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  • Abstract Number: 1548 • ACR Convergence 2025

    Anifrolumab In Systemic Lupus Erythematosus. Spanish Multicenter Registry In Clinical Practice

    Vanesa Calvo-Río1, Carmen Secada-Gómez1, Miriam Retuerto Guerrero2, Judit Font-Urgelles3, Ivette Casafont-Solé3, Adrián Mayo-Juanatey4, Juan José Alegre-Sancho5, DALIFER FREITES6, Cristina Hormigos Martin7, Noemí Garrido8, GUILLERMO GONZALEZ ARRIBAS9, Juan Roberto Miguelez Sanchez10, Andrea García-Valle11, Marta Ibañez12, Fernando Lozano Morillo13, Ángel García Manzanares14, Sebastián Sandoval-Moreno15, Josefina Cortés-Hernández16, Deseada Palma-Sanchez17, LETICIA LOJO-OLIVEIRA18, Evelin Cervantes19, Paz Collado Ramos20, cristina arciniega Larios21, Luis Sala22, Eztizen Labrador-Sánchez23, Cilia Peralta-Ginés24, Nahia Plaza-Aulestia25, Irati Urionaguena Onaindia26, Miguel Medina Malone27, Jose Rosas Gómez de Salazar28, Montserrat Corteguera29, Laura Cebrian30, Fred Anton Pages31, Jose Ramón Lamua-Riazuelo32, María Dolores Fábregas Canales33, María José Alados Hernández34, Marta Garijo Bufort35, Anna Pamies36, Luis Sarabia37, Rodrigo Aguirre-del-Pino38, José Ángel Cabezas Lefler39, alvaro seijas38, Carmen Carrasco-Cubero40, Ana López-Cerón Cofiño41, Vera Ortiz-Santamaria42, Santos Castañeda43, Maria Laino44, Carmen Ordás Calvo45, Celia arconada46, ana Urruticoechea-Arana47, Blanca Garcia-Magallon48, Ana Valeria Acosta Alfaro49, Samuel Leal Rodriguez50, Marina Salido Olivares7, Patricia Lavilla Villar51, Anahy Maria Brandy3, Inmaculada Ros Vilamajo52, Alvaro García Martos53, Berta Magallares54, Guillen Sada Urmeneta55, Cristina Córdoba Martín56, Elena Riera Alonso57, Carmen Bejerano-Herreria58 and Ricardo Blanco,<58, 1Rheumatology Division, Hospital Universitario Marqués de Valdecilla, IDIVAL, Immunopathology Group, Santander, Spain, Santander, Cantabria, Spain, 2Complejo Asistencial Universitario de Leon, Leon, Castilla y Leon, Spain, 3Hospital Universitari Germans Trias i Pujol, Badalona, Spain, 4Hospital Universitario Doctor Peset, Valencia, Comunidad Valenciana, Spain, 5Hospital Universitario Doctor Peset, Valencia, Spain, 6Rheumatology Service, San Carlos Clinical Hospital, Madrid, Madrid, Spain, 7Hospital Clínico San Carlos, Madrid, Spain, 8Hospital Universitario Virgen del Rocío, Sevilla, Andalucia, Spain, 9Facultativo especialista, PALMA DE MALLORCA, Galicia, Spain, 10Department of Rheumatology, Hospital Universtiario de Móstoles, Madrid, Spain, Madrid, Madrid, Spain, 11Rheumatology. Hospital General Río Carrión, Palencia, Castilla y Leon, Spain, 12Hospital Universitario de la Santa Creu i Sant Pau, Barcelona, Catalonia, Spain, 13Hospital Central de La Defensa Gómez Ulla, Madrid, Madrid, Spain, 14Hospital Universitario de Torrevieja, Alicante, Spain, 15Hospital Universitario Vall D'Hebron, Barcelona, Spain, 16Hospital Universitari Vall d’Hebron-Universitat Autónoma de Barcelona, Barcelona, Spain, 17Rheumatology. Hospital Rafael Méndez, Lorca, Murcia, Spain, 18Hospital Universitario Infanta Leonor, Madrid, Spain, 19Hospital Provincial de Pontevedra, Pontevedra, Spain, 20Department of Rheumatology, Hospital Universitario Severo Ochoa, Madrid, Spain,, MADRID, Madrid, Spain, 21Hospital de Mérida, Badajoz, Spain, 22Hospital Universitario de Torrejón, Madrid, Spain, 23Hospital General de La Rioja, Logroño, Spain, 24Hospital Clínico Universitario Lozano Blesa, Zaragoza, Spain, 25Hospital Galdakao, Vizcaya, Spain, 26Rheumatology.Hospital Galdakao, Vizcaya, Pais Vasco, Spain, 27Hospital de Calahorra, Calahorra, Spain, 28Hospital Marina Baixa, PALMA DE MALLORCA, Spain, 29Rheumatology. Complejo Asistencial de Ávila, Ávila, Castilla y Leon, Spain, 30Department of Rheumatology, Hospital Universitario Infanta Leonor / Universidad Complutense de Madrid, Madrid, Spain, Madrid, Spain, 31Hospital General de Segovia, Segovia, Spain, 32Hospital Universitario del Henares, Madrid, Spain, 33Hospital de Barbastro, Huesca, Spain, 34Hospital Universitario Puerta del Mar, Cadiz, Spain, 35Hospital de Sagunto, Valencia, Spain, 36Hospital Verge de la Cinta, Tortosa, Tarragona, Spain, 37Complejo Hospitalario de Jaén, Jaén, Spain, 38Hospital Universitario Lucus Augusti, Lugo, Spain, 39Complejo Asistencial de Zamora, Zamora, Spain, 40Complejo Hospitalario Universitario de Badajoz, Badajoz, Spain, 41Hospital Santa Bárbara, Soria, Spain, 42Hospital General de Granollers, Barcelona, Spain, 43Hospital Universitario de La Princesa, IIS-Princesa, Madrid, Madrid, Spain, 44Hospital Universitario de Navarra, Pamplona, Spain, 45Hospital Universitario de Cabueñes, Gijón, Spain, 46Hospital universitario de Getafe, Getafe, Madrid, Spain, 47Rheumatology Division. Hospital Universitario Son Espases, Palma de Mallorca, Spain, 48Rheumatology, Hospital Universitario Puerta de Hierro, Madrid, Spain, 49Hospital Universitario Infanta Sofia; Universidad Europea de Madrid; FIIB HUIS-HUHEN, Madrid, Spain, 50Hospital Universitario La Fe, Valencia, Valencia, Spain, 51Hospital General de Villalba, Collado Villalba, Madrid, Spain, 52Hospital Son Llàtzer, Palma de Mallorca, Spain, 53Hospital del Tajo, Aranjuez, Madrid, Spain, 54Hospital de Sant Pau, Barcelona, Spain, 55Rheumatology, Hospital Reina Sofía, Tudela, Spain, 56Hospital Universitario Nuestra Señora de la Candelaria, Santa Cruz de Tenerife, Tenerife, Spain, 57Hospital Universitari Mùtua Terrassa, Terrassa, Spain, 58Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL, Immunopathology Group, Santander, Spain.

    Background/Purpose: Anifrolumab (ANI) is a human monoclonal antibody that binds to the type I interferon receptor subunit 1 (IFNAR1). ANI was approved by Spanish authorities…
  • Abstract Number: 1777 • ACR Convergence 2025

    Granzyme B as a regulator of interferon alpha production in cutaneous lupus erythematosus

    Touraj Khosravi1, Ahmed Eldaboush2, Darae Kang3 and Victoria Werth2, 1Department of Dermatology, Perelman Shool of Medicine, University of Pennsylvania, Philadelphia, PA, 2University of Pennsylvania, Philadelphia, PA, 3University of Pennsylvania, Potomac, MD

    Background/Purpose: Recent studies have shown that monocytes, macrophages, and conventional DCs, but not plasmacytoid dendritic cells (pDC), are major sources of IFNα in cutaneous lupus…
  • Abstract Number: 0009 • ACR Convergence 2025

    MRT-6160, a VAV1-Directed Molecular Glue Degrader, Attenuates T and B Cell Effector Functions and Inhibits Disease Progression in a Spontaneous MRL-Faslpr Mouse Model

    Adam Cartwright1, Lucas Gyger1, Foram Desai2, Shailee Vora2, Anna Kostikova1, Xudong Wang2, Peter Trenh2, Katie May2, Sophia Nguyen2, Chris King2, Daniel Lam2, Xavi Lucas1, Mary Zlotosch2, Elisa Liardo1, Daric Wible2, Ilaria Lamberto2, Bradley Demarco2, Debora Bonenfant1, Sharon Townson2, Eswar Krishnan2, Filip Janku2, John Castle1, Laura McAllister1, Alison Paterson2 and Marisa Peluso2, 1Monte Rosa Therapeutics, Basel, Switzerland, 2Monte Rosa Therapeutics, Boston, MA

    Background/Purpose: VAV1, an immune cell restricted guanine nucleotide exchange factor (GEF) and scaffolding protein, plays a critical role in mediating T- and B-cell receptor activity.…
  • Abstract Number: 0067 • ACR Convergence 2025

    Identification of Neutrophil Extracellular Traps in Explanted Human Lungs with Rheumatoid Arthritis-related Interstitial Lung Disease

    Amara Seng1, Kensuke Suga2, Diana Tran3, Anvita Singaraju4, Tanyalak Parimon5, Youn Jung Choi6, Justyna Fert-Bober7, Jon Giles8, Peter Chen5 and Nunzio Bottini9, 1Cedars-Sinai Medical Center, Los Angeles, CA, 2Kao Autoimmunity Institute, Cedars-Sinai Medical Center, Beverly Hills, CA, 3Cedars Sinai Medical Center, La Cañada Flintridge, CA, 4Kao Autoimmunity Institute, Cedars-Sinai Medical Center, Los Angeles, 5Women's Guild Lung Institute, Cedars-Sinai Medical Center, Los Angeles, CA, 6Kao Autoimmunity Institute, Cedars-Sinai Medical Center, Los Angeles, CA, 7Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, 8Cedars Sinai Medical Center, Los Angeles, CA, 9Cedars Sinai Medical Center, Beverly Hills, CA

    Background/Purpose: Symptomatic rheumatoid arthritis-related interstitial lung disease (RA-ILD) is prevalent in about 10% of patients with RA and confers a higher mortality compared with RA…
  • Abstract Number: 1944 • ACR Convergence 2025

    Musculoskeletal Ultrasound Clinic Referral Patterns and Joint Findings in a Tertiary Care Center amongst Patients with Elevated BMI and Inflammatory Arthritis

    Anna Lichtiger1, Ying Jin2, Caroline Rourke1, Kiera Brennan3, Hillary Weisleder4, Melissa Fazzari5 and Melissa Band6, 1Montefiore Medical Center, The Bronx, NY, 2Albert Einstein College of Medicine, Bronx, NY, 3Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY, 4Montefiore Einstein, New York, NY, 5Department of Epidemiology & Population Health, Albert Einstein College of Medicine,, Bronx, NY, 6Montefiore Medical Center, New York, NY

    Background/Purpose: Musculoskeletal ultrasound (MSUS) has been well known to aid in both early diagnosis and monitoring of inflammatory arthritis. Patients with an elevated BMI have…
  • Abstract Number: 1789 • ACR Convergence 2025

    Spatial Analysis of Advanced Osteoarthritis Synovial Tissue

    jacob Dickman1, Stephanie Ruzicka1, Holub Meaghan2, Jutras Brandon3, Adam Edelstein3 and Robert Lochhead4, 1Medical College of Wisconsin, Milwaukee, WI, 2Central Michigan University College of Medicine, Mount Pleasant, MI, 3Northwestern University, Chicago, IL, 4Medical College of Wisconsin, GERMANTOWN, WI

    Background/Purpose: Osteoarthritis (OA) is a joint pathology involving joint cartilage destruction and synovial inflammation. Severe knee OA is often surgically treated with total knee arthroplasty…
  • Abstract Number: 1555 • ACR Convergence 2025

    Prevalence of Organ Involvement and Baseline Predictors of Disease Progression in Patients with Limited Cutaneous Systemic Sclerosis: Insights from the CONQUER Database

    Alain Lescoat1, Virginia Steen2, Monica Harding3, John VanBuren3, Brian Skaug4, Shervin Assassi5, Maureen Mayes6, Zsuzsanna McMahan7, Elana Bernstein8, Flavia Castelino9, Lorinda Chung10, Luke Evnin11, Tracy Frech12, Jessica Gordon13, Faye Hant14, Laura Hummers15, Kimberly Lakin13, Dorota Lebiedz-Odrobina3, Yiming Luo16, Ashima Makol17, Jerry Molitor18, Duncan Moore19, Carrie Richardson19, Nora Sandorfi20, Ami Shah15, Ankoor Shah21, Elizabeth Volkmann22, Carleigh Zahn23 and Dinesh Khanna24, 1CHU Rennes - University Rennes, Rennes, France, 2Georgetown University School of Medicine, Washington, DC, 3University of Utah, Salt Lake City, UT, 4UTHealth Houston Division of Rheumatology, Houston, TX, 5Division of Rheumatology, UTHealth Houston, Houston, Texas, USA, Houston, TX, 6UT Health Houston Division of Rheumatology, Houston, TX, 7UT Health Houston, Houston, TX, 8Columbia University Irving Medical Center, New York, NY, 9Massachusetts General Hospital, Boston, MA, 10Stanford University, Stanford, CA, 11Scleroderma Research Foundation, San Francisco, CA, 12Vanderbilt University Medical Center, Nashville, TN, 13Hospital for Special Surgery, New York, NY, 14Medical University of South Carolina, Charleston, SC, 15Johns Hopkins Rheumatology, Baltimore, MD, 16Columbia University Irving Medical Center, New York, 17Mayo Clinic, Rochester, MN, 18University of Minnesota, Minneapolis, MN, 19Northwestern University, Chicago, 20University of Pennsylvania, Philadelphia, PA, USA, Philadelphia, 21Duke University, Durham, NC, 22Division of Rheumatology, Department of Medicine, University of California, David Geffen School of Medicine, Los Angeles, CA, USA, Los Angeles, CA, 23University of Michigan, Ann Arbor, 24University of Michigan, Ann Arbor, MI

    Background/Purpose: Systemic sclerosis (SSc) is characterized by a wide range of clinical manifestations and available interventions still lack overall efficacy. Limited cutaneous SSc (lcSSc) and…
  • Abstract Number: 1069 • ACR Convergence 2025

    Strengthening Rheumatology Workforce Capacity and Impact on Patient Care in Louisiana: Expanding Fellowship Training Opportunities Through Strategic Partnerships

    Luke Sharrock1, Alexandra Anderson2, Stephen Lindsey3 and Milena Vukelic4, 1Louisiana State University Health Science Center New Orleans, New Orleans, LA, 2Louisiana State University Health Science Center New Orleans, Phoenix, AZ, 3LSU Health Sciences Center-New Orleans, Baton Rouge, LA, 4Rheumatology Fellowship Program Director Louisiana State University, New Orleans, LA

    Background/Purpose: Louisiana, along with other states, has long experienced significant challenges in accessing specialty care, particularly in the field of rheumatology. Limited availability of trained…
  • Abstract Number: 2279 • ACR Convergence 2025

    Long-Term Prevention of RA in high-risk individuals after a 6-Month Placebo-Controlled Intervention with Abatacept -The ARIAA Trial

    Koray Tascilar1, Mikkel Ostergaard2, Verena Schoenau3, Uta Kiltz4, Xenofon Baraliakos4, David Kofler5, Martin Feuchtenberger6, Ulrike Steffen7, Mario Zaiss8, Michael Zaenker9, Reinhard Voll10, Cornelia. Glaser11, Holger Bang12, Eugen feist13, Gerd Burmester14, Kirsten Karberg15, Joachim Strunk16, Juan Cañete17, Esperanza Naredo18, Mária Filková19, Ladislav Šenolt19, Georg Schett20 and Juergen Rech7, 1Department of Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander-Universität Erlangen-Nürnberg and University Hospital Erlangen, Erlangen, Germany, 2Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark, and Copenhagen Center for Arthritis Research, Center for Rheumatology, Rigshospitalet, Glostrup, Denmark, 3- Department of Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander-Universität Erlangen-Nürnberg and Uniklinikum Erlangen, Erlangen, Germany., Erlangen, Germany, 4Rheumazentrum Ruhrgebiet Herne, Ruhr-University Bochum, Herne, Germany, 5University of Cologne, Cologne, Germany, 6MED | BAYERN OST GmbH, Fachbereich Rheumatologie, Burghausen, Germany, Burghausen, Bayern, Germany, 7Friedrich-Alexander University (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen, Department of Internal Medicine 3 - Rheumatology and Immunology, Erlangen, Germany, Erlangen, Bayern, Germany, 81Friedrich-Alexander University (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen, Department of Internal Medicine 3 - Rheumatology and Immunology, Erlangen, Germany, Erlangen, Bayern, Germany, 9Immanuel Klinikum Bernau , Herzzentrum Brandenburg, Abteilung Innere Medizin, Bernau, Germany, Berlin, Germany, 10University Medical Center Freiburg, Freiburg, Germany, 11Department of Rheumatology and Clinical Immunology, Medical Center – University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany, Freiburg, Baden-Wurttemberg, Germany, 12Orgentec, Mainz, Germany, 13Helios Department of Rheumatology, Vogelsang-Gommern, Germany, 14Department of Rheumatology and Clinical Immunology, Charité – Universitätsmedizin Berlin, Berlin, Germany, 15Praxis für Rheumatologie und Innere Medizin, Rheumatologie, Berlin, Germany, Berlin, Germany, 16Krankenhaus Porz am Rhein GmbH, Rheumaklinik, Köln (Porz), Germany, Köln-Porz, Germany, 17Rheumatology Department, Hospital Clínic and IDIBAPS, Barcelona, Spain, Barcelona, Spain, 18Department of Rheumatology and Joint and Bone Research Unit. Fundación Jiménez Díaz University Hospital and Health Research Institute FJD-UAM, Madrid, Spain, MADRID, Spain, 19Institute of Rheumatology and Department of Rheumatology, First Faculty of Medicine, Charles University, Prague, Czech Republic, 20Uniklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany, Erlangen, Germany

    Background/Purpose: A 6-month intervention with abatacept in the ARIAA trial (EUDRA-CT 2014–000555–93) significantly retarded the development of RA compared to placebo in ACPA-positive individuals with…
  • Abstract Number: 1797 • ACR Convergence 2025

    SEV-101 Exosomes Isolated from Induced Pluripotent Stem Cell – Derived Hyaline Cartilage Tissue – Characterization of Immunomodulatory and Chondro-proliferative Effects In Vitro

    Parthasarathy Rangarajan1, Beth Lindborg2, Amanda Vegoe3, Yi Wen Chai4, Anna Tran1, Magie Steinhoff1, Bernhard Hering1, Timothy O'Brien5 and Sabarinathan Ramachandran6, 1Schulze Diabetes Institute, Department of Surgery, University of Minnesota, Minneapolis, 2Sarcio, Inc., St. Paul, 3Department of Veterinary Population Medicine and Stem Cell Institute, University of Minnesota, Sarcio, Inc, St. Paul, 4Stem Cell Institute, University of Minnesota, Minneapolis, 5Department of Veterinary Population Medicine and Stem Cell Institute, University of Minnesota, Sarcio, Inc, Minneapolis, 6Schulze Diabetes Institute, Department of Surgery, University of Minnesota, Minneapolis, MN

    Background/Purpose: SEV-101 are exosomes that are isolated from cultures of Induced Pluripotent Stem Cell (iPSC)-derived hyaline cartilage tissue. Gene expression profiles of the tissue are…
  • Abstract Number: 1800 • ACR Convergence 2025

    The Role of Nociceptor-Expressed Piezo2 in Nervous System Immune Cell Infiltration in a Mouse Model of Osteoarthritis

    Natalie Adamczyk1, Terese Geraghty2, Shingo Ishihara3, alia obeidat2, Jun Li2, Anne-Marie Malfait2 and Rachel Miller1, 1Rush University Medical Center, Chicago, IL, 2Rush University Medical Center, Chicago, 3Rush University, Chicago

    Background/Purpose: Osteoarthritis is one of the leading causes of chronic pain and disability worldwide with 500 million people affected. We have previously reported that nociceptor-conditional…
  • Abstract Number: 1767 • ACR Convergence 2025

    Identification of C3 complement fragments in lesional tissues in ANCA-associated vasculitis

    Claire Galand1, Fei Liu2, Katherine Vernon2, Ravi Vats2, Christine Lian3, V. Michael Holers4, H. Terence Cook5, David Cuthbertson6, Nader Khalidi7, Curry Koening8, Carol Langford9, Carol McAlear10, Paul Monach11, Christian Pagnoux12, Jason Campagna2, Shelia Violette2 and Peter Merkel10, 1Q32 Bio Inc,, Waltham, MA, 2Q32 Bio Inc, Waltham, MA, 3Department of Pathology, Brigham & Women’s Hospital/Harvard Medical School, Boston, MA, 4University of Colorado Anschutz Medical Campus, Aurora, 5Department of Immunology and Inflammation, Imperial College London, London, United Kingdom, 6University of South Florida, Tampa, 7McMaster University, Hamilton, ON, Canada, 8University of Texas Dell Medical School, Austin, TX, 9Cleveland Clinic, Moreland Hills, OH, 10University of Pennsylvania, Philadelphia, PA, 11VA Boston Healthcare System, Boston, MA, 12Mount Sinai Hospital, Toronto, ON, Canada

    Background/Purpose: One proposed mechanism of tissue damage in ANCA-associated vasculitis (AAV) is the formation of neutrophil extracellular traps (NETs) during extravasation of neutrophils into and…
  • Abstract Number: 1071 • ACR Convergence 2025

    Depression and Mental Health Service Gaps in Autoimmune Disease: Insights from a Simulated BRFSS Dataset

    Malay Rathod1, Shivani Modi2, Veera Durga Vaishnavi Kurra3, Karan Yagnik4 and Doantrnag Du4, 1Monmouth Medical Center, Ewing, NJ, 2Jefferson Einstein Montgomery Hospital, Ewign, NJ, 3University of Oklahoma Health Sciences Center, Oklahoma City, OK, 4Monmouth Medical Center, Long Branch, NJ

    Background/Purpose: Autoimmune diseases are complex conditions that may predispose individuals to an increased mental health burden, including depression. The immune system leads to inflammation in…
  • Abstract Number: 0058 • ACR Convergence 2025

    Training for increased inflammatory arthritis in mice is not modulated by type 1 interferon

    Richard Bell1, Mary Huang1, Claire Weigert2, Ruoxi Yuan2, Toolika Singh2, Seda Seren2 and Lionel Ivashkiv1, 1Hospital for Special Surgery, New York, NY, 2Hospital for Special Surgery, New York

    Background/Purpose: Disease flares, or episodic escalating inflammation, is a hallmark of autoimmune diseases, like Rheumatoid Arthritis (RA). They are particularly hard to predict and treat…
  • Abstract Number: 1945 • ACR Convergence 2025

    Significance of Finger Joint Tenderness With or Without Swelling in Relation to MRI, Ultrasound, and X-Ray Findings in Psoriatic Arthritis_Final results

    Victoria Furer1, iris Eshed2, Moshe Iluz1, Ori Elkayam3 and Ari Polachek4, 1Tel-Aviv Medical Center, Tel-Aviv, Israel, 2Department of Diagnostic Imaging, Sheba Medical Center, Tel Hashomer affiliated with School of Medicine, Tel Aviv University, Tel Aviv, Israel, 3Tel Aviv medical center, Tel Aviv, Israel, 4Rheumatology Institute of Beilinson Hospital, Petah Tikva, Israel

    Background/Purpose: Musculoskeletal involvement in psoriatic arthritis (PsA) affects both articular and extra-articular structures, presenting as inflammatory and structural lesions. The relationship between tender and/or swollen…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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