Abstracts Archive - Page 1391 of 2607 - ACR Meeting Abstracts

Abstract Number: 55 • 2017 ACR/ARHP Annual Meeting
Nrf2 Inhibits Apoptosis and Suppresses Oxidative Stress By Activating NOX4/ERK1/2/ELK1 Signaling Axis in Human Chondrocytes
Mohammad N. Khan¹, Imran Ahmad¹, Mohammad Y Ansari² and Tariq M Haqqi¹, ¹Anatomy & Neurobiology, Northeast Ohio Medical University, Rootstown, OH, ²Anatomy & Neurobiology, Northeast Ohio Medical University, Roostown, OH
Background/Purpose: Nrf2 is a redox sensitive transcription factor that regulates the expression of phase II antioxidant enzymes and cytoprotective genes and is crucial for maintaining…
Abstract Number: 56 • 2017 ACR/ARHP Annual Meeting
Baicalein, a Plant-Derived Small Molecule, Activate Nrf2/Autophagy Signaling Axis Via MEK1/2-ERK1/2-Elk1 Pathway to Suppress the Expression of IL-6 in Human Osteoarthritis Chondrocytes
Mohammad N. Khan¹, Imran Ahmad¹, Mohammad Y. Ansari² and Tariq M Haqqi¹, ¹Anatomy & Neurobiology, Northeast Ohio Medical University, Rootstown, OH, ²Anatomy & Neurobiology, Northeast Ohio Medical University, Roostown, OH
Background/Purpose: Inflammation is an important component of osteoarthritis (OA) pathogenesis. IL-6 is implicated in OA pathogenesis as it suppresses anabolic factors and upregulate the expression…
Abstract Number: 57 • 2017 ACR/ARHP Annual Meeting
Accelerated Development of Aging-Associated and Instability-Induced Osteoarthritis in 12/15-Lipoxygenase Deficient Mice
Lauris Habouri¹, Yassine Ouhaddi¹, Gadid Guedi¹, Jean-Pierre Pelletier², Johanne Martel-Pelletier², mohamed benderdour¹ and Hassan Fahmi², ¹Medicine, CRCHUM, Montreal, QC, Canada, ²Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Montreal, QC, Canada
Background/Purpose: 12/15-Lipoxygenase (12/15-LOX) catalyzes the generation of various anti-inflammatory lipid mediators, and has been implicated in several inflammatory and degenerative diseases. However, there is currently…
Abstract Number: 58 • 2017 ACR/ARHP Annual Meeting
Cartilage-like Tissue Generation By 3D-Bioprinting of Induced Pluripotent Stem Cells
Rocío Castro-Viñuelas¹, Alma Forsman², Erdem Karabulut³, Erik Romberg³, Camilla Brantsing², Mats Brittberg⁴, Anders Lindahl², Paul Gatenholm³ and Stina Simonsson², ¹Cell Therapy and Regenerative Medicine research group. Rheumatology Division. Institute of Biomedical Research of A Coruña (INIBIC). Dep. of Biomedical Sciences, Medicine and Physiotherapy, University of A Coruña, A Coruña, Spain, ²Institute of Biomedicine at Sahlgrenska Academy, Department of Clinical Chemistry and Transfusion Medicine, University of Gothenburg., Gothenburg, Sweden, ³3D Bioprinting Center, Dept. of Chemistry and Chemical Engineering, Chalmers University of Technology, Gothenburg, Sweden, ⁴Cartilage Repair Unit, University of Gothenburg, Region Halland Orthopaedics, Kungsbacka Hospital, Kungsbacka, Sweden
Background/Purpose: Cartilage lesions due to traumatic or pathological conditions slowly grow over the time and may lead to osteoarthritis (OA). As a prospective treatment for…
Abstract Number: 59 • 2017 ACR/ARHP Annual Meeting
Abaloparatide, a Novel PTHrP Analog, Increased Bone Mass and Density at Cortical and Trabecular Sites in an Orchiectomized Rat Model of Male Osteoporosis
Heidi Chandler¹ and Gary Hattersley², ¹Research, Radius Health Inc, Waltham, MA, ²Radius Health, Inc., Waltham, MA
Background/Purpose: Male osteoporosis, a disease of reduced bone mass leading to an increased risk of fragility fractures, often results from androgen deficiency caused by hypogonadism…
Abstract Number: 60 • 2017 ACR/ARHP Annual Meeting
Low and Moderate Intensity Exercise Suppresses Inflammatory Responses in an Acute Mouse Model of Gout and Suggests Therapeutic Efficacy
Nicholas A. Young¹, Kyle Jablonski², Juhi Sharma¹, Evelyn Thomas¹, Brian Snoad¹, Jeffrey Hampton³, Wael Jarjour¹ and Naomi Schlesinger⁴, ¹Department of Internal Medicine, Division of Immunology and Rheumatology, The Ohio State University Wexner Medical Center, Columbus, OH, ²The Ohio State University Wexner Medical Center, Columbus, OH, ³Immunology and Rheumatoloty, The Ohio State University Wexner Medical Center, Columbus, OH, ⁴Medicine, Rutgers-Robert Wood Johnson Medical School, New Brunswick, NJ
Background/Purpose: Little is known regarding the potential benefits of exercise on managing acute gout. Consequently, recent clinical practice guidelines released by the American College of…
Abstract Number: 61 • 2017 ACR/ARHP Annual Meeting
Resolution of Systemic Joint Inflammatory Processes and Regeneration of Existing Bone Damage upon TNF Blockade As Monitored By In Vivo Multimodal PET-CT Imaging in Progressed Experimental Arthritis
Silvia Hayer¹, Markus Zeilinger^2,3, Volker Weiss^3,4, Markus Seibt⁵, Birgit Niederreiter¹, Tetyana Shvets⁶, Monika Dumanic⁶, Florian Pichler⁶, Marcus Hacker⁶, Josef S. Smolen⁷, Kurt Redlich⁸ and Markus Mitterhauser⁶, ¹Department of Internal Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria, ²Faulty of Engineering, University of Applied Sciences, Winer Neustadt, Austria, ³Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, ⁴Faculty of Engineering, University of Applied Sciences, Wiener Neustadt, Austria, ⁵Department Internal Medicine III, Division Rheumatology, Medical University of Vienna, Vienna, Austria, ⁶Medical University of Vienna, Vienna, Austria, ⁷Medical University Vienna, Division of Rheumatology, Department of Internal Medicine III, Vienna, Austria, ⁸Division of Rheumatology, Medical University of Vienna, Vienna, Austria
Background/Purpose: To use in vivo multimodal [18F]FDG (fluoro-D-glucose, tracer for inflammation) and [18F]Sodium Fluoride (bone tracer) positron emission tomography/computed tomography (PET-CT) imaging for the monitoring…
Abstract Number: 62 • 2017 ACR/ARHP Annual Meeting
Convergence of Joint Repair and Pain Pathways Via Nerve Growth Factor and p75 Expressing Mesenchymal Stem Cells in Established Osteoarthritis
Thomas Baboolal¹, Sumaiya Al Hinai², Elena Jones², Jill Reckless³, Martyn Foster⁴, Rachel Doyle⁵, Kerry af Forselles⁴, Simon Westbrook⁴ and Dennis McGonagle², ¹PhD, Leeds, United Kingdom, ²Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ³Rxcelerate Ltd, Cambridge, United Kingdom, ⁴Levicept Ltd, Ramsgate, United Kingdom, ⁵Tetrad Discovery Ltd, Ramsgate, United Kingdom
Background/Purpose: Nerve growth factor (NGF) is a key regulator of pain and anti-NGF therapy reduces osteoarthritis (OA) associated pain. However, anti-NGF therapy is associated with…
Abstract Number: 63 • 2017 ACR/ARHP Annual Meeting
MiR-146a a Key Player in Bone Metabolism
Victoria Saferding¹, Melanie Hofmann¹, Julia S. Brunner², Antonia Puchner¹, Melanie Timmen³, Richard Stange³, Josef S. Smolen⁴ and Stephan Blüml⁴, ¹Medical University of Vienna, Austria, Vienna, Austria, ²Vascular Biology and Thrombosis research, Medical University of Vienna, Austria, Vienna, Austria, ³Institute for Experimental Muskuloskeletal Medicine, University Hospital Muenster, Muenster, Germany, ⁴Medical University Vienna, Division of Rheumatology, Department of Internal Medicine III, Vienna, Austria
Background/Purpose: Micro RNAs (miRNAs) play a crucial role in the regulation of bone metabolism. MiR-146a, an important anti-inflammatory miRNA, was found to negatively impact osteogenesis…
Abstract Number: 64 • 2017 ACR/ARHP Annual Meeting
The Effect of Adenosine A2A Receptor Stimulation on Mitochondrial Metabolism in the Pathogenesis and Treatment of Osteoarthritis
Cristina Castro¹, Carmen Corciulo² and Bruce Cronstein³, ¹Medicine, NYU School of Medicine, New York, NY, ²Department of Medicine, Division of Rheumatology, NYU School of Medicine, New York, NY, ³Rheumatology, New York University School of Medicine, Division of Rheumatology, New York, NY
Background/Purpose: Osteoarthritis (OA) is the most common form of arthritis, affecting nearly 10% of the US population. There is no therapy to prevent the progression…
Abstract Number: 65 • 2017 ACR/ARHP Annual Meeting
RA-Associated Antibodies Targeting Post Translational Modification Have Different Osteoclastogenetic Potential
Akilan Krishnamurthy¹, Johanna Steen², Caroline Grönwall³, Gustaf Wigerblad⁴, Camilla Svensson^5,6, Heidi Wähämaa¹, Vivianne Malmström¹, Bence Rethi¹ and Anca I. Catrina¹, ¹Rheumatology Unit, Department of Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden, ²Dept. of Medicine, Rheumatology Unit, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, ³Dep. of Medicine, Rheumatology Unit, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, ⁴Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden, ⁵Dept. of Physiology & Pharmacology, Karolinska Institutet, Stockholm, Sweden, ⁶Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
Background/Purpose: Some but not all antibodies against citrullinated modified proteins (ACPA) promote osteoclastogenesis and bone destruction in vitro and in vivo. We aimed to investigate…
Abstract Number: 66 • 2017 ACR/ARHP Annual Meeting
Genome-Wide DNA Methylation Profiling of OA PBMCs Reveals Slowed Epigenetic Aging Among Rapid Radiographic Progressors: Data from the Osteoarthritis Initiative (OAI)
Alexander Rivas¹, Madison Andrews² and Matlock A. Jeffries³, ¹Rheumatology, Immunology, and Allergy, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ²College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ³Department of Medicine, Division of Rheumatology, Immunology, and Allergy, University of Oklahoma Health Sciences Center, Oklahoma City, OK
Background/Purpose: Extensive evidence has correlated epigenetic alterations in articular tissues with both the presence and progression of human osteoarthritis. A recent study demonstrated that accelerated…
Abstract Number: 67 • 2017 ACR/ARHP Annual Meeting
The Oxygen Sensor PHD1 Is an Indispensable Regulator of Arthritis Development
Katelijne De Wilde¹, Peggy Jacques² and Dirk Elewaut³, ¹Inflammation Research Center - VIB UGhent, Molecular Immunology and Inflammation Unit, Ghent, Belgium, ²Ghent University Hospital, Ghent, Belgium, ³VIB Inflammation Research Center, University of Ghent, Ghent, Belgium
Background/Purpose: Oxygen supply is a fundamental requirement for all living tissues. Some tissues such as articular joints are characterized by a physiological state of hypoxia.…
Abstract Number: 68 • 2017 ACR/ARHP Annual Meeting
Tankyrase/Wnt Inhibitor Upregulates Osteoclastogenesis and Osteoblastogenesis Via SH3BP2
Shunichi Fujita¹, Tomoyuki Mukai¹, Takafumi Mito¹, Shoko Kodama¹, Akiko Nagasu¹, Mizuho Kittaka², Yasuyoshi Ueki³ and Yoshitaka Morita¹, ¹Department of Rheumatology, Kawasaki Medical School, Kurashiki, Okayama, Japan, ²Department of Oral and Craniofacial Sciences, School of Dentistry, University of Missouri-Kansas City, Missouri-Kansas City, MO, MO, ³Department of Oral and Craniofacial Sciences, School of Dentistry, University of Missouri-Kansas City, Missouri-Kansas City, MO
Background/Purpose: Tankyrase is a poly (ADP-ribose) polymerase that leads to ubiquitination and degradation of target proteins. Since tankyrase inhibitors increase Axin protein, a negative regulator…
Abstract Number: 69 • 2017 ACR/ARHP Annual Meeting
The Effect of Myostatin Inhibition on Bone Loss in Murine Osteoporosis Models
Tomoyuki Mukai¹, Takafumi Mito¹, Shunichi Fujita¹, Shoko Kodama¹, Akiko Nagasu¹, Teruki Sone², Shinichiro Nishimatsu³, Yutaka Ohsawa⁴, Yoshihide Sunada⁴ and Yoshitaka Morita¹, ¹Department of Rheumatology, Kawasaki Medical School, Kurashiki, Okayama, Japan, ²Department of Nuclear Medicine, Kawasaki Medical School, Kurashiki, Okayama, Japan, ³Department of Natural Sciences, Kawasaki Medical School, Kurashiki, Okayama, Japan, ⁴Department of Neurology, Kawasaki Medical School, Kurashiki, Okayama, Japan
Background/Purpose: Myostatin, also called as growth differentiation factor-8 (GDF-8), is a secreted member of TGF-β superfamily. Myostatin is a negative regulator of skeletal muscle mass…

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