Abstracts Archive - Page 1434 of 2425 - ACR Meeting Abstracts

Abstract Number: 241 • 2016 ACR/ARHP Annual Meeting
Analysis of 84 Patients with IgG4-Related Disease and Malignancy
Kazunori Yamada^1,2, Ichiro Mizushima², Hideki Nomura³ and Mitsuhiro Kawano², ¹Department of Advanced Research in Community Medicine, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan, ²Division of Rheumatology, Kanazawa University Hospital, Kanazawa, Japan, ³Department of General Medicine, Kanazawa University Hospital, Kanazawa, Japan
Background/Purpose: IgG4-related disease (IgG4-RD) is a systemic inflammatory disease characterized by an elevated serum level of IgG4, infiltration of IgG4-positive cells in affected organs and…
Abstract Number: 242 • 2016 ACR/ARHP Annual Meeting
Clinical and Laboratory Features of IgG4-Related Retroperitoneal Fibrosis/Periarteritis in Japan: Retrospective Multicenter Study of 99 Cases
Ichiro Mizushima¹, Satomi Kasashima², Motohisa Yamamoto³, Takako Saeki⁴, Kazunori Yamada⁵, Dai Inoue⁶, Fuminori Kasashima⁷, Yasushi Matsumoto⁷, Eisuke Amiya⁸, Kenji Notohara⁹, Yasuharu Sato¹⁰, Yoh Zen¹¹, Shigeyuki Kawa¹², Mitsuhiro Kawano¹ and Nobukazu Ishizaka¹³, ¹Division of Rheumatology, Kanazawa University Hospital, Kanazawa, Japan, ²Department of Clinical Laboratory and Pathology, National Hospital Organization, Kanazawa Medical Center, Kanazawa, Japan, ³First Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan, ⁴Department of Internal Medicine, Nagaoka Red Cross Hospital, Nagaoka, Japan, ⁵Department of Advanced Research in Community Medicine, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan, ⁶Department of Radiology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan, ⁷Department of Cardiovascular Surgery, National Hospital Organization, Kanazawa Medical Center, Kanazawa, Japan, ⁸Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Tokyo, Japan, ⁹Department of Pathology, Kurashiki Central Hospital, Kurashiki, Japan, ¹⁰Department of Pathology, Okayama University Graduate School of Medicine, Okayama, Japan, ¹¹Department of Diagnostic Pathology, Kobe University Graduate School of Medicine, Kobe, Japan, ¹²Center for Health, Safety and Environmental Management, Shinshu University, Matsumoto, Japan, ¹³Department of Cardiology, Osaka Medical College, Osaka, Japan
<span">Background/Purpose: IgG4-related disease (IgG4-RD) is a recently recognized systemic inflammatory disorder that can affect many organs. It frequently causes retroperitoneal/periarterial lesions, which are referred to…
Abstract Number: 243 • 2016 ACR/ARHP Annual Meeting
Eosinophilic Angiocentric Fibrosis : A Mimic of Vasculitis in IgG4 Related Disease Spectrum
Raphaël Lecomte¹, Antoine Néel², Olivier Malard³, Jérôme Martin⁴, Michael Hénoux³, Elisabeth Cassagnau⁵ and Mohamed Hamidou^6,7, ¹Internal Medicine Department, CHU Nantes, Nantes, France, ²Department of Internal Medicine, Nantes University Hospital, Nantes, France, ³ENT, ENT department, Nantes University Hospital, Nantes, France, ⁴Immunology laboratory, Immunology laboratory, Nantes University Hospital, Nantes, France, ⁵Histopathology, Histopathology department, Nantes University Hospital, Nantes, France, ⁶Hotel Dieu, Service de médecine interne, Hôpital Universitaire de Nantes, Nantes, France, Nantes, France, ⁷Internal Medicine Department, Internal Medicine Department, Nantes University Hospital, Nantes, France
Background/Purpose: Eosinophilic angiocentric fibrosis (EAF) is a rare localized fibro-inflammatory lesion involving usually upper respiratory tract and the orbit. It could mimic ENT manifestations of…
Abstract Number: 244 • 2016 ACR/ARHP Annual Meeting
Leflunomide and Glucocorticoids Combination Therapy for the Induction and Maintenance of Remission in Patients with IgG4-Related Disease
Yiwen Wang¹, Dai Gao¹, Gui Luo², Kunpeng Li¹, Zheng Zhao¹ and Jian Zhu¹, ¹Rheumatology, Chinese PLA General Hospital, Beijing, China, ²Chinese PLA General Hospital, Beijing, China
Background/Purpose: Good response could be observed after applying glucocorticoids (GCs) in patients with IgG4-related disease (IgG4-RD), however, the risk of disease relapse was reported relatively…
Abstract Number: 245 • 2016 ACR/ARHP Annual Meeting
Efficacy of Cyclophosphamide Therapy in Idiopathic Retroperitoneal Fibrosis in a Retrospective Monocentric Analysis
Bimba F. Hoyer¹, Caroline Kumpert², Marcus Makowski³, Birgit Rudolph⁴, U. Schneider⁵, Gerd R. Burmester⁶ and Falk Hiepe⁷, ¹Charité University Medicine, Department of Medicine/Rheumatology and Clinical Immunology and German Rheumatism Research Centre Berlin (DRFZ), Berlin, Germany, ²department of Rheumatology and clinical Immunology, Charité University Medicine Berlin,, Berlin, Germany, ³Department for Radiology, Charité Universityhospital, Berlin, Germany, ⁴Department for pathology, Charité Universityhospital, Berlin, Germany, ⁵Rheumatology and Clinical Immunology, Charité, Rheumatology and Clinical Immunology, Berlin, Germany, ⁶Charité – University Medicine Berlin, Berlin, Germany, ⁷Charité – Universitätsmedizin, Berlin, Germany
Background/Purpose: Ormond’s disease (idiopathic retroperitoneal fibrosis ,IRF) is a rare disease. Main clinical symptom is compression of the ureters leading to renal failure. A majority…
Abstract Number: 246 • 2016 ACR/ARHP Annual Meeting
Efficacy of Colchicine and IL-1 Inhibitors in Amyloidosis Associated with Familial Mediterranean Fever: A Retrospective Analysis
Bahtiyar Toz¹, Seher Tecer², Emin Oğuz¹, Murat Erdugan¹, Bahar Artim-Esen¹, Sevil Kamali³, Murat Inanc⁴, Lale Ocal³, Burak Erer¹ and Ahmet Gul¹, ¹Department of Internal Medicine, Division of Rheumatology, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey, ²Department of Internal Medicine, Istanbul faculty of medicine Istanbul University, Istanbul, Turkey, ³Department of Internal Medicine, Rheumatology Division, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey, ⁴Department of Internal Medicine, Division of Rheumatology, Istanbul University, Istanbul Faculty of Medicine, İstanbul, Turkey
Background/Purpose: Familial Mediterranean fever (FMF), the most common form of hereditary autoinflammatory diseases, is associated with increased risk for secondary (AA) amyloidosis. We herein aimed…
Abstract Number: 247 • 2016 ACR/ARHP Annual Meeting
ANTI-Interleukin 1 Therapy in FMF Amyloidosis: A Single Center Experience
Serdal Ugurlu, Bilgesu Ergezen and Huri Ozdogan, Division of Rheumatology, Department of Internal Medicine, Cerrahpasa Medical Faculty, University of Istanbul, Istanbul, Turkey
Background/Purpose: Recently there is increasing number of reports pointing out the efficacy of anti-interleukin 1(anti-IL1)therapy to control AA amyloidosis secondary to autoinflammatory diseases. Here we…
Abstract Number: 248 • 2016 ACR/ARHP Annual Meeting
Disease Severity and High Attack Frequency Under Colchicine Treatment Is Associated with Increased Carotid Intima Media Thickness in FMF
Murat Karabacak¹, Ali Ugur Unal², Gulsen Ozen³, Zeynep Erturk⁴, Yasemin Yalcinkaya³, Zeynep Komesli¹, Nevsun Inanc³, Pamir Atagunduz³ and Haner Direskeneli⁵, ¹Marmara University Faculty of Medicine, Istanbul, Turkey, ²Marmara University, School of Medicine, Rheumatology, Istanbul, Turkey, ³Department of Rheumatology, Marmara University Faculty of Medicine, Istanbul, Turkey, ⁴Rheumatology, Marmara University Faculty of Medicine, Istanbul, Turkey, ⁵Rheumatology, Marmara University, School of Medicine, Istanbul, Turkey
Background/Purpose: Cardiovascular (CV) risk assessment is infrequently performed in Familial Mediterranean Fever (FMF), an autoinflammatory disorder with only acute attacks of inflammation. As a surrogate…
Abstract Number: 249 • 2016 ACR/ARHP Annual Meeting
MiR-204-3p Associates with an Increased Level of IL-6 in Familial Mediterranean Fever By Targeting the PIK3 Signaling Pathway
Tomohiro Koga¹, Kiyoshi Migita², Akihiro Yachie³, Yukitaka Ueki⁴, Kazunaga Agematsu⁵, Junya Masumoto⁶, Koh-ichiro Yoshiura⁷, Katsumi Eguchi⁸ and Atsushi Kawakami¹, ¹Unit of Advanced Preventive Medical Sciences, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ²Department of Rheumatology and Clinical Research Center, Nagasaki Medical Center, Omura, Japan, ³Department of Pediatrics, School of Medicine, Institute of Medical, Pharmaceutical, and Health Sciences, Kanazawa University, Kanazawa, Japan, ⁴Rheumatic and Collagen Disease Center, Sasebo Chuo Hospital, Sasebo, Japan, ⁵Department of Infectious Immunology, Shinshu University, Graduate School of Medicine, Shinshu, Japan, ⁶Department of Pathology, Division of Analyticalpathology, Ehime University Graduate School of Medicine, Toon, Japan, ⁷Department of Human Genetics, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ⁸Department of Rheumatology and Metabolism, Sasebo City General Hospital, Sasebo, Japan
Background/Purpose: Familial Mediterranean fever (FMF) is caused by a number of mutations of the MEFV gene, coding for a protein named pyrin that acts as…
Abstract Number: 250 • 2016 ACR/ARHP Annual Meeting
Application of the 2016 European Leage Against Rheumatism (EULAR) /American College of Rheumatology (ACR)/Paediatric Rheumatology International Trials Organisation (PRINTO) Classification Criteria of Macrophage Activation Syndrome in Patients with Adult Onset Still’s Disease
Sung Soo Ahn¹, Seung Min Jung², Sang-Won Lee¹, Yong-Beom Park¹ and Jason Jungsik Song¹, ¹Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea, ²Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea, The Republic of
Background/Purpose: Macrophage activation syndrome (MAS) is acute systemic inflammation arising in the context of various autoimmune and autoinflammatory conditions, which is often life-threatening. In 2016,…
Abstract Number: 251 • 2016 ACR/ARHP Annual Meeting
Persistent Pruritic Skin Lesions with Dyskeratotic Cells in Upper Layer of Epidermis Are Specific and Associated with High Levels of Serum IL-18 in Adult-Onset Still’s Disease
Natsuki Maeda^1,2, Yoshinori Taniguchi³, Kimiko Nakajima⁴, Yoshiko Shimamura⁵, Hirofumi Nishikawa⁶, Shuichi Nakayama⁴, Shigetoshi Sano⁴, Shimpei Fujimoto⁶ and Yoshio Terada⁵, ¹Endocrinology,Metabolism,Nephrology and Rheumatology, Kochi Medical School, Nankoku, Japan, ²Dermatology, Kochi Medical School, Nankoku, Japan, ³Endocrinology, Metabolism,Nephrology and Rheumatology, Kochi University, Kochi, Japan, ⁴Kochi Medical School, Nankoku, Japan, ⁵Kochi University, Nankoku, Japan, ⁶Endocrinology, Metabolism, Nephrology and Rheumatology, Kochi Medical School, Nankoku, Japan
Background/Purpose: Adult-onset Still’s disease (AOSD) is an acute and systemic inflammatory disorder that is characterized by high spiking fever, evanescent rash, arthralgia/arthritis and hyperferritinemia. However,…
Abstract Number: 252 • 2016 ACR/ARHP Annual Meeting
Cytokine Profiles of Korean Patients with Adult Onset Still’s Disease Treated with Biologic Agents
Seung Taek Song¹, SuMan Kang², Sung Won Lee³, Seoung Wan Nam², Hyukhee Kwon² and Dae-Hyun Yoo⁴, ¹Division of Rheumatology, Department of Internal Medicine, Cheongju St. Mary's Hospital, Cheongju, Korea, The Republic of, ²Division of Rheumatology, Department of Internal Medicine, Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea, The Republic of, ³Department of Rheumatology, Division of Rheumatology, Department of Internal Medicine, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea, ⁴Division of Rheumatology, Department of Internal Medicine, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea
Background/Purpose: Adult onset Still’s disease (AOSD) is a rare inflammatory disorder of unknown etiology. Several studies have reported that pro-inflammatory cytokines including interleukin (IL)-1, IL-6,…
Abstract Number: 253 • 2016 ACR/ARHP Annual Meeting
Corticosteroid-Free Tocilizumab Monotherapy for Adult Onset Still’s Disease: Results in Six Month
Tsuneo Kondo¹, Yusuke Okada², Akiko Shibata¹, Kentaro Chino¹, Ayumi Okuyama¹, Hirofumi Takei¹ and Koichi Amano¹, ¹Department of Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama Medical University, Saitama, Japan, ²Saitama Medical Center, Saitama Medical University, Kawagoe, Japan
Background/Purpose: To assess the efficacy and safety of tocilizumab (TCZ) monotherapy for the induction therapy of adult onset Still’s disease (AOSD) in a prospective, single-arm, single-center, cohort,…
Abstract Number: 254 • 2016 ACR/ARHP Annual Meeting
NLRP12 Autoinflammatory Disease: A Chinese Case Series and Literature Review
Min Shen¹, Lin Tang², Xiaochun Shi³, Xiaofeng Zeng¹ and Qingping Yao⁴, ¹Rheumatology, Peking Union Medical College Hospital, Beijing, China, ²Rheumatology, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, China, ³Infectious Disease, Peking Union Medical College Hospital, Beijing, China, ⁴Rheumatology, Allergy, and Immunology, Stony Brook University School of Medicine, Stony Brook, NY
Background/Purpose: Systemic autoinflammatory diseases (SAIDs) are a genetically heterogeneous group of rheumatic diseases that are driven by abnormal activation of the innate immune system.…
Abstract Number: 255 • 2016 ACR/ARHP Annual Meeting
Safety and Efficacy of Long-Term Canakinumab Therapy in Patients with CAPS: Final Results from Beta-Confident Registry
Hal M. Hoffman¹, Jasmin B. Kuemmerle-Deschner², Philip N. Hawkins³, Tom van der Poll⁴, Ulrich A. Walker⁵, Antonio Speziale⁶, Yolandi Joubert⁶ and Hugh H. Tilson⁷, ¹Division of Rheumatology, Allergy, and Immunology, University of California at San Deigo, La Jolla, CA, ²Pediatrics, University Hospital Tuebingen, Tuebingen, Germany, ³University College London Medical School, London, United Kingdom, ⁴Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, ⁵Department of Rheumatology, University Hospital Basel, Basel, Switzerland, ⁶Novartis Pharma AG, Basel, Switzerland, ⁷University of North Carolina, Gillings School of Global Public Health, Chapel Hill, NC
Background/Purpose: Cryopyrin-associated periodic syndrome (CAPS) is a rare auto-inflammatory disease encompassing a spectrum of 3 phenotypes: familial cold auto-inflammatory syndrome (FCAS), Muckle–Wells syndrome (MWS), and…

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