Abstracts Archive - Page 1381 of 2607 - ACR Meeting Abstracts

Abstract Number: 2922 • 2018 ACR/ARHP Annual Meeting
Magnetic Resonance Imaging of Sacroiliac Joints in Patients with Osteitis Condensans Ilii Reveals a Typical Pattern of Lesions Relevant for Differential Diagnosis with Axial Spondyloarthritis
Denis Poddubnyy^1,2, Torsten Diekhoff³, Nino Gobejishvili³, Henning Weineck³, Maria Llop Vilaltella³, Valeria Rios Rodriguez³, Joachim Sieper² and Kay-Geert Hermann³, ¹German Rheumatism Research Centre, Berlin, Germany, ²Charité Universitätsmeidzin Berlin, Berlin, Germany, ³Charité Universitätsmedizin Berlin, Berlin, Germany
Background/Purpose: Osteitis condensans ilii (OCI) is regarded to as a non-inflammatory disorder induced by mechanical stress and mechanical instability of the sacroiliac joints (SIJ). OCI…
Abstract Number: 2923 • 2018 ACR/ARHP Annual Meeting
Is All MRI-SIJ Inflammation the Same? Gradient of Structural Damage with Increasing Cumulative Inflammation at the SIJ Quadrant Level in Axial Spondyloarthritis – 5-Year Data from the DESIR Cohort
Santiago Rodrigues Manica^1,2, Alexandre Sepriano^1,3, Sofia Ramiro^3,4, Robert B.M. Landewé⁵, Pascal Claudepierre⁶, Anna Moltó⁷, Maxime Dougados⁸, Miranda van Lunteren³ and Désirée van der Heijde⁹, ¹CEDOC, NOVA Medical School, Lisbon, Portugal, ²Rheumatology, Hospital de Egas Moniz - Centro Hospitalar Lisboa Ocidental, EPE, Lisbon, Portugal, ³Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁴Department of Rheumatology, Zuyderland Medical Center, Heerlen, Netherlands, ⁵Amsterdam Rheumatology & Clinical Immunology Center and Zuyderland Medical Center, Amsterdam; Heerlen, Netherlands, ⁶Hôpital Henri Mondor, Créteil, France, ⁷Paris Descartes University, Cochin Hospital, Paris, France, ⁸Department of Rheumatology, Paris Descartes University and Cochin Hospital, Paris, France, ⁹Leiden University Medical Centre, Leiden, Netherlands
Background/Purpose: Axial inflammation is a key feature in axial spondyloarthritis (axSpA). An (overall) definition of bone marrow oedema (BMO) on the MRI of the SIJ…
Abstract Number: 2924 • 2018 ACR/ARHP Annual Meeting
Spinal Radiographic Progression in Early Axial Spondyloarthritis: 5-Year Data from the DESIR Cohort
Sofia Ramiro¹, Désirée van der Heijde², Alexandre Sepriano³, Miranda van Lunteren⁴, Anna Molto⁵, Maria Antonietta D'Agostino⁶, Damien Loeuille⁷, Maxime Dougados⁸, M. Reijnierse⁹ and Pascal Claudepierre¹⁰, ¹Zuyderland Medical Center, Heerlen & Leiden University Medical Center, Leiden, Netherlands, ²Leiden University Medical Centre, Leiden, Netherlands, ³Leiden University Medical Center, Leiden, Netherlands, ⁴Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁵Hôpital Cochin, Department of Rheumatology, Paris Descartes University, Paris, France, ⁶Department of Rheumatology, Assistance publique-Hôpitaux de Paris Ambroise Paré Hospital, Boulogne-Billancourt , Université Versailles Saint Quentin en Yvelines, Paris, France, ⁷Rheumatology, University Hospital of Nancy, NANCY, France, ⁸Department of Rheumatology, Paris Descartes University and Cochin Hospital, Paris, France, ⁹Radiology, Leiden University Medical Center, Leiden, Netherlands, ¹⁰Hôpital Henri Mondor, Créteil, France
Background/Purpose: Spinal radiographic progression has been investigated in patients with r-axSpA, but not yet as thoroughly in early axSpA. We aimed to analyse the progression…
Abstract Number: 2925 • 2018 ACR/ARHP Annual Meeting
Fatty Lesions Detected on MRI Scans in Patients with Ankylosing Spondylitis Are Based on the Deposition of Fat in the Vertebral Bone Marrow
Xenofon Baraliakos¹, Heinrich Boehm², Ahmed Samir³, Georg Schett⁴, Jürgen Braun⁵ and Andreas Ramming⁶, ¹Ruhr-University Bochum, Herne, Germany, ²Clinic for spinal surgery, Bad Berka, Germany, ³Orthopedic and Traumatology Department, Cairo University, Cairo, Egypt, ⁴Department of Internal Medicine 3, University of Erlangen-Nuremberg, Erlangen, Germany, Erlangen, Germany, ⁵Ruhr Universität Bochum, Bochum, Germany, ⁶Department of Internal Medicine 3 and Institute for Clinical Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany
Background/Purpose: Fatty lesions (FL), similar to bone marrow edema (BME) and sclerosis (SCL), are characteristic findings in MRI examinations of patients with ankylosing spondylitis (AS)…
Abstract Number: 2926 • 2018 ACR/ARHP Annual Meeting
Which MRI Lesions in the Sacroiliac Joint Are Associated with the Diagnosis of Axial Spondyloarthritis after 2 Years Follow up in the Echography in Spondyloarthritis Cohort?
Walter P. Maksymowych^1,2, Damien Loeuille³, Stephanie Wichuk⁴, Joel Paschke⁵, Olivia Judet⁶, Maxime Breban³, Maria-Antonietta D'Agostino⁷ and Robert G. Lambert⁸, ¹University of Alberta, Edmonton, AB, Canada, ²CaRE Arthritis, Edmonton, AB, Canada, ³Ambroise Paré Hospital, Boulogne-Billancourt, France, ⁴Medicine, Medicine, University of Alberta, Edmonton, AB, Canada, ⁵CaRE Arthritis, Edmonton, Canada, Edmonton, AB, Canada, ⁶CHRU Vandoeuvre les Nancy, Vandœuvre-lès-Nancy, France, ⁷CHRU Vandoeuvre les Nancy, Vandoeuvre les Nancy, France, ⁸Radiology, Radiology, University of Alberta, Edmonton, AB, Canada
Background/Purpose: MRI of the sacroiliac joint (SIJ) is emerging as an important prognostic tool for assessment of patients presenting with axSpA. A major challenge in…
Abstract Number: 2927 • 2018 ACR/ARHP Annual Meeting
What Are the Optimal MRI Lesion Cut-Offs That Define Active and Structural Lesions in the Sacroiliac Joint As Being Typical of Axial Spondyloarthritis By Expert Readers?
Walter P. Maksymowych^1,2, Pedro Machado³, Ulrich Weber⁴, Xenofon Baraliakos⁵, Joachim Sieper⁶, Stephanie Wichuk¹, Denis Poddubnyy⁶, Mikkel Østergaard⁷, Joel Paschke², Robert G. Lambert¹ and Susanne J Pedersen⁷, ¹University of Alberta, Edmonton, AB, Canada, ²CaRE Arthritis, Edmonton, AB, Canada, ³University College London, London, United Kingdom, ⁴University of Southern Denmark, Odense, Denmark, ⁵Rheumazentrum Ruhrgebiet Herne, Herne, Germany, ⁶Charité Universitätsmeidzin Berlin, Berlin, Germany, ⁷COPECARE University of Copenhagen, Copenhagen, Denmark
Background/Purpose: Defining what constitutes a definite MRI lesion in the SIJ typical of axSpA has been hampered by lack of international consensus for standardized lesion…
Abstract Number: 2928 • 2018 ACR/ARHP Annual Meeting
Validation of New Systemic Lupus Erythematosus Classification Criteria
Martin Aringer¹, Karen Costenbader², Ralph Brinks³, Dimitrios Boumpas⁴, David Daikh⁵, David Jayne⁶, Diane L. Kamen⁷, Marta Mosca⁸, Rosalind Ramsey-Goldman⁹, Josef S. Smolen¹⁰, David Wofsy¹¹, Betty Diamond¹², Søren Jacobsen¹³, W. Joseph McCune¹⁴, Guillermo Ruiz-Irastorza¹⁵, Matthias Schneider¹⁶, Murray Urowitz¹⁷, George Bertsias¹⁸, Bimba Hoyer¹⁹, Nicolai Leuchten¹, Chiara Tani²⁰, Sara K. Tedeschi²¹, Zahi Touma²², Branimir Anic²³, Florence Assan²⁴, Tak Mao Chan²⁵, Ann E. Clarke²⁶, Peggy Crow²⁷, László Czirják²⁸, Andrea Doria²⁹, Winfried Graninger³⁰, Bernadett Halda-Kiss²⁸, Sarfaraz A. Hasni³¹, Peter M. Izmirly³², Michelle Jung³³, Gabor Kumanovics²⁸, Xavier Mariette²⁴, Ivan Padjen²³, JM Pego-Reigosa³⁴, Juanita Romero-Díaz³⁵, Iñigo Rúa-Figueroa³⁶, Raphaele Seror³⁷, Georg Stummvoll³⁸, Yoshiya Tanaka³⁹, Maria Tektonidou⁴⁰, Carlos Vasconcelos⁴¹, Edward M Vital⁴², Daniel J. Wallace⁴³, Sule Yavuz⁴⁴, Raymond P. Naden⁴⁵, Thomas Dörner⁴⁶ and Sindhu Johnson⁴⁷, ¹Medicine III, University Medical Center and Faculty of Medicine TU Dresden, Dresden, Germany, ²Rheumatology, Immunology and All, Brigham & Women's Hospital, Boston, MA, ³Department of Rheumatology & Hiller Research Unit, Heinrich-Heine University, Düsseldorf, Germany, ⁴University of Athens, Athens, Greece, ⁵Rheumatology, UCSF and VA Medical Center, San Francisco, CA, ⁶Department of Medicine, University of Cambridge, Cambridge, United Kingdom, ⁷Medicine/Rheumatology & Immunology, Medical University of South Carolina, Charleston, SC, ⁸Rheumatology Unit, University of Pisa, Pisa, Italy, ⁹FSM, Northwestern University, Chicago, IL, ¹⁰Division of Rheumatology, Department of Medicine 3, Medical University of Vienna, Vienna, Austria, ¹¹University of California San Francisco, San Francisco, CA, ¹²Autoimmune Musculoskeletal and Hematopoietic Diseases, The Feinstein Institute for Medical Research, Manhasset, NY, ¹³University of Copenhagen, Copenhagen, Denmark, ¹⁴Int Med/ Rheum, University of Michigan, Ann Arbor, MI, ¹⁵Autoimmune Diseases Research Unit, BioCruces, Hospital Universitario Cruces, Baracaldo, Spain, ¹⁶Department and Hiller Research Center for Rheumatology, Heinrich-Heine University, Duesseldorf, Germany, ¹⁷University of Toronto Lupus Research Program, Toronto Western Hospital, Toronto, ON, Canada, ¹⁸Department of Rheumatology, Clinical Immunology and Allergy, University of Crete, School of Medicine, Heraklion, Greece, ¹⁹University of Schleswig-Holstein, Kiel, Germany, ²⁰University of Pisa, Pisa, Italy, ²¹Rheumatology Immunology & Allergy, Brigham & Women's Hospital, Boston, MA, ²²University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ²³Department of Internal Medicine, University Hospital Zagreb and University of Zagreb School of Medicine, Zagreb, Croatia, ²⁴Université Paris Sud, Paris, France, ²⁵University of Hong Kong, Hong Kong, Hong Kong, ²⁶Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, ²⁷Department of Medicine, Hospital for Special Surgery, New York, NY, ²⁸Rheumatology and Immunology, University of Pécs, Pécs, Hungary, ²⁹University and Azienda Ospedaliera of Padova, Padova, Italy, ³⁰Rheumatology and Immunology, Medical University of Graz, Graz, Austria, ³¹Lupus Clinical Research Program, Office of the Clinical Director, NIH/NIAMS, Bethesda, MD, ³²NYU Langone Health, New York, NY, ³³University of Calgary, Calgary, AB, Canada, ³⁴Complexo Hospitalario Universitario de Vigo, Vigo, Spain, ³⁵Immunology and Rheumatology, Instituto Nacional de Ciencias Medicas y Nutricion, Mexico City, Mexico, ³⁶Rheumatology Division, Hospital Doctor Negrin, Las Palmas GC, Spain, ³⁷Center for Immunology of Viral Infections and Autoimmune Diseases, Assistance Publique – Hôpitaux de Paris, Hôpitaux Universitaires Paris-Sud, Le Kremlin-Bicêtre, Université Paris Sud, INSERM, Paris, France, Paris, France, ³⁸Rheumatology, Medical University Vienna, Vienna, Austria, ³⁹University of Occupational and Environmental Health, Kitakyushu, Japan, ⁴⁰Rheumatology Unit, 1st Dept. of Propaedeutic Internal Medicine, Joint Academic Rheumatology Program, Athens University Medical School, Athens, Greece, ⁴¹Centro Hospitalar do Porto, University of Porto, Porto, Portugal, ⁴²University of Leeds, Leeds, United Kingdom, ⁴³Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, ⁴⁴Department of Rheumatology, Marmara University, Istanbul, Turkey, ⁴⁵New Zealand Ministry of Health, New Zealand Ministry of Health, Auckland, New Zealand, ⁴⁶Charité Universitätsmedizin Berlin, Berlin, Germany, ⁴⁷Rheumatology, Mount Sinai Hospital and University Health Network, Toronto, ON, Canada
Background/Purpose: Correct classification of patients with systemic lupus erythematosus (SLE) is critical for clinical trials and clinical and translational science. The ACR 1997 criteria were…
Abstract Number: 2929 • 2018 ACR/ARHP Annual Meeting
Validation of Remission and Lupus Low Disease Activity State As Predictors of Organ Damage in SLE
Michelle Petri¹, Daniel Goldman¹ and Laurence S Magder², ¹Medicine (Rheumatology), Johns Hopkins University School of Medicine, Baltimore, MD, ²Epidemiology and Public health, University of Maryland School of Medicine, Baltimore, MD
Background/Purpose: Outcome measures that combine control of SLE activity and prednisone reduction are clinically relevant. A clinical goal in SLE is to reduce risk of…
Abstract Number: 2930 • 2018 ACR/ARHP Annual Meeting
Prospective Comparison of Remission and Lupus Low Disease Activity State – Effect on Disease Outcomes in Systemic Lupus Erythematosus
Vera Golder¹, Rangi Kandane-Rathnayake², Molla Huq³, Worawit Louthrenoo⁴, Shue-Fen Luo⁵, Yeong-Jian Wu⁶, Aisha Lateef⁷, Sargunan Sockalingam⁸, Susan Morton⁹, Sandra V. Navarra¹⁰, Leonid Zamora¹¹, Laniyati Hamijoyo¹², Yasuhiro Katsumata¹³, Masayoshi Harigai¹⁴, Madelynn Chan¹⁵, Sean O'Neill¹⁶, Fiona Goldblatt¹⁷, Chak Sing Lau¹⁸, Zhan-Guo Li¹⁹, Alberta Y. Hoi², Mandana Nikpour²⁰ and Eric Morand²¹, ¹School of Clinical Sciences at Monash Health, School of Clinical Sciences at Monash Health, Monash University, Melbourne, Australia, ²School of Clinical Sciences at Monash Health, Monash University, Melbourne, Australia, ³The University of Melbourne at St Vincent's Hospital, Melbourne, Australia, ⁴Division of Rheumatology, Department of Internal Medicine, Chiang Mai University, Chiang Mai, Thailand, ⁵Division of Rheumatology, Allergy and Immunology, Chang Gung Memorial Hospital, Taoyuan, Taiwan, ⁶Chang Gung University, Taoyuan County, Taiwan, ⁷Medicine, Division of Rheumatology, National University Hospital of Singapore, Singapore, Singapore, ⁸University of Malaya, Kuala Lumpur, Malaysia, ⁹Monash Health, Melbourne, Australia, ¹⁰University of Santo Tomas Hospital, Manila, Philippines, ¹¹Rheumatology, University of Santo Tomas Hospital, Manila, Philippines, ¹²University of Padjadjaran, Bandung, Indonesia, ¹³Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan, ¹⁴Tokyo Women's Medical University, Division of Epidemiology and Pharmacoepidemiology of Rheumatic Diseases, Institute of Rheumatology, Tokyo, Japan, ¹⁵Tan Tock Seng Hospital, Singapore, Singapore, ¹⁶University of New South Wales, Sydney, Australia, ¹⁷Royal Adelaide Hospital, Adelaide, Australia, ¹⁸Medicine, The University of Hong Kong, Hong Kong, Hong Kong, ¹⁹Rheum/Immunology, Peking University People's Hospital, Beijing, China, ²⁰The University of Melbourne, Melbourne, Australia, Melbourne, Australia, ²¹Medicine, School of Clinical Sciences at Monash Health, Monash University, Melbourne, Australia
Background/Purpose: The Definitions of Remission in SLE (DORIS) group has proposed multiple definitions of remission, but these are infrequently attained and have not previously been…
Abstract Number: 2931 • 2018 ACR/ARHP Annual Meeting
Missing Outcomes in SLE Clinical Trials: Impact on Estimating Treatment Effects
Mimi Kim¹, Joan T. Merrill², Kenneth C. Kalunian³, Leslie Hanrahan⁴ and Peter M. Izmirly⁵, ¹Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, ²University of Oklahoma Health Sciences Center, Oklahoma City, OK, ³Division of Rheumatology, Allergy and Immunology, UCSD School of Medicine, La Jolla, CA, ⁴Lupus Foundation of America, Washington DC, DC, ⁵NYU Langone Health, New York, NY
Background/Purpose: Missing data due to drop-out and loss to follow-up is a common problem in SLE trials. The usual approaches for handling this issue include…
Abstract Number: 2932 • 2018 ACR/ARHP Annual Meeting
Systemic Lupus Erythematosus Biomarkers Identified Using Multi-Omic and Artificial Intelligence Analysis through Interrogative Biology
Eric Grund¹, Lixia Zhang¹, Leonardo Rodrigues¹, Viatcheslav Akmaev¹, Rangaprasad Sarangarajan¹, Michael Kiebish¹, Niven Narain¹ and Gary S. Gilkeson², ¹BERG, LLC, Framingham, MA, ²Department of Medicine, Medical University of South Carolina, Charleston, SC
Background/Purpose: Biomarkers for use in developing treatments and diagnostics for Systemic Lupus Erythematosus (SLE) are a large unmet need. The wide differential in patient progression…
Abstract Number: 2933 • 2018 ACR/ARHP Annual Meeting
Non-Invasive Tape Sampling Reveals RNA Gene Clusters in Cutaneous Lupus Erythematosus That Discriminate Affected from Unaffected and Healthy Volunteer Skin
Joseph F. Merola¹, Wenting Wang², Carrie Wager³, Stefan Hamann², Xueli Zhang³, Alice Thai², Chris Roberts², Christina Lam⁴, Cristina Musselli², Galina Marsh², Dania Rabah², Catherine Barbey⁵, Nathalie Franchimont² and Taylor L. Reynolds², ¹Clinical Unit for Research Innovation & Trials, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ²Biogen, Cambridge, MA, ³Formerly of Biogen, Cambridge, MA, ⁴Boston University Medical School, Boston, MA, ⁵Biogen, Zug, Switzerland
Background/Purpose: Punch biopsy, the standard diagnostic and monitoring procedure for patients with cutaneous lupus erythematosus (CLE), impedes patient recruitment and follow up due to risk…
Abstract Number: 2934 • 2018 ACR/ARHP Annual Meeting
Myocardial Microscopic Fibrosis Assessed By T1 Mapping Sequences on Cardiac Magnetic Resonance Imaging Predicts Cardiac Events in Systemic Sclerosis: Data from a Prospective Cohort Study on 40 Patients
Benjamin Terrier¹, Agnès Dechartres², Hervé Gouya³, Alexis Régent⁴, Bertrand Dunogué⁵, Pascal Cohen⁶, Alice Berezne⁷, Claire Le Jeunne⁸, Paul Legmann³, Olivier Vignaux³ and Luc Mouthon⁹, ¹National Referral Center for Rare Systemic Autoimmune Diseases, Paris Cochin, France, Paris, France, ²Epidemiology, Hotel Dieu, Paris, France, ³Radiology, Cochin hospital, Paris, France, ⁴Department of Internal Medicine, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris (APHP), Université Paris Descartes, Paris, France, ⁵Internal Medicine, Department of Internal Medicine, National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France, ⁶Department of Internal Medicine, INSERM Unité 1016, Centre de Référence pour les Maladies Auto-immunes Rares, Hôpital Cochin, Université Paris Descartes, Sorbonne Paris Cité, Paris, France, ⁷Internal Medicine, CH Annecy, Annecy, France, ⁸Department of Internal Medicine, National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France, ⁹Department of Internal Medicine, INSERM Unité 1016, Centre de Référence pour les Maladies Auto-immunes Rares, National Referral Center for Rare Systemic Autoimmune Diseases, Paris Cochin, France, Paris, France
Background/Purpose: Studies have shown that myocardial involvement may occur in systemic sclerosis (SSc) and lead to cardiac failure. We showed previously that cardiac magnetic resonance…
Abstract Number: 2935 • 2018 ACR/ARHP Annual Meeting
A Practical Classification of Systemic Sclerosis Using Subset and Autoantibodies for the Purpose of Early Risk Stratification
Svetlana I. Nihtyanova¹, Emma C. Derrett-Smith², Carmen Maria Fonseca³, Voon H. Ong² and Christopher P. Denton⁴, ¹Division of Medicine, Centre for Rheumatology and Connective Tissue Diseases, University College London, London, United Kingdom, ²Division of Medicine, University College London, London, United Kingdom, ³Department of Rheumatology and Connective Tissue Disease, University College London, London, United Kingdom, ⁴University College London, London, United Kingdom
Background/Purpose: The Le Roy et al. classification of SSc into limited and diffuse cutaneous subtype remains the most commonly used. Nevertheless, autoantibodies are much better…
Abstract Number: 2936 • 2018 ACR/ARHP Annual Meeting
Esophageal Erosion Predicts Progression of Lung Disease in Patients with Systemic Sclerosis
Silvia Laura Bosello¹, Enrico De Lorenzis¹, Gerlando Natalello², Giovanni Battista Canestrari¹, Laura Gigante¹, Lucrezia Verardi¹, Ludovica Berardini³ and Elisa Gremese¹, ¹Division of Rheumatology, Fondazione Policlinico Universitario A.Gemelli IRCCS, Catholic University of the Sacred Heart, Rome, Italy, ²Division of Rhematology, Fondazione Policlinico Universitario A.Gemelli IRCCS, Catholic University of the Sacred Heart, Rome, Italy, ³Division of Respiratory Medicine, Fondazione Policlinico Universitario A.Gemelli IRCCS, Catholic University of the Sacred Heart, Rome, Italy
Background/Purpose: Interstitial lung disease (ILD) is the leading cause of death in Systemic Sclerosis (SSc) but its pathogenesis is not fully understood. Esophageal disease is…

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