Abstracts Archive - Page 1447 of 2607 - ACR Meeting Abstracts

Abstract Number: 896 • 2017 ACR/ARHP Annual Meeting
The Steroid Tapering in ANCA Vasculitis Evaluation Study (STAVE) 2: A Systematic Review and Meta-Analysis
Jennifer Rodrigues¹, David Collister¹, Amy Archer², Kim Cheema³, Paul Alexander⁴, Christian Pagnoux⁵, Lehana Thabane⁴, Peter A. Merkel⁶, David Jayne⁷ and Michael Walsh¹, ¹Nephrology, McMaster University, Hamilton, ON, Canada, ²Rheumatology, Northwestern University, Chicago, IL, ³Nephrology, University of Calgary, Calgary, AB, Canada, ⁴Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada, ⁵Division of Rheumatology, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada, ⁶Division of Rheumatology, University of Pennsylvania; Perelman School of Medicine, Philadelphia, PA, ⁷Vasculitis and Lupus Clinic, Department of Medicine, University of Cambridge, Cambridge, United Kingdom
Background/Purpose: Relapses of ANCA-associated vasculitis (AAV) are associated with death, decreased renal function, and end-stage renal disease. Whether longer-term treatment with glucocorticoids (GC) reduces the…
Abstract Number: 897 • 2017 ACR/ARHP Annual Meeting
Cutaneous Lupus Is Driven By an Exaggerated Interferon Kappa Loop Which Primes for Interferon Alpha Responses
Johann Gudjonsson¹, Mrinal Sarkar¹, Alex Tsoi², Celine C. Berthier³, Grace Hile⁴, Yun Liang⁴, Jianhua Liu⁵, Paul Harms⁶ and J. Michelle Kahlenberg⁷, ¹Dermatology, University of Michigan, Ann Arbor, MI, ²Departments of Dermatology and Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, ³Nephrology, Division of Nephrology, University of Michigan Medical Center, Ann Arbor, MI, ⁴University of Michigan, Ann Arbor, MI, ⁵Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor, MI, ⁶Pathology, University of Michigan, Ann Arbor, MI, ⁷Internal Medicine, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI
Background/Purpose: Cutaneous inflammation is a common and disfiguring manifestation for 70% of patients with systemic lupus erythematosus, yet our understanding of the pathogenesis of cutaneous…
Abstract Number: 898 • 2017 ACR/ARHP Annual Meeting
B Cell Specific TLR9 Suppresses Disease in Murine Lupus
Jeremy Tilstra¹, Rachael Gordon², Shinu John³, Brady Marburger², Sheldon Bastacky⁴, Kevin Nickerson² and Mark Shlomchik⁵, ¹Rheumatology, Univ of Pittsburgh Medical Center, Pittsburgh, PA, ²University of Pittsburgh, Pittsburgh, PA, ³Moderna Therapeutics, Cambridge, MA, ⁴Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, ⁵Immunology, University of Pittsburgh, Pittsburgh, PA
Background/Purpose: Toll-like receptor (TLR) signaling is a central to lupus pathogenesis. GWAS studies have repeatedly identified components of TLR signaling pathway in SLE patients. Furthermore,…
Abstract Number: 899 • 2017 ACR/ARHP Annual Meeting
Neutrophil Gene Signature and Low Density Granulocyte Subsets Associate with Coronary Plaque Burden and Vascular Inflammation in Systemic Lupus Erythematosus
Philip Carlucci¹, Monica Purmalek¹, Simantini Sakhardande¹, Yenealem Temesgen-Oyelakin¹, Amit K. Dey², Aditya A. Joshi², Joseph B. Lerman³, Alice Fike¹, Michael Davis⁴, Hong-Wei Sun¹, Jonathan H. Chung², Martin P. Playford², Pragnesh Mistry¹, Gustavo Gutierrez-Cruz¹, Stefania Dell'Orso¹, Faiza Naz¹, Heather Teague², Zerai G. Manna⁵, Peter C. Grayson¹, Mohammad Naqi¹, Marcus Chen², Sarfaraz A. Hasni¹, Nehal N. Mehta² and Mariana J. Kaplan¹, ¹NIH/NIAMS, Bethesda, MD, ²NIH/NHLBI, Bethesda, MD, ³NIH/CC, Bethesda, MD, ⁴NIH/NIAMS, Bethesda, IA, ⁵NIH/NIAMS, Bethesda, MD, Afghanistan
Background/Purpose: Systemic lupus erythematosus (SLE) increases a young woman’s risk of myocardial infarction by up to 50-fold. This marked increase in cardiovascular disease (CVD) risk…
Abstract Number: 900 • 2017 ACR/ARHP Annual Meeting
Choroid Plexus Tertiary Lymphoid Structures in Lupus: A Novel Neuro-Immune Interface
Ariel Stock¹, Evan Der², Sivan Gelb³, Ayal Ben-Zvi³ and Chaim Putterman⁴, ¹Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, ²Albert Einstein College of Medicine, Bronx, NY, ³Hebrew University, Jerusalem, Israel, ⁴Division of Rheumatology, Albert Einstein College of Medicine, Bronx, NY, USA, Bronx, NY
Background/Purpose: The central nervous system (CNS) manifestations of SLE remain poorly understood. Although potentially neuropathic autoantibodies have been identified in the serum, lupus patients show…
Abstract Number: 901 • 2017 ACR/ARHP Annual Meeting
Role of Epstein Barr Virus Serologic Reactivation in Transitioning to Systemic Lupus Erythematosus in at Risk Individuals
Neelakshi R. Jog¹, Kendra A. Young², Melissa E. Munroe¹, Michael T Harmon³, Joel M. Guthridge⁴, Diane L. Kamen⁵, Gary S. Gilkeson⁶, Michael Weisman⁷, David Karp⁸, John B. Harley^9,10, Daniel J. Wallace¹¹, Jill M. Norris¹² and Judith A. James^13,14, ¹Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Epidemiology, Colorado School of Public Health, Aurora, CO, ³Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁴Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, OKC, OK, ⁵Medicine/Rheumatology & Immunology, Medical University of South Carolina, Charleston, SC, ⁶Department of Medicine, Medical University of South Carolina, Charleston, SC, ⁷Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, ⁸Rheumatology, UT Southwestern Med Ctr, Dallas, TX, ⁹US Department of Veterans Affairs Medical Center, Cincinnati, OH, ¹⁰Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ¹¹Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, ¹²Department of Epidemiology, Colorado School of Public Health, Aurora, CO, ¹³Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ¹⁴Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK
Background/Purpose: Systemic Lupus Erythematosus (SLE) is a systemic autoimmune disease characterized by autoantibody production and periods of elevated and suppressed disease activity. Various genetic and…
Abstract Number: 902 • 2017 ACR/ARHP Annual Meeting
Evidence for Inhibition of Osteoclastogenesis By Cytomegalovirus Infection: Implication in RA Bone Erosion and Identification of a Cellular Protein As a Therapeutic Target
Benjamin Rauwel¹, Michel Baron¹, Adeline Ruyssen-Witrand², Delphine Nigon³, Yannick Degboé², Jacques Izopet¹, Alain Cantagrel¹ and Jean-Luc Davignon¹, ¹CPTP, INSERM UMR 1043, Toulouse, France, ²Rheumatology, Purpan Hospital, Toulouse III University, Toulouse, France, ³Rheumatology, Purpan University Hospital, Toulouse Cedex 9, France
Background/Purpose: Exacerbated differentiation of monocytes into osteoclasts (OC) contributes to the pathogenesis of rheumatoid arthritis (RA) resulting in severe bone erosion and functional damage. Osteoclastogenesis…
Abstract Number: 903 • 2017 ACR/ARHP Annual Meeting
Increased Expression of CCN4/WISP1 in Osteoarthritic Articular Cartilage Is Epigenetically Regulated and Disrupts Cartilage Homeostasis
Martijn H. van den Bosch¹, Yolande F. Ramos², Wouter den Hollander², Nils Bömer², Rob G. Nelissen³, Judith V. Bovée⁴, Peter L. van Lent¹, Arjen B. Blom¹, Peter M. van der Kraan¹ and Ingrid Meulenbelt², ¹Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ²Department of Molecular Epidemiology, Leiden University Medical Center, Leiden, Netherlands, ³Department of Orthopedics, Leiden University Medical Center, Leiden, Netherlands, ⁴Department of Pathology, Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: Previously, we described increased expression of Wnt-1-induced signaling protein 1 (Wisp1) in murine synovium and cartilage after induction of experimental osteoarthritis (OA) models. WISP1…
Abstract Number: 904 • 2017 ACR/ARHP Annual Meeting
Deficient Autophagy Induces Lamin a/C Accumulation in Aging and Osteoarthritis
Paloma Lopez de Figueroa¹, Uxia Nogueira-Recalde², Fernando Osorio³, Martin Lotz⁴, Carlos Lopez-Otin³, Francisco J Blanco² and Beatriz Carames¹, ¹Cartilage Biology Group. Rheumatology Division, INIBIC-CHUAC, A Coruña, Spain, A Coruña, Spain, ²Cartilage Biology Group. Rheumatology Division, INIBIC-CHUAC, A Coruña, A Coruña, Spain, ³Degradome Lab, Universidad de Oviedo, Oviedo, Spain, ⁴Department of Molecular & Experience Medicine, Scripps Research Institute, LaJolla, CA
Background/Purpose: Autophagy, an essential chondrocyte homeostasis mechanism, is defective in Aging and Osteoarthritis (OA). However, the targets regulating this mechanism are still unknown. Here, we…
Abstract Number: 905 • 2017 ACR/ARHP Annual Meeting
Regenerating Cartilage and Reversing Osteoarthritis (OA) Stimulation of Adenosine A2A Receptors (A2AR) Increases Cartilage Volume and Matrix in Vitro and In Vivo
Carmen Corciulo¹, Cristina Castro², Thomas Coughlin³, Tuere Wilder¹, Oran Kennedy⁴ and Bruce Cronstein⁵, ¹Department of Medicine, Division of Rheumatology, NYU School of Medicine, New York, NY, ²Medicine, NYU School of Medicine, New York, NY, ³Orthopaedic Surgery, NYU School of Medicine, New York, NY, ⁴Department of Anatomy, Royal College of Surgeons, Dublin, Ireland, ⁵Rheumatology, New York University School of Medicine, Division of Rheumatology, New York, NY
Background/Purpose: We have recently reported that endogenously produced adenosine, interacting with A2AR, is a critical autocrine factor for maintenance of chondrocyte and cartilage homeostasis and…
Abstract Number: 906 • 2017 ACR/ARHP Annual Meeting
Anp32a Is a Critical Regulator of Oxidative Stress in Cartilage and Protects Against Osteoarthritis
Frederique Cornelis¹, Silvia Monteagudo¹, Wouter den Hollander², Tine Peeters³, Laura-An Guns¹, Lies Storms¹, Ingrid Meulenbelt² and Rik Lories¹, ¹Skeletal Biology and Engineering Research Center, KU Leuven, Leuven, Belgium, ²Department of Molecular Epidemiology, Leiden University Medical Center, Leiden, Netherlands, ³Skeletal Biology and Engineering Research Center, KU Leuven, 3000, Belgium
Background/Purpose: We described an association between polymorphisms in the ANP32a gene and osteoarthritis. Osteoarthritis is one of the most common chronic musculoskeletal disorders and a…
Abstract Number: 907 • 2017 ACR/ARHP Annual Meeting
Five-Year Evolution of the Center of Excellence in Musculoskeletal Care and Education: A National Resource for the Continuum of Health Professions Education and Scholarship
Andrea Barker¹, J. Peter Beck², Grant Cannon³, Marissa Grotzke⁴, Scott Swasey^5,6, Curry L. Koening⁷, Dorota Lebiedz-Odrobina⁶, Yasuharu Okuda⁸ and Michael J. Battistone¹, ¹Veterans Affairs Salt Lake City Health Care System and University of Utah School of Medicine, Salt Lake City, UT, ²Orthopaedics, Salt Lake City VA Medical Center and University of Utah, Salt Lake City, UT, ³Salt Lake City VA Medical Center and University of Utah, Salt Lake City, UT, ⁴Division of Endocrinology, Veterans Affairs Salt Lake City Health Care System and University of Utah School of Medicine, Salt Lake City, UT, ⁵Salt Lake City VA Medical Center, Salt Lake City, UT, ⁶University of Utah, Salt Lake City, UT, ⁷Rheumatology, University of Utah, Salt Lake City, UT, ⁸VHA SimLEARN National Center, Orlando, FL
Background/Purpose: In 2011, the Veterans Affairs (VA) Office of Academic Affiliations funded the creation of the Center of Excellence (COE) in Musculoskeletal (MSK) Care and…
Abstract Number: 908 • 2017 ACR/ARHP Annual Meeting
Impact of a National Training Program on Primary Care Providers Utilization of Knee MRI
Erica Jaffe¹, Andrea Barker², J. Peter Beck³, Grant Cannon⁴ and Michael J. Battistone², ¹Internal Medicine, Veterans Affairs Salt Lake City Health Care System and University of Utah School of Medicine, Salt Lake City, UT, ²Veterans Affairs Salt Lake City Health Care System and University of Utah School of Medicine, Salt Lake City, UT, ³Orthopaedics, Salt Lake City VA Medical Center and University of Utah, Salt Lake City, UT, ⁴Salt Lake City VA Medical Center and University of Utah, Salt Lake City, UT
Background/Purpose: The US Department of Veterans Affairs (VA) has developed a national continuing professional development program to train primary care providers (PCPs) in the care…
Abstract Number: 909 • 2017 ACR/ARHP Annual Meeting
Two-Year Impact of a Continuing Professional Education Program to Train Primary Care Providers to Perform Arthrocentesis
Michael J. Battistone¹, Andrea Barker¹, J. Peter Beck², Phillip Lawrence³ and Grant Cannon⁴, ¹Veterans Affairs Salt Lake City Health Care System and University of Utah School of Medicine, Salt Lake City, UT, ²Orthopaedics, Salt Lake City VA Medical Center and University of Utah, Salt Lake City, UT, ³Salt Lake City VA Medical Center and Roseman University of Health Sciences, Salt Lake City, UT, ⁴Salt Lake City VA Medical Center and University of Utah, Salt Lake City, UT
Background/Purpose: Initial reports of a local continuing professional education (CPE) program designed for primary care providers (PCPs) described an increase in in the number of…
Abstract Number: 910 • 2017 ACR/ARHP Annual Meeting
Training Adult Rheumatology Fellows in Young Adult Transition and Transfer Skills
Rebecca Sadun¹, Gary Maslow², Richard Chung³ and Lisa Criscione-Schreiber⁴, ¹Rheumatology Adult and Pediatric, Duke University Medical Center, Durham, NC, ²Psychiatry and Pediatrics, Duke University Medical Center, Durham, NC, ³Internal Medicine and Pediatrics, Duke University Medical Center, Durham, NC, ⁴Internal Medicine, Duke University Medical Center, Durham, NC
Background/Purpose: The transition from pediatric to adult healthcare is a vulnerable time for adolescents and young adults (AYA) with chronic conditions. EULAR and the Pediatric…

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