Abstracts Archive - Page 1365 of 2607 - ACR Meeting Abstracts

Abstract Number: 2682 • 2018 ACR/ARHP Annual Meeting
Novel Antibody Against Commensal Bacterial Antigen in Prediction of the Response of Rituximab in Systemic Lupus Erythematosus
Yu-Min Kuo^1,2, Jenhao Chen³, Jean-san Chia⁴, Chiau-jing Jung⁵ and Song-Chou Hsieh⁶, ¹Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei, Taiwan, Taipei, Taiwan, ²Division of Allergy, Immunology and Rheumatology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan, ³Division of Allergy, Immunology and Rheumatology, Department of Internal Medicine, National Taiwan University Hospital,Yunlin branch, Yunlin County, Taiwan, ⁴Graduate Institute of Immunology, National Taiwan University College of Medicine, Taipei, Taiwan, ⁵Department of Microbiology and Immunology, School of Medicine,, College of Medicine, Taipei Medical University, Taipei, Taiwan, ⁶National Taiwan University Hospital, Taipei, Taiwan
Background/Purpose: Streptoccocal infections can cause rheumatic fever sharing clinical presentations similar to SLE. Whether oral commensal streptococci could induce cross-reactive and pathogenic antibodies remained unknown.…
Abstract Number: 2683 • 2018 ACR/ARHP Annual Meeting
Selective Expansion and Targeting of FoxP3+CD127lo Regulatory T Cells By Low-Dose IL-2 Therapy in Active SLE
Jens Humrich¹, Caroline von Spee-Mayer², Philipp Enghard³, Angelika Rose⁴, Elise Siegert⁵, Tobias Alexander⁵, Falk Hiepe⁶, Gerd R. Burmester⁷ and Gabriela Riemekasten⁸, ¹Department of Rheumatology, University Hospital Schleswig-Holstein - Campus Lübeck, Lübeck, Germany, ²Immunology, University Hospital Freiburg, Freiburg, Germany, ³Department of Nephrology, Charité – University Medicine Berlin, Berlin, Germany, ⁴Rheumatology and Clinical Immunology, Charité – University Medicine Berlin, Berlin, Germany, ⁵Rheumatology and Clinical Immunology, Charité - University Medicine Berlin, Berlin, Germany, ⁶Rheumatology, Charité – University Medicine Berlin, Berlin, Germany, ⁷Rheumatology and Clinical Immunology, Charité-University Medicine Berlin, Berlin, Germany, ⁸Rheumatology, University Hospital Schleswig-Holstein - Campus Lübeck, Lübeck, Germany
Background/Purpose: Interleukin-2 (IL-2) is crucial for the growth and survival of regulatory T cells (Treg), and thus for the control of autoimmunity. In previous studies…
Abstract Number: 2684 • 2018 ACR/ARHP Annual Meeting
Type I IFN, TLR7, MHC Class I, B Cell and OX40 Pathways Suppressed By Anifrolumab (anti-type I IFN receptor) in Moderate to Severe SLE Patients
Katie Streicher¹, Jixin Wang¹, Philip Z. Brohawn², Brandon W. Higgs², Raj Tummala³ and Koustubh Ranade⁴, ¹Translational Medicine, MedImmune, Gaithersburg, MD, ²MedImmune LLC, Gaithersburg, MD, ³MedImmune, Gaithersburg, MD, ⁴Translational Medicine, MedImmune LLC, Gaithersburg, MD
Background/Purpose: Type I interferon has been identified as one of the central mediators in the pathogenesis of SLE, such that patients are characterized by activation…
Abstract Number: 2685 • 2018 ACR/ARHP Annual Meeting
Interferon-Inducible Gene Expression Kit As a Potential Diagnostic Test for Anifrolumab: Analytical Validation for Use in Clinical Trials
Philip Z. Brohawn¹, Brandon W. Higgs¹, Sabina Patel², Adrian Moody³, Peter Cooper³ and Koustubh Ranade⁴, ¹MedImmune LLC, Gaithersburg, MD, ²AstraZeneca, Cambridge, United Kingdom, ³QIAGEN Manchester Ltd., Manchester, United Kingdom, ⁴Translational Medicine, MedImmune LLC, Gaithersburg, MD
Background/Purpose: Anifrolumab is a fully human monoclonal antibody that binds to the type I interferon (IFN) receptor. Its efficacy and safety in the treatment of…
Abstract Number: 2686 • 2018 ACR/ARHP Annual Meeting
Podocyte Foot Process Width Is a Prediction Marker for Complete Renal Remission at 6 and 12 Months after Induction Therapy in Lupus Nephritis
Kunihiro Ichinose¹, Mineaki Kitamura², Shuntaro Sato³, Keita Fujikawa⁴, Yoshiro Horai⁵, Naoki Matsuoka⁶, Masahiko Tsuboi⁶, Fumiaki Nonaka⁷, Masataka Umeda¹, Tomohiro Koga⁸, Takashi Igawa⁸, Tomoya Nishino² and Atsushi Kawakami⁸, ¹Department of Immunology and Rheumatology, Unit of Advanced Preventive Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ²Department of Nephrology, Nagasaki University Hospital, Nagasaki, Japan, ³Clinical Research Center, Nagasaki University Hospital, Nagasaki, Japan, ⁴Japan Community Health care Organization Isahaya General Hospital, Nagasaki, Japan, ⁵Department of Rheumatology, Clinical Research Center, NHO Nagasaki Medical Center, Omura, Japan, ⁶Nagasaki Medical Hospital of Rheumatology, Nagasaki, Japan, ⁷Department of Internal Medicine, Sasebo City General Hospital, Sasebo, Japan, ⁸Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
Background/Purpose: Lupus nephritis (LN) is a most important predictor of morbidity and mortality in patients with systemic lupus erythematosus (SLE).Histopathology samples from patients with LN…
Abstract Number: 2687 • 2018 ACR/ARHP Annual Meeting
Patient-Level Evaluation of Components of the American College of Rheumatology Combined Response Index in Systemic Sclerosis (CRISS) Using Patient-Reported Anchors
Vivek Nagaraja¹, John Powers², Celia J. F. Lin³, Benjamin Brennan⁴, Veronica J. Berrocal⁵ and Dinesh Khanna¹, ¹Division of Rheumatology, Department of Internal Medicine, University of Michigan Scleroderma Program, University of Michigan, Ann Arbor, MI, ²University of Maryland School of Medicine, Rockville, MD, ³Genentech, Inc., South San Francisco, CA, ⁴School of Public Health, University of Michigan, Ann Arbor, MI, ⁵Div of Rheumatology, University of Michigan, Ann Arbor, MI
Background/Purpose: Treatment benefit is demonstrated by evidence that interventions have positive impacts on how patients feel, function, and/or survive (FDA Guidance, 21CFR314.510). The ACR CRISS,…
Abstract Number: 2688 • 2018 ACR/ARHP Annual Meeting
Increased Serum Uric Acid Levels Are Associated with a Higher Risk of Digital Ulcers in Patients with Systemic Sclerosis
Han-Na Lee¹, Seung-Geun Lee¹, Eunsung Kim¹, JungHee Koh¹, Yun-Kyung Kim², Ho-Jae Kim² and Geun-Tae Kim³, ¹Division of Rheumatology, Department of Internal Medicine, Pusan National University School of Medicine, Pusan National University Hospital, Busan, Korea, Republic of (South), ²Division of Rheumatology, Department of Internal Medicine, Kosin University College of Medicine, Busan, Korea, Republic of (South), ³Kosin University College of Medicine, Busan, Korea, Republic of (South)
Background/Purpose: Endothelial cell dysfunction and/or injury are considered critical early events in the pathogenesis of vasculopathy in patients with systemic sclerosis (SSc). Hyperuricemia is known…
Abstract Number: 2689 • 2018 ACR/ARHP Annual Meeting
Association between Small Vessel Disease and Arterial Stiffness in Systemic Sclerosis
Stergios Soulaidopoulos¹, Eleni Pagkopoulou¹, Eva Triantafyllidou¹, Niki Katsiki², George D. Kitas^3,4, Asterios Karagiannis², Alexandros Garyfallos¹ and Theodoros Dimitroulas¹, ¹Fourth Department of Internal Medicine, Hippokration University Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece, ²Second Department of Propaedeutic Internal Medicine, Hippokration University Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece, ³Department of Rheumatology, Dudley Group of Hospitals, NS Foundation Trust, Dudley, United Kingdom, ⁴Arthritis Research UK Centre for Epidemiology, University of Manchester, Manchester, United Kingdom
Background/Purpose: Microangiopathy predominates in the pathophysiology of Systemic Sclerosis (SSc). However, large vessel involvement leading to higher risk for cardiovascular disease in SSc remains unclear.…
Abstract Number: 2690 • 2018 ACR/ARHP Annual Meeting
Potential Markers of Skin Involvement in Systemic Sclerosis
Radim Becvar¹, Hana Storkanova², Barbora Sumova¹, Maja Spiritovic¹, Sabina Oreska², Ladislav Šenolt¹ and Michal Tomcik², ¹Institute of Rheumatology, Prague, Czech Republic, Prague, Czech Republic, ²Department of Rheumatology, First Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic
Background/Purpose: Skin fibrosis is a hallmark of systemic sclerosis (SSc). There are no widely accepted biomarkers of skin involvement in this condition. Several serum or…
Abstract Number: 2691 • 2018 ACR/ARHP Annual Meeting
Increased Plasma Angiopoietin-2 in Systemic Sclerosis: Potential for Use As a Biomarker of Vasculopathy and Fibrosis
Victoria Flower^1,2, Shaney Barratt^3,4, Darren Hart⁵, Amanda MacKenzie², Jacqueline Shipley⁵, Stephen Ward² and John Pauling^1,2, ¹Department of Rheumatology, Royal National Hospital for Rheumatic Diseases, Royal United Hospitals NHS Foundation Trusts, Bath, United Kingdom, ²Centre for Therapeutic Innovations & Department of Pharmacy and Pharmacology, University of Bath, Bath, United Kingdom, ³Academic Respiratory Unit, School of Clinical Sciences, University of Bristol, Bristol, United Kingdom, ⁴North Bristol NHS Trust, Bristol, United Kingdom, ⁵Clinical Measurement Department, Royal National Hospital for Rheumatic Diseases, Royal United Hospitals NHS Foundation Trusts, Bath, United Kingdom
Background/Purpose: Angiogenic pathways are likely to contribute to pathogenesis of both vasculopathy and fibrosis in Systemic sclerosis (SSc). The angiogenic actions of Angiopoietins (pro-angiogenic Ang1…
Abstract Number: 2692 • 2018 ACR/ARHP Annual Meeting
High Frequency Ultrasound As a Novel Approach to Quantifying the Digital Microangiopathy of Systemic Sclerosis
Victoria Flower^1,2, Shaney Barratt^3,4, Darren Hart⁵, Amanda MacKenzie², Jacqueline Shipley⁵, Stephen Ward² and John Pauling^1,2, ¹Department of Rheumatology, Royal National Hospital for Rheumatic Diseases, Royal United Hospitals NHS Foundation Trusts, Bath, United Kingdom, ²Centre for Therapeutic Innovations & Department of Pharmacy and Pharmacology, University of Bath, Bath, United Kingdom, ³North Bristol NHS Trust, Bristol, United Kingdom, ⁴Academic Respiratory Unit, School of Clinical Sciences, University of Bristol, Bristol, United Kingdom, ⁵Clinical Measurement Department, Royal National Hospital for Rheumatic Diseases, Royal United Hospitals NHS Foundation Trusts, Bath, United Kingdom
Background/Purpose: Structural and functional vascular abnormalities occur in Systemic Sclerosis (SSc). We report on the use of High Frequency Ultrasound (HFUS) with Superb Microvascular Imaging…
Abstract Number: 2693 • 2018 ACR/ARHP Annual Meeting
What Is the Effect of Cyclophosphamide Iv Pulse Therapy in Patients with Diffuse Cutaneous Systemic Sclerosis on Skin Involvement: An Observational Study
Brigit Kersten, Nathan den Broeder, Frank van den Hoogen, Els van den Ende and Madelon Vonk, Rheumatology, Radboud University Medical Center, Nijmegen, Netherlands
Background/Purpose: Patients with systemic sclerosis who have proximal skin involvement are classified as diffuse cutaneous systemic sclerosis (DcSSc). Patients with progressive skin involvement have worse prognosis.…
Abstract Number: 2694 • 2018 ACR/ARHP Annual Meeting
Performance of Anti-Scl-70 Antibody Testing By Multiple-Bead, Enzyme-Linked Immunosorbent Assay, and Immunodiffusion in a University Setting
Kate Homer¹, Jeffery Warren², Dmitry Karayev³, Puja P. Khanna⁴, Amber Young⁵, Vivek Nagaraja⁵, Allan L. Metzger⁶ and Dinesh Khanna⁵, ¹Department of Internal Medicine, Rheumatology Division, Scleroderma Program, University of Michigan, Ann Arbor, MI, ²Department of Pathology, University of Michigan, Ann Arbor, MI, ³RDL Reference Laboratory, Santa Monica, CA, ⁴University of Michigan, Ann Arbor, MI, ⁵Division of Rheumatology, Department of Internal Medicine, University of Michigan Scleroderma Program, University of Michigan, Ann Arbor, MI, ⁶RDL Reference Laboratory, Los Angeles, CA
Background/Purpose: The gold standard for anti-Scl-70 antibody testing in systemic sclerosis (SSc) uses immunodiffusion (ID) techniques, but enzyme-linked immunosorbent assay (ELISA) and multi-bead technology are…
Abstract Number: 2695 • 2018 ACR/ARHP Annual Meeting
Progressive Skin Fibrosis, Internal Organ Involvement and All-Cause Mortality in an Early Diffuse Cutaneous Systemic Sclerosis United States Multicenter Registry
Kate Homer¹, Benjamin Brennan², Shervin Assassi³, Elana J. Bernstein⁴, Flavia V. Castelino⁵, Robyn T. Domsic⁶, Jessica K. Gordon⁷, Faye N. Hant⁸, Monique Hinchcliff⁹, Ami A. Shah¹⁰, Victoria Shanmugam¹¹, Virginia D. Steen¹², Veronica J. Berrocal¹³, Melanie Hemmrich¹⁴, Tracy M. Frech¹⁵ and Dinesh Khanna¹⁶, ¹Department of Internal Medicine, Rheumatology Division, Scleroderma Program, University of Michigan, Ann Arbor, MI, ²School of Public Health, University of Michigan, Ann Arbor, MI, ³University of Texas McGovern Medical School, Houston, TX, ⁴Rheumatology, Columbia University, New York, NY, ⁵Rheumatology, Harvard Medical School, Boston, MA, ⁶Medicine - Rheumatology, University of Pittsburgh, Pittsburgh, PA, ⁷Rheumatology, Hospital for Special Surgery, New York, NY, ⁸Medicine/Rheumatology & Immunology, Medical University of South Carolina, Charleston, SC, ⁹Rheumatology, Northwestern University, Chicago, IL, ¹⁰Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ¹¹Rheumatology, The George Washington University, Washington, DC, ¹²Rheumatology, MedStar Georgetown University Hospital, Washington, DC, ¹³Div of Rheumatology, University of Michigan, Ann Arbor, MI, ¹⁴Bayer AG, Wuppertal, Germany, ¹⁵Division of Rheumatology, University of Utah, Salt Lake City, UT, ¹⁶Division of Rheumatology, Department of Internal Medicine, University of Michigan Scleroderma Program, University of Michigan, Ann Arbor, MI
Background/Purpose: Early diffuse cutaneous systemic sclerosis (dcSSc) carries a high morbidity and mortality, predominantly due to internal organ involvement. The purpose of this study was…
Abstract Number: 2696 • 2018 ACR/ARHP Annual Meeting
Increased Mortality in Black and Asian Patients with Systemic Sclerosis in Northern California
Melody Chung¹, Makdine Dontsi², Debbie Postlethwaite², Sumana Kesh³, Lisa Zaba⁴ and Lorinda Chung^5,6, ¹Internal Medicine Residency, Kaiser Permanente Santa Clara, Santa Clara, CA, ²Division of Research, Kaiser Permanente Northern California, Oakland, CA, ³Department of Internal Medicine, Kaiser Permanente Santa Clara, Santa Clara, CA, ⁴Department of Dermatology, Kaiser Permanente Santa Clara, Santa Clara, CA, ⁵Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, ⁶VA Palo Alto Health Care System, Palo Alto, CA
Background/Purpose: Studies indicate that black patients with systemic sclerosis (SSc) demonstrate a distinct phenotypic profile, with more severe disease, heightened mortality, and poorer prognosis compared…

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