University of Pennsylvania; Perelman School of Medicine, Philadelphia, PA, ⁷Rheumatic and Immunologic Diseases, Cleveland Clinic, Cleveland, OH, ⁸Rheumatology, Cleveland Clinic, Cleveland, OH, ⁹Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ¹⁰Medicine, Johns Hopkins University, Baltimore, MD, ¹¹Rheumatology, Hospital for Special Surgery, New York, NY, ¹²Department of Medicine, Duke University Medical Center, Durham, NC, ¹³Massachusetts General Hospital Rheumatology Unit, Harvard Medical School, Boston, MA, ¹⁴Mayo Clinic College of Medicine, Rochester, MN, ¹⁵Boston University School of Medicine, Boston, MA
Background/Purpose: To evaluate serum cytokine and chemokine profiles in patients with ANCA-associated vasculitis (AAV) classified by ANCA specificity (proteinase 3 (PR3)-ANCA versus myeloperoxidase (MPO)-ANCA) or…
Abstract Number: 1845 • 2017 ACR/ARHP Annual Meeting
Comparison of Magnetic Resonance Angiography (MRA) and 18f-Fluorodeoxyglucose Positron Emission Tomography (PET) in Large Vessel Vasculitis
Kaitlin A. Quinn^1,2, Ashkan Malayeri³, Mark Ahlman³, Armin Bagheri⁴, Robert Evers⁵, Ali Cahid Civelek³, Elaine Novakovich⁶ and Peter C. Grayson⁷, ¹Rheumatology, MedStar Georgetown University Hospital, Washington, DC, ²NIAMS/NIH, Bethesda, MD, ³Radiology and Imaging Sciences, National Institutes of Health, Bethesda, MD, ⁴Vasculitis Translational Research Program, NIAMS, NIH, Bethesda, MD, ⁵NIH, Bethesda, MD, ⁶Systemic Autoimmunity Branch, NIAMS, National Institutes of Health, Bethesda, MD, ⁷National Institute of Arthritis, Musculoskeletal and Skin Disease (NIAMS), Bethesda, MD
Background/Purpose: Magnetic resonance imaging (MRI) and 18F-fluorodeoxyglucose positron emission tomography (PET) may provide unique or redundant information in large vessel vasculitis (LVV). The study objective…
Abstract Number: 1846 • 2017 ACR/ARHP Annual Meeting
Increased CD38hiCD27+ Plasmablast Frequency in Remission Predicts Relapsing Disease in Granulomatosis with Polyangiitis Patients
Anouk von Borstel¹, Wayel H. Abdulahad², Abraham Rutgers², Judith Land², Coen A. Stegeman¹, Peter Heeringa³ and Jan-Stephan F. Sanders¹, ¹Internal Medicine, Division of Nephrology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ²Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ³Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands
Background/Purpose: Patients with granulomatosis with polyangiitis (GPA) are prone to disease relapse. Changes in anti-neutrophil cytoplasmic autoantibodies (ANCA) levels can predict relapses in individual patients…
Abstract Number: 1847 • 2017 ACR/ARHP Annual Meeting
The IgG4:IgG RNA Ratio in Peripheral Blood Perfectly Differentiates Active Disease from Remission in Granulomatosis with Polyangiitis. a New Disease Activity Marker?
Aram Al-Soudi^1,2,3, Marieke E. Doorenspleet⁴, Rebecca Esveldt⁵, Lot Burgemeister⁵, Liesbeth Hak⁵, Sander W. Tas⁶, Ronald F van Vollenhoven⁷, Paul L. Klarenbeek^5,8 and Niek de Vries^5,9, ¹Dept of Experimental Immunology, Academic Medical Center, Amsterdam, Netherlands, ²Dept of Clinical Immunology & Rheumatology, ARC | Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, ³Dept of Genome Analysis, Academic Medical Center, Amsterdam, Netherlands, ⁴ARC | Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, ⁵Clinical Immunology & Rheumatology, ARC | Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, ⁶Department of Clinical Immunology & Rheumatology and Laboratory for Experimental Immunology, ARC | Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, ⁷Amsterdam Rheumatology and Immunology Center, Amsterdam, Netherlands, ⁸Dept. of Experimental Immunology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, ⁹Laboratory of Experimental Immunology, Academic Medical Center / University of Amsterdam, Amsterdam, Netherlands
Background/Purpose: Granulomatosis with Polyangiitis (GPA) is characterized by vasculitis in lungs, kidneys and the ear, nose and throat region. Regular monitoring and treatment adjustments are…
Abstract Number: 1848 • 2017 ACR/ARHP Annual Meeting
NMR-Based Serum Metabolomics of Patients with Takayasu Arteritis (TA) and Relationship with Disease Activity
Ramnath Misra¹, Avinash Jain², Dinesh Kumar³, Durga Prasanna Misra⁴, Anupam Guleria⁵, Sandeep Kumar⁴, Atul Rawat³, Smriti Chaurasia⁴, Umesh Kumar⁶, Abhishek Zanwar⁴, Durgesh Dubey⁷, Ruchika Goel⁸, Debashish Danda⁹ and Paul Bacon¹⁰, ¹Clinical Immunology, Sanjay Gandhi Postgraduate of Medical Sciences, Lucknow, India, ²Clinical Immunology, Senior Resident, Lucknow, India, ³Centre for Biomedical Research, Lucknow, India, ⁴Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India, ⁵Centre for Biomedical Research, DST-INSPIRE Faculty, Lucknow, India, ⁶Centre for Biomedical Research, Research Scholar, Lucknow, India, ⁷Centre for Biomedical Research, PhD Student, Lucknow, India, ⁸Rheumatology, Christian Medical College, Vellore Tamilnadu, India, ⁹Clinical Immunology & Rheumatology, Christian Medical College, Vellore, India, Vellore, India, ¹⁰Rheumatology, Emeritus Professor, Birmingham, United Kingdom
Background/Purpose: Takayasu arteritis (TA) is a large vessel vasculitis of unknown pathogenesis. The current serological and radiological parameters used to assess disease activity are not…
Abstract Number: 1849 • 2017 ACR/ARHP Annual Meeting
Urinary Epidermal Growth Factor and Monocyte Chemoattractant Protein-1 As Biomarkers of Renal Involvement in ANCA-Associated Vasculitis
Catherine E. Najem¹, Wenjun Ju², Viji Nair², David Cuthbertson³, Rennie L. Rhee¹, Laura Mariani⁴, Simon Carette⁵, Nader A. Khalidi⁶, Curry L. Koening⁷, Carol A. Langford⁸, Carol A. McAlear⁹, Paul A. Monach¹⁰, Larry W. Moreland¹¹, Christian Pagnoux⁵, Philip Seo¹², Ulrich Specks¹³, Antoine G. Sreih¹, Steven R. Ytterberg¹⁴, Jeffrey Krischer¹⁵, Matthias Kretzler⁴ and Peter A. Merkel¹⁶, ¹Rheumatology, University of Pennsylvania, Philadelphia, PA, ²University of Michigan, Ann Arbor, MI, ³Biostatistics and Informatics, Department of Pediatrics, University of South Florida, Tampa, FL, ⁴Division of Nephrology, University of Michigan, Ann Arbor, MI, ⁵Division of Rheumatology, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada, ⁶Rheumatology, McMaster University, Hamilton, ON, Canada, ⁷Rheumatology, University of Utah, Salt Lake City, UT, ⁸Rheumatic and Immunologic Diseases, Cleveland Clinic, Cleveland, OH, ⁹University of Pennsylvania, Philadelphia, PA, ¹⁰Boston University School of Medicine, Boston, MA, ¹¹Rheumatology & Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ¹²Medicine, Johns Hopkins University, Baltimore, MD, ¹³Mayo Clinic College of Medicine, Rochester, MN, ¹⁴Rheumatology, Mayo Clinic, Rochester, MN, ¹⁵University of South Florida, Tampa, FL, ¹⁶Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, PA
Background/Purpose :Epidermal growth factor (EGF) mediates distal tubular epithelial cell function and regeneration. Monocyte chemoattractant protein-1 (MCP-1) participates in recruitment of leukocytes to areas of…
Abstract Number: 1850 • 2017 ACR/ARHP Annual Meeting
Efficacy of Zoledronic Acid and Denosumab in the Treatment of Patients with Low Back Pain and Modic Changes: A Proof of Principle Trial
Guoqi Cai¹, Laura Laslett¹, Dawn Aitken², Andrew Halliday³, Feng Pan², Petr Otahal¹, Deb Speden⁴, Tania Winzenberg¹ and Graeme Jones², ¹Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia, ²Musculoskeletal Unit, Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia, ³Radiology, Royal Hobart Hospital, Hobart, Australia, ⁴Royal Hobart Hospital, Hobart, Australia
Background/Purpose: Low back pain (LBP) is a common and debilitating problem. There are currently very limited pharmacological treatments for LBP. Vertebral endplate subchondral bone abnormalities…
Abstract Number: 1851 • 2017 ACR/ARHP Annual Meeting
Improving Walking Ability in Degenerative Lumbar Spinal Stenosis: A Randomized Trial Comparing 2 Self-Management Training Programs
Carlo Ammendolia¹, Pierre Côté², Danielle Southerst³, Michael Schneider⁴, Brian Budgell³, Claire Bombardier⁵, Gillian Hawker⁶ and Y. Raja Rampersaud⁷, ¹Surgery, University of Toronto, Toronto, ON, Canada, ²University of Ontario Institute of Technology, Toronto, ON, Canada, ³Canadian Memorial Chiropractic College, Toronto, ON, Canada, ⁴University of Pittsburgh, Pittsburgh, PA, ⁵Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada, ⁶Professor, Full SGS Member Department of Medicine, University of Toronto Chief of Medicine, Women's College Hospital 76 Grenville Street 8th Floor East, Room 815, University of Toronto, Toronto, ON, Canada, ⁷University of Toronto, Toronto, ON, Canada
Background/Purpose: Degenerative lumbar spinal stenosis (DLSS) is a leading cause of pain, disability and loss of independence in older adults. It is caused by age…
Abstract Number: 1852 • 2017 ACR/ARHP Annual Meeting
Validating Patient Reported Outcomes in Older Veterans with Chronic Back Pain
Rabih Nayfe¹, Matthieu Chansard², Thiru Annaswamy³, Katharine McCallister², Liana Fraenkel⁴, Eric Mortensen⁵ and Una E. Makris⁶, ¹Department of Medicine, UT Southwestern Medical Center, Dallas, TX, ²Clinical Sciences, UT Southwestern Medical Center, Dallas, TX, ³Physical Medicine & Rehabilitation,, VA North Texas Health Care System, Dallas, TX, ⁴Rheumatology, Rheumatology, Yale University School of Medicine, New Haven, CT, New Haven, CT, ⁵Department of Medicine, University of Connecticut, Farmington, CT, ⁶Department of Medicine, VA North Texas Health Care System, Dallas, TX
Background/Purpose: Chronic back pain is the second most common reason for a physician’s visit and results in significant physical and psychosocial consequences in older adults.…
Abstract Number: 1853 • 2017 ACR/ARHP Annual Meeting
Exercise and Adherence over Two Years: Beliefs of Adults with Knee Osteoarthritis
Aileen Ledingham¹, Ellen Cohn², Kristin Baker³ and Julie Keysor¹, ¹Physical Therapy, Boston University, Boston, MA, ²Occupational Therapy, Boston University, Boston, MA, ³Physical Therapy, Boston University Sargent College, Boston, MA
Background/Purpose: Exercise is an established treatment to improve pain and physical function in adults with knee osteoarthritis (KOA), which is a leading cause of disability…
Abstract Number: 1854 • 2017 ACR/ARHP Annual Meeting
Identifying Vulnerable Patient Populations Based on Age and Physical Function on Clinical Outcomes Following Total Knee Arthroplasty
Jesse Christensen¹, Andrew Kittelson², Brian Loyd³, Jackie Del Giorno⁴, Brian Burnikel⁵ and Jennifer Stevens-Lapsley⁶, ¹University of Utah, SLC, UT, ²Rehabilitation Science PhD Program, University of Colorado Anschutz Medical Campus, Aurora, CO, ³University of Colorado Anschutz Medical Campus, Aurora, CO, ⁴ATI Physical Therapy, Greenville, SC, ⁵Steadman Hawkins Clinic of the Carolinas, Greenville Health Systems, Greenville, SC, ⁶Universtiy of Colorado, Anschutz Medical Campus, Aurora, CO
Background/Purpose: : Total knee arthroplasty (TKA) has historically been viewed as a surgical procedure of last resort for older adults suffering with chronic arthritis. However,…
Abstract Number: 1855 • 2017 ACR/ARHP Annual Meeting
Feasibility and Preliminary Effects of a Novel Rehabilitation Strategy to Improve Hand and Arm Function in Systemic Sclerosis
Susan L. Murphy¹, Mary Barber², Kristen Homer³, Carole Dodge² and Dinesh Khanna⁴, ¹Phyiscal Medicine & Rehabilitation, University of Michigan, Ann Arbor, MI, ²Physical Medicine and Rehabilitation, University of Michigan, Ann Arbor, MI, ³Department of Internal Medicine, Rheumatology Division, University of Michigan, Ann Arbor, MI, ⁴University of Michigan, Ann Arbor, MI
Background/Purpose: Individuals with systemic sclerosis (SSc) suffer from limited arm and hand function due to skin thickening and contractures. Evidence-based medical rehabilitation strategies for these…

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