Abstracts Archive - Page 1406 of 2607 - ACR Meeting Abstracts

Abstract Number: 280 • 2017 ACR/ARHP Annual Meeting
Reasons Why Patients Failed Vaccinations Vs Influenza and Pneumococcus. Monocentric Cross-Sectional Study.
Maria Chiara Ditto¹, Alberto Batticciotto¹, Maria Chiara Gerardi¹, Federica Rigamonti², Rossella Talotta¹ and Piercarlo Sarzi-Puttini¹, ¹Rheumatology Unit, ASST Fatebenefratelli - Sacco, L. Sacco University Hospital, Milano, Italy, ²Rheumatology Unit, ASST Fatebenefratelli - Sacco, L. Sacco University Hospital, Milan, Italy
Background/Purpose: immunosuppressive therapies and bDAMRDs expecially, increase the risk of infections. According to the EULAR guidelines, all patients affected by autoimmune/inflammatory diseases should receive vaccinations…
Abstract Number: 281 • 2017 ACR/ARHP Annual Meeting
Direct Medical Costs Associated with the Extrahepatic Manifestations of Hepatitis C Virus Infection in France
Patrice Cacoub¹, Mathieu vautier², Anne-Claire Desbois³, David Saadoun⁴ and Zobair Younossi⁵, ¹Department of Internal Medicine and Clinical Immunology, Groupe Hospitalier Pitié-Salpêtrière, Paris, France, ²Médecine Interne 1, Hôpital Pitié-Salpêtrière, Paris, France, ³Hôpital Pitié-Salpêtrière, Internal Medicine and Clinical Immunology, Paris, France, ⁴Sorbonne Universités, UPMC Univ Paris 06, UMR 7211, and Inflammation-Immunopathology-Biotherapy Department (DHU i2B), F-75005, Paris, France; INSERM, UMR_S 959, F-75013, Paris, France; CNRS, FRE3632, F-75005, Paris, France; AP-HP, Groupe Hospitalier, Paris, France, ⁵Medicine, Inova Fairfax Hospital, Falls Church, Falls Church, VT
Background/Purpose: The economic impact of the extrahepatic manifestations (EHM) of hepatitis C virus (HCV) infection remains unknown for France. To estimate the prevalence of HCV-EHM…
Abstract Number: 282 • 2017 ACR/ARHP Annual Meeting
The Value of Imaging As an Early Noninvasive Test for Prosthetic Joint Septic Arthritis
Kevin Byrne¹, Mary Louise Fowler², Sarah Lieber³, Robert Shmerling⁴ and Ziv Paz³, ¹Boston University School of Medicine, Boston, MA, ²2Boston University School of Medicine, Boston, MA, ³Beth Israel Deaconess Medical Center, Boston, MA, ⁴Rheumatology, Beth Israel Deaconess Medical Center, Boston, MA
Background/Purpose: Medical imaging is commonly obtained in evaluating patients with suspected prosthetic joint septic arthritis (PJSA); it may be helpful to detect other pathology in…
Abstract Number: 284 • 2017 ACR/ARHP Annual Meeting
Metabolic Activity Sustains Macrophage Cytokine Production in Rheumatoid Arthritis and Coronary Artery Disease
Cornelia M. Weyand¹, Markus Zeisbrich¹, Lukas Brosig², Barbara Wallis¹, Niall Roche³, Janice Lin¹ and Jorg Goronzy⁴, ¹Medicine: Immunology and Rheumatology, Stanford University, Stanford, CA, ²Medicine: Immunology and Rheumatology, Stanford University, Stanfod, CA, ³The Arthritis Center, Pleasanton, CA, ⁴Medicine/Division of Immunology & Rheumatology, Stanford University School of Medicine, Stanford, CA
Background/Purpose: Accelerated atherosclerosis has become increasingly recognized as a complication of chronic inflammatory disease, such as in patients with rheumatoid arthritis (RA). RA patients have…
Abstract Number: 285 • 2017 ACR/ARHP Annual Meeting
Liver X Receptor-α (LXRα) Modulates Macrophage Phenotype and Disease Activity in SLE
Shuhong Han¹, Haoyang Zhuang¹, Pui Lee², Stepan Shumyak¹, Jingfan Wu¹, Chao Xie³, Hui Li³, Lijun Yang³ and Westley Reeves⁴, ¹Medicine, University of Florida, Gainesville, FL, ²Harvard Medical School, Boston, MA, ³Pathology, Immunology and laboratory medicine, University of Florida, Gainesville, FL, ⁴Rheumatology & Clinical Immology, University of Florida, Gainesville, FL
Background/Purpose: LXRα is an oxysterol-regulated transcription factor that plays a key role in reverse cholesterol transport by inducing the expression of ATP binding cassette A1…
Abstract Number: 286 • 2017 ACR/ARHP Annual Meeting
Serum Amyloid a Aggravates Rheumatoid Arthritis By Activating NFAT5-Mediated Migration of Macrophages
Yu-Mi Kim Sr.¹, Donghyun Kim Sr.¹, Seung-Ah Yoo Sr.², Jung Hee Koh Sr.², Jin-Sun Kong Sr.² and Wan-Uk Kim Sr.³, ¹Center for Integrative Rheumatoid Transcriptomics and Dynamics, The Catholic University of Korea, Seoul, Korea, Republic of (South), ²The Catholic University of Korea, Center for Integrative Rheumatoid Transcriptomics and Dynamics, seoul, Korea, Republic of (South), ³The Catholic University of Korea, Department of Internal Medicine, seoul, Korea, Republic of (South)
Background/Purpose: Serum amyloid A (SAA) is an acute phase protein and its serum levels may increase up to 1000-fold over normal levels during inflammation, triggering…
Abstract Number: 287 • 2017 ACR/ARHP Annual Meeting
Anti-TNF Agents Induce Alternative Macrophages
Yannick Degboé¹, Benjamin Rauwel², Michel Baron², Jean Frédéric Boyer², Alain Cantagrel², Arnaud Constantin³ and Jean-Luc Davignon², ¹Centre de Physiopathologie Toulouse Purpan, INSERM UMR 1043, Toulouse, France, ²CPTP, INSERM UMR 1043, Toulouse, France, ³Department of Rheumatology, Purpan Hospital, Toulouse III University, Toulouse, France, Toulouse, France
Background/Purpose: Macrophages contribute to the pathogenesis of rheumatoid arthritis (RA). They can display various states of activation or « polarization », characterized by distinct functions…
Abstract Number: 288 • 2017 ACR/ARHP Annual Meeting
The Rheumatoid Arthritis Susceptibility Gene C5orf30 Is an Immunomodulator in Macrophages
Emma Dorris¹, Karen Creevey¹, John Moylett¹, Simon Tazzyman², Munitta Muthana² and Anthony G. Wilson¹, ¹UCD School of Medicine and Medical Science, Conway Institute, University College Dublin, Dublin, Ireland, ²University of Sheffield Medical School, Sheffield, United Kingdom
Background/Purpose: rs26232 in the first intron of C5orf30 has been associated with risk of developing rheumatoid arthritis (RA) and severity of tissue damage. C5orf30 is…
Abstract Number: 289 • 2017 ACR/ARHP Annual Meeting
HDL Modified with Malondialdehyde-Acetaldehyde (MAA) Is Bound and Rapidly Internalized By Human THP-1 Monocytes
Michael J. Duryee¹, Dahn L Clemens², Logan M. Duryee², Karen C. Easterling³, Carlos D. Hunter⁴, Lynell W. Klassen⁵, James R. O'Dell⁶, Daniel R. Anderson², Ted R. Mikuls⁵ and Geoffrey M. Thiele², ¹Research Services, Omaha VA Medical Center, Omaha, NE, ²University of Nebraska Medical Center, Omaha, NE, ³Internal Medicine, Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, ⁴Internal Medicine Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, ⁵Veteran Affairs Nebraska-Western Iowa Health Care System and University of Nebraska Medical Center, Omaha, NE, ⁶Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE
Background/Purpose: Rheumatoid arthritis (RA) is associated with an increased cardiovascular disease (CVD) burden, one that appears to be mitigated by increased concentrations of circulating HDL…
Abstract Number: 290 • 2017 ACR/ARHP Annual Meeting
Characterization of Neutrophil Subsets and Neutrophil Extracellular Traps in Pyogenic Arthritis, Pyoderma Gangrenosum and Acne (PAPA) Syndrome
Pragnesh Mistry¹, Carmelo Carmona-Rivera¹, Nickie Seto¹, Monica Purmalek¹, Amanda Ombrello², Ivona Aksentijevich², Daniel L. Kastner² and Mariana J. Kaplan¹, ¹Systemic Autoimmunity Branch, NIAMS/NIH, Bethesda, MD, ²Inflammatory Disease Section, NHGRI/NIH, Bethesda, MD
Background/Purpose: Pyogenic arthritis, pyoderma gangrenosum and acne (PAPA) syndrome is an autosomal dominant autoinflammatory disorder caused by mutations in the PSTPIP1/CD2BP1 gene. PAPA syndrome is…
Abstract Number: 291 • 2017 ACR/ARHP Annual Meeting
A Novel Real-Time Imaging Technique to Quantify Neutrophil Extracellular Traps and Distinguish Mechanisms of Cell Death in Neutrophils
Sarthak Gupta¹, Diana Chan², Kristien Zaal³, Evelyn Ralston⁴ and Mariana J. Kaplan², ¹Systemic Autoimmunity Branch, National Institue of Arthritis, and Musculoskelatal and Skin Diseases/NIH, Bethesda, MD, ²Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases/NIH, Bethesda, MD, ³Light Imaging Section, Office of Science and Technology, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ⁴Light Imaging Section, Office of Science and Technology, National Institute of Arthritis and Musculoskeletal and Skin Diseases/NIH, Bethesda, MD
Background/Purpose: Neutrophils play a key role in host defenses and have recently been implicated in the pathogenesis of autoimmune diseases by several mechanisms including formation…
Abstract Number: 292 • 2017 ACR/ARHP Annual Meeting
Neutrophil Extracellular Traps Are Induced By Adenosine and Stimulate Release of TNF Alpha from Macrophages in Deficiency of Adenosine Deaminase 2 (DADA2)
Carmelo Carmona-Rivera¹, Kyawt W. Shwin², Jorge A. irizarry-Caro³, Sami S. Khaznadar⁴, Yudong Liu³, Kenneth A. Jacobson⁴, Amanda Ombrello⁵, Deborah L. Stone⁵, Wanxia Li Tsai³, Massimo G. Gadina⁶, Daniel L. Kastner⁵, Ivona Aksentijevich⁵, Mariana J. Kaplan³ and Peter C. Grayson⁷, ¹Systemic Autoimmunity Branch, NIAMS/NIH, Bethesda, MD, ²Division of Rheumatic Diseases, Dallas VA Medical Center/ UT Southwestern Medical Center, Dallas, TX, ³NIAMS/NIH, Bethesda, MD, ⁴Molecular Recognition Section, NIDDK-NIH, Bethesda, MD, ⁵Inflammatory Disease Section, NHGRI/NIH, Bethesda, MD, ⁶Translational Immunology Section, Office of Science and Technology, NIAMS/NIH, Bethesda, MD, ⁷National Institute of Arthritis, Musculoskeletal and Skin Disease (NIAMS), Bethesda, MD
Background/Purpose: Reduction of adenosine deaminase 2 (ADA2) activity due to autosomal recessive loss of function mutations in the CECR1 gene results in a systemic illness…
Abstract Number: 293 • 2017 ACR/ARHP Annual Meeting
Expanded Therapeutic ACPA Utility for Different NET-Driven Human (Autoimmune) Diseases
Renato G.S. Chirivi^1,2, Jos W.G. van Rosmalen¹, Kostantinos Kambas³, Gonny Schmets¹, Hans Kalisvaart¹, Galina S. Bogatkevich⁴, Tim Shaw², Helmuth van Es² and Jos M.H. Raats^1,2, ¹ModiQuest BV, Oss, Netherlands, ²Citryll BV, Nijmegen, Netherlands, ³Laboratory of Molecular Hematology, Democritus University of Thrace, Alexandroupolis, Greece, ⁴Division of Rheumatology and Immunology, Department of Medicine, Medical University of South Carolina, Charleston, SC
Background/Purpose: Aberrant Neutrophil Extracellular Trap (NET) formation contributes to the induction and propagation of inflammation and plays a key role in causing tissue damage in…
Abstract Number: 294 • 2017 ACR/ARHP Annual Meeting
DNA Area and Netosis Analysis (DANA): A High-Throughput Method to Quantify Neutrophil Extracellular Traps in Fluorescent Microscope Images
Ryan Rebernick¹, Lauren Fahmy², Christopher Glover², Nicole Rademacher², Hemanth Potluri², Mandar Bawadekar¹, Christie M. Bartels³ and Miriam A. Shelef^1,4, ¹Department of Medicine, Division of Rheumatology, University of Wisconsin - Madison, Madison, WI, ²University of Wisconsin - Madison, Madison, WI, ³Rheumatology/Medicine, University of Wisconsin - Madison, Madison, WI, ⁴William S. Middleton Memorial Veterans Hospital, Madison, WI
Background/Purpose: Neutrophil extracellular traps (NETs), extracellular structures composed of decondensed chromatin, are released in a process called NETosis. NETs, which are part of normal host…
Abstract Number: 295 • 2017 ACR/ARHP Annual Meeting
Ex Vivo Induced Neutrophil Extracellular Traps Are Intrinsically Different in Anca-Associated Vasculitis and Systemic Lupus Erythematosus
Laura van Dam¹, Tineke Kraaij¹, Sylvia Kamerling¹, Hans U. Scherer², Charles Pusey³, Ton Rabelink¹, Cees van Kooten¹ and Onno Teng¹, ¹Nephrology, Leiden University Medical Center, Leiden, Netherlands, ²Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ³Imperial College, London, United Kingdom
- Background/Purpose: Neutrophil extracellular traps (NETs) are immunogenic, extracellular DNA structures that harness important autoantigens to be recognized by the adaptive immune system. NETs are…

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