ACR Meeting Abstracts

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  • Abstract Number: 0253 • ACR Convergence 2025

    Ophthalmology Screening for Asymptomatic Uveitis in Sarcoidosis Patients: A Single-Center Investigation

    Justin Nguyen1, Philip Bucur2, Sai Patel2, Aamer Syed2, Thomas Iden3, Jessica McLaughlin2, Neha Gupta2, Jordana Kron2, Kelly Gwathmey2, Ryan Canissario2, Vaishali Patel2 and Huzaefah Syed2, 1Virginia Commonwealth University Medial Center, Richmond, VA, 2Virginia Commonwealth University Medical Center, Richmond, VA, 3Virginia Commonwealth University Medical Center, Richmond

    Background/Purpose: Asymptomatic ocular involvement must be considered in any patient with sarcoidosis. If left untreated, severe complications, including vision loss, can occur. As a result,…
  • Abstract Number: 0254 • ACR Convergence 2025

    Comparative Outcomes in MAGIC Syndrome versus Relapsing Polychondritis Alone: A Propensity-Matched Analysis

    Justin Riley Lam1, Emmanuel Otabor2, Laith Alomari2, Michael Hamilton2, Maxim Barnett2, Shahrzad Abdollahi3 and Irene Tan4, 1Albert Einstein Medical Center, Philadelphia, PA, 2Jefferson Einstein Hospital Philadelphia, Philadelphia, PA, 3Jefferson Einstein Hospital, Philadelphia, PA, 4Einstein Healthcare Network Philadelphia - Jefferson Health, Bala Cynwyd, PA

    Background/Purpose: MAGIC syndrome, a rare overlap of relapsing polychondritis (RP) and Behçet’s disease manifestations, remains poorly characterized compared to isolated RP. Behçet’s-associated features such as…
  • Abstract Number: 0241 • ACR Convergence 2025

    Efficacy and Safety of JAK Inhibitors in Behçet’s Syndrome: A Systematic Literature Review

    Bercemhan Sulu1, Sinem Nihal Esatoglu1, Ibrahim Hatemi2, Aykut Ferhat Celik3 and Gulen Hatemi1, 1Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty, Department of Internal Medicine, Division of Rheumatology, Istanbul, Turkey, 2Istanbul University-Cerrahpasa / Cerrahpasa Medical Faculty, Department of Internal Medicine, Division of Gastroenterology, Istanbul, Turkey, 3Istanbul University-Cerrahpasa / Cerrahpasa Medical Faculty / Department of Internal Medicine / Division of Gastroenterology, Istanbul, Turkey

    Background/Purpose: Tumor necrosis factor inhibitors (TNFi) are a key treatment modality for major organ involvement, one of the main contributors to morbidity and mortality, as…
  • Abstract Number: 0259 • ACR Convergence 2025

    Inhaled pirfenidone as an innovative therapeutic approach to treat autoimmune ILD and other forms of Progressive Pulmonary Fibrosis: Phase 2b Study Design

    Kristin Highland1, Colin Reisner2, Allison Trucillo3, Deepthi Nair4, Felix Woodhead4, Howard Lazarus4, Craig Conoscenti4 and Martin Kolb5, 1Cleveland Clinic, Shaker Heights, OH, 2DevPro Biopharma, Basking Ridge, NJ, 3Avalyn Pharma, Austin, TX, 4Avalyn Pharma, Cambridge, MA, 5McMaster University, Hamilton, ON, Canada

    Background/Purpose: Progressive Pulmonary Fibrosis (PPF) is an increasingly recognized condition, defined in 2022 to address the progression of pulmonary fibrosis in patients with interstitial lung…
  • Abstract Number: 0282 • ACR Convergence 2025

    Clinical Meaningfulness and Improvement Thresholds of Myositis Core Set Measures: Association with Patient-Reported Outcomes

    Shiri Keret1, Raisa Lomanto Silva2, Irada Choudhuri3, Eugenia Gkiaouraki3, Tanya Chandra3, Nantakarn Pongtarakulpanit3, Shreya Sriram3, Niladri Bhowmick3, Vaidehi Kothari3, Kaushik Sreerama Reddy3, Eaman Alhassan4, Anushka Aggarwal5, Maha Almackenzie6, Siamak Moghadam-Kia4, Dana Ascherman7, Chester V. Oddis7 and Rohit Aggarwal8, 1Bnai Zion Medical Center, Atlit, Israel, 2Massachusetts General Hospital, Boston, MA, 3University of Pittsburgh Medical Center, Pittsburgh, 4University of Pittsburgh Medical Center, Pittsburgh, PA, 5Indraprastha Apollo Hospital, New Delhi, India, 6Medical Cities of the Ministry of the Interior, Riyadh, Saudi Arabia, 7University of Pittsburgh, Pittsburgh, PA, 8University of Pittsburgh, Rheumatology and Clinical Immunology, Pittsburgh, United States of America, Pittsburgh, PA

    Background/Purpose: The six myositis core set measures (CSMs) are widely utilized to assess disease activity in idiopathic inflammatory myopathies (IIM). However, their association with how…
  • Abstract Number: 0263 • ACR Convergence 2025

    A Multicenter Retrospective Case Series of Patients with Susac Syndrome treated with Rituximab

    Michelle Benjamin1, Mattia Wruble Clark2, Shamik Bhattacharyya3, Audra Horomanski1 and Kristin Galetta4, 1Stanford University, Palo Alto, CA, 2Mass General Brigham, Somerville, MA, 3Brigham and Women's Hospital, Malden, MA, 4Stanford Medical Center, Palo Alto

    Background/Purpose: Susac Syndrome (SuS) is a rare immune-mediated vasculo-occlusive disease characterized by a triad of encephalopathy, hearing loss, and branched retinal artery occlusions. Deficits can…
  • Abstract Number: 0057 • ACR Convergence 2025

    TNF Inhibition with Small-molecule Agents Results in Amelioration of Inflammation Similar to that of Anti-TNF Biologics While Preserving TNFR2 Signaling and Maintaining a Suppressive Regulatory T cell Phenotype

    Rajesh Singh1, Bindi Patel2, Rameshwari Rayaji2, Archana Sidalaghatta Nagaraja2, Saranya Chandrasekar2, Yihong Guan2, Ritu Kushwaha2, Yue Tong Lee2, Cesar Meleza2, Matthew Epplin2, Brandon Rosen2, Manmohan R Leleti2, Matthew J Walters2 and Daniel DiRenzo2, 1Arcus Biosciences, inc., Santa Clara, CA, 2Arcus Biosciences, inc., Hayward, CA

    Background/Purpose: Anti-TNF biologics are effective in the treatment of inflammatory diseases such as rheumatoid arthritis and psoriasis. However, they can lead to de novo inflammation…
  • Abstract Number: 0261 • ACR Convergence 2025

    Randomized Confirmatory Basket Trial: Performance Evaluation of a Simulated Application Example in Rare Disease Using Real World Data

    Daphne Guinn1, Linchen He2, Yuru Ren1, Valeriy Korostyshevskiy1 and Robert Beckman1, 1Georgetown University, Washington, 2Novartis, East Hanover

    Background/Purpose: Basket trials group together participants who share a common biomarker or disease pathway across several diseases or phenotypes in a single clinical study. Such…
  • Abstract Number: 0251 • ACR Convergence 2025

    Impact of Mepolizumab on Idiopathic Hypereosinophilic Syndromes: Preliminary Analysis of a Monocentric Retrospective Cohort

    Jacopo Mora1, Francesca Regola1, Paola Toniati2, Giulia Fontana1, Alessia Gatti1, Ilaria Cavazzana3 and Franco Franceschini4, 1Rheumatology and Clinical Immunology Unit – ERN ReCONNET, ASST Spedali Civili and University of Brescia, Brescia, Lombardia, Italy, 2Rheumatology and Clinical Immunology Unit – ERN ReCONNET, ASST Spedali Civili of Brescia, Brescia, Lombardia, Italy, 3Rheumatology and Clinical Immunology Unit, Clinical and Experimental Sciences Department, ERN ReCONNET, ASST Spedali Civili of Brescia and University of Brescia, Brescia, Italy, Brescia, Lombardia, Italy, 4University of Brescia, Brescia, Brescia, Italy

    Background/Purpose: Idiopathic hypereosinophilic syndromes (iHES) are a group of disorders characterized by persistent eosinophilia and eosinophil-mediated organ damage. Mepolizumab, an anti-interleukin-5 monoclonal antibody, has proven…
  • Abstract Number: 0276 • ACR Convergence 2025

    Plasma Proteomic Profiling Identifies Inflammatory Proteins and Pathways Associated With Non-idiopathic and Idiopathic Retroperitoneal Fibrosis

    Thomas Pelowitz, Benjamin Hur, Kenneth Warrington, Jaeyun Sung and Matthew Koster, Mayo Clinic, Rochester, MN

    Background/Purpose: Retroperitoneal fibrosis (RPF) is a rare fibroinflammatory disease of the retroperitoneum that can lead to obstructive uropathy and other life-threatening complications. While RPF can…
  • Abstract Number: 0278 • ACR Convergence 2025

    Classic and Clinically Amyopathic Dermatomyositis: Autoantibody Positivity

    Xiwei Yang1, Shae Chambers2, Aretha On1, Hammad Ali2, Touraj Khosravi3, Lais Lopes Almeida Gomes2, Rui Feng4 and Victoria Werth5, 1Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 2University of Pennsylvania, Philadelphia, PA, 3Department of Dermatology, Perelman Shool of Medicine, University of Pennsylvania, Philadelphia, PA, 4Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania, Philadelphia, PA, 5University of Pennsylvania, Wynnewood, PA

    Background/Purpose: Dermatomyositis (DM) is an idiopathic inflammatory myopathy subclassified as classic (CDM) and clinically amyopathic (CADM). It can involve myositis-associated (MAA) and myositis-specific (MSA) autoantibodies.…
  • Abstract Number: 0172 • ACR Convergence 2025

    Cancer Screening for Patients with Rheumatic Diseases: A Scoping Review

    Teresa Xiao1, Namrata Singh2 and Pankti Reid3, 1University of Chicago, Chicago, IL, 2University of Washington, Bellevue, WA, 3University of Chicago Medical Center, Chicago, IL

    Background/Purpose: There is minimal guidance on specific cancer screening practices for rheumatic diseases (RDs) other than for myositis. The aim of this scoping review was…
  • Abstract Number: 0273 • ACR Convergence 2025

    Effector CD8+ T cells and PD-1hi CXCL13hi CD4+ T cells contribute to recurrent immune checkpoint inhibitor mediated inflammatory arthritis

    Synat Keam1, Yuanteng Li2, Yanshuo Chu1, Jean Tayar3, Huifang Lu4, Michael Wu5, Sandeep Agarwal6, Nitin Jain7, Pavlos Msaouel1, Adi Diab2, Cara Haymaker1, Linghua Wang1, Roza Nurieva8 and Sang Kim9, 1The University of Texas MD Anderson Cancer Center, houston, 2MD Anderson Cancer Center, Houston, TX, 3The University of Texas, MD Anderson Cancer Center, Houston, TX, 4UT MD Anderson Cancer Center, Houston, TX, 5Baylor College of Medicine, Houston, 6Baylor College of Medicine, Houston, TX, 7The Universty of Texas MD Anderson Cancer Center, Houston, 8University of Texas MD Anderson, Houston, TX, 9Yale University, Branford, CT

    Background/Purpose: Immune checkpoint inhibitor (ICI) therapy is associated with life- and/or organ-threatening immune-related adverse events, including inflammatory arthritis (ICI-IA). However, the mechanisms behind ICI-IA, especially…
  • Abstract Number: 0189 • ACR Convergence 2025

    “Try it, you’ll love it”: Patterns of AI Scribes Use Among Rheumatologists

    Megan Creasman1, Jing Li2, Augusto Garcia-Agundez3, gabriela Schmajuk4 and Jinoos Yazdany3, 1UC San Francisco, San Francisco, CA, 2University of California, San Francisco, San Francisco, CA, 3UCSF, San Francisco, CA, 4University of California, San Francisco, and San Francisco Veterans Affairs Medical Center, San Francisco, CA

    Background/Purpose: Heavy documentation contributes to clinician workload and burnout. Rheumatology carries one of the highest documentation burdens among Internal Medicine (IM) subspecialties. While recent advances…
  • Abstract Number: 0218 • ACR Convergence 2025

    Creating an EHR Lupus Outreach Workbench to Address Care Gaps

    Ross Gilbert1, Starla Blanks2, Joy Buie3, Mary Cronin4, Jake Decker5, Laura Dickmann6, Cristina Drenkard7, Sancia Ferguson8, Shivani Garg9, David Gazeley5, Andrea Gilmore-Bykovskyi10, Gale Johnson11, Patti Katz12, Tristan Lazewski13, S. Sam Lim14, Jenna McGoldrick15, Katrina Phelps10, Edmond Ramly16, Rosalind Ramsey-Goldman17, Ann Rosenthal18, Dawn Thomas-Semanko19, Sarah Stoltz13, Patricia Tellez-giron20, Amannda Weber21, Andrea Wipperfurth13 and Christie Bartels10, 1Johns Hopkins University, Baltimore, MD, 2American College of Rheumatology, Atlanta, GA, 3Lupus Foundation of America, Washington, DC, 4retired, Fox Point, WI, 5Medical College of Wisconsin, Milwaukee, WI, 6Froedtert Health, Waukesha, WI, 7Rollins School of Public Health, Emory University, Atlanta, Georgia, USA, Acworth, GA, 8University of Wisconsin School of Medicine and Public Health, Madison, Madison, WI, 9University of Madison, School of Medicine and Public Health, Madison, WI, 10University of Wisconsin School of Medicine and Public Health, Madison, WI, 11Wisconsin Department of Health Services, Madison, WI, 12UCSF, San Rafael, CA, 13UW Health, Madison, WI, 14Emory University School of Medicine, Atlanta, GA, 15SSM Health, Madison, WI, 16Indiana University - Bloomington, Bloomington, IN, 17Northwestern University Feinberg School of Medicine, Chicago, IL, 18Department of Medicine, Division of Rheumatology, Medical College of Wisconsin, Wisconsin, 19WI Chapter - LFA, Milwaukee, WI, 20University of Wisconsin, School of Medicine and Public Health, Madison, Madison, WI, 21University of Wisconsin (UW), UW Health, Madison, WI

    Background/Purpose: Lupus affects up to 1.5 million people in the US with significant health disparities in care and outcomes that call for care delivery innovation.…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM CT on October 25. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].

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