Abstracts Archive - Page 1492 of 2425 - ACR Meeting Abstracts

Abstract Number: 1115 • 2016 ACR/ARHP Annual Meeting
Non-Esterified Fatty Acids Are Associated with Clinical Features and an Enhanced Th1 Response in Rheumatoid Arthritis: Towards Disease Profiling
Javier Rodríguez-Carrio¹, Mercedes Alperi-López², Patricia López¹, Francisco Javier Ballina-García² and Ana Suárez¹, ¹Area of Immunology, Department of Functional Biology, University of Oviedo, Oviedo, Spain, ²Department of Rheumatology, Hospital Universitario Central de Asturias, Asturias, Spain
Background/Purpose: Non-Esterified Fatty Acids (NEFA) are important lipid mediators which can play a role in a number of biological functions other than energy supply. NEFA…
Abstract Number: 1116 • 2016 ACR/ARHP Annual Meeting
Anti-Citrullinated Protein Antibodies Promote Synovial Fibroblasts Migration and Adhesion through a Peptidylarginine Deiminases (PAD) Dependent Pathway
Meng Sun¹, Vijay Joshua¹, Akilan Krishnamurthy¹, Yanying Liu², Aase Hensvold¹, Sergiu-Bogdan Catrina³, Caroline Ospelt⁴, Vivianne Malmström⁵, Khaled Amara¹, Johanna Steen¹, Muhammad Sohel Mia¹, Marianne Engström¹, Heidi Wähämaa¹, Jimmy Ytterberg¹, Bence Rethi¹ and Anca I Catrina¹, ¹Rheumatology Unit, Department of Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden, ²Rheumatology Unit, Department of Medicine, Peking University People's Hospital, Beijing, China, ³Molecular Medicine and Surgery, Molecular Medicine and Surgery, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden, ⁴University Hospital Zurich, Center of Experimental Rheumatology, Switzerland, Zurich, Switzerland, ⁵Department of Medicine, Rheumatology Unit, Department of Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden
Background/Purpose: Synovial fibroblasts (SFs) contribute to rheumatoid arthritis (RA) pathogenesis by growing into the synovial space and by producing pro-angiogenic and tissue remodelling factors, chemokines…
Abstract Number: 1117 • 2016 ACR/ARHP Annual Meeting
EGCG Down-Regulates TNF-α-Induced Mcl-1 Expression By Modulating Mule/Huwe1, β-TrCP, and USP9X Ubiquitin/De-Ubiquitin Ligases in Rheumatoid Arthritis Synovial Fibroblasts
Nahid Akhtar¹, Sadiq Umar², David Fox³ and Salahuddin Ahmed¹, ¹Department of Pharmaceutical Sciences, Washington State University, College of Pharmacy, Spokane, WA, ²Department of Pharmaceutical Science, Washington State University, College of Pharmacy, Spokane, WA, ³Department of Medicine [Division of Rheumatology], University of Michigan, Ann Arbor, MI
Background/Purpose: Myeloid cell leukemia (Mcl-1) phosphorylation at Ser64 position (p-Mcl-1Ser64) has been shown to enhance Mcl-1’s stability and resistance to proteasomal degradation. However, the…
Abstract Number: 1118 • 2016 ACR/ARHP Annual Meeting
Increased Population of Myeloid Dendritic Cells and Upregulated Gene Expression of Tnfα Is Associated with Poor Response to Hydroxychloroquine
Majid Zeidi^1,2, Hee Joo Kim^1,3,4 and Victoria P. Werth^1,3, ¹Department of Dermatology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, ²Department of Dermatology, Corporal Michael J. Crescenz VAMC, PHILADELPHIA, PA, ³Department of Dermatology, Corporal Michael J. Crescenz VAMC, Philadelphia, PA, ⁴Department of Dermatology, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea, The Republic of
Background/Purpose: Cutaneous lupus erythematosus (CLE) is an autoimmune disease with various subsets and wide-ranging clinical manifestations. T lymphocytes are the predominant cell type found in…
Abstract Number: 1119 • 2016 ACR/ARHP Annual Meeting
The Enhanced Expression of mRNA for Calgranulins, S100A8, S100A9 and S100A12, in CD34+ Cells of the Bone Marrow in Rheumatoid Arthritis
Tatsuo Nagai¹, Yu Matsueda², Tetsuya Tomita³, Hideki Yoshikawa³ and Shunsei Hirohata², ¹Rheumatology and Infectious Diseases, Kitasato University School of Medicine, Sagamihara, Japan, ²Rheumatology and Infectious Diseases, Kitasato University School of Medicine, Kanagawa, Japan, ³Department of Orthopedics, Osaka University Graduate School of Medicine, Suita Osaka, Japan
Background/Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory arthritis of unknown etiology. A subset of S100 proteins known as calgranulins (S100A8, S100A9 and S100A12) are…
Abstract Number: 1120 • 2016 ACR/ARHP Annual Meeting
Interleukin-1β Stabilize CXCL2 mRNA and Increase Its Expression
Satoshi Yamasaki, Yusuke Yoshida and Eiji Sugiyama, Department of Clinical Immunology and Rheumatology, Hiroshima University Hospital, Hiroshima, Japan
Background/Purpose: Changes in gene expression are closely related to inflammation and joint destruction in RA. Recently, it has been recognized that post-transcriptional regulation of the…
Abstract Number: 1121 • 2016 ACR/ARHP Annual Meeting
IFN Regulatory Factor-5 Signaling Increases IFN-Gamma Production and Suppresses IL-2 Production from CD4+ T Cells, and Controls IgG Production in B Cells
Kei Yasuda¹, Prachi Shukla², Ramon G. Bonegio¹ and Ian Rifkin¹, ¹Renal Section, Boston Univ Schl of Med, Boston, MA, ²Boston University School of Medicine, Boston, MA
Background/Purpose: Recent studies of human genetics and mouse models have shown that interferon regulatory factor-5 (IRF5) is associated with the development of autoimmune disease. However,…
Abstract Number: 1122 • 2016 ACR/ARHP Annual Meeting
Infliximab Suppresses the Monocyte Chemotaxis in Human TNF-Transgenic Mice
Qi Quan Huang¹, Robert Birkett¹, Elyssa L Roberts² and Richard M. Pope³, ¹Medicine/Rheumatology, Northwestern University Feinberg school of Medicine, Chicago, IL, ²northwestern University, Chicago, IL, ³Medicine/Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose: Macrophages in rheumatoid arthritis (RA) synovium produce high levels of inflammatory cytokines/chemokines and play the pivotal role in promoting inflammation and joint destruction. Treatment…
Abstract Number: 1123 • 2016 ACR/ARHP Annual Meeting
Targeted Mutations Identify the Active Site of Glucocorticoid-Induced Leucine Zipper (GILZ)
Huapeng Fan¹, Die Wang², Qiang Cheng³, James Harris³, Sarah Jones³, Yuan Hang Yang⁴ and Eric Morand⁴, ¹Lupus Research Group, Center for Inflammatory Diseases, School of Clinical Sciences at Monash Health, Faculty of Medicine, Nursing and Health Sciences, Monash University, Calyton, Australia, ²Hudson Institute of Medical Research, Clayton, Australia, ³Lupus Research Group, Center for Inflammatory Diseases, School of Clinical Sciences at Monash Health, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, Australia, ⁴Lupus Research Group, Center for Inflammatory Diseases, School of Clinical Sciences at Monash Health, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Australia
Background/Purpose: Glucocorticoids (GC) have been used to treat inflammatory disease for more than six decades, but the broad spectrum of therapeutic effects is accompanied by…
Abstract Number: 1124 • 2016 ACR/ARHP Annual Meeting
IL37 Rescues Human OA Cartilage Explants from GAG Release
Ellen van Geffen¹, Arjan van Caam², Henk van Beuningen², Elly Vitters², Esmeralda Blaney Davidson² and Peter M. van der Kraan², ¹Experimential Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ²Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands
Background/Purpose: In healthy cartilage, there is a balance between anabolic and catabolic activities of chondrocytes that maintains the functional integrity of the extracellular matrix. However,…
Abstract Number: 1125 • 2016 ACR/ARHP Annual Meeting
Targeted Lipidomics Reveals Incomplete Activation of Resolution Pathways in Knee Osteoarthritis
Hulda Jonasdottir¹, Hilde Brouwers², Mukundan Attur³, Joanneke Kwekkeboom², Jonathan Samuels³, Eric Strauss⁴, Enrike van der Linden-van der Zwaag⁵, TWJ Huizinga⁶, M. Kloppenburg⁷, REM Toes⁸, Martin Giera⁹, Steven B. Abramson³ and Andreea Ioan-Facsinay², ¹Center for Proteomics and Metabolomics, Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ³Department of Medicine, NYU School of Medicine, NYU Langone Medical Center, New York, NY, ⁴Department of Orthopedic Surgery, NYU School of Medicine, NYU Langone Medical Center, New York, NY, ⁵Department of Orthopaedics, Leiden University Medical Center, Leiden, Netherlands, ⁶Leiden University Medical Centre, Leiden, Netherlands, ⁷Rheumatology and Clinical Epidemiology, Leiden University Medical Center, Leiden, Netherlands, ⁸Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁹Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: Persistent inflammation is a characteristic of several joint diseases, including OA. It is nowadays appreciated that this could be a result of a failure…
Abstract Number: 1126 • 2016 ACR/ARHP Annual Meeting
Interleukin-1 Is Not Involved in Synovial Inflammation and Cartilage Destruction in Collagenase-Induced Osteoarthritis
Stephanie van Dalen¹, Arjen Blom¹, Annet Sloetjes¹, Monique M. Helsen¹, Johannes Roth², Thomas Vogl², Wim B. van den Berg¹, Martijn van den Bosch¹ and Peter L. E. M. van Lent¹, ¹Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ²Institute of Immunology, University of Münster, Münster, Germany
Background/Purpose: Osteoarthritis (OA) is characterized by severe cartilage destruction, with a putative role for synovial macrophages. Up to 50% of the patients also show low…
Abstract Number: 1127 • 2016 ACR/ARHP Annual Meeting
Extracellular Macrophage Migration Inhibitory Factor Is Essential for Hypoxia-Induced Angiogenesis in a Hypoxia Inducible Factor Independent Manner
Mathias Mursell^1,2, Martin Hahne^1,2,3, Peggy Kunath^1,2, Cindy Strehl^1,2, Paula Hoff^1,2, Frank Buttgereit² and Timo Gaber^1,2, ¹German Rheumatism Research Center (DRFZ), Berlin, Germany, ²Department of Rheumatology and Clinical Immunology, Charité – Universitätsmedizin Berlin, Berlin, Germany, ³Miltenyi Biotec GmbH, Bergisch Gladbach, Germany
Background/Purpose: Angiogenesis is a hallmark of the pathogenesis of rheumatoid arthritis (RA) but also of other inflammatory processes, tissue regeneration and progressing tumors. In RA,…
Abstract Number: 1128 • 2016 ACR/ARHP Annual Meeting
Anti-Fractalkine Monoclonal Antibody Inhibits Cartilage Destruction and Bone Erosion in Collagen-Induced Arthritis Model
Kana Hoshino¹, Masayoshi Ohkuro², Wataru Ikeda¹, Tomoya Nakatani¹, Yoshikazu Kuboi³, Naoto Ishii¹, Toshihiko Yamauchi¹, Nobuyuki Yasuda¹ and Toshio Imai¹, ¹KAN Research Institute Inc., Chuo-ku, Kobe-shi, Japan, ²Research Project Promotion Group, EA Pharma Co., Ltd., Kawasaki-ku, Kawasaki-shi, Japan, ³Medicine Creation. Neuro Business Group, Eisai Co., Ltd., Tsukuba-shi, Japan
Background/Purpose: Rheumatoid arthritis (RA) is a chronic disease leading to joint destruction. In the previous Phase 1/2 clinical study, E6011, a novel humanized anti-fractalkine (FKN)…
Abstract Number: 1129 • 2016 ACR/ARHP Annual Meeting
Tumor Necrosis Factor Receptor 2 Is Crucial for Regulatory T Cells Activity with Consequences in a Model of Chronic Inflammation and in Anti-TNF Treated Rheumatoid Arthritis
Francois Santinon¹, Maxime Batignes¹, Magali Breckler¹, Roxane Herve¹, Fredéric Caux^1,2, Patrice Decker³, Marie-Christophe Boissier^1,4, Luca Semerano^1,4 and Natacha Bessis⁵, ¹INSERM UMR 1125 University of Paris 13, Sorbonne Paris Cité, bobigny, France, ²Dermatology Dpt, Avicenne teaching Hospital, APHP, bobigny, France, ³UMR 1125, Inserm, Bobigny, France, ⁴Rheumatology Dpt, Avicenne teaching Hospital, APHP, bobigny, France, ⁵INSERM UMR 1125 University of Paris 13, Sorbonne Paris Cité, Bobigny, France
Background/Purpose: CD4+FoxP3+ regulatory T cells (Tregs) are essential for maintaining immune homeostasis, and are functionally defective in rheumatoid arthritis (RA) and other chronic inflammatory diseases.…

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