Abstract Number: 2977 • 2017 ACR/ARHP Annual Meeting
Molecular Phenotypes Associated with Clinical Disease Activity in Adult Systemic Lupus Erythematosus
Background/Purpose : Remarkable clinical and pathophysiological diversity complicate diagnosis, treatment and therapeutic development in systemic lupus erythematosus (SLE). This study used molecular phenotyping to identify…Abstract Number: 2978 • 2017 ACR/ARHP Annual Meeting
OX40/OX40L Axis Impairs Follicular and Natural Regulatory T Cell Function in Human Systemic Lupus
Background/Purpose: Regulatory T cells (Treg) are impaired in human Systemic Lupus Erythematosus (SLE) and contribute to T cell activation. However, the mechanisms responsible for the…Abstract Number: 2979 • 2017 ACR/ARHP Annual Meeting
The Expression of Mitochondrial Molecules in Microparticle Immune Complexes in the Blood of Patients with Systemic Lupus Erythematosus
Background/Purpose: Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterized by immune complexes, especially those with nuclear molecules bound by antinuclear antibodies. Although the…Abstract Number: 2980 • 2017 ACR/ARHP Annual Meeting
Chemokine CCL21 As a Potential Serum Biomarker for Pulmonary Arterial Hypertension in Systemic Sclerosis
Background/Purpose : Systemic sclerosis (SSc) is a major cause of pulmonary arterial hypertension (PAH). Murine models indicate key roles of chemokines CCL19/21 and their receptor…Abstract Number: 2981 • 2017 ACR/ARHP Annual Meeting
Evaluation of American College of Rheumatology Provisional Composite Response Index in Systemic Sclerosis (CRISS) in the Fasscinate Trial
Background/Purpose: Treatment with Interleukin-6R inhibitor, tocilizumab (TCZ), in early progressive systemic sclerosis (SSc; the faSScinate trial) resulted in consistent, but not statistically significant, improvements in…Abstract Number: 2982 • 2017 ACR/ARHP Annual Meeting
Morbidity and Mortality of Scleroderma in African Americans
Background/Purpose: Retrospective cohorts have demonstrated that African Americans (AAs) with scleroderma are more likely to have severe disease and higher mortality than non-AAs. A prior…Abstract Number: 2983 • 2017 ACR/ARHP Annual Meeting
Predictors for Disease Worsening Defined By Organ Failure in Diffuse Systemic Sclerosis: A European Scleroderma Trials and Research (EUSTAR) Analysis
Background/Purpose: Mortality and worsening of organ function would be desirable endpoints for clinical trials in systemic sclerosis (SSc). However, these events are relatively rare, making…Abstract Number: 2984 • 2017 ACR/ARHP Annual Meeting
Predictive Value of a Combined Index for Weight Loss in Systemic Sclerosis
Background/Purpose: Malnutrition and severe gastrointestinal (GI) dysfunction are the cause of mortality in 4-15% of systemic sclerosis (SSc) patients whereas overall GI involvement is observed…Abstract Number: 2986 • 2017 ACR/ARHP Annual Meeting
Omega Polyunsaturated Fatty Acids and Systemic Lupus Erythematosus (SLE): the Michigan Lupus Epidemiology & Surveillance (MILES) Program
Background/Purpose: Omega fatty acids have immunomodulatory properties; omega-3 (n-3) fatty acids are generally anti-inflammatory and omega-6 (n-6) pro-inflammatory. High n-6:n-3 ratios (up to 16:1) are…Abstract Number: 2987 • 2017 ACR/ARHP Annual Meeting
Moderate and Serious Psychological Distress Among US Adults with and without Arthritis, 2002 to 2015
Background/Purpose: US population-health surveys frequently measure current mental health status using the Kessler-6 (K-6) which indicates psychological distress level. Among all US adults, moderate and…Abstract Number: 2988 • 2017 ACR/ARHP Annual Meeting
Characteristics of People with Work-Related Versus Non-Work Related Carpal Tunnel Syndrome: National Health Interview Survey, 2010 & 2015
Background/Purpose: The underlying causes of carpal tunnel syndrome (CTS) are complex and may be unrelated to work status. Yet, too often, CTS is viewed and…Abstract Number: 2989 • 2017 ACR/ARHP Annual Meeting
Hydration and Gout: Looking at New Modes of Uric Acid Management
Background/Purpose: Gout affects more than 4% of adults in the United States, and it is the most common form of inflammatory arthritis among men. Studies…Abstract Number: 2990 • 2017 ACR/ARHP Annual Meeting
Is Risk of Retinopathy Among Hydroxychloroquine Users of SLE Patients Accurate? a Simulation Study Accounting for Competing Risk of Death
Background/Purpose: Hydroxychloroquine (HCQ) is used for the long-term treatment of systemic lupus erythematosus (SLE) patients. HCQ is generally well-tolerated with wide-ranging benefits, including reduced disease…Abstract Number: 2991 • 2017 ACR/ARHP Annual Meeting
Is a Growing Waistline over 8 Years Associated with Incident Functional Limitation and Low Health-Related Quality of Life in Knee Osteoarthritis?
Background/Purpose: A large waist circumference (WC) is associated with walking difficulty in people with or at risk for knee osteoarthritis (OA). To date, it is…Abstract Number: 2992 • 2017 ACR/ARHP Annual Meeting
Curbing the Opioid Epidemic: Predictors of Opioid Use in Juvenile Fibromyalgia Syndrome
Background/Purpose: Despite the lack of evidence to support the use of opioids in the treatment of adult fibromyalgia syndrome, approximately 30% of patients receive an…
ACR Meeting Abstracts