Abstracts Archive - Page 1419 of 2607 - ACR Meeting Abstracts

Abstract Number: 476 • 2017 ACR/ARHP Annual Meeting
Novel Interaction between Anti-Citrulline Monoclonal Antibodies and Apoptotic Cells Is Mediated through Citrullinated Nuclear Antigens
Katy A. Lloyd¹, Peter Sahlström², Johanna Steen¹, Philip J. Titcombe^3,4, Diana Zhou¹, Christina Lundqvist⁵, Olov Ekwall^6,7, Jimmy Ytterberg¹, Johan Rönnelid⁸, Daniel L. Mueller³, Lars Klareskog¹, Vivianne Malmström¹ and Caroline Grönwall⁹, ¹Dept. of Medicine, Rheumatology Unit, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, ²Dept. of Medicine, Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden, ³Dept. of Medicine, University of Minnesota Medical School, Minneapolis, MN, ⁴Dept. of Medicine, Rheumatology Unit, Karolinska Institutet, Karolinska University Hospital, Sweden, Sweden, ⁵Dept. of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden, ⁶Dept. of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy University of Gothenburg, Göteborg, Sweden, ⁷Dept of Pediatrics, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden, ⁸Department of Immunology Genetics and Pathology, Uppsala University, Uppsala, Sweden, ⁹Dep. of Medicine, Rheumatology Unit, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
Background/Purpose: Anti-citrullinated protein antibodies (ACPA) display broad cross-reactivities and target proteins including a-enolase, filaggrin, vimentin, fibrinogen, and histones. However, every monoclonal ACPA has a distinct…
Abstract Number: 477 • 2017 ACR/ARHP Annual Meeting
Monoclonal ACPA-IgG Feature Extensive Fab Glycosylation
Katy A. Lloyd¹, Johanna Steen¹, Philip J. Titcombe^2,3, Khaled Amara⁴, Diana Zhou¹, Lena Israelsson⁵, Susanna L. Lundström⁶, Daniel L. Mueller³, Lars Klareskog¹, Vivianne Malmström¹ and Caroline Grönwall⁷, ¹Dept. of Medicine, Rheumatology Unit, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, ²Dept. of Medicine, Rheumatology Unit, Karolinska Institutet, Karolinska University Hospital, Sweden, Sweden, ³Dept. of Medicine, University of Minnesota Medical School, Minneapolis, MN, ⁴Department of Medicine, Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden, ⁵Dept. of Medicine, Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden, ⁶Dept. of Medical Biochemistry and Biophysics, Division of Physiological Chemistry, Karolinska Institutet, Stockholm, Sweden, ⁷Dep. of Medicine, Rheumatology Unit, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
Background/Purpose: Fab-glycosylation is found in ~15-25% serum IgG and while its exact consequence remains unknown, it may alter IgG functionality. Recent data revealed elevated Fab-glycosylation…
Abstract Number: 478 • 2017 ACR/ARHP Annual Meeting
Ectopic Lymphoid Tissue in the Lung Is Uniquely Associated with the ACPA IgA Isotype Even in Absence of Classifiable RA
Lindsay B. Kelmenson¹, M. Kristen Demoruelle¹, Carlyne D. Cool² and Kevin D. Deane¹, ¹Rheumatology Division, University of Colorado Denver, Aurora, CO, ²Pathology, University of Colorado Denver, Aurora, CO
Background/Purpose: Antibodies to citrullinated protein antigens (ACPA) precede the development of rheumatoid arthritis (RA) and may be generated in the lung of established and preclinical…
Abstract Number: 479 • 2017 ACR/ARHP Annual Meeting
Protein Carbamylation Is Induced By Activated Neutrophil: Ex Vivo Analysis
Shuichiro Nakabo¹, Koichiro Ohmura¹, Shuji Akizuki¹, Nobuo Kuramoto¹, Kosaku Murakami², Ran Nakashima², Motomu Hashimoto³, Hajime Yoshifuji¹, Masao Tanaka³ and Tsuneyo Mimori¹, ¹Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan, ²Clinical Immunology and Rheumatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan, ³Department of Advanced Medicine for Rheumatic Diseases, Graduate School of Medicine, Kyoto University, Kyoto, Japan
Protein carbamylation is induced by activated neutrophil: ex vivo analysisBackground/Purpose: Anti-carbamylated protein (anti-CarP) antibodies were reported to be detected in 45% of rheumatoid arthritis (RA)…
Abstract Number: 480 • 2017 ACR/ARHP Annual Meeting
ANTI-Carbamylated Protein Antibodies (CARP) in Palindromic Rheumatism: Prevalence and Clinical Significance
Raul Castellanos-Moreira Sr.¹, Virginia Ruiz-Esquide¹, María José Gomara², Sonia Cabrera-Villalba¹, Sebastian C Rodriguez-Garcia¹, Georgina Salvador³, Andrea Cuervo¹, Julio Ramírez¹, M. Victoria Hernández¹, Juan Cañete¹, Isabel Haro² and Raimon Sanmartí¹, ¹Rheumatology Service, Hospital Clínic de Barcelona, Barcelona, Spain, ²Unit of Synthesis and Biomedical Applications of Peptides, IQAC-CSIC, Barcelona, Spain, ³Hospital Universitario Mutua Terrassa, Barcelona, Spain
Background/Purpose: Autoantibodies (RF or ACPA) are found in sera from patients with palindromic rheumatism (PR) but there are no studies analyzing the presence of Anti-carbamylated…
Abstract Number: 481 • 2017 ACR/ARHP Annual Meeting
Immunocompetent Cells Expressing Citrullinated Proteins in Joint Synovium of Osteoarthritis and Rheumatoid Arthritis
Kyoko Honne¹, Masahiro Iwamoto², Shunichiro Hanai¹, Satoshi Machida³, Hitoshi Sekiya⁴, Reina Tsuda⁵, Tatsuhiko Ozawa⁵, Tadayoshi Karasawa⁶, Atsushi Muraguchi⁵, Masafumi Takahashi⁶, Hiroyuki Kishi⁵ and Seiji Minota⁷, ¹Division of Rheumatology and Clinical Immunology, Jichi Medical University, Shimotsuke, Japan, ²Deivision of Rheumatology and Clinical Immunology, Jichi Medical University, Shimotsuke, Japan, ³Department of Orthopaedic Surgery, Orthopedics Clinic Medical Papas, Tochigi, Japan, ⁴Department of orthopedic surgery, Jichi Medical University, Shimotsuke, Japan, ⁵Department of Immunology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan, ⁶Division of Inflammation Research Center for Molecular Medicine, Jichi Medical University, Shimotsuke, Japan, ⁷Division of Rheumatology and Clinical Immunology, Jichi Medical University, Tochigi, Japan
Background/Purpose: Human monoclonal ACPA (Human-ACPA) is reported to strongly bind to synovium in RA patients [1]. The aims of our study were 1) To investigate…
Abstract Number: 482 • 2017 ACR/ARHP Annual Meeting
The Link between ACPA and Erosion Development: Is ACPA Sufficient? an Association Study in Clinically Suspect Arthralgia
Robin M ten Brinck¹, REM Toes² and Annette H.M. van der Helm-van Mil¹, ¹Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Rheumatology, Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: Anti-citrullinated protein antibodies (ACPA) associate with more severe joint erosions in rheumatoid arthritis (RA), but the underlying mechanism is unclear. Recent in vitro and…
Abstract Number: 483 • 2017 ACR/ARHP Annual Meeting
Anti-Peptidylarginine Deiminase-4 Antibodies Are Present in the Sputum of RA Patients and Can Activate Peptidylarginine Deiminase-4 Enzyme Activity
M. Kristen Demoruelle¹, Hong Wang², Ryan L. Davis², A. Itzam Marin¹, Jill M. Norris³, V. Michael Holers¹, Kevin D. Deane¹ and Erika Darrah², ¹Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, ²Division of Rheumatology, The Johns Hopkins University, Baltimore, MD, ³Department of Epidemiology, Colorado School of Public Health, Aurora, CO
Background/Purpose: Anti-peptidylarginine deiminase (PAD)-4 antibodies (Abs) are present in a portion of RA patients and associate with more severe joint disease, suggesting that they play…
Abstract Number: 484 • 2017 ACR/ARHP Annual Meeting
Sputum Neutrophils Demonstrate Increased Neutrophil Extracellular Trap Formation in RA-Free Subjects at-Risk of Future RA
Yuko Okamoto¹, Michael P. Mohning², Stacey M. Thomas², Ashley Visser¹, Lindsay B. Kelmenson³, Jill M. Norris⁴, Mariana J. Kaplan⁵, William J. Janssen², V. Michael Holers¹, Kevin D. Deane¹ and M. Kristen Demoruelle¹, ¹Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, ²Division of Pulmonary Disease and Critical Care Medicine, National Jewish Health, Denver, CO, ³Division of Rheumatoloty, University of Colorado School of Medicine, Aurora, CO, ⁴Department of Epidemiology, Colorado School of Public Health, Aurora, CO, ⁵Systemic Autoimmunity Branch, NIAMS/NIH, Bethesda, MD
Background/Purpose: Data support that ACPAs are generated in the lung in RA-free subjects At-Risk of future RA. Our group previously demonstrated a significant positive correlation…
Abstract Number: 485 • 2017 ACR/ARHP Annual Meeting
Different Citrullination Profiles in Spontaneous Versus Leukemia-Associated Rheumatoid Arthritis
Tal Gazitt¹, Son Hong Nguyen², Ari Salinger², Christian Lood³, Xizhang Sun¹, Lena M. Tanaka¹, David Feith⁴, Jeffrey Ledbetter⁵, Gordon Starkebaum⁶, Thomas Loughran Jr.⁷, Paul R. Thompson² and Keith B. Elkon⁸, ¹Division of Rheumatology, University of Washington, Seattle, WA, ²Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA, ³Division of Rheumatology, Division of Rheumatology, Department of Medicine, University of Washington, Seattle, WA, ⁴Hematology and Oncology, University of Virginia, Charlottesville, VA, ⁵University of Washington, Seattle, WA, ⁶Department of Medicine, Division of Rheumatology, University of Washington, Seattle, WA, ⁷Hematology Oncology, University of Virginia, Charlottesville, VA, ⁸Division of Rheumatology, Department of Medicine, University of Washington, Seattle, WA
Background/Purpose: Protein citrullination, the post-translational conversion of arginine to citrulline, mediated by peptidylarginine deiminase (PAD) enzymes, is considered a likely mechanism for the stimulation of…
Abstract Number: 486 • 2017 ACR/ARHP Annual Meeting
Anti-Citrullinated Protein Antibody Reactivities in Treatment NaïVe Early Rheumatoid Arthritis
Maria K. Jonsson^1,2, Aase Hensvold³, Monika Hansson⁴, Linda Mathsson-Alm⁵, Anna-Birgitte Aga², Joseph Sexton², Bjørg-Tilde Fevang^1,6, Siri Lillegraven², Anca I. Catrina³ and Espen A. Haavardsholm^2,7, ¹Dept. of Rheumatology, Haukeland University Hospital, Bergen, Norway, ²Dept. of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ³Karolinska Institute, Stockholm, Sweden, ⁴Rheumatology Unit, Department of Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden, ⁵Thermo Fisher Scientific, Uppsala, Sweden, ⁶Dept. of Clinical Science, University of Bergen, Bergen, Norway, ⁷University of Oslo, Oslo, Norway
Background/Purpose: Anti-citrullinated protein antibody (ACPA) reactivities can precede RA onset, and may be involved in the pathogenesis of the disease. We wanted to assess the…
Abstract Number: 487 • 2017 ACR/ARHP Annual Meeting
ARE ANTI-Citrullinated Protein Antibody Levels Associated with Periodontal Disease in Rheumatoid Arthritis?
Jerián González Febles¹, Fernando Sánchez-Alonso², Jorge Luis Garnier Rodríguez³, Mariano Sanz Alonso¹, Federico Díaz-González⁴ and Beatriz Rodriguez Lozano^5,6, ¹Periodontology, Universidad Complutense de Madrid, Madrid, Spain, ²Unidad de Investigación, Spanish Society of Rheumatology, Madrid, Spain, ³Odontology, Dental Clinic Garnier, S/C Tenerife, Spain, ⁴Servicio de Reumatología. Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain, ⁵Rheumatology, Rheumatology Department. Hospital Universitario de Canarias, S/C TENERIFE, Spain, ⁶Rheumatology, Hospital de Canarias, S/C Tenerife, Spain
Background/Purpose: Positivity of anti-citrullinated peptides antibodies (ACPA) indicates severity in Rheumatoid Arthritis (RA). There is evidence for chronic periodontitis (PD) in RA autoimmune response by…
Abstract Number: 488 • 2017 ACR/ARHP Annual Meeting
Increased Expression of TNF-α and PAD-2 in Human Monocytes Following Treatment with Protein Modified with Malondialdehyde-Acetaldehyde (MAA) and Citrulline
Logan M. Duryee¹, Michael J. Duryee², Dahn L Clemens¹, Evan M. Ryan¹, Carlos D. Hunter², Lynell W. Klassen³, James R. O'Dell³, Daniel R. Anderson¹, Ted R. Mikuls⁴ and Geoffrey M. Thiele¹, ¹University of Nebraska Medical Center, Omaha, NE, ²Internal Medicine Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, ³Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, ⁴Internal Medicine, Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE
Background/Purpose: We have previously shown that malondialdehyde-acetaldehyde (MAA) and citrullinated proteins are present together in the synovial tissues of rheumatoid arthritis (RA) patients. Macrophage are…
Abstract Number: 489 • 2017 ACR/ARHP Annual Meeting
Endotypic Clustering of Rheumatoid Arthritis Patients through the Use of Tissue Specific Serum Biomarkers Identifies Structural Progressors
Joseph Patrick Michele Blair¹, Cecilie Liv Bager¹, Line Mærsk Staunstrup¹, Henning Bay Nielsen¹, Morten Karsdal² and Anne-C. Bay-Jensen³, ¹ProScion, Herlev, Denmark, ²Biomarkers and Reseacrh, Nordic Bioscience, Herlev, Denmark, ³Biomarkers and Reseach, Nordic Bioscience, Herlev, Denmark
Background/Purpose: Treatment of RA patients is guided by measures of disease activity such as DAS28, best practice recommendation, and less often by a treat-to-target approach.…
Abstract Number: 490 • 2017 ACR/ARHP Annual Meeting
Clinical and Biomarker Factors in the Prediction of Future Inflammatory Arthritis in ACPA Positive Subjects without Inflammatory Arthritis at Baseline
John P. Gerstenberger¹, Colin I. O'Donnell², Sarah L. Dill³, Randall Tagg⁴, Masoud Asadi-Zeydabadi⁴, M. Kristen Demoruelle⁵, V. Michael Holers⁶ and Kevin D. Deane⁷, ¹Department of Medicine, University of Colorado Denver School of Medicine, Aurora, CO, ²University of Colorado Denver School of Medicine, Aurora, CO, ³Division of Rheumatology, University of Colorado Denver School of Medicine, Aurora, CO, ⁴Department of Physics, University of Colorado Denver, Denver, CO, ⁵1775 Aurora Ct, 1775 Aurora Ct, Aurora, CO, ⁶Rheumatology Division, University of Colorado School of Medicine, Aurora, CO, ⁷Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO
Background/Purpose: Antibodies to citrullinated protein antigens (ACPA) can identify individuals who may develop future inflammatory arthritis (IA) and classifiable rheumatoid arthritis (RA). Indeed, there are…

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