Abstracts Archive - Page 1390 of 2425 - ACR Meeting Abstracts

Abstract Number: 2767 • 2017 ACR/ARHP Annual Meeting
Active Yet Sedentary: The Association of Moderate to Vigorous Physical Activity and Sedentary Behavior with Incident Functional Limitation in Knee OA
Hiral Master¹, Louise Thoma¹, Meredith Christiansen¹, Dana Mathews² and Daniel White³, ¹Physical Therapy and Biomechanics and Movement Science, University of Delaware, Newark, DE, ²Physical Therapy, Biomechanics and Movement Science, University of Delaware, Newark, DE, ³Department of Physical Therapy, University of Delaware, Newark, DE
Background/Purpose: Engaging in adequate levels of moderate to vigorous physical activity (MVPA) reduces the risk of functional limitation in people with knee osteoarthritis (OA). Sedentary…
Abstract Number: 2768 • 2017 ACR/ARHP Annual Meeting
Effects of a Home-Based Telephone-Supported Physical Activity Program on Physical Function Among Older Adults with Chronic Low Back Pain
Adam P. Goode¹, Shannon Taylor², Susan Hastings³, Catherine Stanwyck³, Cynthia Coffman³ and Kelli Allen⁴, ¹O, Duke University, Durham, NC, ²Health Services Research and Development, Durham VA Medical Center, Durham, NC, ³Durham VA Medical Center, Durham, NC, ⁴Rheumatology, University of North Carolina at Chapel Hill and Durham VA Medical Center, Durham, NC
Background/Purpose: The majority of older adults with chronic low back pain (cLBP) are inactive and have significant functional limitations, highlighting the need for continued efforts…
Abstract Number: 2769 • 2017 ACR/ARHP Annual Meeting
Predictive Value of Leisure-Time Physical Activity in Women with Systemic Erythematosus Lupus on Physical and Mental Health
Alix St-Aubin¹, Anne-Sophie Julien², Carolyn Neville³, Ellie Aghdassi⁴, Stacey Morrison⁵, Jiandong Su⁶, Janet E. Pope⁷, Sara Hewitt⁸, Christian Pineau⁹, Paula Harvey¹⁰, Michal Abrahamowicz¹¹, Deborah Da Costa¹², Paul Poirier¹³ and Paul R. Fortin¹⁴, ¹Division of Rheumatology, Department of Medicine, CHU de Québec – Université Laval, Quebec, QC, Canada, ²CHU de Quebec - Universite Laval, Quebec City, QC, Canada, ³Department of Medicine, McGill University Health Center, Montreal, QC, Canada, ⁴Epidemiology Division, The Toronto Western Hospital, Toronto, ON, Canada, ⁵Rheumatology, Krembil Research Institute, Toronto, ON, Canada, ⁶Rheumatology, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital and University of Toronto, Toronto, ON, Canada, ⁷Department of Medicine, Division of Rheumatology, University of Western Ontario, St Joseph's Health Care, London, ON, Canada, ⁸Department of Medicine, Division of Rheumatology, University of Western Ontario, St-Joseph Health Care, London, ON, Canada, ⁹Rheumatology, McGill University Health Center, Montreal, QC, Canada, ¹⁰Cardiology, Women's College Hospital, University of Toronto, Toronto, ON, Canada, ¹¹Department of Medicine, McGill University Health Centre, Montreak, QC, Canada, ¹²Department of Medicine, McGill University Health Center, Montréal, Quebec, Canada., Montreal, QC, Canada, ¹³Deparment of Medicine, Division of Cardiology, Institut universitaire de cardiologie et de pneumologie de Québec and Université Laval, Quebec City, QC, Canada, ¹⁴Medicine, CHU de Quebec - Universite de Laval, Quebec, QC, Canada
Background/Purpose: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that is associated with a higher mortality due to higher risk of cardiovascular events. Although…
Abstract Number: 2770 • 2017 ACR/ARHP Annual Meeting
Using Fitbits. Fitabase®, and Remote Coaching to Increase Physical Activity in Employees with Knee Osteoarthritis Symptoms
Pamela Semanik¹, Julia (Jungwha) Lee², Christine Pellegrini³, Jing Song⁴ and Rowland W. Chang⁵, ¹College of Nursing, Rush University, Chicago, IL, ²Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, ³Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁴Center for Healthcare Studies, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁵Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose: Knee osteoarthritis (OA) affects approximately 6% of adults and is a leading cause of disability among U.S. adults. Physical activity (PA) is known to…
Abstract Number: 2771 • 2017 ACR/ARHP Annual Meeting
NOMID-Associated Complications in Mice Are Prevented By CDD-450, a Small Molecule Inhibitor of the Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 (MK2) Pathway
Gabriel Mbalaviele¹, Chun Wang¹, Susan Hockerman², Jon Jacobsen², Jeff Hirsch², Steve Mnich², Heidi Hope², Matt Saabye², Hal Hoffman³ and Joseph Monahan², ¹Medicine, Washington University School of Medicine,, St. Louis, MO, ²Confluence Life Sciences, Inc, St. Louis, MO, ³University of California, San Diego, San Diego, CA
Background/Purpose: NLRP3-activating mutations cause cryopyrinopathies of which NOMID is the most severe phenotype. NLRP3 assembles a protein complex, responsible for the maturation of IL-1β and…
Abstract Number: 2772 • 2017 ACR/ARHP Annual Meeting
Unbound IL-18 Distinguishes Human Macrophage Activation Syndrome from Familial Hemophagocytic Lymphohistiocytosis and Affects Innate Versus Adaptive Murine Lymphocytes Differently
Paul Tsoukas¹, Eric Weiss², Dirk Holzinger³, Charlotte Girard⁴, Dirk Foell⁵, Alexei A. Grom⁶, Sandra Ammann⁷, Stephan Ehl⁷, Eduardo Schiffrin⁸, Adriana Almeida de Jesus⁹, Raphaela Goldbach-Mansky⁹, Cem Gabay¹⁰ and Scott Canna¹¹, ¹Pediatric Rheumatology, Children’s Hospital of Pittsburgh, Pittsburgh, PA, ²RK Mellon Institute, Children’s Hospital of Pittsburgh, Pittsburgh, PA, ³Department of Pediatric Rheumatology and Immunology, University of Muenster, Muenster, Germany, ⁴Division of Rheumatology, Department of Internal Medicine Specialties, University Hospital of Geneva, Geneva, Switzerland, ⁵University of Muenster, Muenster, Germany, ⁶Pediatric Rheumatology, Cincinnati Children’s Hospital, Cincinnati, OH, ⁷Center for Chronic Immunodeficiency, Faculty of Medicine, University of Freiburg, Freiburg, Germany, ⁸AB2 Bio, Lausanne, Switzerland, ⁹Translational Autoinflammatory Disease Studies (TADS), Laboratory of Clinical Investigation and Microbiology (LCIM), NIAID/NIH, Bethesda, MD, ¹⁰SCQM, Geneva, Switzerland, Geneva, Switzerland, ¹¹Richard King Mellon Foundation Institute for Pediatric Research, Children's Hospital of Pittsburgh, Pittsburrgh, PA
Background/Purpose: Persistently and extremely elevated serum IL-18 has been associated with Macrophage Activation Syndrome (MAS). Chronic IL-18 is hypothesized to contribute to excessive interferon (IFN)-g…
Abstract Number: 2773 • 2017 ACR/ARHP Annual Meeting
Severe Juvenile Arthritis Associated with a De Novo Gain-of-Function Germline Mutation in MYD88
Keith A. Sikora¹, Joshua R. Bennett², Laurens Vyncke³, Zuoming Deng⁴, Wanxia Li Tsai², Ewald Pauwels⁵, Gerlinde Layh-Schmitt², April D. Brundidge², Fatemeh Navid², Kristien Zaal⁶, Eric Hanson², Massimo G. Gadina⁷, Louis M. Staudt⁸, Thomas A. Griffin⁹, Jan Tavernier³, Frank Peelman³ and Robert Colbert², ¹Pediatric Translational Research Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ²National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ³Department of Biochemistry, Ghent University, Ghent, Belgium, ⁴Biodata Mining & Discovery, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ⁵Center for Molecular Modeling, Ghent University, Ghent, Belgium, ⁶Light Imaging Section, Office of Science and Technology, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ⁷Translational Immunology, Office of Science and Technology, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ⁸National Cancer Institute, National Institutes of Health, Bethesda, MD, ⁹Levine Children’s Hospital at Carolinas Medical Center, Charlotte, NC
Background/Purpose: Using whole exome sequencing, we discovered a de novo heterozygous germline mutation in MYD88 (myeloid differentiation primary response 88) (c.666T>G, p.S222R) in a child…
Abstract Number: 2774 • 2017 ACR/ARHP Annual Meeting
Activation of a Cytosolic DNA Sensor Pathway in the Etiopathogenesis of Sjögren’s Syndrome
Harini Bagavant¹, Joanna Papinska¹, Grezgorz Gmyrek¹, Magdalena Sroka¹, Indranil Biswas², Sai Tummala² and Umesh S Deshmukh¹, ¹Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Oklahoma Medical Research Foundation, Oklahoma City, OK
Background/Purpose: Patients with Sjögren’s syndrome (SjS) often present with a heightened type I IFN response. Recognition of DNA within the cytosol by a multitude of…
Abstract Number: 2775 • 2017 ACR/ARHP Annual Meeting
Critical Role of Neutrophil Extracellular Traps (NETs) in Patients with Behcet’s Disease
Alexandre LE JONCOUR^1,2, Stephane Loyau³, Nicolas Lelay⁴, Marie-Christine Bouton⁵, Antoine Dossier⁶, Anne-Claire Desbois⁷, Fanny Domont⁸, Thomas Papo⁹, Martine Jandrot-Perrus⁵, Patrice Cacoub¹⁰, Nadine Ajzenberg⁵, David saadoun⁷ and Yacine Boulaftali², ¹Département Hospitalo-Universitaire Inflammation-Immunopathologie-Biotherapie (DHU i2B), F-75005, Paris, France., National center for Autoimmune and Systemic rare diseases and for Autoinflammatory diseases, Paris, France, ²INSERM 1148, CHU Xavier Bichat, paris, France, ³Unité INSERM 1148, CHU Xavier Bichat, Faris, France, ⁴2. Unité INSERM 1148, CHU Xavier Bichat, paris, France, ⁵Unité INSERM 1148, CHU Xavier Bichat, paris, France, ⁶3. Service de Médecine Interne, CHU Xavier Bichat, paris, France, ⁷Département Hospitalo-Universitaire Inflammation-Immunopathologie-Biotherapie, National center for Autoimmune and Systemic rare diseases and for Autoinflammatory diseases, Paris, France, ⁸Département Hospitalo-Universitaire Inflammation-Immunopathologie-Biotherapie, National center for Autoimmune and Systemic rare diseases and for Autoinflammatory diseases, paris, France, ⁹Service de Médecine Interne, CHU Xavier Bichat, Paris, France, ¹⁰Département de Médecine Interne et Immunologie Clinique, National center for Autoimmune and Systemic rare diseases and for Autoinflammatory diseases, Paris, France
Background/Purpose: Behçet's disease (BD) is a chronic systemic vasculitis characterised by muco-cutaneous, ocular, gastrointestinal, cerebral recurrent lesions. Venous thrombosis, is a frequent and life-threatening complication.…
Abstract Number: 2776 • 2017 ACR/ARHP Annual Meeting
Plasmacytoid Dendritic Cells in Systemic Fibrosis: Pathogenic Role in Bleomycin-Induced Fibrosis Model and Correlation with Disease in Patients with Systemic Sclerosis
Suzanne Kafaja¹, Isela Valera², Anagha Divekar³, Rajan Saggar⁴, Dinesh Khanna⁵, Daniel E. Furst⁶ and Ram R. Singh⁷, ¹Department of Internal Medicine, University of California Los Angeles, David Geffen School of Medicine, Division of Rheumatology, Los Angeles, CA, ²Autoimmunity and Tolerance Laboratory, Division of Rheumatology, Department of Medicine, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA, ³Biolegend, Sa Diego, CA, ⁴Medicine, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA, ⁵University of Michigan, Ann Arbor, MI, ⁶David Geffen School of Medicine at UCLA, Los Angeles, CA, ⁷Autoimmunity and Tolerance Laboratory, Department of Medicine/Rheumatology, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA
Background/Purpose: Fibrosis is the end-result of most inflammatory conditions, but its pathogenesis remains unclear. Studies in patients and animal models suggest a role for T-cells…
Abstract Number: 2777 • 2017 ACR/ARHP Annual Meeting
Factors Associated with Readiness for Adopting Osteoporosis Treatment Change
Maria I. Danila¹, Elizabeth J. Rahn², Amy S. Mudano¹, Ryan C. Outman³, Peng Li⁴, David T. Redden⁴, Fred A. Anderson⁵, Susan L. Greenspan⁶, Andrea Z. LaCroix⁷, Jeri W. Nieves⁸, Stuart L. Silverman⁹, E.S. Siris¹⁰, Nelson B. Watts¹¹, Sigrid Ladores¹², Karen Meneses¹², Jeffrey R. Curtis³ and Kenneth Saag³, ¹University of Alabama at Birmingham, Birmingham, AL, ²Department of Medicine, Division of Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ³Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ⁴Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, ⁵University of Massachusetts Medical School, Worcester, MA, ⁶Medicine, University of Pittsburgh, Pittsburgh, PA, ⁷Group Health Cooperative, Seattle, WA, ⁸Helen Hayes, West Haverstraw, NY, ⁹Cedars-Sinai Medical Center, Los Angeles, CA, ¹⁰Columbia University Medical Center, New York, NY, ¹¹University of Cincinnati, Cincinnati, OH, ¹²Nursing, University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: Understanding factors associated with the readiness for adopting osteoporosis treatment change may inform the design of behavioral interventions to improve osteoporosis treatment uptake in…
Abstract Number: 2778 • 2017 ACR/ARHP Annual Meeting
Preventing Rheumatoid Arthritis: North American Perspectives of Patients and First-Degree Relatives on the Risk of Developing the Disease and of Potential Preventative Interventions
Mark Harrison¹, Luke Spooner², Marie Hudson³, Katherine Milbers⁴, Cheryl L. Koehn⁵, Axel Finckh⁶ and Nick Bansback⁷, ¹Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada, ²University of British Columbia, Vancouver, BC, Canada, ³Division of Rheumatology, Jewish General Hospital, Lady David Institute for Medical Research, Montreal, QC, Canada, ⁴Centre for Health Evaluation and Outcomes Sciences, Vancouver, BC, Canada, ⁵Arthritis Consumer Expert, Vancouver, BC, Canada, ⁶University Hospital of Geneva, Geneva, Switzerland, ⁷School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada
Background/Purpose: Increasingly, evidence suggests that treatment of people at risk of rheumatoid arthritis (RA) with anti-rheumatic drugs could prevent the onset of disease. Ongoing randomized…
Abstract Number: 2779 • 2017 ACR/ARHP Annual Meeting
The Patient Perspective on Bdmard Dose Reduction: A Mixed Methods Study
L.M. Verhoef¹, E.M.H. Selten¹, J.E. Vriezekolk¹, A.J.L. de Jong², F.H.J. van den Hoogen^1,3, A.A. Den Broeder^1,3 and M.E.J.L. Hulscher⁴, ¹Rheumatology, Sint Maartenskliniek, Nijmegen, Netherlands, ²Department of Rheumatology, Rijnstate Arnhem, Arnhem, Netherlands, ³Rheumatology, Radboud university medical centre, Nijmegen, Netherlands, ⁴Radboud Institute for Health Sciences, IQ healthcare, Radboud university medical centre, Nijmegen, Netherlands
Background/Purpose: biological DMARDs (bDMARDs) are effective in the treatment of RA, but are also associated with side-effects and high costs. Dose reduction of bDMARDs, after…
Abstract Number: 2780 • 2017 ACR/ARHP Annual Meeting
Preference Phenotypes Can be Used to Support Shared Decision Making at the Point-of-Care
Liana Fraenkel¹, Pauline Binder-Finnema², Betty Hsiao², Carole Wiedmeyer³, George Michel² and W. Benjamin Nowell⁴, ¹Rheumatology, Rheumatology, Yale University School of Medicine, New Haven, CT, New Haven, CT, ²Yale University School of Medicine, New Haven, CT, ³CreakyJoints/Global Health Living Foundation, Upper Nyack, NY, ⁴Global Healthy Living Foundation, Upper Nyack, NY
Background/Purpose: Many important treatment decisions for patients with rheumatoid arthritis (RA) are conditional on patient preferences and mandate a shared decision making (SDM) approach. Furthermore,…
Abstract Number: 2781 • 2017 ACR/ARHP Annual Meeting
Assessing RA Disease Activity with Promis Measures Using Smartphone Technology
Huifeng Yun¹, Shuo Yang², W. Benjamin Nowell³, Cooper Filby¹, Lang Chen¹ and Jeffrey R. Curtis⁴, ¹University of Alabama at Birmingham, Birmingham, AL, ²Division of Clinical Immunology & Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ³Global Healthy Living Foundation, Upper Nyack, NY, ⁴Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: Health information technology has enabled efficient measurement of PROs using Computer Adaptive Testing (CAT) methods, which have been shown to minimize missing data and…

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