Abstracts Archive - Page 1354 of 2425 - ACR Meeting Abstracts

Abstract Number: 2227 • 2017 ACR/ARHP Annual Meeting
S100A9 Induces a Pain Response during Experimentally Induced Acute Synovitis
Arjen B. Blom¹, Edwin J. W. Geven¹, Martijn H. van den Bosch¹, Esmeralda N. Blaney Davidson¹, Peter M. van der Kraan¹ and Peter L. van Lent², ¹Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ²Radboud University Nijmegen Medical Center, Rheumatology, Nijmegen, Netherlands
Background/Purpose: Synovitis-associated pain is an important aspect of arthritis pathology. Several inflammatory mediators released by the synovium have been implicated in the regulation of pain,…
Abstract Number: 2228 • 2017 ACR/ARHP Annual Meeting
Involvement of Receptor Tyrosine Kinase a Signaling in Rhumatoid Arthritis Using Trka/C Knock-in Mice: A Multimodal Approach
Lauriane Delay¹, Julie Barbier¹, Ludivine Boudieu¹, Denis Ardid¹, Arnaud Briat², Philippe Auzeloux², Elisabeth Moit-Noirault², Aziz Moqrich³ and Fabien Marchand¹, ¹Inserm U1107 NeuroDol, Université Clermont Auvergne, Clermont-Ferrand, France, ²4UMR 1240 Imagerie Moléculaire et Stratégies Théranostiques (IMoST), Université Clermont Auvergne, Clermont-Ferrand, France, ³UMR 6216 CNRS-Université de la Méditerranée, Institut de Biologie du Développement de Marseille Luminy, Marseille, France
Background/Purpose: Rheumatoid Arthritis (RA) is an autoimmune disease very commonly associated with chronic pain which is often resistant to currents analgesics. Targeting Nerve Growth Factor…
Abstract Number: 2229 • 2017 ACR/ARHP Annual Meeting
The Effect of Intra-Articular Neurotoxin on Arthritis Pain and Substance P Expression in the Dorsal Root Ganglion: Results from Murine Arthritis Models
Hollis Krug^1,2, Sandra Frizelle³, Nicole Blanshan⁴, Christopher W. Dorman³ and Maren Mahowald^2,5, ¹Medicine, Minneapolis VAHCS, Minneapolis, MN, ²Medicine, University of Minnesota Medical School, Minneapolis, MN, ³Research, Minneapolis VA Health Care System, Minneapolis, MN, ⁴Research, Minneapolis VAHCS, Minneapolis, MN, ⁵Rheumatology/ Dept of Medicine, Minneapolis VA and Univ MN Med School, SAINT PAUL, MN
Background/Purpose : Substance P (SP) release and binding to NK-1 produces pain transmission. Neurotoxins (NT) that prevent release of SP, such as onabotulinum toxin (BoNT/A),…
Abstract Number: 2230 • 2017 ACR/ARHP Annual Meeting
Use of Prescription Opioids Among Patients with Systemic Inflammatory Diseases (SID) Versus Patients with Hypertension but No Sid
Sarah Chen¹, Candace H. Feldman², Gregory Brill³, Yvonne C. Lee⁴, Rishi J. Desai⁵ and Seoyoung C. Kim⁶, ¹Brigham and Women's Hospital, Boston, MA, ²Rheumatology, Brigham & Women's Hospital, Boston, MA, ³Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women’s Hospital/Harvard Medical School, Boston, MA, ⁴Rheumatology Immunology & Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ⁵Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women’s Hospital, Boston, MA, ⁶Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA
Background/Purpose: Opioid prescribing in the U.S. has increased at an alarming rate amid uncertainty over effectiveness and rising concerns over safety of this practice. Patients…
Abstract Number: 2231 • 2017 ACR/ARHP Annual Meeting
MCC22, a Novel Compound That Targets Both CCR5 and Mu Opioid Receptors, Is Highly Effective in Treating Inflammatory Arthritis Pain
Raini Dutta¹, Mary Lunzer², Jennifer L. Auger³, Eyup Akgün², Philip Porthoghese² and Bryce A. Binstadt³, ¹Pediatrics, University of Minnesota, Minneapolis, MN, ²Department of Medicinal Chemistry, University of Minnesota, Minneapolis, MN, ³Center for Immunology and Department of Pediatrics, University of Minnesota, Minneapolis, MN
Background/Purpose: The pain that accompanies rheumatoid arthritis and other chronic inflammatory conditions is difficult to manage. Although opioids provide potent analgesia, chronic opioid use is…
Abstract Number: 2232 • 2017 ACR/ARHP Annual Meeting
A Role for CCR2 in Chronic Behavioral and Neuroimmune Changes in the DMM Model of Osteoarthritis
Phuong Tran¹, Shingo Ishihara², Rachel E. Miller³, Richard J. Miller⁴ and Anne-Marie Malfait¹, ¹Rheumatology, Rush University Medical Center, Chicago, IL, ²Internal Medicine, Rush University Medical Center, Chicago, IL, ³Biochemistry, Rush University Medical Center, Chicago, IL, ⁴Pharmacology/Medical Humanities and Bioethics, Northwestern University, Chicago, IL
Background/Purpose: The aim of this study was to explore pain-related behaviors and associated cellular changes in the pain pathway in experimental osteoarthritis (OA) induced by…
Abstract Number: 2233 • 2017 ACR/ARHP Annual Meeting
The Role of Life Purpose in Disability and Depression in Patients with Acute Low Back Pain
Elizabeth Salt¹, Leslie Crofford², Mary Kay Rayens³ and Suzanne Segerstrom⁴, ¹University of Kentucky, Lexington, KY, ²Vanderbilt University, Nashville, KY, ³College of Nursing, University of Kentucky, Lexington, KY, ⁴Psychology, University of Kentucky, Lexington, KY
The Role of Life Purpose in Disability and Depression in Patients with Acute Low Back PainBackground/Purpose: Life purpose (also termed purpose in life or meaning…
Abstract Number: 2234 • 2017 ACR/ARHP Annual Meeting
Disability in Acute Low Back Pain: The Role of Pain Severity, Pain Catastrophizing, Depression, and Exercise
Elizabeth Salt¹, Leslie J. Crofford², Mary Kay Rayens³ and Suzanne Segerstrom⁴, ¹University of Kentucky, Lexington, KY, ²Medicine, Vanderbilt University Medical Center, Nasville, TN, ³College of Nursing, University of Kentucky, Lexington, KY, ⁴Psychology, University of Kentucky, Lexington, KY
Disability in Acute Low Back Pain: The Role of Pain Severity, Pain Catastrophizing, Depression, and ExerciseBackground/Purpose: The effectiveness of cognitive treatments for low back pain,…
Abstract Number: 2235 • 2017 ACR/ARHP Annual Meeting
Factors Associated with Opioid Use in End-Stage Knee, Hip and Spine Osteoarthritis
J. Denise Power¹, Anthony V. Perruccio¹, Rajiv Gandhi¹, Christian Veillette¹, J. Roderick Davey¹, Stephen J. Lewis¹, Khalid Syed¹, Nizar Mahomed¹ and Y. Raja Rampersaud², ¹Arthritis Program, Krembil Research Institute, University Health Network, Toronto, ON, Canada, ²Arthritis Program, Krembil Research Institute, University Health Network, Torotno, ON, Canada
Background/Purpose: The use of prescription opioids has been under increasing scrutiny due to concerns about the potential for misuse, dependency and increased adverse events. The…
Abstract Number: 2236 • 2017 ACR/ARHP Annual Meeting
Neuropathic Pain in End-Stage Hip and Knee Osteoarthritis: Differences between Men and Women and Differential Associations with Pain at Rest and Pain on Activity
J. Denise Power¹, Anthony V. Perruccio¹, Rajiv Gandhi¹, Christian Veillette¹, J. Roderick Davey¹, Khalid Syed¹, Nizar Mahomed¹ and Y. Raja Rampersaud², ¹Arthritis Program, Krembil Research Institute, University Health Network, Toronto, ON, Canada, ²Arthritis Program, Krembil Research Institute, University Health Network, Torotno, ON, Canada
Background/Purpose: There is increasing support in the literature for a neuropathic component to OA pain. Our primary objective was to determine whether pain at rest…
Abstract Number: 2237 • 2017 ACR/ARHP Annual Meeting
Work Productivity and Activity Impairment in Primary Sjögren’s Syndrome
Marisel Bejarano¹, Anastasia Secco¹, Antonio Catalan Pellet², Marta Mamani³, Silvia Papasidero⁴, Julia Demarchi⁵, Cecilia Asnal⁶, Catherine Crow⁷, Alejandro Nitsche⁸, Laura Encinas⁹, Francisco Caeiro¹⁰, Carla Gobbi¹¹, Eduardo Albiero¹², Andrea Gomez¹³, Juan Carlos Barreira¹⁴, Rodrigo Aguila Maldonado¹⁵, Mercedes Garcia¹⁶, Maria Gallardo¹⁷, Enrique R Soriano¹⁸, Laura Raiti¹⁹, Gabriela Salvatierra²⁰ and Alicia Eimon²¹, ¹Hospital Bernardino Rivadavia, CABA, Argentina, ²Rheumatology, Hospital Bernardino Rivadavia, Buenos Aires, Argentina, ³Rheumatology Department, Hospital Bernardino Rivadavia, Buenos Aires, Argentina, ⁴Section of Rheumatology, Hospital General de Agudos “Dr. E. Tornú”, Buenos Aires, Argentina, Buenos Aires, Argentina, ⁵Hospital General de Agudos “Dr. E. Tornú”, CABA, Argentina, ⁶Rheumatology, Hospital Alemán, Buenos Aires, Argentina, ⁷[email protected], Hospital Alemán, Buenos Aires, Argentina, ⁸Hospital Alemán, CABA, Argentina, ⁹Hospital Privado Centro Médico de Córdoba, Córdoba, Argentina, ¹⁰Rheumatology, Hospital Privado Centro Médico de Córdoba, Córdoba, Argentina, ¹¹Rheumatology, Hospital Córdoba, Cordoba, Argentina, ¹²Universidad Nacional de Cordoba, Rheumatology Unit Cordoba Hospital, Córdoba, Argentina, ¹³Hospital Britanico de Buenos Aires, CABA, Argentina, ¹⁴Rheumatology Unit, Hospital Británico de Buenos Aires, CABA, Argentina, ¹⁵Rheumatology, HIGA General San Martin La Plata, La Plata, Argentina, ¹⁶Hospital San Martín de la Plata, La Plata, Argentina, ¹⁷Hospital Italiano de Buenos Aires, CABA, Argentina, ¹⁸Argentina, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, ¹⁹Rheumatology Department, Clinica Bessone, Buenos Aires, Argentina, ²⁰IPRI, Santiago del Estero, Argentina, ²¹CEMIC, Buenos Aires, Argentina
Background/Purpose: To describe the work productivity and activity impairment in adult patients diagnosed with primary Sjögren´s Syndrome (pSS). To evaluate the association between activity impairment…
Abstract Number: 2238 • 2017 ACR/ARHP Annual Meeting
Mapping Paindetect, a Neuropathic Pain Screening Tool, to Patient-Reported Outcomes Measurement Information System (PROMIS) 29 in Patients with Rheumatoid Arthritis: Developing a Neuropathic Pain Scale As a Measure of Treatment Outcome
Yong Gil Hwang¹, Lei Zhu², Ajay Wasan³ and Larry W. Moreland¹, ¹Rheumatology & Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ²University of Pittsburgh, Pittsburgh, PA, ³Departments of Anesthesiology and Psychiatry, University of Pittsburgh, Pittsburgh, PA
Background/Purpose: To investigate relationships between painDETECT (PDQ), neuropathic pain screening tool, and patient-reported outcomes measurement information system (PROMIS) 29 in patients with rheumatoid arthritis…
Abstract Number: 2239 • 2017 ACR/ARHP Annual Meeting
The Recall Program: Data from a Multicenter Educational Event on Patients with Rheumatoid Arthritis
Andrea Delle Sedie¹, Emilio Filippucci², Oscar Epis³, Pierluigi Macchioni⁴, Sebastiano Tropea⁵, Carlo Bonali⁶, Marco Canzoni⁷ and Annamaria Iagnocco⁸, ¹Department Rheumatology, University of Pisa, Pisa, Italy, ²Rheumatology Unit, Università Politecnica delle Marche, Jesi, Italy, ³Rheumatology Unit, Ospedale Niguarda, Milano, Italy, ⁴Arcispedale Santa Maria Nuova, Reggio Emilia, Italy, ⁵ASP7, Busacca Hospital, Ragusa, Italy, ⁶Rheumatology Unit,, Ospedale San Paolo, Bari, Italy, ⁷Local Health Unit (ASL) Rome 1, Rome, Italy, ⁸Academic Rheumatology Unit, Università degli Studi di Torino, Torino, Italy
Background/Purpose: ultrasound (US) is able to show subclinical synovitis in patients (pts) with rheumatoid arthritis (RA) who are in clinical remission (CR); this has been…
Abstract Number: 2240 • 2017 ACR/ARHP Annual Meeting
Partnering in Research: Maximizing Benefits & Minimizing Risks in Patient-Researcher Relationships
Jenny Leese¹, Graham Macdonald², Bao Chau Tran¹, Lianne Gulka³, Alison Hoens³, Sheila Kerr³, Wendy Lum³ and Linda Li⁴, ¹Physical Therapy, University of British Columbia, Vancouver, BC, Canada, ²Occupational Science and Occupational Therapy, University of British Columbia, Vancouver, BC, Canada, ³Arthritis Research Canada, Richmond, BC, Canada, ⁴Rheumatology, Arthritis Research Canada, Richmond, BC, Canada
Background/Purpose: Patient engagement in research has become a key requirement of many research funding organizations in Western countries. The principle of justice is central to…
Abstract Number: 2241 • 2017 ACR/ARHP Annual Meeting
Patterns and Outcomes on Disease Activity in Patients with Ankylosing Spondylitis (AS) Using Smart System of Disease Management (SSDM): Analysis of T2T Pattern Shift and Influential Factors
Jing Xue¹, Wenqiang Fan², Hua Wei³, Jing Yang⁴, Hui Song⁵, Hongbin Li⁶, Hongzhi Wang⁷, Xinwang Duan⁸, Zhenchun Zhang⁹, Jianlin Huang¹⁰, Yasong Li¹¹, Jian Ding¹², Xiaofei Shi¹³, Miaojia Zhang¹⁴, Zhenbiao Wu¹⁵, Cundong Mi¹⁶, Fei Xiao¹⁷, Hui Xiao¹⁷, Yuhua Jia¹⁷, Rui Bai¹⁷, Yan Bu¹⁷ and Huaxiang Wu¹⁸, ¹88 Jiefang Road, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China, ²Department of rheumatology, Central Hospital of XinXiang, Henan, XinXiang, China, ³No 98,Nantong West Rd,Yangzhou, Northern Jiangsu People's Hospital, Yangzhou, China, ⁴Department of rheumatology, Central Hospital of MianYang, Sichuan, Mian Yang, China, ⁵Beijing Jishuitan Hospital, Beijing, China, ⁶The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China, ⁷The First Hospital of Jiaxing, Jiaxing, China, ⁸Department of rheumatology, The Second Affiliated Hospital of Nanchang University, Nanchang, China, ⁹People's Hospital of Linyi, Shandong, Linyi, China, ¹⁰Department of rheumatology, The Sixth Hospital Affiliated to Sun yat-sen University, Guangzhou, China, ¹¹Zhejiang Provincal People's Hospital, Hangzhou, China, ¹²Ningbo City Medical Treatment Center Lihuili Hospital, Ningbo, China, ¹³The First Affiliated Hospital of Henan University of Science and Technology, Luoyang, China, ¹⁴Department of Rheumatology and Immunology, Jiangsu Province Hospital, Nanjing, China, ¹⁵The First Affiliated Hospital of The Fourth Military Medical University, Xi'an, China, ¹⁶The Second Affiliated Hospital of Guangxi Medical University, Nanning, China, ¹⁷Gothic Internet Technology Corporation, Shanghai, China, ¹⁸The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China
Background/Purpose: This study is to evaluate pattern shifts and outcome trends of treat-to-target (T2T) under standard of care in ankylosing spondylitis (AS) patients with interactive…

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