Abstracts Archive - Page 1504 of 2607 - ACR Meeting Abstracts

Abstract Number: 1751 • 2017 ACR/ARHP Annual Meeting
Association of a TNFSF4 Upstream Region Single Nucleotide Polymorphism with Susceptibility to Proteinase 3-ANCA Positive Vasculitis in a Japanese Population
Yuka Iwahashi¹, Aya Kawasaki¹, Fumio Hirano², Ken-ei Sada³, Daisuke Tsukui⁴, Yuya Kondo⁵, Shigeto Kobayashi⁶, Hidehiro Yamada⁷, Hiroshi Furukawa¹, Kenji Nagasaka⁸, Takahiko Sugihara⁹, Kunihiro Yamagata¹⁰, Takayuki Sumida⁵, Shigeto Tohma¹¹, Hajime Kono⁴, Shoichi Ozaki⁷, Seiichi Matsuo¹², Hiroshi Hashimoto¹³, Hirofumi Makino¹⁴, Yoshihiro Arimura¹⁵, Masayoshi Harigai¹⁶ and Naoyuki Tsuchiya¹, ¹Molecular and Genetic Epidemiology Laboratory, University of Tsukuba, Faculty of Medicine, Tsukuba, Japan, ²Departments of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan, ³Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan, ⁴Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan, ⁵Department of Internal Medicine, University of Tsukuba, Faculty of Medicine, Tsukuba, Japan, ⁶Department of Internal Medicine, Juntendo University Koshigaya Hospital, Koshigaya, Japan, ⁷Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Japan, ⁸Department of Rheumatology, Ome Municipal General Hospital, Ome, Japan, ⁹Department of Medicine and Rheumatology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan, ¹⁰Department of Nephrology, University of Tsukuba, Faculty of Medicine, Tsukuba, Japan, ¹¹Clinical Research Center for Allergy and Rheumatology, Sagamihara Hospital, National Hospital Organization, Sagamihara, Japan, ¹²Department of Nephrology, Nagoya University Graduate School of Medicine, Nagoya, Japan, ¹³Juntendo University School of Medicine, Tokyo, Japan, ¹⁴Okayama University Hospital, Okayama, Japan, ¹⁵First Department of Internal Medicine, Kyorin University School of Medicine, Tokyo, Japan, ¹⁶Division of Epidemiology and Pharmacoepidemiology of Rheumatic Diseases, Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan
Background/Purpose: In the epidemiology of ANCA-associated vasculitis (AAV), an obvious difference between European and Asian populations has been reported. According to the clinical classification, granulomatosis…
Abstract Number: 1752 • 2017 ACR/ARHP Annual Meeting
Pharmacokinetics of Rituximab and Clinical Outcomes in Patients with ANCA-Associated Vasculitis
Divi Cornec¹, Brian Kabat¹, John Mills¹, Melissa Cheu², Amber Hummel¹, Darrell Schroeder¹, Matthew Cascino³, Paul Brunetta³, David Murray¹, Melissa Snyder¹, Fernando Fervenza¹, Gary S. Hoffman⁴, Cees G.M. Kallenberg⁵, Carol A. Langford⁶, Peter A. Merkel⁷, Paul A. Monach⁸, Philip Seo⁹, Robert F. Spiera¹⁰, E. William St Clair¹¹, John H. Stone¹², David Barnidge¹ and Ulrich Specks¹³, ¹Mayo Clinic, Rochester, MN, ²Genentech Inc., South San Francisco, CA, ³Genentech, Inc., South San Francisco, CA, ⁴Rheumatology, Cleveland Clinic, Cleveland, OH, ⁵Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ⁶Rheumatic and Immunologic Diseases, Cleveland Clinic, Cleveland, OH, ⁷University of Pennsylvania, Philadelphia, MN, ⁸Boston University School of Medicine, Boston, MA, ⁹Medicine, Johns Hopkins University, Baltimore, MD, ¹⁰Rheumatology, Hospital for Special Surgery, New York, NY, ¹¹Rheumatology, Duke University Medical Center, Durham, NC, ¹²Massachusetts General Hospital Rheumatology Unit, Harvard Medical School, Boston, MA, ¹³Mayo Clinic College of Medicine, Rochester, MN
Background/Purpose: Response to rituximab (RTX) is variable in patients with ANCA-associated vasculitis (AAV), and predictors of treatment efficacy/relapse risk would be useful. Previous studies have…
Abstract Number: 1753 • 2017 ACR/ARHP Annual Meeting
“Recurrent Venous Thromboembolic Events in Granulomatosis with Polyangiitis Patients”
Alana Nevares¹, William Messner², Hiromichi Tamaki³, Yaseen Kinanah⁴ and Alexandra Villa-Forte⁵, ¹Rheumatology, Cleveland Clinic Foundation, Cleveland, OH, ²Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH, ³Rheumatology, Cleveland Clinic, Cleveland, OH, ⁴Internal Medicine, Cleveland Clinic Foundation, Cleveland, OH, ⁵Rheumatology, Celevand Clinic Foundation, Shaker Heights, OH
Background/Purpose: The incidence of first-time venous thromboembolic events (VTE) is high in granulomatosis with polyangiitis (GPA). The incidence of recurrent VTE in these patients has…
Abstract Number: 1754 • 2017 ACR/ARHP Annual Meeting
Childhood- Vs. Adult-Onset ANCA-Associated Vasculitides: A Nested, Matched Case–Control Study from the French Vasculitis Study Group Registry
Michele Iudici¹, Christian Pagnoux², Pierre Quartier³, Mathias Büchler⁴, Ramiro Cevallos⁵, Pascal Cohen⁶, Claire de Moreuil⁷, Philippe Guilpain⁸, Alain Le Quellec⁸, Jacques Serratrice⁹, Benjamin Terrier⁶, Claire Le Jeunne⁶, Loïc Guillevin¹, Luc Mouthon¹⁰ and Xavier Puéchal for the French Vasculitis Study Group¹, ¹National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France, ²Mount Sinai Hospital, Toronto, ON, Canada, ³Necker-Enfants Malades Hospital, Paris, France, ⁴Tours, Tours, France, ⁵Strasbourg, Strasbourg, France, ⁶Service de Médecine Interne, Hôpital Cochin, Centre de référence national pour les maladies systémiques autoimmunes rares d’Ile de France, DHU Authors, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France, Paris, France, ⁷CHU de Brest, Brest, France, ⁸Montpellier, Montpellier, France, ⁹Marseille, Marseille, France, ¹⁰Service de Médecine Interne, Hôpital Cochin, Centre de référence national pour les maladies systémiques autoimmunes rares d’Ile de France, DHU Authors, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France ;Université Paris Descartes Sorbonne Paris, Paris, France
Background/Purpose: ANCA-associated vasculitides (AAVs) are potentially life-threatening diseases rarely observed in childhood. Whether AAVs in children (cAAVs) differ from adult-onset AAVs (aAAVs) is still not…
Abstract Number: 1755 • 2017 ACR/ARHP Annual Meeting
Safety of Methotrexate and Low-Dose Trimethoprim-Sulfamethoxazole in Patients with ANCA-Associated Vasculitis
Hiromichi Tamaki¹, Robert Butler² and Carol A. Langford³, ¹Rheumatology, Cleveland Clinic, Cleveland, OH, ²Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH, ³Rheumatic and Immunologic Diseases, Cleveland Clinic, Cleveland, OH
Background/Purpose: Low-dose trimethoprim-sulfamethoxazole (LDTS, 160mg-800mg 3x/week or 80mg-400mg/day) is effective for prevention of Pneumocystis jiroveci pneumonia (PCP), a serious opportunistic infection seen in patients with…
Abstract Number: 1756 • 2017 ACR/ARHP Annual Meeting
Interstitial Lung Disease in ANCA Associated Vasculitis: A Distinct or an Incomplete Subset in ANCA Vasculitis Patients?
Simone Barsotti^1,2, Francesco Ferro¹, Elena Elefante¹, Rossella Neri³, Marta Mosca¹ and Chiara Baldini⁴, ¹Rheumatology Unit, University of Pisa, Pisa, Italy, ²Department of Medical Biotechnologies, University of Siena, Siena, Italy, ³Rheumatology Unit, University of Pisa, PISA, Italy, ⁴Internal Medicine, Rheumatology Unit, University of Pisa, Pisa, Italy
Background/Purpose: ANCA-associated vasculitis (AAV) are heterogeneous disorders with a clinical presentation that may range from a full-blown disease to incomplete forms with isolated organ involvement.…
Abstract Number: 1757 • 2017 ACR/ARHP Annual Meeting
Rituximab for Induction and Maintenance Therapy of Granulomatosis with Polyangiitis: A Single-Center Cohort Study on 114 Patients
Xavier Puéchal¹, Michele Iudici¹, Ana Luisa Calich², Alexandre Vivot³, Benjamin Terrier⁴, Alexis Regent¹, Pascal Cohen⁴, Claire Le Jeunne⁴, Luc Mouthon⁵, Philippe Ravaud⁶ and Loïc Guillevin for the French Vasculitis Study Group⁷, ¹National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France, ²Universidade Federal de São Paulo, Hospital São Paulo, São Paulo, Brazil, ³Epidemiology, Hotel Dieu, Paris, France, ⁴Service de Médecine Interne, Hôpital Cochin, Centre de référence national pour les maladies systémiques autoimmunes rares d’Ile de France, DHU Authors, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France, Paris, France, ⁵Service de Médecine Interne, Hôpital Cochin, Centre de référence national pour les maladies systémiques autoimmunes rares d’Ile de France, DHU Authors, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France ;Université Paris Descartes Sorbonne Paris, Paris, France, ⁶Paris Hotel Dieu, Paris, France, ⁷Service de Médecine Interne, Centre de Référence Maladies Auto-Immunes et Auto-Inflammatoires Systémiques Rares, Hôpital Cochin, Paris, France
Background/Purpose: Randomized–controlled trials (RCTs) showed rituximab’s (RTX) noninferiority to cyclophosphamide for induction therapy of severe ANCA-associated vasculitides and significantly lower relapse rate than azathioprine maintenance.…
Abstract Number: 1758 • 2017 ACR/ARHP Annual Meeting
Risk of Serious Infection in Granulomatosis with Polyangiitis or Microscopic Polyangiitis: Long-Term Outcomes of 126 Wegent Trial Patients
Xavier Puéchal¹, Christian Pagnoux², Elodie Perrodeau³, Mohamed Hamidou⁴, Jean-Jacques Boffa⁵, Xavier Kyndt⁶, François Lifermann⁷, Thomas Papo⁸, Dominique Merrien⁹, Amar Smail¹⁰, Philippe Delaval¹¹, Catherine Hanrotel-Saliou¹², Bernard Imbert¹³, Chahéra Khouatra¹⁴, Marc Lambert¹⁵, Charles Leské¹⁶, Kim H. Ly¹⁷, Edouard Pertuiset¹⁸, Pascal Roblot¹⁹, Marc Ruivard²⁰, Jean-François Subra²¹, Jean-Francois Viallard²², Benjamin Terrier²³, Pascal Cohen²³, Luc Mouthon²⁴, Philippe Ravaud³ and Loïc Guillevin for the French Vasculitis Study Group²⁵, ¹National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France, ²Mount Sinai Hospital, Toronto, ON, Canada, ³Paris Hotel Dieu, Paris, France, ⁴Medecine Interne, CHU Hôtel Dieu, Nantes, France, ⁵Paris Tenon, Paris, France, ⁶Valenciennes, Valenciennes, France, ⁷Dax, Dax, France, ⁸Paris Bichat, Paris, France, ⁹Compiègne, Compiègne, France, ¹⁰Amiens, Amiens, France, ¹¹Rennes, Rennes, France, ¹²Brest, Brest, France, ¹³Grenoble, Grenoble, France, ¹⁴Lyon, Lyon, France, ¹⁵Lille, Lille, France, ¹⁶Cholet, Cholet, France, ¹⁷Limoges, Limoges, France, ¹⁸Pontoise, Pontoise, France, ¹⁹Poitiers, Poitiers, France, ²⁰CHU Estaing, Department of Internal Medicine, Clermont-Ferrand, France, Clermont Ferrand, France, ²¹Angers, Angers, France, ²²Bordeaux, Bordeaux, France, ²³Service de Médecine Interne, Hôpital Cochin, Centre de référence national pour les maladies systémiques autoimmunes rares d’Ile de France, DHU Authors, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France, Paris, France, ²⁴Service de Médecine Interne, Hôpital Cochin, Centre de référence national pour les maladies systémiques autoimmunes rares d’Ile de France, DHU Authors, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France ;Université Paris Descartes Sorbonne Paris, Paris, France, ²⁵Service de Médecine Interne, Centre de Référence Maladies Auto-Immunes et Auto-Inflammatoires Systémiques Rares, Hôpital Cochin, Paris, France
Background/Purpose: Adverse events, rather than active vasculitis, are the greatest threat to patients with ANCA-associated vasculitides (AAVs) during the first year of therapy but long-term…
Abstract Number: 1759 • 2017 ACR/ARHP Annual Meeting
Economic Evaluation of Rituximab Versus Azathioprine for Maintenance Treatment of ANCA-Associated Vasculitis. a Prospective, Multicenter Study
Annalisa Montante¹, Alicia Le Bras², Benjamin Terrier³, Pascal Cohen³, Xavier Puéchal⁴, Alexandre Karras⁵, Philippe Ravaud⁶, Loïc Guillevin⁷ and Isabelle Durand-Zaleski⁸, ¹UNITÉ DE RECHERCHE ECONOMIQUE, UNIVERSITE PARIS DESCARTES, PARIS, France, ²UNITE DE RECHERCHE ECONOMIQUE, UNIVERSITE PARIS DESCARTES, PARIS, France, ³Service de Médecine Interne, Hôpital Cochin, Centre de référence national pour les maladies systémiques autoimmunes rares d’Ile de France, DHU Authors, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France, Paris, France, ⁴Service de Médecine Interne, Centre de Référence Maladies Auto-Immunes et Auto-Inflammatoires Systémiques Rares, Hôpital Cochin, Paris, France, ⁵Nephrology, HEGP, Paris, France, ⁶Hôpital Hôtel Dieu, Paris, France, ⁷Internal medicine, Cochin University Hospital, paris, France, ⁸UNITE DE RECHERCHE ECONOMIQUE, UNIVERSITE DE PARIS-CRETEIL, PARIS, France
Background/Purpose: Rituximab was proven to be superior to azathioprine as maintenance therapy for ANCA-associated vasculitides (AAVs) at month 28 of MAINRITSAN-1–trial follow-up. Because of rituximab’s…
Abstract Number: 1760 • 2017 ACR/ARHP Annual Meeting
Pulmonary Manifestations in Microscopic Polyangiitis and Granulomatosis with Polyangiitis: A Multicenter Cohort Analysis
Saara M. Rawn¹, Gerard Cox¹, Christian Pagnoux², David Cuthbertson³, Simon Carette², Curry L. Koening⁴, Carol A. Langford⁵, Carol A. McAlear⁶, Paul A. Monach⁷, Larry W. Moreland⁸, Philip Seo⁹, Ulrich Specks¹⁰, Antoine G. Sreih¹¹, Steven R. Ytterberg¹², Renee Borchin¹³, Peter A. Merkel¹¹ and Nader A. Khalidi¹, ¹St. Joseph's Healthcare, McMaster University, Hamilton, ON, Canada, ²Division of Rheumatology, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada, ³Department of Biostatistics, University of South Florida, Tampa, FL, ⁴Rheumatology, University of Utah, Salt Lake City, UT, ⁵Rheumatic and Immunologic Diseases, Cleveland Clinic, Cleveland, OH, ⁶Division of Rheumatology, University of Pennsylvania, Philadelphia, PA, ⁷Rheumatology, Boston University, Boston, MA, ⁸Rheumatology & Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ⁹Division of Rheumatology, Johns Hopkins University, Baltimore, MD, ¹⁰Mayo Clinic, Rochester, MN, ¹¹Rheumatology, University of Pennsylvania, Philadelphia, PA, ¹²Division of Rheumatology, Mayo Clinic, Rochester, MN, ¹³University of South Florida, Tampa, FL
Background/Purpose: Pulmonary involvement in microscopic polyangiitis (MPA) and granulomatosis with polyangiitis (GPA) includes pulmonary nodules (PN), diffuse alveolar hemorrhage (DAH), and infiltrates attributed to vasculitis,…
Abstract Number: 1761 • 2017 ACR/ARHP Annual Meeting
Differential Characteristics of MPO-ANCA Positive and Negative Eosinophilic Granulomatosis with Polyangiitis
Shunsei Hirohata¹, Yu Matsueda² and Yoshiyuki Arinuma², ¹Kitasato University School of Medicine, Sagamihara, Japan, ²Rheumatology and Infectious Diseases, Kitasato University School of Medicine, Kanagawa, Japan
Background/Purpose: Eosinophilic granulomatosis with polyangiitis (EGPA) is characterized by the preceding history of type I allergic disorders, mostly bronchial asthma, followed by the development of…
Abstract Number: 1762 • 2017 ACR/ARHP Annual Meeting
Association of ETS1 Polymorphism in 3’ Untranslated Region with Susceptibility to Granulomatosis with Polyangiitis and Proteinase 3-ANCA Positive Vasculitis in a Japanese Population
Aya Kawasaki¹, Keita Yamashita², Fumio Hirano³, Ken-ei Sada⁴, Daisuke Tsukui⁵, Yuya Kondo⁶, Yoshitaka Kimura⁵, Kurumi Asako⁵, Shigeto Kobayashi⁷, Hidehiro Yamada⁸, Hiroshi Furukawa¹, Kenji Nagasaka⁹, Takahiko Sugihara¹⁰, Kunihiro Yamagata¹¹, Takayuki Sumida⁶, Shigeto Tohma¹², Hajime Kono⁵, Shoichi Ozaki⁸, Seiichi Matsuo¹³, Hiroshi Hashimoto¹⁴, Hirofumi Makino¹⁵, Yoshihiro Arimura¹⁶, Masayoshi Harigai¹⁷ and Naoyuki Tsuchiya¹, ¹Molecular and Genetic Epidemiology Laboratory, University of Tsukuba, Faculty of Medicine, Tsukuba, Japan, ²Molecular and Genetic Epidemiology, University of Tsukuba, Faculty of Medicine, Tsukuba, Japan, ³Departments of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan, ⁴Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan, ⁵Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan, ⁶Department of Internal Medicine, University of Tsukuba, Faculty of Medicine, Tsukuba, Japan, ⁷Department of Internal Medicine, Juntendo University Koshigaya Hospital, Koshigaya, Japan, ⁸Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Japan, ⁹Department of Rheumatology, Ome Municipal General Hospital, Ome, Japan, ¹⁰Department of Medicine and Rheumatology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan, ¹¹Department of Nephrology, University of Tsukuba, Faculty of Medicine, Tsukuba, Japan, ¹²Clinical Research Center for Allergy and Rheumatology, Sagamihara Hospital, National Hospital Organization, Sagamihara, Japan, ¹³Department of Nephrology, Nagoya University Graduate School of Medicine, Nagoya, Japan, ¹⁴Juntendo University School of Medicine, Tokyo, Japan, ¹⁵Okayama University Hospital, Okayama, Japan, ¹⁶First Department of Internal Medicine, Kyorin University School of Medicine, Tokyo, Japan, ¹⁷Division of Epidemiology and Pharmacoepidemiology of Rheumatic Diseases, Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan
Background/Purpose: ETS Proto-oncogene 1, transcription factor (ETS1) is a transcription factor involved in immune responses. Genome-wide association studies on systemic lupus erythematosus (SLE) in Chinese…
Abstract Number: 1763 • 2017 ACR/ARHP Annual Meeting
Time to Diagnosis of ANCA-Associated Vasculitides : Data from French Vasculitis Study Group Registry
Caroline Morbieu, Maher Banjari, Benjamin Terrier, Pascal Cohen, Claire Le Jeunne, Luc Mouthon, Xavier Puéchal and Loïc Guillevin for the French Vasculitis Study Group, National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France
Background/Purpose: Diagnosing ANCA-associated vasculitides (AAVs) can be challenging. Their clinical presentations are numerous and the time to diagnosis may range from days to years.1,2 The…
Abstract Number: 1764 • 2017 ACR/ARHP Annual Meeting
Small RNA Sequencing Shows Differential Plasma Microrna Expression in Patients with ANCA-Associated Vasculitis: A Pilot Study
Kevin Byram¹, Joseph F. Solus¹, Quanhu Sheng¹, Yan Guo¹, C Michael Stein¹ and Michelle J. Ormseth², ¹Vanderbilt University Medical Center, Nashville, TN, ²Rheumatology, Vanderbilt Medical Center, Nashville, TN
Background/Purpose: MicroRNAs (miRNAs) are small RNA molecules (~22 nucleotides) that participate in post-transcriptional gene regulation. miRNAs have potential both as biomarkers for diagnosis and prognosis…
Abstract Number: 1765 • 2017 ACR/ARHP Annual Meeting
Validation of the ACR EULAR Provisional 2017 Classification Criteria of Granulomatosis with Polyangiitis (GPA) Amongst Patients with ANCA Associated Vasculitis
Aman Sharma¹, Adarsh MB², Shankar Naidu³, Manish Rathi⁴, Benzeeta Pinto⁵, Varun Dhir⁶, Roshan Verma⁷, Kusum Sharma⁸, Ritambhra Nada⁹, Sanjay Jain⁵ and Ranjana Minz¹⁰, ¹Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India, ²Internal Medicine, PGIMER, Chandigarh, India, ³PGIMER, cHANDIGARH, India, ⁴Department of Nephrology,, Postgraduate Institute of Medical Education and Research, Chandigarh, India, ⁵PGIMER, CHANDIGARH, India, ⁶Internal Medicine (Rheumatology Unit), Postgraduate Institute of Medical Education and Research, Chandigarh, India, ⁷PGIMER, Chandigarh, India, ⁸Department of Medical Microbiology,, PGIMER,, Chandigarh, India, ⁹Histopathology, Professor, Chandigarh, India, ¹⁰Department of Immunopathology,, PGIMER,, Chandigarh, India
Background/Purpose: The purpose of this study was to validate the recently proposed ACR EULAR 2017 classification criteria of GPA in a real life cohort of…

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