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  • Abstract Number: 2392 • 2017 ACR/ARHP Annual Meeting

    Impact of the Pattern of Interstitial Lung Disease on Mortality in Rheumatoid Arthritis: A Systematic Review and Meta-Analysis

    Namrata Singh1, Jimmy Varghese2, Bryant R. England3, Joshua J. Solomon4, Kaleb Michaud5, Ted R. Mikuls6 and Marin Schweizer7, 1Internal Medicine, University of Iowa Hospitals and Clinics and Iowa City VA, Iowa City, IA, 2Internal Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA, 3Division of Rheumatology & Immunology, Department of Internal Medicine, Nebraska-Western IA VA Health Care System & University of Nebraska Medical Center, Omaha, NE, 4Division of Pulmonary and Critical Care Medicine, National Jewish Health, Denver, CO, 5University of Nebraska Medical Center, Omaha, NE, 6Internal Medicine, Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, 7Internal Medicine, Iowa City VA, Iowa City, IA

    ABSTRACT Impact of the Pattern of Interstitial Lung Disease on Mortality in Rheumatoid Arthritis: A systematic review and meta-analysis Background/Purpose: Interstitial lung disease affects 10-15%…
  • Abstract Number: 2393 • 2017 ACR/ARHP Annual Meeting

    Evaluation of Live Zoster Vaccine in a Subset of Patients with Rheumatoid Arthritis Treated with Tofacitinib with or without Methotrexate, and Adalimumab with Methotrexate: Results from a Phase 3b/4 Randomized Trial

    Leonard H. Calabrese1, Carlos Abud-Mendoza2, Stephen Lindsey3, Sang Heon Lee4, Liza Takiya5, Noriko Iikuni6, Koshika Soma7, Zhen Luo8 and Roy Fleischmann9, 1Cleveland Clinic Foundation, Cleveland, OH, 2Hospital Central, San Luis Potosí, Mexico, 3Ochsner Medical Center, Baton Rouge, LA, 4Konkuk University School of Medicine, Seoul, Korea, Republic of (South), 5Pfizer Inc, Collegeville, PA, 6Pfizer Inc, New York, NY, 7Pfizer Inc, Groton, CT, 8Pfizer Inc, Shanghai, China, 9Metroplex Clinical Research Center and University of Texas Southwestern Medical Center, Dallas, TX

    Background/Purpose: Tofacitinib is an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis (RA). Patients (pts) with RA are at increased risk for herpes…
  • Abstract Number: 2394 • 2017 ACR/ARHP Annual Meeting

    Differential Effect of Corticosteroids and Biological Dmards on Five-Year Radiographic Progression in Rheumatoid Arthritis: Results from a Weighted Cumulative Exposure Model Developed on the Espoir Cohort

    Baptiste Louveau1, Yann De Rycke1, Alexandre Lafourcade1, Alain Saraux2, Francis Guillemin3, Florence Tubach4, Bruno Fautrel5 and David Hajage1, 1APHP, Pitié Salpêtrière Hospital, Département Biostatistics and Public health, Pharmacoepidémiology center (Cephepi), 75018 75013, Paris, France, Paris, France, 2Rheumatology Department, Rheumatology Department, CHU de la Cavale Blanche, Brest, France, Brest Cedex, France, 3University of Lorraine, Nancy, France, Nancy, France, 4Université Pierre et Marie Curie (UPMC)-Paris 6; APHP, Pitié Salpêtrière Hospital, Département Biostatistics and Public health, Pharmacoepidémiology center (Cephepi), 75018 75013, Paris, France, Paris, France, 5UPMC University Paris 06, Pitié-Salpétrière Hospital, Paris, France

    Background/Purpose: In rheumatoid arthritis (RA), a strategic approach to achieve low-disease activity or remission is now recommended. Controlling joint damage is thus an important concern…
  • Abstract Number: 2395 • 2017 ACR/ARHP Annual Meeting

    Recommendations on the Management of Rheumatoid Arthritis in Patients with Cancer: A Systematic Review of Clinical Practice Guidelines and Consensus Statements

    Maria A. Lopez-Olivo1, Ines Colmegna2, Aliza Matusevich1, Susan Ruyu Qi3, Natalia Zamora1, Robin Sharma1, Gregory Pratt4 and Maria Suarez-Almazor1, 1Section of Rheumatology and Clinical Immunology, Department of General Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA, Houston, TX, 2Division of Rheumatology, Department of Medicine, Division of Experimental Medicine, McGill University, Montreal, Quebec, Canada, Montreal, QC, Canada, 3Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada, Montreal, QC, Canada, 4Research Medical Library, The University of Texas MD Anderson Cancer Center, Houston, TX, USA, Houston, TX

    Background/Purpose: To compare the recommendations of clinical practice guidelines (CPGs) and consensus statements (CSs) regarding the management of rheumatoid arthritis (RA) in patients with cancer.…
  • Abstract Number: 2396 • 2017 ACR/ARHP Annual Meeting

    Safety and Humoral and Cell-Mediated Immune Responses to Herpes Zoster Vaccine in Patients with Rheumatoid Arthritis

    JungHee Koh1, Ji-Won Kim2, Seung-Ki Kwok3, Ji Hyeon Ju4 and Sung-Hwan Park5, 1Seochogu, Banpodaero, 222, Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of (South), 2Medicine, Division of Rheumatology, Department of Internal Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of (South), 3[email protected], Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of (South), 4Division of Rheumatology, Department of Internal Medicine,, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of (South), 5Kangnam St Mary's Hosp, Seoul, Korea, Republic of (South)

    Background/Purpose: To examine humoral and cellular immune responses induced by a live attenuated herpes zoster (HZ) vaccine in patients with rheumatoid arthritis (RA) compared with…
  • Abstract Number: 2397 • 2017 ACR/ARHP Annual Meeting

    Bilateral Femoral DXA Scan in Patients with Rheumatoid Arthritis

    Marco Massarotti1 and Marwan Bukhari2, 1Rheumatology, Royal Lancaster Infirmary, University Hospital of Morecambe Bay NHS Foundation Trust, Lancaster, United Kingdom, 2Royal Lancaster Infirmary, Lancaster, United Kingdom

    Background/Purpose: RA is in independent risk factor for osteoporosis and fractures. The diagnosis of osteoporosis is based on T-score at lumbar spine or hip and…
  • Abstract Number: 2398 • 2017 ACR/ARHP Annual Meeting

    A Population-Based Cohort Study of Chronic Obstructive Pulmonary Disease Among Patients with Rheumatoid Arthritis: Comorbidity and Mortality

    Charlotte Hyldgaard1, Elisabeth Bendstrup1, Alma Becic Pedersen2, Sinna Pilgaard Ulrichsen3, Anders Løkke1, Ole Hilberg4 and Torkell Ellingsen5,6, 1Pulmonology, Århus University Hospital, Århus, Denmark, 2Clinical Epidemiology, Århus University Hospital, Århus, Denmark, 3Clinicla Epidemiology, Århus University Hospital, Århus, Denmark, 4Internal medicine, Vejle Hospital, Vejle, Denmark, 5Diagnostic Centre, Region Hospital Silkeborg, Silkeborg, Denmark, 6Department of Rheumatology, Odense University Hospital, Odense, DK, Odense, Denmark

    Background/Purpose: Only few studies have addressed the prognostic impact of chronic obstructive pulmonary disease (COPD) among patients with rheumatoid arthritis (RA), although both diseases are…
  • Abstract Number: 2399 • 2017 ACR/ARHP Annual Meeting

    Rheumatoid Arthritis Have Lower Glomerular Filtration Rate Compared to Healthy Population: Role of Inflammation

    Suad Hannawi1 and Issa Al Salmi2, 1Rheumatology, Asst.Prof, Dubai, United Arab Emirates, 2Prof, Muscat, Oman

    Background/Purpose: Rheumatoid Arthritis-(RA) is associated with subclinical kidney impairment which contributes to increase mortality and morbidity. The role of inflammation on kidney function in inflammatory…
  • Abstract Number: 2400 • 2017 ACR/ARHP Annual Meeting

    In Rheumatoid Arthritis: Vitamin-D Deficiency Is an Outcome and a Cause of Subclinical Renal Impairment

    Suad Hannawi1 and Issa Al Salmi2, 1Rheumatology, Asst.Prof, Dubai, United Arab Emirates, 2Prof, Muscat, Oman

    Background/Purpose: Vitamin D deficiency is highly prevalent in patients with rheumatoid arthritis (RA), and it is linked to RA disease severity. Two steps of hydroxylation…
  • Abstract Number: 2401 • 2017 ACR/ARHP Annual Meeting

    Rheumatoid Arthritis with Kidney Dysfunction Contributes to Higher Risk of Cardiovascular Disease Development

    Suad Hannawi1 and Issa Al Salmi2, 1Rheumatology, Asst.Prof, Dubai, United Arab Emirates, 2Prof, Muscat, Oman

    Background/Purpose: Reduced kidney function render patients with RA rheumatoid arthritis (RA), have an increased risk of cardtiovascular disease (CVD), particulary ischemic heart disease (IHD). This…
  • Abstract Number: 2402 • 2017 ACR/ARHP Annual Meeting

    Rituximab in Rheumatoid Arthritis with Interstitial Lung Disease: A Multicenter Study of 32 Patients

    Carlos Fernández-Díaz1, Delia Reina2, Paula Rubio-Muñoz3, Ana Urruticoechea-Arana4, María Carrasco-cubero5, María Martín-López6, Jose A. Miranda-Filloy7, Ignacio Villa-Blanco8, Ana Milena Millan9, Ivan Castellví10, Olga Maiz-Alonso11, Antonio Juan12, Fátima Álvarez Reyes13, José Luis Martín-Varillas1, Nuria Vegas-Revenga1, Ricardo Blanco1 and Miguel Angel González-Gay1, 1Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Universidad de Cantabria. Spain, Santander, Spain, 2Rheumatology, Hospital de Sant Joan Despí Moisès Broggi, Barcelona, Spain, 3Rheumatology,, Hospital Universitario Germans Trias i Pujol, Badalona, Spain, 4Rheumatology Department. Hospital Can Misses, IBIZA, Spain, 5Hospital Infanta Cristina, Badajoz, Spain, 6Rheumatology, Hospital Universitario 12 de Octubre, Madrid, Spain, 7Rheumatology Division, Hospital Lucus Augusti, Lugo, Spain, 8Hospital de Sierrallana, Sierrallana, Spain, 9Unitat de Reumatologia. Hospital de la Santa Creu i Sant Pau, Barcelona, Spain, 10Rheumatology, Hospital Universitari de la Santa Creu i Sant Pau, Barcelona, Spain, 11Hospital Universitario Donostia. San Sebastian. Spain, Donostia, Spain, 12Hospital Universitario Son Llàtzer. Rheumatology, Palma de Mallorca, Spain, 13Rheumatology, University Hospital Ntra. Sra. de La Candelaria, Santa Cruz de Tenerife, Spain

    Background/Purpose: Anti-TNFα drugs and several conventional disease-modifying anti-rheumatic drugs (DMARDs) such as methotrexate (MTX) have been involved in the development of Interstitial Lung Disease (ILD).…
  • Abstract Number: 2403 • 2017 ACR/ARHP Annual Meeting

    Amylin in the Insulin Resistance of Patients with Rheumatoid Arthritis

    Ivan Ferraz-Amaro1, Beatriz-Segura Tejera2, De Vera-González AM3, Alejandra González Delgado4, José Luis Hernandez5, Jose M Olmos6, Begoña Ubilla7, Raquel Lopez-Mejias8 and Miguel Angel González-Gay9, 1Rheumatology, Hospital Universitario de Canarias, La Laguna, Tenerife, Spain, 2Rheumatology, Rheumatology Division, Hospital Universitario de Canarias, San Cristobal de La Laguna, Spain, 3Central Laboratory Division, University Hospital of Canary Islands, Tenerife, Spain, 4Central Laboratory Division. Hospital Universitario de Canarias, Tenerife, Spain., Tenerife, Spain, 5Division of Internal Medicine., Hospital Universitario Marqués de Valdecilla, IDIVAL,, Santander, Spain, 6Division of Internal Medicine. Hospital Universitario Marqués de Valdecilla, IDIVAL.Universidad de Cantabria. RETICEF, Santander, Spain, 7Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, IDIVAL, Santander, Spain, 8Department of Rheumatology, Hospital Marquez de Valdecilla, Santander, Spain, 9Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Universidad de Cantabria. Spain, Santander, Spain

    Background/Purpose: Amylin is a 37-amino acid peptide that is stored in pancreatic beta cells and is co-secreted with insulin. Amylin and insulin levels rise and…
  • Abstract Number: 2404 • 2017 ACR/ARHP Annual Meeting

    Use of Dmards after the Diagnosis of Cancers in Patients with RA

    Young Bin Joo, Yune-Jung Park, Ki-Jo Kim and Kyung-Su Park, Internal Medicine, St. Vincent's Hospital, The Catholic University of Korea, Suwon, Korea, Republic of (South)

    Background/Purpose: Although there are many studies about the association of disease-modifying anti-rheumatic drugs (DMARDs) with cancers in patients with rheumatoid arthritis (RA), there are few…
  • Abstract Number: 2405 • 2017 ACR/ARHP Annual Meeting

    Biological Function Integrated Prediction of Severe Radiographic Progression in Rheumatoid Arthritis: A Nested Case Control Study

    Young Bin Joo1, Yul Kim2, Youngho Park3, Kwangwoo Kim4, Jeong Ah Ryu5, Seunghun Lee6, So-Young Bang7, Hye-Soon Lee8, Gwan-Su Yi9 and Sang-Cheol Bae7, 1Internal Medicine, St. Vincent's Hospital, The Catholic University of Korea, Suwon, Korea, Republic of (South), 2Bio and Brain Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Korea, Republic of (South), 3Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea, Republic of (South), 44Department of Biology, Kyung Hee University, Seoul, Korea, Republic of (South), 5Department of Radiology, Hanyang University Hospital, Seoul, Korea, Republic of (South), 617 Haengdang-Dong, Seongdong-G, Hanyang University Hospital, Seoul, Korea, Republic of (South), 7Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea, Republic of (South), 8Hanyang University Guri Hospital, Gyeonggi-do, Korea, Republic of (South), 9Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Korea, Republic of (South)

    Background/Purpose: Radiographic progression is reported to be highly heritable in rheumatoid arthritis (RA). However, previous study using genetic loci showed an insufficient accuracy of prediction…
  • Abstract Number: 2406 • 2017 ACR/ARHP Annual Meeting

    Increased Cartilage Damage in Metacarpophalangeal Joints of ACPA Positive Rheumatoid Arthritis (RA) Patients Using T2 Mapping in 3 Tesla Magnetresonance Imaging (MRI)

    Nina Renner1, Arnd Kleyer2, David Simon2, Gerhard Krönke3, Juergen Rech2, Georg Schett2, Goetz Welsch4 and Milena L. Pachowsky1, 1Department of Trauma and Orthopedic Surgery, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany, Erlangen, Germany, 2Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Department of Internal Medicine 3 – Rheumatology and Immunology, Universitätsklinikum Erlangen, Erlangen, Germany., Erlangen, Germany, 3Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Department of Internal Medicine 3 – Rheumatology and Immunology, Universitätsklinikum Erlangen, Erlangen, Germany., Erlangen, Austria, 4UKE Athleticum, University Hospital Hamburg-Eppendorf, Hamburg, Germany

    Background/Purpose: T2 mapping is a non-invasive MRI approach to measure cartilage quality, reflecting cartilage hydration and collagen integrity without using contrast enhancement. It has been…
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