Abstracts Archive - Page 1452 of 2607 - ACR Meeting Abstracts

Abstract Number: 971 • 2017 ACR/ARHP Annual Meeting
Synovial Fibroblast CD318 Expression Mediates T Cell Adhesion and Migration in Rheumatoid Arthritis
Ray A. Ohara¹, Stephanie M. Rasmussen¹, W. Alexander Stinson¹, Huadong Cui¹, Yuxuan Du¹, Daniel P. Weber¹, M. Asif Amin¹, Phillip L. Campbell², Nora Singer³, Feng Lin⁴, David A. Fox¹ and Jeffrey H. Ruth⁵, ¹Division of Rheumatology and Clinical Autoimmune Center of Excellence, University of Michigan, Ann Arbor, MI, Ann Arbor, MI, ²Ann Arbor, MI, ³Division of Rheumatology, MetroHealth Medical Center, Cleveland, OH, Cleveland, OH, ⁴Department of Immunology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, Cleveland, OH, ⁵Internal Medicine, Division of Rheumatology and Clinical Autoimmune Center of Excellence, University of Michigan, Ann Arbor, MI, Ann Arbor, MI
Background/Purpose: CD6 is an important marker and regulator of T cells and interacts with its known ligand, CD166. Our group has previously shown that interferon…
Abstract Number: 972 • 2017 ACR/ARHP Annual Meeting
JAK/STAT Mediated Inhibition of Mir-23a~24-2~27a Cluster Potentiates Activation of CD14+ Monocytes in Treatment-Resistant RA
Marina Frleta-Gilchrist, Donna McIntyre, Aziza Elmesmari, Lynn Stewart, Derek Baxter, Mariola Kurowska-Stolarska, Derek Gilchrist and Iain B. McInnes, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom
Background/Purpose: While emerging and existing treatments of RA allow better options and clinical outcomes for patients, studies informing drug resistant states and further clinical therapeutic…
Abstract Number: 973 • 2017 ACR/ARHP Annual Meeting
IL-6 and TNF-a Cooperate to Modulate the Cell Cycle of RA-Fibroblast-like Synoviocytes Via Cyclin Dependent Kinase Inhibitors
Kenta Kaneshiro¹, Kohsuke Yoshida¹, Ayako Nakai¹, Kohjin Suzuki¹, Koto Uchida¹, Teppei Hashimoto², Yoshiko Kawasaki³, Natsuko Nakagawa⁴, Koji Tateishi⁵, Nao Shibanuma⁶, Yoshitada Sakai⁷ and Akira Hashiramoto¹, ¹Department of Biophysics, Kobe University Graduate School of Health Sciences, Kobe, Japan, ²Department of Rheumatology, Kobe Kaisei Hospital, Kobe, Japan, ³The Center of Rheumatic Diseases, Department of Rheumatology, Kobe Kaisei Hospital, Kobe, Japan, ⁴Department of Orthopaedic Surgery, Konan-Kakogawa Hospital, Kakogawa, Japan, ⁵Orthpaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan, ⁶Departmant of Orthopaedic Surgery, Kobe Kaisei Hospital, Kobe, Japan, ⁷Division of Rehabilitation Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
Background/Purpose: IL-6 and TNF-α play an important role in the pathogenesis of RA, and the proliferation of RA-synoviocytes (FLS) is controlled by cell cycle regulators…
Abstract Number: 974 • 2017 ACR/ARHP Annual Meeting
Leucine-Rich α-2 Glycoprotein Promotes Lung Fibrosis By Modulating TGF-β Signaling in Fibroblasts
Hiromi Honda, Minoru Fujimoto, Satoshi Serada, Hyun Lee, Tomoharu Ohkawara and Tetsuji Naka, Center for Intractable Immune Disease, Kochi University, Nankoku, Japan
Background/Purpose: Interstitial lung disease (ILD) is one of the most common extraarticular manifestation of rheumatoid arthritis. ILD is characterized by progressive fibrosis of the lung…
Abstract Number: 975 • 2017 ACR/ARHP Annual Meeting
IL-17A Induced Autophagy That the Proliferation of Rheumatoid Arthritis Fibroblast-like Synoviocytes through Down-Regulation of PI3K/AKT/mTOR Signaling Pathway
Sang-Hyon Kim¹, Jihye Bang², Ji-Min Kim¹, Chang-Nam Son¹, Jin-Nyeong Chae¹ and Hye-Jin Jeong³, ¹Division of Rheumatology, Department of Internal Medicine, Keimyung University Dongsan Medical Center, Keimyung University School of Medicine, Daegu, Republic of Korea, Daegu, Korea, Republic of (South), ²Division of Rheumatology, Department of Internal Medicine, Dongsan Medical Center, Keimyung University School of Medicine, Daegu, Korea, Republic of (South), ³Department of Rheumatology, Keimyung University Dongsan Medical Center, Daegu, Korea, Republic of (South)
Background/Purpose: Autophagy is generally thought of as a survival mechanism, although its deregulation has been linked to non-apoptotic cell death. Fibroblast-like synoviocytes (FLS) resistance to…
Abstract Number: 976 • 2017 ACR/ARHP Annual Meeting
Cannabinoid Receptor 2 Agonist (JWH-015) Inhibits Interleukin-1β-Induced Inflammation in Rheumatoid Arthritis Synovial Fibroblasts
Sabrina Fechtner and Salahuddin Ahmed, Department of Pharmaceutical Sciences, Washington State University, College of Pharmacy, Spokane, WA
Background/Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by activated synovial fibroblasts in which pro-inflammatory cytokine interleukin-1β (IL-1β) mediates inflammation. The endocannabinoid system…
Abstract Number: 977 • 2017 ACR/ARHP Annual Meeting
Association of Leisure-Time Physical Activity with Late-Life Mobility Limitation Among Women with Total Joint Replacement for Hip or Knee Osteoarthritis
Aladdin Shadyab¹, Wenjun Li², Charles Eaton³ and Andrea LaCroix⁴, ¹Family Medicine and Public Health, University of California, San Diego, La Jolla, CA, ²Medicine, University of Massachusetts Medical School, Worcester, MA, ³Family Medicine and Epidemiology, Warren Alpert Medical School, School of Public Health, Brown University, Providence, RI, ⁴Family Medicine and Public Health, University of California, San Diego School of Medicine, La Jolla, CA
Background/Purpose: Maintaining mobility in old age is an important public health goal for patients with hip or knee osteoarthritis (OA), who are vulnerable to functional…
Abstract Number: 978 • 2017 ACR/ARHP Annual Meeting
Dietary Patterns and Risk of Developing Knee Osteoarthritis: Data from the Osteoarthritis Initiative
Bing Lu¹, Jeffrey B. Driban², Timothy E. McAlindon³ and Charles Eaton⁴, ¹Rheumatoloy, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ²Rheumatology, Tufts Medical Center, Boston, MA, ³Division of Rheumatology, Tufts Medical Center, Boston, MA, ⁴Family Medicine and Epidemiology, Warren Alpert Medical School, School of Public Health, Brown University, Providence, RI
Background/Purpose: Few studies have examined the effect of diet on future risk of knee OA development. The association between overall dietary patterns and risk of…
Abstract Number: 979 • 2017 ACR/ARHP Annual Meeting
What Have We Learned from Trajectory Analysis of Clinical Outcomes in Osteoarthritis?
Maud Wieczorek¹, Anne-Christine Rat^1,2,3, Francis Guillemin^1,2 and Christine Rotonda¹, ¹Université de Lorraine, EA4360, APEMAC, Nancy, France, ²Inserm, CIC-1433 Epidémiologie Clinique, Vandoeuvre-lès-Nancy, France, ³Rheumatology Department, CHRU Nancy, Vandoeuvre-lès-Nancy, France
Background/Purpose: The aims of this review were to summarize the literature on the trajectories of clinical outcomes in knee and hip OA, to describe the…
Abstract Number: 980 • 2017 ACR/ARHP Annual Meeting
Is Intra-Articular Injection of Synvisc Associated with a Delay to Knee Arthroplasty in Knee OA Patients?
Kevin Ong¹, Maria Runa¹, Edmund Lau² and Roy Altman³, ¹Exponent, Inc., Philadelphia, PA, ²Exponent, Inc., Menlo Park, CA, ³UCLA Medical Center, Los Angeles, CA
Background/Purpose: Knee OA patients may undergo intra-articular (IA) hyaluronic acid (HA) injection treatment, but there is debate about its effectiveness. We asked: (1) What is…
Abstract Number: 981 • 2017 ACR/ARHP Annual Meeting
The Common Risk Factors for Hyperuricemia and Gout Do Not Predict Incident Gout Once Hyperuricemia Is Established
Richard J. Reynolds¹ and Jasvinder A. Singh², ¹Medicine, University of Alabama at Birmingham, Birmingham, AL, ²Rheumatology, University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: Metabolic syndrome, chronic kidney disease and hypertension are known to be associated with hyperuricemia and gout. Hypertension is associated with incident gout. The Normative…
Abstract Number: 982 • 2017 ACR/ARHP Annual Meeting
Epidemiology and Mortality in Systemic Sclerosis in South Korea: A Nationwide Population-Based Study
Kyong-Hee Jung¹, Seong-Ryul Kwon¹, Joo-Hyun Lee², Hyeong Sik Ahn³, Hyun Jung Kim³ and Gil Won Kang⁴, ¹Rheumatology, Inha University, Incheon, Korea, Republic of (South), ²Rheumatology, Inje University Ilsan Paik Hospital, Goyang, Korea, Republic of (South), ³Korea University, Seoul, Korea, Republic of (South), ⁴Chungbuk University, Cheongju, Korea, Republic of (South)
Background/Purpose: Systemic sclerosis (SSc) is an autoimmune connective tissue disease characterized by small vessel vasculopathy, autoantibody production, and excessive collagen deposition in the skin and…
Abstract Number: 983 • 2017 ACR/ARHP Annual Meeting
Identifying Exposures to Chemicals in Patients with SLE – a Non-Targeted Exposome Approach Reveals Enrichment for Phthalates
Cristina Lanata¹, Thomas Lin², Maria Dall'Era¹, Jinoos Yazdany³, Patricia P. Katz¹, Laura Trupin³, Charles G. Helmick⁴, Roy Gerona⁵ and Lindsey A. Criswell¹, ¹Medicine/Rheumatology, University of California, San Francisco, San Francisco, CA, ²Univeristy of California, San Francisco, SAN FRANCISCO, CA, ³Medicine/Rheumatology, University of California San Francisco, San Francisco, CA, ⁴Centers for Disease Control and Prevention, Atlanta, GA, ⁵Obstetrics and Gynecology, University of California, San Francisco, SAN FRANCISCO, CA
Background/Purpose: Environmental exposures may play a substantial role in the pathogenesis of SLE. The goal of this study is to characterize the serum levels of…
Abstract Number: 984 • 2017 ACR/ARHP Annual Meeting
Identification of Key Screening Characteristics for Systemic Lupus Erythematosus Natural History
Kendra A. Young¹, Melissa E. Munroe², Joel M. Guthridge³, Diane L. Kamen⁴, Gary S. Gilkeson⁵, Michael Weisman⁶, David Karp⁷, John B. Harley⁸, Daniel J. Wallace⁶, Judith A. James⁹ and Jill M. Norris¹⁰, ¹Epidemiology, University of Colorado Denver, Aurora, CO, ²Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ³Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, OKC, OK, ⁴Medicine/Rheumatology & Immunology, Medical University of South Carolina, Charleston, SC, ⁵Department of Medicine, Medical University of South Carolina, Charleston, SC, ⁶Cedars-Sinai Medical Center Division of Rheumatology, Los Angeles, CA, ⁷Rheumatology, UT Southwestern Med Ctr, Dallas, TX, ⁸Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁹Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ¹⁰Department of Epidemiology, Colorado School of Public Health, Aurora, CO
Background/Purpose: A prospective study of preclinical SLE disease evolution is needed to help elucidate critical aspects of disease etiology and early pathogenesis, and to identify…
Abstract Number: 985 • 2017 ACR/ARHP Annual Meeting
Heart Failure Hospitalizations Among SLE and Diabetes Mellitus Patients Compared to the General U.S. Medicaid Population
Sarah Chen¹, Medha Barbhaiya², Michael A. Fischer³, Hongshu Guan⁴, Candace H. Feldman⁵, Brendan M. Everett⁶ and Karen H. Costenbader⁷, ¹Brigham and Women's Hospital, Boston, MA, ²Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ³Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ⁴Rheumatology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ⁵Rheumatology, Brigham & Women's Hospital, Boston, MA, ⁶Division of Cardiovascular Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ⁷Brigham and Women's Hospital, Harvard Medical School, Boston, MA
Background/Purpose: Cardiovascular disease (CVD) risk is increased in SLE patients, compared to the general population and age- and sex-matched diabetes mellitus (DM) patients. Heart failure…

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