Abstracts Archive - Page 1497 of 2425 - ACR Meeting Abstracts

Abstract Number: 1190 • 2016 ACR/ARHP Annual Meeting
Incidence and Prevalence of Polymyalgia Rheumatic and Giant Cell Arteritis: A 15-Year Study in a Health Care Management Organization
Jose Maximiliano Martinez P¹, Florencia Beatriz Mollerach², Facundo Vergara², Ignacio Javier Gandino², Marina Scolnik³, Luis J. Catoggio⁴, Javier Rosa² and Enrique R. Soriano², ¹Rheumatology, Internal Medicine Service, Rheumatology Unit, Internal Medicine Service, Hospital Italiano de Buenos Aires, Instituto Universitario Hospital Italiano de Buenos Aires, and Fundacion PM Catoggio, Buenos Aires, Argentina, ²Rheumatology Unit, Internal Medicine Service, Hospital Italiano de Buenos Aires, Instituto Universitario Hospital Italiano de Buenos Aires, and Fundacion PM Catoggio, Buenos Aires, Argentina, ³Rheumatology Section, Rheumatology Unit, Internal Medicine Service, Hospital Italiano de Buenos Aires, Instituto Universitario Hospital Italiano de Buenos Aires, and Fundacion PM Catoggio, Buenos Aires, Argentina, ⁴Rheumatology Unit, Internal Medicine Service, Hospital Italiano de Buenos Aires, Instituto Universitario Hospital Italiano de Buenos Aires, and Fundacion PM Catoggio, Argentina., Buenos Aires, Argentina
Background/Purpose: There is scarce information on the epidemiology of polymyalgia rheumatic (PMR) and giant cell arteritis (GCA) in Latin America. To estimate incidence and prevalence rates of…
Abstract Number: 1191 • 2016 ACR/ARHP Annual Meeting
Retinal Vessel Morphometry Associations with Polymyalgia Rheumatica; Findings from the European Prospective Investigation of Cancer (EPIC) in Norfolk
Max Yates¹, Shabina Hayat², Robert N. Luben³, Roshan Welikala⁴, Alicja Rudnicka⁵, Christopher Owen⁵, Sarah Barman⁴, Eoin O'Sullivan⁶, Sarah Mackie⁷, Richard Watts¹, Paul Foster⁸, Kay-Tee Khaw³, Nick Wareham³ and Alex J Macgregor⁹, ¹Norwich Medical School, University of East Anglia, Norwich, United Kingdom, ²Strangeways Research Laboratory, University of Cambridge, Cambridge, United Kingdom, ³Department of Public Health and Primary Care, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom, ⁴Faculty of Science, Engineering and Computing, University of Kingston, London, United Kingdom, ⁵Population Health Research Institute, St George's University of London, London, United Kingdom, ⁶Ophthalmology, Kings College Hospital, London, United Kingdom, ⁷NIHR-Leeds Musculoskeletal Biomedical Research Unit and Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, University of Leeds, Leeds, United Kingdom, ⁸Division of Epidemiology and Genetics, University College London, London, United Kingdom, ⁹Rheumatology, Norfolk and Norwich University Hospital, Norwich, United Kingdom
Background/Purpose: Increasing evidence suggests that characteristic changes in retinal vessel morphometry are biomarkers for vascular health. Polymyalgia Rheumatica (PMR) has been associated with increased risk…
Abstract Number: 1192 • 2016 ACR/ARHP Annual Meeting
Mortality and Survival of Patients Diagnosed with GCA in Bergen (Western Norway) 1972-2012
Lene K Brekke¹, Andreas P Diamantopoulos¹, Bjørg-Tilde Fevang^2,3, Jörg Aβmus⁴ and Clara G Gjesdal^3,5, ¹Haugesund Hospital for Rheumatic Diseases, Haugesund, Norway, ²Dept. of Rheumatology, Haukeland University Hospital, Bergen, Norway, ³Department of Clinical Science, University of Bergen, Bergen, Norway, ⁴Centre for Clinical Research, Haukeland University Hospital, Bergen, Norway, ⁵Department of Rheumatology, Haukeland University Hospital, Bergen, Norway
Background/Purpose: Giant cell arteritis (GCA) is the most common systemic vasculitis in people ³ 50 years of age and the disease is associated with potentially…
Abstract Number: 1193 • 2016 ACR/ARHP Annual Meeting
Mortality Rate According to Cause in Patients with Hemophagocytic Lymphohistiocytosis: A Meta-Analysis
Khushboo Sheth^1,2, Chia-Ling Kuo³, Dhruv Modi⁴ and Christopher Scola⁵, ¹Internal Medicine, University of Connecticut, Farmington, CT, Farmington, CT, ²Rheumatology, Stanford University, Palo Alto, CA, ³Department of Community Medicine and Health Care, University of Connecticut, Farmington, CT, ⁴Internal Medicine, Jamaica Hospital and Medical Center, New York, NY, ⁵Rheumatology, Hartford Hospital, Hartford, CT
Background/Purpose: Hemophagocytic lymphohistiocytosis (HLH) is a rare syndrome of excessive immune activation associated with high mortality. Early diagnosis and treatment can reduce mortality among these patients.…
Abstract Number: 1194 • 2016 ACR/ARHP Annual Meeting
Low Body Mass Index and Smoking Are Associated with a Lower Risk of Sarcoidosis: A Population-Based Nested Case-Control Study
Patompong Ungprasert¹, Cynthia S. Crowson² and Eric L. Matteson¹, ¹Rheumatology, Mayo Clinic, Rochester, MN, ²Health Sciences Research, Mayo Clinic, Rochester, MN
Low Body Mass Index and Smoking Are Associated With a Lower Risk of Sarcoidosis: A Population-Based Nested Case-Control Study Background/Purpose: Sarcoidosis is a systemic disorder…
Abstract Number: 1195 • 2016 ACR/ARHP Annual Meeting
Risk of Hospitalized Infection Among Patients with Sarcoidosis: A Population-Based Retrospective Cohort Study
Patompong Ungprasert¹, Cynthia S. Crowson² and Eric L. Matteson¹, ¹Rheumatology, Mayo Clinic, Rochester, MN, ²Health Sciences Research, Mayo Clinic, Rochester, MN
Risk of Hospitalized Infection Among Patients With Sarcoidosis: A Population-Based Retrospective Cohort Study Background/Purpose: Increased risk of infection has been observed in several autoimmune disorders. …
Abstract Number: 1196 • 2016 ACR/ARHP Annual Meeting
AA Amyloidosis: An Evaluation of Epidemiology and Prevalence in the US and EU5 Countries
WIlliam Andrews¹, Denis Garceau², Tomascz Sablinski³, Paul Zhang⁴ and Todd Waldman⁴, ¹Auven Therapeutics, Hopkinton, MA, ²Auven Therapeutics, Montreal, QC, Canada, ³Auven Therapeutics, St. Thomas, Virgin Islands (U.S.), ⁴Navigant Consulting, Inc., New York City, NY
Background/Purpose: AA amyloidosis (AAA) is a rare, systemic form of amyloidosis, which mostly occurs secondary to chronic inflammatory conditions, predominantly systemic arthritides. AAA is characterized…
Abstract Number: 1197 • 2016 ACR/ARHP Annual Meeting
Certain Serum Micro-RNAs Are Associated with Osteoarthritis
Jean-Charles Rousseau¹, Elisabeth Sornay-Rendu¹, Olivier Borel¹ and Roland Chapurlat², ¹INSERM UMR 1033, Lyon, France, ²Service de Rhumatologie et Pathologie Osseuse, Hôpital Edouard Herriot, INSERM UMR 1033 and Université de Lyon and Hospices Civils de Lyon, Lyon, France
Background/Purpose: Sensitive and specific blood biomarkers to detect the initial stages of osteoarthritis (OA) and to predict the future development of the disease are not…
Abstract Number: 1198 • 2016 ACR/ARHP Annual Meeting
Gene Enrichment Analysis Identifies Active CD40-CD40L Signaling in Early and Established Rheumatoid Arthritis
Yanxia Guo¹, Alice Walsh¹, Ursula Fearon², Malcolm D. Smith³, Mihir D Wechalekar⁴, Xuefeng Yin¹, Suzanne Cole¹, Carl Orr⁵, Trudy McGarry⁵, Mary Canavan⁵, Stephan Kelly⁶, Costantino Pitzalis⁷, Tai-An Lin¹, Xuejun Liu¹, Susanna Proudman⁸, Douglas J. Veale⁹ and Sunil Nagpal¹, ¹Immunology, Janssen Research & Development, Spring House, PA, ²St. Vincent's University Hospital, Centre for Arthritis and Rheumatic Diseases, Dublin Academic Medical Centre, Dublin 4, Ireland, ³Flinders University, Adelaide, Australia, ⁴Royal Adelaide Hospital, Adelaide, Australia, ⁵St. Vincent's University Hospital, Dublin, Ireland, ⁶Queen Mary University of London, London, United Kingdom, ⁷Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Barts and The London, School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom, ⁸University of Adelaide, Adelaide, Australia, ⁹Consultant Rheumatologist, Centre for Arthritis and Rheumatic Disease, St. Vincent’s University Hospital and University College Dublin, Dublin 4, Ireland
Background/Purpose: CD40 and CD40L (CD154) are tumor necrosis factor (TNF) family members involved in the pathogenesis of various autoimmune diseases. While this pathway is active…
Abstract Number: 1199 • 2016 ACR/ARHP Annual Meeting
A Genome-Wide Association Study of Methotrexate-Pneumonitis in Rheumatoid Arthritis: Results from the Pneumonitis Study Consortium
James Bluett¹, Sally-Ann Owen¹, Jonathan Massey², Darren Plant², Munir Pirmohamed³, Suzanne M.M. Verstappen⁴ and Anne Barton^5,6, ¹Arthritis Research UK Centre for Genetics and Genomics, The University of Manchester, Manchester, United Kingdom, ²NIHR Manchester Musculoskeletal Biomedical Research Unit, Manchester Academy of Health Sciences, Manchester, United Kingdom, ³Institute of Translational Medicine, The University of Liverpool, Liverpool, United Kingdom, ⁴Arthritis Research UK Centre for Epidemiology, The University of Manchester, Manchester, United Kingdom, ⁵NIHR Manchester Musculoskeletal Biomedical Research Unit, Manchester Academic Health Science Centre, Manchester, United Kingdom, ⁶Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, University of Manchester, Manchester, UK, Manchester, United Kingdom
Background/Purpose: Methotrexate (MTX) is associated with a rare but potentially life-threatening lung disease, MTX-pneumonitis (MTX-P). MTX-P is an idiosyncratic hypersensitivity reaction to MTX inducing inflammation,…
Abstract Number: 1200 • 2016 ACR/ARHP Annual Meeting
Transcriptional Profiling of Early RA Synovial Tissue Reveals the Impact of Triple DMARD Treatment on T Cell Activation Pathways
Alice M Walsh¹, Sunil Nagpal¹, Mihir D Wechalekar², Yanxia Guo¹, Xuefeng Yin¹, Helen Weedon², Susanna Proudman³ and Malcolm D. Smith², ¹Immunology, Janssen Research & Development, Spring House, PA, ²Flinders University, Adelaide, Australia, ³University of Adelaide, Adelaide, Australia
Background/Purpose: While several transcriptional profiling studies of synovial biopsies have been reported from RA patients with advanced disease, there is relatively little data available from…
Abstract Number: 1201 • 2016 ACR/ARHP Annual Meeting
Deconvolution of Immune Cell Proportions from Whole Blood RNA Using Next-Generation Sequencing
Omar Jabado¹, Sarah Hu², Julie Carman³, Suzanne Suchard³, Deborah Lee⁴, Zhenhao Qi⁵, Stefan Kirov⁶, Ryan Golhar⁷, Aiqing He⁷, Cate Speake⁸, Peter S. Linsley⁸, Steven G. Nadler⁹ and Somnath Bandyopadhyay², ¹3551 Lawrenceville Princeton, Bristol-Myers Squibb, Princeton, NJ, ²Bristol-Myers Squibb, Princeton, NJ, ³Discovery Translational Sciences Group, Bristol-Myers Squibb, Princeton, NJ, ⁴Discovery Immunoscience, Bristol-Myers Squibb, Princeton, NJ, ⁵Exploratory Clinical and Translational Research, Bristol-Myers Squibb, Princeton, NJ, ⁶Genetically Defined Diseased & Genomics, Bristol-Myers Squibb, Princeton, NJ, ⁷Genetically Defined Diseases & Genomics, Bristol-Myers Squibb, Princeton, NJ, ⁸Systems Immunology, Benaroya Research Institute at Virginia Mason, Seattle, WA, ⁹Immunosciences Translational Research, Bristol-Myers Squibb, Princeton, NJ
Background/Purpose: Measurements of immune cell proportions from whole blood can be used to detect pharmacodynamic effects, as a marker for prognosis and to aid in…
Abstract Number: 1202 • 2016 ACR/ARHP Annual Meeting
Characteristic Compositional and Functional Alteration of Gut Microbiota in Patients with Behcet’s Disease
Noboru Suzuki¹, Jun Shimizu² and Takao Kubota³, ¹Department of Immunology and medicine, St. Marianna University School of Medicine, Kawasaki-shi, 216-8511, Japan, ²Department of Immunology and Medicine, St. Marianna University School of Medicine, Kawasaki, Japan, ³The Japan Self Defense Forces Central Hospital, Tokyo, Japan
Background/Purpose: We have presented evidence that the frequency of helper T (Th)17 cells increased and the cells had already been activated in vivo in patients…
Abstract Number: 1203 • 2016 ACR/ARHP Annual Meeting
Differential Synovial Expression Patterns in Early Osteoarthritis Predict Pain and Progression of Joint Damage
Arjen B. Blom¹, Martijn H. van den Bosch¹, Hans Cats², F van den Hoogen³, Floris PJ Lafeber⁴, Wim B. van den Berg¹, Peter L. van Lent¹ and Peter M. van der Kraan¹, ¹Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ²Hengstdal 3, Sint Maartenskliniek, Ubbergen, Netherlands, ³Rheumatology, Radboud UMC, Nijmegen, Netherlands, ⁴Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands
Background/Purpose: The cause for chronic pain in OA is largely unknown. Over 50% of osteoarthritis (OA) patients show synovial inflammation, even at early stages of…
Abstract Number: 1204 • 2016 ACR/ARHP Annual Meeting
Methotrexate Is an Antibacterial Drug Metabolized By Human Gut Bacteria
Renuka R. Nayak^1,2, Colleen O'Loughlin³, Michael Fischbach⁴ and Peter J. Turnbaugh⁵, ¹Department of Microbiology & Immunology, University of California, San Francisco, San Francisco, CA, ²Department of Medicine, UCSF, Rosalind Russell / Ephraim P. Engleman Rheumatology Research Center, San Francisco, CA, ³Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA, ⁴Department of Bioengineering and Therapeutic Sciences,, University of California, San Francisco, San Francisco, CA, ⁵Microbiology and Immunology, University of California, San Francisco, San Francisco, CA
Background/Purpose: Rheumatoid arthritis (RA) is an autoimmune disease of unknown etiology that causes inflammation and irreversible damage in joints and other organs. Methotrexate (MTX) is…

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