Abstracts Archive - Page 1335 of 2607 - ACR Meeting Abstracts

Abstract Number: 2231 • 2018 ACR/ARHP Annual Meeting
An Ancestral-Specific Interaction of TRIM46 with a Past-History of Smoking May Influence Gout Risk
Niamh Fanning¹, Tony R. Merriman², Amanda Phipps-Green², John Pearson³, Ruth Topless², Murray Cadzow², Douglas White⁴, Nicola Dalbeth⁵ and Lisa K. Stamp⁶, ¹Medicine, University of Otago, Christchurch, Christchurch, New Zealand, ²University of Otago, Dunedin, New Zealand, ³University of Otago, Christchurch, Christchurch, New Zealand, ⁴Department of Rheumatology, Waikato Clinical School, Hamilton, New Zealand, ⁵University of Auckland, Auckland, New Zealand, ⁶University of Otago, Christchurch, New Zealand
Background/Purpose: Gout is caused by an interplay of genetic and environmental factors. Epidemiological and prospective studies suggest that current-smoking may be protective for developing gout…
Abstract Number: 2232 • 2018 ACR/ARHP Annual Meeting
Prevalence of Gout in the Surviving U.S. Solid Organ Transplant Population
Mark D. Brigham¹, Thilan Tudor¹, Gavin Miyasato¹, Jeffrey D. Kent², Brian LaMoreaux³ and Brian F. Mandell⁴, ¹Trinity Partners, Waltham, MA, ²Medical Affairs, Horizon Pharma USA, Inc, Lake Forest, IL, ³Horizon Pharma USA, Inc, Lake Forest, IL, ⁴Rheumatology, Cleveland Clinic, Cleveland, OH
Background/Purpose: Although incidence and survival are frequent topics within the solid organ transplant (SOT) literature, there are no recent publications on the total size of…
Abstract Number: 2233 • 2018 ACR/ARHP Annual Meeting
Activation and Deficiency of Circulating Mucosal-Associated Invariant T Cells in Patients with Gouty Arthritis
Yong-Wook Park¹, Young-Nan Cho², Hye-Mi Jin¹ and Seung-Jung Kee³, ¹Rheumatology, Chonnam National University Medical School and Hospital, Gwangju, Korea, Republic of (South), ²Rheumatology, Chonnam National University Medical School and Hospital, Gwangju, MN, Korea, Republic of (South), ³Laboratory Medicine, Chonnam National University Medical School and Hospital, Gwangju, Korea, Republic of (South)
Background/Purpose: Mucosal-associated invariant T (MAIT) cells contribute to protection against certain microorganism infections and play an important role in mucosal immunity. Upon antigen recognition, MAIT…
Abstract Number: 2234 • 2018 ACR/ARHP Annual Meeting
Liver Safety of Febuxostat Compared with Allopurinol in Gout Patients with Fatty Liver Disease
Jung Sun Lee¹, Seokchan Hong², Jebum Won¹, Oh Chan Kwon², Ji Seon Oh², Yong-Gil Kim², Chang Keun Lee² and Bin Yoo², ¹Division of Rheumatology, Department of Internal Medicine,, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea, Republic of (South), ²Division of Rheumatology, Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea, Republic of (South)
Background/Purpose: Although febuxostat has been widely used for lowering uric acid levels because of its renal safety compared with allopurinol, data on the hepatic safety…
Abstract Number: 2235 • 2018 ACR/ARHP Annual Meeting
Monosodium Urate Deposition Distribution in the Knees, Hands, and Feet of Treated Gout Patients: A Dual-Energy CT Study
Chio Yokose¹, Nicola Dalbeth², Savvas Nicolaou³, Scott Baumgartner⁴, Jia Hu⁵, Maple Fung⁴, F. Joseph Simeone⁶ and Hyon K. Choi¹, ¹Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Boston, MA, ²University of Auckland, Auckland, New Zealand, ³Radiology, University of British Columbia, Vancouver, BC, Canada, ⁴Formerly Ardea Biosciences, San Diego, CA, ⁵Heron Therapeutics, San Diego, CA, ⁶Department of Radiology, Massachusetts General Hospital, Boston, MA
Background/Purpose: Prior studies have demonstrated that monosodium urate (MSU) deposits on dual-energy CT (DECT) are commonly found in joints as well as tendons of the…
Abstract Number: 2236 • 2018 ACR/ARHP Annual Meeting
Contemporary Comorbidity Burden of Gout and Hyperuricemia in the US during the Past Decade (National Health And Nutrition Examination Survey [NHANES] 2007-2016)
Michael Chen-Xu¹, Chio Yokose², Michael Pillinger³ and Hyon K. Choi², ¹General Medicine, Wairarapa District Health Board, Masterton, New Zealand, ²Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Boston, MA, ³Medicine/Rheumatology, NYU School of Medicine, New York, NY
Background/Purpose: Precise estimates of the comorbidity burden of gout and hyperuricemia are critical as their presence has important implications for the treatment of both gout…
Abstract Number: 2237 • 2018 ACR/ARHP Annual Meeting
Prevalence of Urate-Lowering Therapy Use and Target Urate Level Achievement Among Gout Patients in the United States (National Health And Nutrition Examination Survey [NHANES] 2007-2014)
Michael Chen-Xu¹, Chio Yokose², Michael Pillinger³ and Hyon K. Choi², ¹General Medicine, Wairarapa District Health Board, Masterton, New Zealand, ²Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Boston, MA, ³Medicine/Rheumatology, NYU School of Medicine, New York, NY
Background/Purpose: To determine the latest national prevalence of urate-lowering therapy (ULT) use and achievement of a therapeutic target serum urate level (SUL) in gout patients,…
Abstract Number: 2238 • 2018 ACR/ARHP Annual Meeting
Non-Coding Urate-Associated Variants Function in a Conserved Lincrna Regulatory Domain That Alters MAF transcription
Megan Leask¹, Tony R. Merriman¹, Amy Dowdle¹, Hamish Salvesen¹, Ruth Topless¹, Tayaza Fadason², Wenhua Wei¹, William Schierding², Justin O'Sullivan² and Julia Horsfield¹, ¹University of Otago, Dunedin, New Zealand, ²University of Auckland, Auckland, New Zealand
Background/Purpose: Genome-wide association studies (GWAS) have revealed that the large majority of disease-associated single nucleotide polymorphisms (SNPs) are located in the non-coding regions of the…
Abstract Number: 2239 • 2018 ACR/ARHP Annual Meeting
Tenocytes Extracted from Rotator Cuff Tendons Are Able to Induce Mineral Deposition in Vitro and Express Genes Related to a Chondrocyte Differentiation
Christelle Darrieutort-Laffite^1,2, Paul Arnolfo¹, Benoit Le Goff^1,2 and Frédéric Blanchard¹, ¹INSERM U1238, PHY-OS Laboratory, Nantes, France, ²Rheumatology, Nantes University Hospital, Nantes, France
Background/Purpose: Calcific tendonitis is a frequent cause of shoulder pain. The calcium deposits are composed of carbonated apatite and their origin stays still largely unknown.…
Abstract Number: 2240 • 2018 ACR/ARHP Annual Meeting
Hip Involvement in Patients with Gout: Results of an Ultrasound Study
Andrea Di Matteo¹, Emilio Filippucci¹, Edoardo Cipolletta², Alice Musca³, María Victoria Martire⁴, Daniele Pierucci¹, Eleonora Di Donato¹ and Walter Grassi¹, ¹Polytechnic University of Marche, Rheumatology Clinic, Jesi, Italy, ²Polytechnic University of Marche, Rheumatology Clinic, jesi, Italy, ³Internal Medicine and Rheumatology Department, Bucharest, Romania, ⁴Instituto Médico Platense, La Plata, Argentina
Background/Purpose: Although considered as uncommon, the hip represents one of the possible targets of gout. To date, hip involvement in patients with gout has been…
Abstract Number: 2241 • 2018 ACR/ARHP Annual Meeting
What Can Variation in Clinical Practice Teach Us about Treatment Strategies for Patients with Gout?
Ritch te Kampe¹, Caroline van Durme¹, Matthijs Janssen², Annelies Boonen¹ and Tim Jansen², ¹Department of Rheumatology, Maastricht University Medical Center, Maastricht, The Netherlands, Maastricht, Netherlands, ²Department of Rheumatology, VieCuri Medical Center, Venlo, The Netherlands, Venlo, Netherlands
Background/Purpose: To improve quality of care for patients with gout, two hospitals in the Netherlands initiated a protocolized gout clinic. One clinic adopted a patient-centred…
Abstract Number: 2242 • 2018 ACR/ARHP Annual Meeting
Cardiovascular Outcomes of Treatment with Febuxostat and Allopurinol in Gout Patients with Kidney Disease
William B. White¹ and Lhanoo Gunawardhana², ¹Cardiology, University of Connecticut School of Medicine, Farmington, CT, ²Takeda Pharmaceuticals International, Deerfield, IL
Background/Purpose: The Cardiovascular Safety of Febuxostat and Allopurinol in Patients with Gout and Cardiovascular Comorbidities (CARES) trial demonstrated that major cardiovascular (CV) outcomes on febuxostat…
Abstract Number: 2243 • 2018 ACR/ARHP Annual Meeting
Sex Difference of the Association between Serum Urate and Blood Pressure in Young Adults
Angelo Gaffo¹, Elizabeth J. Rahn², Tanja Dudenbostel¹, Amy S. Mudano¹, Peng Li³, David T. Redden³, Stephanie Biggers¹, Phillip J. Foster², Paul M. Muntner⁴, Suzanne Oparil⁵, David A. Calhoun⁵ and Kenneth Saag¹, ¹University of Alabama at Birmingham, Birmingham, AL, ²Department of Medicine, Division of Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ³Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, ⁴Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, ⁵Department of Medicine, Division of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: Serum urate (sUA) has been associated with blood pressure in most but not all studies. This study aims to test whether there are sex…
Abstract Number: 2244 • 2018 ACR/ARHP Annual Meeting
Comparison of an Interactive Voice Response (IVR) to Smart Phone App to Determine Patient Preference for Reporting Gout Flares
Nada Elmagboul¹, Brian W Coburn², Kenneth Saag¹, Phillip J. Foster³, Amy S. Mudano¹, Joshua A. Melnick⁴, Debra A Bergman², Shuo Yang¹, David T. Redden⁵, Lang Chen¹, Filby Cooper¹, Jeffrey R. Curtis¹ and Ted R. Mikuls⁶, ¹University of Alabama at Birmingham, Birmingham, AL, ²Division of Rheumatology, VA Nebraska-Western Iowa Health Care System and University of Nebraska Medical Center, Omaha, NE, ³Department of Medicine, Division of Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ⁴Clinical Immunology & Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ⁵Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, ⁶Internal Medicine, Division of Rheumatology, VA Nebraska-Western Iowa Health Care System and University of Nebraska Medical Center, Omaha, NE
Background/Purpose: Gout flares are a major cause of morbidity and are an important outcome in clinical studies. Significant limitations for timely flare ascertainment exist, and…
Abstract Number: 2245 • 2018 ACR/ARHP Annual Meeting
Lubricin/Proteoglycan 4 (PRG4) Inhibits NLRP3 Inflammasome Assembly in Monosodium Urate (MSU)-Crystal Induced Arthritis.
Anthony M. Reginato¹, Changqi Sun², Elsaid A. Khaled³, Tannin A. Schmidt⁴, Olin D. Liang⁵ and Gregory D Jay⁶, ¹Division of Rheumatology, Rhode Island Hospital, Providence, RI, ²Division of Rheumatology, Rhode Island Hospital, Providence, MA, ³Department of Biomedical and Phramaceutical Science, Chapman University School of Pharmacy, Irvine, CA, ⁴Biomedical Engineering, University of Connecticut Health Center, Framington, CT, ⁵Division of Hematology/Oncology, Rhode Island Hospital, Providence, RI, ⁶Department of Emergency Medicine, Rhode Island Hospital, Providence, RI
Background/Purpose: Lubricin/proteoglycan-4 (PRG4) is a mucinous glycoprotein secreted by synovial fibroblast and superficial zone chondrocytes. PRG4 has a multifaceted homeostatic role in the joint including…

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