Abstract Number: 1548 • ACR Convergence 2025
Anifrolumab In Systemic Lupus Erythematosus. Spanish Multicenter Registry In Clinical Practice
Background/Purpose: Anifrolumab (ANI) is a human monoclonal antibody that binds to the type I interferon receptor subunit 1 (IFNAR1). ANI was approved by Spanish authorities…Abstract Number: 1777 • ACR Convergence 2025
Granzyme B as a regulator of interferon alpha production in cutaneous lupus erythematosus
Background/Purpose: Recent studies have shown that monocytes, macrophages, and conventional DCs, but not plasmacytoid dendritic cells (pDC), are major sources of IFNα in cutaneous lupus…Abstract Number: 0009 • ACR Convergence 2025
MRT-6160, a VAV1-Directed Molecular Glue Degrader, Attenuates T and B Cell Effector Functions and Inhibits Disease Progression in a Spontaneous MRL-Faslpr Mouse Model
Background/Purpose: VAV1, an immune cell restricted guanine nucleotide exchange factor (GEF) and scaffolding protein, plays a critical role in mediating T- and B-cell receptor activity.…Abstract Number: 0067 • ACR Convergence 2025
Identification of Neutrophil Extracellular Traps in Explanted Human Lungs with Rheumatoid Arthritis-related Interstitial Lung Disease
Background/Purpose: Symptomatic rheumatoid arthritis-related interstitial lung disease (RA-ILD) is prevalent in about 10% of patients with RA and confers a higher mortality compared with RA…Abstract Number: 1944 • ACR Convergence 2025
Musculoskeletal Ultrasound Clinic Referral Patterns and Joint Findings in a Tertiary Care Center amongst Patients with Elevated BMI and Inflammatory Arthritis
Background/Purpose: Musculoskeletal ultrasound (MSUS) has been well known to aid in both early diagnosis and monitoring of inflammatory arthritis. Patients with an elevated BMI have…Abstract Number: 1789 • ACR Convergence 2025
Spatial Analysis of Advanced Osteoarthritis Synovial Tissue
Background/Purpose: Osteoarthritis (OA) is a joint pathology involving joint cartilage destruction and synovial inflammation. Severe knee OA is often surgically treated with total knee arthroplasty…Abstract Number: 1555 • ACR Convergence 2025
Prevalence of Organ Involvement and Baseline Predictors of Disease Progression in Patients with Limited Cutaneous Systemic Sclerosis: Insights from the CONQUER Database
Background/Purpose: Systemic sclerosis (SSc) is characterized by a wide range of clinical manifestations and available interventions still lack overall efficacy. Limited cutaneous SSc (lcSSc) and…Abstract Number: 1069 • ACR Convergence 2025
Strengthening Rheumatology Workforce Capacity and Impact on Patient Care in Louisiana: Expanding Fellowship Training Opportunities Through Strategic Partnerships
Background/Purpose: Louisiana, along with other states, has long experienced significant challenges in accessing specialty care, particularly in the field of rheumatology. Limited availability of trained…Abstract Number: 2279 • ACR Convergence 2025
Long-Term Prevention of RA in high-risk individuals after a 6-Month Placebo-Controlled Intervention with Abatacept -The ARIAA Trial
Background/Purpose: A 6-month intervention with abatacept in the ARIAA trial (EUDRA-CT 2014–000555–93) significantly retarded the development of RA compared to placebo in ACPA-positive individuals with…Abstract Number: 1797 • ACR Convergence 2025
SEV-101 Exosomes Isolated from Induced Pluripotent Stem Cell – Derived Hyaline Cartilage Tissue – Characterization of Immunomodulatory and Chondro-proliferative Effects In Vitro
Background/Purpose: SEV-101 are exosomes that are isolated from cultures of Induced Pluripotent Stem Cell (iPSC)-derived hyaline cartilage tissue. Gene expression profiles of the tissue are…Abstract Number: 1800 • ACR Convergence 2025
The Role of Nociceptor-Expressed Piezo2 in Nervous System Immune Cell Infiltration in a Mouse Model of Osteoarthritis
Background/Purpose: Osteoarthritis is one of the leading causes of chronic pain and disability worldwide with 500 million people affected. We have previously reported that nociceptor-conditional…Abstract Number: 1767 • ACR Convergence 2025
Identification of C3 complement fragments in lesional tissues in ANCA-associated vasculitis
Background/Purpose: One proposed mechanism of tissue damage in ANCA-associated vasculitis (AAV) is the formation of neutrophil extracellular traps (NETs) during extravasation of neutrophils into and…Abstract Number: 1071 • ACR Convergence 2025
Depression and Mental Health Service Gaps in Autoimmune Disease: Insights from a Simulated BRFSS Dataset
Background/Purpose: Autoimmune diseases are complex conditions that may predispose individuals to an increased mental health burden, including depression. The immune system leads to inflammation in…Abstract Number: 0058 • ACR Convergence 2025
Training for increased inflammatory arthritis in mice is not modulated by type 1 interferon
Background/Purpose: Disease flares, or episodic escalating inflammation, is a hallmark of autoimmune diseases, like Rheumatoid Arthritis (RA). They are particularly hard to predict and treat…Abstract Number: 1945 • ACR Convergence 2025
Significance of Finger Joint Tenderness With or Without Swelling in Relation to MRI, Ultrasound, and X-Ray Findings in Psoriatic Arthritis_Final results
Background/Purpose: Musculoskeletal involvement in psoriatic arthritis (PsA) affects both articular and extra-articular structures, presenting as inflammatory and structural lesions. The relationship between tender and/or swollen…
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