Abstracts Archive - Page 1344 of 2425 - ACR Meeting Abstracts

Abstract Number: 2077 • 2017 ACR/ARHP Annual Meeting
Statin Use and Mortality in Gout: A General Population-Based Cohort Study
Sarah Keller¹, Sharan K. Rai², Na Lu¹, Amar Oza³, Yuqing Zhang⁴ and Hyon K. Choi², ¹Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ²Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ³Allergy, Immunology, and Rheumatology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ⁴School Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA
Background/Purpose: Although the cardinal feature of gout is inflammatory arthritis, it is also a metabolic condition closely associated with an elevated uric acid burden and…
Abstract Number: 2078 • 2017 ACR/ARHP Annual Meeting
Hypersensitivity Reactions with Allopurinol and Febuxostat in Adults 65 Years or Older: A Study Using the Medicare Claims Data
Jasvinder A. Singh¹ and John Cleveland², ¹Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ²Rheumatology, University of Alabama at Birmingham (UAB), Birmingham, AL
Background/Purpose: Clinicians using allopurinol are always concerned about the risk of rare hypersensitivity reaction. Allopurinol and febuxostat are the two most common urate-lowering agents used…
Abstract Number: 2079 • 2017 ACR/ARHP Annual Meeting
Rotator Cuff Calcific Tendinopathy: Chondrocyte-like Cells Surrounding Calcific Deposits Express TNAP and ENPP1, Two Key Enzymes of the Mineralization Process.
Christelle Darrieutort-Laffite^1,2, Aurélie Najm^1,3, Thomas Garraud^1,2, Pierre Layrolle², Frédéric Blanchard³ and Benoit Le Goff^1,2, ¹Rheumatology, Nantes University Hospital, Nantes, France, ²INSERM U1238, PHY-OS Laboratory, Nantes, France, ³INSERM U1238 University of medicine, PHY-OS Laboratory, Nantes, France
Background/Purpose: Calcific tendinopathy represents 10 to 42% of chronic painful shoulders. These calcium deposits are composed of carbonated apatite. Although the disease is frequent, its…
Abstract Number: 2080 • 2017 ACR/ARHP Annual Meeting
Serum Uric Acid and Incident Dementia: A Population Based Study
Lieke E.J.M. Scheepers¹, Mats Dehlin¹, Lennart TH Jacobsson¹, Lena Johansson² and Ingmar Skoog², ¹Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, ²Department of Psychiatry and Neurochemistry, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
Background/Purpose: Elevated serum uric acid (sUA) is an established risk factor for gout. Its role in the development of dementia is controversial, low levels of…
Abstract Number: 2081 • 2017 ACR/ARHP Annual Meeting
Synovial Fluid Leukocyte Count and Its Association with Crystal Deposition in Asymptomatic Hyperuricemia
Mariano Andrés^1,2, José Antonio Bernal³, María Dolores Arenas⁴ and Eliseo Pascual^1,5, ¹Sección de Reumatología, Hospital General Universitario de Alicante, Alicante, Spain, ²Departamento de Medicina Clínica, Universidad Miguel Hernández, Alicante, Spain, ³Reumatología, Hospital Universitario del Vinalopó, Elche, Spain, ⁴Unidad de Nefrología, Hospital Vithas Perpetuo Socorro, Alicante, Spain, ⁵Emeritus Professor, Universidad Miguel Hernández, Elche, Spain
Background/Purpose: Articular and periarticular deposits of monosodium urate (MSU) crystals in asymptomatic hyperuricemia (AH) may associate with more severe forms of atherosclerosis [Andrés 2016]. This…
Abstract Number: 2082 • 2017 ACR/ARHP Annual Meeting
Clinical Presentation, Management, and Prognosis of Pseudogout in Prosthetic Joint Implant Patients: A Retrospective Study
Merit P. George¹, Floranne C. Ernste², Aaron J. Tande³, Douglas R. Osmon³, Tad M. Mabry⁴ and Elie F. Berbari³, ¹Mayo Clinic School of Medicine, Rochester, MN, ²Division of Rheumatology, Mayo Clinic Rochester, Rochester, MN, ³Division of Infectious Diseases, Mayo Clinic Rochester, Rochester, MN, ⁴Division of Orthopedic Surgery, Mayo Clinic Rochester, Rochester, MN
Background/Purpose: The prevalence of total knee arthroplasty (TKA) and total hip arthroplasty (THA) has risen considerably in the U.S. There has been a relative lack…
Abstract Number: 2083 • 2017 ACR/ARHP Annual Meeting
The Inflammation Induced By Four Types of Calcium Pyrophosphate Crystals Depends on Their Capacity to Stimulate NF-κb and MAPK Pathways
Félix Renaudin¹, Laure Campillo-Gimenez², Pierre Gras³, Christèle Combes⁴, Martine Cohen-Solal¹, Frederic Liote⁵ and Hang-Korng Ea¹, ¹INSERM UMR1132, Paris Diderot University, Paris, France, ²Inserm UMR1132 Bioscar, Paris, France, ³CIRIMAT, INPT-UPS-CNRS, Toulouse, France, ⁴ENSIACET, CIRIMAT, INPT-UPS-CNRS, Toulouse, France, ⁵University Paris Diderot, Paris, France
Background/Purpose: Calcium pyrophosphate (CPP) crystal-induced inflammation is mainly driven by interleukin (IL)-1β. IL-1β production involves a two-step process including the formation of pro-IL-1β through NF-κB…
Abstract Number: 2084 • 2017 ACR/ARHP Annual Meeting
Patients with Early Onset Gout Develop Earlier Severe Joint Involvement and Metabolic Comorbid Conditions
Tristan Pascart¹, Laurène Norberciak², Hang-Korng Ea³, Sabine Lanz⁴, Charles Lambert⁵, Pascal Guggenbuhl⁶ and Frederic Liote⁷, ¹Rheumatology, Lille Catholic University, Lille, France, ²Lille Catholic University, Lille, France, ³INSERM UMR1132, Paris Diderot University, Paris, France, ⁴Laboratoire Mayoli Spindler, Chatou, France, ⁵Laboratoire Ipsen Pharma, Boulogne, France, ⁶Rennes University, Rennes, France, ⁷University Paris Diderot, Paris, France
Patients with Early Onset Gout develop Earlier Severe Joint Involvement and Metabolic Comorbid Conditions Background/Purpose: Early onset gout might encompass more severe cases along with genetic defects,…
Abstract Number: 2085 • 2017 ACR/ARHP Annual Meeting
Relationship between Gout and Asthma: A National Database Analysis
Yiming Luo¹, Jiehui Xu², Yumeng Wen¹, Alvaro Ramos-Rodriguez³, Changchuan Jiang¹, Shuyang Fang¹, Mustafa Kagalwalla¹ and Neha Ohri⁴, ¹Department of Medicine, Mount Sinai St Luke's and Mount Sinai West Hospitals, Icahn School of Medicine at Mount Sinai, New York, NY, ²Department of Biostatistics, Mailman School of Public Health, Columbia University Medical Center, New York, NY, ³Mount Sinai St Luke's and Mount Sinai West Hospitals, Icahn School of Medicine at Mount Sinai, New York, NY, ⁴Division of Rheumatology, Department of Medicine, Mount Sinai St Luke's and Mount Sinai West Hospitals, Icahn School of Medicine at Mount Sinai, New York, NY
Background/Purpose: Gout is an inflammatory disorder related to hyperuricemia and abnormal deposition of monosodium urate crystals in joints or other tissues. The relationship between serum…
Abstract Number: 2086 • 2017 ACR/ARHP Annual Meeting
Calcium Pyrophosphate Crystal Size, Shape and Appearance Variability
Monica Zell¹, Ann Rosenthal², Thanda Aung³, Marian Kaldas³ and John Fitzgerald⁴, ¹Albert Einstein College of Medicine, New York, NY, ²Division of Rheumatology, Medical College of Wisconsin, Milwaukee, WI, ³UCLA, Los Angeles, CA, ⁴Rheumatology, UCLA, Los Angeles, CA
Background/Purpose: To better understand the variation in calcium pyrophosphate (CPP) crystal, size, shape and appearance under compensated polarized microscope, synovial fluid crystals were examined by…
Abstract Number: 2087 • 2017 ACR/ARHP Annual Meeting
Allelic Variants of ABCG2 and Gout Risk
Blanka Stiburkova^1,2, Katerina Pavelcova^2,3, Jakub Zavada², Lenka Petru^2,3, Marketa Pavlikova^2,4, Hirotaka Matsuo⁵, Tony R. Merriman⁶ and Karel Pavelka⁷, ¹Institute of Inherited Metabolic Disorders, First Faculty of Medicine, Charles University, Prague, Czech Republic, ²Institute of Rheumatology, Prague, Czech Republic, ³Department of Rheumatology, First Faculty of Medicine, Charles University, Prague, Czech Republic, ⁴Department of probability and mathematical statistics, Faculty of Mathematics and Physics, Charles University, Prague, Czech Republic, ⁵Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Tokorozawa, Japan, ⁶Department of Biochemistry, University of Otago, Dunedin, New Zealand, ⁷Institute of Rheumatology, Praha, Czech Republic
Background/Purpose: Common dysfunctional variants of ABCG2, a high-capacity urate transporter gene, that result in decreased urate excretion, are major causes of hyperuricemia and gout. In…
Abstract Number: 2088 • 2017 ACR/ARHP Annual Meeting
Clinical Significance of Urate Deposition in Tendon: A Dual-Energy CT Study
In Young Kim¹, Yeonghee Eun², Ji young Chai³, Chan Hong Jeon⁴, Jinseok Kim⁵, Hyungjin Kim², Jaejoon Lee¹, Eun-Mi Koh² and Hoon-Suk Cha⁶, ¹Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea, Republic of (South), ²Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea, Republic of (South), ³Department of Rheumatology, Bundang Jesaeng Hospital, Seongnam, Korea, Republic of (South), ⁴Department of Internal Medicine, Soonchunhyang University College of Medicine, Bucheon, Korea, Republic of (South), ⁵Department of Internal Medicine, Jeju National University Hospital, Jeju National University School of Medicine, Jeju, Korea, Republic of (South), ⁶Department of Medicine,Division of Rheumatology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea, Republic of (South)
Background/Purpose: Dual-energy computed tomography (DECT) is advanced imaging modality that shows the deposition of monosodium urate (MSU) crystal in tissue as a color signal. In…
Abstract Number: 2089 • 2017 ACR/ARHP Annual Meeting
Arhalofenate Acid Inhibits Urate Crystal-Induced Inflammatory Responses through Activation of AMP-Activated Protein Kinase (AMPK) Signaling
Charles McWherter¹, Robert Terkeltaub^2,3 and Ru Liu-Bryan^3,4, ¹CymaBay Therapeutics, Inc., Newark, CA, ²Rheumatology, VA San Diego Healthcare System, San Diego, CA, ³Medicine-Rheumatology, University of California, San Diego, La Jolla, CA, ⁴VA San Diego Healthcare System, San Diego, CA
Background/Purpose: Arhalofenate is an investigational drug with dual uricosuric and anti-inflammatory properties. Arhalofenate reduced the risk of acute flare while lowering serum urate levels in…
Abstract Number: 2090 • 2017 ACR/ARHP Annual Meeting
Utility of Anakinra in Acute Crystalline Diseases: A Retrospective Study Comparing a University Hospital with Veterans Affairs Medical Center
Julianna Desmarais¹ and Cong-Qiu Chu², ¹Department of Arthritis and Rheumatic Diseases, Oregon Health & Science University, Portland, OR, ²Rheumatology, Oregon Health & Science University, Portland, OR
Background/Purpose: Anakinra is an IL-1 blocking medication used off label to relieve acute inflammation from gout and pseudogout. The efficacy and safety of this treatment…
Abstract Number: 2091 • 2017 ACR/ARHP Annual Meeting
Initial Phase 2 Clinical Data of SEL-212 in Symptomatic Gout Patients: Monthly Dosing of a Pegylated Uricase (Pegsiticase) with Svp-Rapamycin Enables Sustained Reduction of Serum Uric Acid Levels By Mitigating Formation of Anti-Drug Antibodies
Earl Sands¹, Alan J. Kivitz², Wesley DeHaan Ph.D.¹, Lloyd Johnston¹ and Takashi Kei Kishimoto¹, ¹Selecta Biosciences, Watertown, MA, ²Department of Rheumatology, Altoona Center for Clinical Research, Duncansville, PA
Background/Purpose: Pegylated uricases are promising therapies for the treatment of severe chronic gout, particularly for the rapid resolution of tophi. However uricases are limited…

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