Abstracts Archive - Page 1383 of 2425 - ACR Meeting Abstracts

Abstract Number: 2662 • 2017 ACR/ARHP Annual Meeting
The EULAR Systemic Sclerosis Impact of Disease (ScleroID) Score – a New Patient-Reported Outcome Measure for Patients with Systemic Sclerosis – Preliminary Results from the Ongoing Validation Study
Rucsandra Dobrota¹, Mike Oliver Becker¹, Kim Fligelstone², Jaap Fransen³, Ann Kennedy⁴, Yannick Allanore⁵, Patricia Carreira⁶, László Czirják⁷, Christopher Denton⁸, Roger Hesselstrand⁹, Gunnel Sandqvist¹⁰, Otylia Kowal-Bielecka¹¹, Marco Matucci-Cerinic¹², Carina Mihai¹³, Ana Maria Gheorghiu¹⁴, Ulf Müller-Ladner¹⁵, MC Vonk¹⁶, Turid Heiberg¹⁷ and Oliver Distler¹⁸, ¹Department of Rheumatology, Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland, ²Royal Free Hospital, Scleroderma Unit and Scleroderma Society, London, United Kingdom, ³Department of Rheumatolgy, Radboud University Medical Center, Nijmegen, Netherlands, ⁴Federation of European Scleroderma Associations (FESCA), Tournai, Belgium, ⁵Department of Rheumatology, Cochin Hospital, Paris Descartes University, Paris, France, ⁶Department of Rheumatology, Hospital Universitario 12 de Octubre, Madrid, Spain, ⁷Department of Rheumatology and Immunology, University of Pécs, Faculty of Medicine, Pécs, Hungary, ⁸Department of Rheumatology, University College London, Royal Free Hospital, London, United Kingdom, ⁹Lund University, Lund, Sweden, ¹⁰Department of Rheumatology, Lund University Hospital, Lund, Sweden, ¹¹Department of Rheumatology and Internal Medicine, Medical University of Białystok, Białystok, Poland, ¹²Dept of Medicine/Div of Rheum, University of Florence, Florence, Italy, ¹³Internal Medicine and Rheumatology Dept., Cantacuzino Clinical Hospital, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania, ¹⁴Carol Davila University of Medicine and Pharmacy,Internal Medicine and Rheumatology Department ,,Dr.I.Cantacuzino'' Clinical Hospital, Bucharest, Romania, ¹⁵Justus-Liebig-University Giessen, Department of Internal Medicine and Rheumatology, Kerckhoff-Klinik, Bad Nauheim, Germany, Bad-Nauheim, Germany, ¹⁶Rheumatology, Radboud University Medical Centre, Nijmegen, Netherlands, ¹⁷Department of Health and Social Sciences, Oestfold University College, Oslo, Norway, ¹⁸Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland
Background/Purpose: Patient reported outcome measures (PROM) are acknowledged a key role in clinical trials in systemic sclerosis (SSc). Given the unmet need of a validated,…
Abstract Number: 2663 • 2017 ACR/ARHP Annual Meeting
Changes in Disability over Time, and Their Relationship with Degree of Skin Thickening, in Patients with Limited and Diffuse Cutaneous Systemic Sclerosis: A Retrospective Cohort Study
Sébastien Peytrignet¹, Joanne Manning², Elizabeth Wragg³, Tonia Moore⁴, Muditha Samaranayaka³ and Ariane L. Herrick⁵, ¹Manchester Academic Health Sciences Centre, Centre for Musculoskeletal Research, Institute of Inflammation and Repair, The University of Manchester, Manchester, United Kingdom, ²Rheumatology Department, Salford Royal NHS Foundation Trust, Salford, United Kingdom, ³Salford Royal NHS Foundation Trust, Salford, United Kingdom, ⁴Centre for Musculoskeletal Research, University of Manchester, MAHSC, Salford Royal Hospital, Salford, United Kingdom, ⁵Centre for Musculoskeletal Research, University of Manchester, MAHSC, Salford Royal Hospital, Manchester, United Kingdom
Background/Purpose: The burden of disability of systemic sclerosis (SSc) is increasingly recognised. What is less known are the factors driving this disability and how it…
Abstract Number: 2664 • 2017 ACR/ARHP Annual Meeting
Anti-SSA (Ro52/Ro60) and SSB Autoantibodies in Patients with Systemic Sclerosis
Myo-Pale' Aye¹, Ghaith Noaiseh², Thomas A. Medsger Jr.¹, Robert A. Lafyatis³, Maureen Laffoon¹, Lei Zhu¹ and Robyn T. Domsic⁴, ¹Rheumatology, University of Pittsburgh Medical Center, Pittsburgh, PA, ²University of Pittsburgh Medical Center, Pittsburgh, PA, ³Medicine, Rheumatology, University of Pittsburgh Medical Center, Pittsburgh, PA, ⁴Medicine - Rheumatology, University of Pittsburgh Medical Center, Pittsburgh, PA
Background/Purpose: Anti-SSA (Ro52/Ro60) and anti-SSB autoantibodies are the cardinal serological markers for SjogrenÕs syndrome. They are also present in other systemic autoimmune diseases. There is…
Abstract Number: 2665 • 2017 ACR/ARHP Annual Meeting
Mortality in an Early Diffuse Cutaneous Systemic Sclerosis Cohort—Data from the Prospective Registry for Early Systemic Sclerosis
Tracy M. Frech¹, Shervin Assassi², Elana J. Bernstein³, Flavia V. Castelino⁴, Robyn T. Domsic⁵, Jessica K. Gordon⁶, Faye Hant⁷, Monique Hinchcliff⁸, Bernie LaSalle⁹, Victoria K. Shanmugam¹⁰, Virginia D. Steen¹¹ and Dinesh Khanna¹², ¹Division of Rheumatology, University of Utah, Salt Lake City, UT, ²University of Texas McGovern Medical School, Houston, TX, ³Department of Medicine, Division of Rheumatology, Columbia University, New York, NY, ⁴Rheumatology, Allergy, Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ⁵Medicine - Rheumatology, University of Pittsburgh, Pittsburgh, PA, ⁶Rheumatology, Hospital for Special Surgery, New York, NY, ⁷Medicine/Rheumatology & Immunology, Medical University of South Carolina, Charleston, SC, ⁸Department of Medicine Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁹University of Utah, Salt Lake City, UT, ¹⁰Rheumatology, The George Washington University, Washington, DC, ¹¹Division of Rheumatology, Department of Medicine, MedStar Georgetown University Hospital, Washington, DC, ¹²University of Michigan, Ann Arbor, MI
Background/Purpose: The Prospective Registry of Early Systemic Sclerosis (PRESS) cohort is an early diffuse cutaneous systemic sclerosis (dcSSc) that provides an opportunity to assess the…
Abstract Number: 2666 • 2017 ACR/ARHP Annual Meeting
The Clinical Utility of Flow-Mediated Dilation in Systemic Sclerosis Digital Ulcer Assessment
Tracy M. Frech¹, Daniel Machin², Maureen Murtaugh³ and Anthony Donato², ¹Division of Rheumatology, University of Utah, Salt Lake City, UT, ²University of Utah and Salt Lake Veterans Affair Medical Center, Salt Lake City, UT, ³University of Utah, Salt Lake, UT
Background/Purpose: Systemic sclerosis (SSc, scleroderma) patients can have the end-stage vasculopathy manifestation of a digital ulcer (DU). Brachial artery flow mediated dilation (FMD) is an…
Abstract Number: 2667 • 2017 ACR/ARHP Annual Meeting
The Association between Two Non-Invasive Methods for the Assessment of Severity of Gastrointestinal Involvement and Malnutrition in Systemic Sclerosis: Self-Reported Questionnaires and Nail Fold Video-Capillaroscopy
Yasemin Yalçınkaya¹, Zeynep Erturk¹, Ozlem Pehlivan², Ali Ugur Unal³, Pamir Atagunduz¹, Haner Direskeneli¹ and Nevsun Inanc¹, ¹Departement of İnternal Medicine, Division of Rheumatology, Marmara University, Istanbul, Turkey, ²Department of Internal Medicine, Division of Rheumatology, Umraniye Education and Research Hospital, Istanbul, Turkey, ³Departement of Internal Medicine, Division of Rheumatology, Marmara University, Istanbul, Turkey
Background/Purpose: Gastrointestinal (GI) system involvement is commonly seen in sytemic sclerosis (SSc) up to 90% of the patients during disease duration and one of the…
Abstract Number: 2668 • 2017 ACR/ARHP Annual Meeting
Responsiveness of University of California Los Angeles Scleroderma Clinical Trial Consortium (GIT2.0) and Intestinal Visual Analogue Scale to Change in Systemic Sclerosis Patients
Yossra A Suliman¹, Suzanne Kafaja², Mohamed Alemam³, yasser Shaweesh⁴, Kasra Tavakoli⁵ and Daniel E. Furst⁶, ¹Rheumatology and Rehabilitation dept., Rheumatology and Rehabilitation dept. Assiut university hospital, Assiut Egypt, Assiut, Egypt, ²Department of Internal Medicine, University of California Los Angeles, David Geffen School of Medicine, Division of Rheumatology, Los Angeles, CA, ³Clinical Pathology and Laboratory Medicine Department, Assistant Lecturer, Qena, Egypt, ⁴John H. Stroger Jr. Hospital of cook county, chicago, IL, ⁵Department of medicine, university of California Los Angeles, Los Angeles, CA, ⁶David Geffen School of Medicine at UCLA, Los Angeles, CA
Background/Purpose: Gastrointestinal tract (GIT) involvement in systemic sclerosis (SSc) is the most common internal organ involvement. Among the few validated patient-reported outcome measures for GI…
Abstract Number: 2669 • 2017 ACR/ARHP Annual Meeting
Microvascular Flow Assessed By Dynamic Optical Coherence Tomography: First Non-Invasive Quantitative Outcome Measure of Microvascular Disease in Systemic Sclerosis
Giuseppina Abignano^1,2, Alexandra Daniel^1,3, Lorraine Green^1,3, Sookhoe Eng^1,3, Paul Emery^1,3 and Francesco Del Galdo^1,3, ¹Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ²Rheumatology Department of Lucania, San Carlo Hospital of Potenza and Madonna delle Grazie Hospital of Matera, Rheumatology Institute of Lucania (IReL), Potenza, Italy, ³Leeds Musculoskeletal Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom
Background/Purpose: Virtual skin biopsy by Optical Coherence Tomography (OCT) has been proposed as quantitative outcome measure of fibrosis in Systemic Sclerosis (SSc). Dynamic OCT (D-OCT)…
Abstract Number: 2670 • 2017 ACR/ARHP Annual Meeting
Trigeminal Neuralgia in Systemic Sclerosis
Nancy Maltez¹, Marie Hudson², Yves Troyanov³, May Choi⁴, Mianbo Wang⁵, Marvin J. Fritzler⁶, Murray Baron⁷ and Doug Smith⁸, ¹Rheumatology, The Ottawa Hospital, Ottawa, ON, Canada, ²Division of Rheumatology, Jewish General Hospital, Lady David Institute for Medical Research, Montreal, QC, Canada, ³Rheumatology, Hôpital du Sacré-Coeur de Montréal, Montréal, QC, Canada, ⁴University of Calgary, Calgary, AB, Canada, ⁵Lady Davis Institute for Medical Research, Montreal, QC, Canada, ⁶Medicine, University of Calgary, Calgary, AB, Canada, ⁷Rheumatology, McGill University, Jewish General Hospital, Montreal, QC, Canada, ⁸Division of Rheumatology, Department of Medicine, The Ottawa Hospital - University of Ottawa, Ottawa, ON, Canada
Background/Purpose: Trigeminal neuralgia (TN) is characterized by pain and spasms affecting one or more divisions of the fifth cranial nerve. Of note, TN is one…
Abstract Number: 2671 • 2017 ACR/ARHP Annual Meeting
Bosentan in Scleroderma Renal Crisis: A National Open Label Prospective Study
Alice Bérezné^1,2, Hendy ABDOUL³, Alexandre Karras⁴, Isabelle Marie⁵, Antoine Huart⁶, Maxence Ficheux⁷, Viviane Queyrel⁸, Bernard Imbert⁹, Xavier Puéchal¹, Arnaud Hot¹⁰, Boris Bienvenu¹¹, Elisabeth Diot¹², Bruno Moulin¹³, Thomas Quémeneur¹⁴, Jean-Emmanuel Kahn¹⁵, Luc Mouthon¹ and Loïc Guillevin for the French Vasculitis Study Group¹, ¹Service de Médecine Interne, Centre de Référence Maladies Auto-Immunes et Auto-Inflammatoires Systémiques Rares, Hôpital Cochin, Paris, France, ²Centre de Compétence Maladies Auto-Immunes et Auto-Inflammatoires Systémiques Rares, Centre de Compétence Eosinophiles CEREO, Hôpital Annecy Genevois, Anency, France, ³Centre d'investigation Clinique Paris Descartes, Necker–Cochin, Paris, Unité de Recherche Clinique, paris, France, ⁴Nephrology, HEGP, Paris, France, ⁵Internal medicine, Hôpital Bois Guillaume, ROUEN, France, ⁶Nephrology, Hôpital Rangueil, Toulouse, France, ⁷Nephrologie, Hôpital Clémenceau, CAEN, France, ⁸Internal medicine, Hôpital de l'Archet, NICE, France, ⁹Grenoble, Grenoble, France, ¹⁰Department of Internal Medicine, Edouard Herriot University Hospital, Hospices Civils de Lyon, Lyon cedex 03, France, ¹¹Internal Medicine, Hôpital de la côte de Nacre, Caen, France, ¹²Pôle médecine interne et gériatrique, pneumologie, Hôpital Bretonneau, Tours, France, ¹³Nephrology, Hôpital Civil, STRASBOURG, France, ¹⁴Service de néphrologie, médecine interne et vasculaire, Hôpital de Valenciennes, Valenciennes, France, ¹⁵foch hospital, foch, France
Background/Purpose: Scleroderma renal crisis (SRC), a life-threatening complication of systemic sclerosis (SSc), arises despite therapy combining an angiotensin-converting–enzyme inhibitor (AECI) and/or dialysis. Endothelin-1 (ET-1), a…
Abstract Number: 2672 • 2017 ACR/ARHP Annual Meeting
Perceived Barriers to Mental Health Care Among Patients with Systemic Sclerosis: A Qualitative Study
Karima Becetti¹, Laura Robbins², Carol Mancuso³, Jessica K. Gordon¹ and Robert F. Spiera¹, ¹Rheumatology, Hospital for Special Surgery, New York, NY, ²Education & Academic Affairs, Hospital for Special Surgery, New York, NY, ³Medicine, Hospital for Special Surgery, New York, NY
Background/Purpose: Systemic Sclerosis (SSc) is characterized by disfigurement, morbidity, and increased mortality. The diagnosis carries significant psychosocial impact on patients, and many suffer with depression,…
Abstract Number: 2673 • 2017 ACR/ARHP Annual Meeting
Real-Life Treatment Strategies for Systemic Sclerosis According to Experts
Andreu Fernández-Codina^1,2, Kyle M Walker³ and Janet E. Pope⁴, ¹Rheumatology, University of Western Ontario, London, ON, Canada, ²Systemic Autoimmune Diseases, Hospital Universitari Vall d'Hebron, Barcelona, Spain, ³Dept. of Medicine, Division of Rheumatology, University of Ottawa, Ottawa, ON, Canada, ⁴University of Western Ontario, London, ON, Canada
Background/Purpose:Second line treatment options for Systemic Sclerosis (SSc) are limited, and scarce data are available for choosing the order of treatment. The aim of this…
Abstract Number: 2674 • 2017 ACR/ARHP Annual Meeting
The Association between the Extent of Skin Thickness and Organ Involvement, Function and Quality of Life in Early Diffuse Cutaneous Systemic Sclerosis
Janet E. Pope¹, Murray Baron², Tatiana Nevskaya³, Carl Baxter⁴ and Dena Ramey⁵, ¹Medicine, Divsion of Rheumatology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada, ²Rheumatology, McGill University, Jewish General Hospital, Montreal, QC, Canada, ³Rheumatology Division, St. Joseph’s Health Care London, London, ON, Canada, ⁴Global Outcomes Research, MSD Ltd, Hoddesdon, United Kingdom, ⁵Epidemiology, Merck & Co., Upper Gwynedd, PA
Background/Purpose: To estimate whether severity of skin thickness is associated with disease severity, function, quality of life (QoL) and progression of internal organ involvement over…
Abstract Number: 2675 • 2017 ACR/ARHP Annual Meeting
Lung Transplant Trends in Patients’ with Systemic Sclerosis Using UNOS (United Network Organ Sharing) Database from 2000-2014
Osman Bhatty¹, Rouhin Sen¹, Douglas Moore² and Joseph Nahas³, ¹Department of Medicine, CHI Creighton University Medical Center, Omaha, NE, ²Department of Pulmonary/Critical Care, CHI Creighton University Medical Center, Omaha, NE, ³Department of Rheumatology, CHI Creighton University Medical Center, Omaha, NE
Background/Purpose: Systemic sclerosis (SSc) is a chronic autoimmune disease once characterized by high mortality rates now with better outcomes. Pulmonary disease has overtaken renal failure…
Abstract Number: 2676 • 2017 ACR/ARHP Annual Meeting
Reduction of Dlco and FVC in Patients with GERD and Systemic Sclerosis
Rodrigo Aguila Maldonado¹, Pierina Sansinanea², Claudia Elizabeth Pena¹, Ana Carolina Costi¹, Ariel Vulcano², Adriana Testi², Mariana Pera³, Lucila García², Valeria Arturi³, Viviana Nagua² and Mercedes Garcia¹, ¹Rheumatology, HIGA General San Martin La Plata, La Plata, Argentina, ²Rheumatology, HIGA General San Martin La Plata, la plata, Argentina, ³HIGA General San Martin La Plata, la plata, Argentina
Background/Purpose: Esophageal involvement is common in Systemic Sclerosis (SSc). It is estimated to occur in 70-90% of patients. Esophageal motor dysfunction is characterized by hypotonia…

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