Abstracts Archive - Page 1335 of 2425 - ACR Meeting Abstracts

Abstract Number: 1942 • 2017 ACR/ARHP Annual Meeting
CTLA4-Ig Directly Inhibits Osteoclast Generation from Human Peripheral Monocytes and Tumor Necrosis Factor α-Treated Inflammatory Monocytes
Katsuhiro Oi¹, Tadahiro Tokunaga¹, Tatsuomi Kuranobu¹, Yusuke Yoshida², Shintaro Hirata¹, Takaki Nojima³ and Eiji Sugiyama², ¹Clinical Immunology and Rheumatology, Hiroshima University Hospital, Hiroshima, Japan, ²Department of Clinical Immunology and Rheumatology, Hiroshima University Hospital, Hiroshima, Japan, ³Clinical Immunology and Rheumatolog, Graduate School of Medicine, Kyoto University, Kyoto, Japan
Background/Purpose: CTLA-4 is a surface protein on T lymphocytes, which negatively regulates the co-stimulation process between antigen-presenting cells and T cells. CTLA-4 binds to monocytes…
Abstract Number: 1943 • 2017 ACR/ARHP Annual Meeting
Adipocytokines in an Osteoarthritis Mouse Model
Marie-Lisa Hülser¹, Carina Schreiyäck¹, Yubin Luo², Aline Bozec², Georg Schett³, Elena Neumann⁴ and Ulf Müller-Ladner⁵, ¹Department of Internal Medicine and Rheumatology, Justus-Liebig-University Giessen, Department of Internal Medicine and Rheumatology, Kerckhoff-Klinik, Bad Nauheim, Germany, Bad Nauheim, Germany, ²Department Clinic of Medicine 3 - Immunology und Rheumatology, University of Erlangen-Nürnberg, Department Clinic of Medicine 3 - Immunology and Rheumatology, Erlangen, Germany, Erlangen, Germany, ³Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Department of Internal Medicine 3 – Rheumatology and Immunology, Universitätsklinikum Erlangen, Erlangen, Germany., Erlangen, Germany, ⁴Justus-Liebig-University Giessen, Department of Internal Medicine and Rheumatology, Kerckhoff-Klinik, Bad Nauheim, Germany, Bad Nauheim, Germany, ⁵Justus-Liebig-University Giessen, Department of Internal Medicine and Rheumatology, Kerckhoff-Klinik, Bad Nauheim, Germany, Bad-Nauheim, Germany
Background/Purpose: In the Western society adiposity and metabolic syndrome are an increasing field of medical research. Both entities influence the expression of adipokines such as…
Abstract Number: 1944 • 2017 ACR/ARHP Annual Meeting
A Dual Role for IL-23 Receptor Signaling in Normal Bone Remodeling Versus Inflammation-Mediated Bone Damage during Arthritis
Wida Razawy¹, Marijke Koedam², Patrick Asmawidjaja³, Anne-Marie Otten-Mus⁴, Bram van der Eerden² and Erik Lubberts³, ¹Rheumatology and Immunology, Erasmus MC, Rotterdam, Netherlands, ²Internal Medicine, Erasmus MC, Rotterdam, Netherlands, ³Rheumatology and Immunology, Erasmus MC, University Medical Center, Rotterdam, Netherlands, ⁴Immunology, Erasmus MC, University Medical Center, Rotterdam, Netherlands
Background/Purpose: The interleukin (IL)-23/IL-17A immune pathway is critical for the development of autoimmune arthritis. Systemic exposure of IL-23 induced chronic arthritis, increased osteoclast differentiation and…
Abstract Number: 1945 • 2017 ACR/ARHP Annual Meeting
Repositioning Suramin As a Cartilage-Protective Drug
Laura-An Guns¹, Silvia Monteagudo¹, Maryna Kvasnytsia¹, Greet Kerckhofs¹, Jennifer Vandooren², Ghislain Opdenakker², Frederic Cailotto^1,3 and Rik Lories⁴, ¹Skeletal Biology and Engineering Research Center, KU Leuven, Leuven, Belgium, ²Rega Institute, KU Leuven, Leuven, Belgium, ³University of Lorraine, Nancy, France, ⁴Rheumatology, UZ Leuven, Leuven, Belgium
Background/Purpose: Drug repositioning is a recent pharmaceutical strategy to discover new uses for market-approved drugs with known safety profiles that can provide quick transition from…
Abstract Number: 1946 • 2017 ACR/ARHP Annual Meeting
Development of a Multi-Component 3D Arthritic Joint Model
Alexandra Damerau^1,2, Lisa Ehlers^1,2, Moritz Pfeiffenberger^1,2, Igor Ponomarev³, Frank Buttgereit^2,4, Timo Gaber^4,5 and Annemarie Lang^1,2, ¹Rheumatologie und klinische Immunologie, Charité-Universitätsmedizin Berlin, Berlin, Germany, ²Deutsches Rheuma-Forschungszentrum Berlin, Berlin, Germany, ³Research Center of Medical Technology and Biotechnology, Bad Langensalza, Germany, ⁴Rheumatologie und klinische Immunologie, Charité Universitätsmedizin Berlin, Berlin, Germany, ⁵German Rheumatism Research Center (DRFZ) Berlin, Berlin, Germany
Background/Purpose: Our goal is to develop an in vitro 3D joint model to simulate the immune mediated pathogenesis of arthritides in order to present an…
Abstract Number: 1947 • 2017 ACR/ARHP Annual Meeting
Thy1 Is a Positive Regulator of Osteoblast Differentiation and Modulates Bone Homeostasis in Obese Mice
Ananta Paine¹, Collynn Woeller², Nelson Huertas¹, Maria de la Luz Garcia-Hernandez³, Richard Phipps² and Christopher T. Ritchlin⁴, ¹Department of Medicine, Division of Allergy, Immunology and Rheumatology, School of Medicine and Dentistry, University of Rochester, Rochester, New York, USA, Rochester, NY, ²Department of Environmental Medicine, School of Medicine and Dentistry,, Department of Environmental Medicine, School of Medicine and Dentistry, University of Rochester, Rochester, New York, USA, Rochester, NY, ³Department of Medicine,, Division of Allergy, Immunology and Rheumatology, School of Medicine and Dentistry, University of Rochester, Rochester, New York, USA, Rochester, NY, ⁴Division of Allergy, Immunology and Rheumatology, School of Medicine and Dentistry, Division of Allergy, Immunology and Rheumatology, School of Medicine and Dentistry, University of Rochester, Rochester, New York, USA, Rochester, NY
Background/Purpose: Thy1 (CD90) is a glycosylated, glycophosphatidylinositol (GPI)-anchored membrane protein originally identified as a marker for mouse T cells but subsequent reports noted expression on…
Abstract Number: 1948 • 2017 ACR/ARHP Annual Meeting
TNF-α Overrides the Ability of RANK Ligand to Induce Osteoclast Differentiation of Classical Circulating Precursors
Cecilia Ansalone¹, Flavia Sunzini¹, Caitlin Duncan¹, Sabarinadh Chilaka¹, Iain B. McInnes² and Carl S. Goodyear³, ¹Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom, ²University of Glasgow, Glasgow, United Kingdom, ³Institute of Infection, Immunity and Inflammation, College of Medicine, Veterinary Medicine and Life Sciences, University of Glasgow, Glasgow, United Kingdom
Background/Purpose: TNF-α is well known to be involved in inflammatory-induced bone destruction. This is widely supported by clinical studies showing reduced bone pathology after anti-TNF-α…
Abstract Number: 1949 • 2017 ACR/ARHP Annual Meeting
Anti-Inflammatory Effects of Standardized Platelet-Rich Plasma Releasates in Knee and Hip OA Chondrocytes
Lucia Gato-Calvo¹, Ángela Vela-Anero², Elena F. Burguera¹ and Francisco J Blanco³, ¹Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade de A Coruña (UDC), A Coruña, Spain, ²Cell Therapy and Regenerative Medicine Group, Department of Medicine, University of A Coruña, A Coruña, Spain, ³Proteomics Group, Rheumatology Division, ProteoRed, PRB2-ISCIII. INIBIC-Hospital Universitario A Coruña,15006 A Coruña-Spain, A Coruña, Spain
Background/Purpose : There is a need to standardize platelet-rich plasma (PRP)-derived products and their dosage to evaluate efficacy for each intended indication. Our purpose here…
Abstract Number: 1950 • 2017 ACR/ARHP Annual Meeting
Cross-Sectional Analysis of Foot Osteoarthritis Frequency and Associated Factors: The Johnston County Osteoarthritis Project
Portia Flowers¹, Amanda Nelson², Howard J. Hillstrom³, Jordan B. Renner⁴, Joanne M. Jordan⁵ and Yvonne M. Golightly⁶, ¹Thurston Arthritis Research Center, University of North Carolina - Chapel Hill, Chapel Hill, NC, ²Division of Rheumatology, Allergy, and Immunology and Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, ³Rehabilitation, Hospital Special Surgery (HSS), New York, NY, ⁴UNC School of Medicine, University of North Carolina, Chapel Hill, NC, ⁵Thurston Arthritis Research Center, University of North CArolina at Chapel Hill, Chapel Hill, NC, ⁶Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC
Background/Purpose: The rising number of adults with arthritis and associated activity limitations present a serious public health problem. Although studies have explored lower limb…
Abstract Number: 1951 • 2017 ACR/ARHP Annual Meeting
Effect of Initiating Metformin Vs. Sulfonylureas on the Risk of Total Knee Arthroplasty
Yuqing Zhang¹, Christine Peloquin², Na Lu³, Tuhina Neogi³ and David T. Felson³, ¹School Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ²Boston University School of Medicine, Boston, MA, ³Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA
Background/Purpose: Metformin is the most widely used first-line therapy for type 2 diabetes. Studies have suggested that metformin reduces inflammation and lowers levels of PGE2,…
Abstract Number: 1952 • 2017 ACR/ARHP Annual Meeting
Trend of Arthrocentesis Utilization Among Inpatients over 10 Years – Data from National Inpatient Sample
Dilli Poudel¹, Rashmi Dhital², Sijan Basnet², Sushil Ghimire², Pragya Shrestha³, Prakash Paudel⁴, Raju Khanal² and Paras Karmacharya⁵, ¹Internal Medicine, Reading Health System, WEST READING, PA, ²Internal Medicine, Reading Health System, West Reading, PA, ³Internal medicine, Reading Health System, West Reading, PA, ⁴Internal Medicine, Berkshire Medical Center, Pittsfield, MA, ⁵Rheumatology, C1-R-041, Leiden University Medical Center (LUMC), Rochester, MN
Background/Purpose: Arthrocentesis (AC) is a common and simple yet invasive procedure with potential of serious complications. There are no studies evaluating how often this procedure…
Abstract Number: 1953 • 2017 ACR/ARHP Annual Meeting
Dietary Quality and Risk of SLE in the Nurses’ Health Studies
Medha Barbhaiya¹, Bing Lu¹, Sara K. Tedeschi², Susan Malspeis³, Jeffrey A. Sparks⁴, Walter C. Willett^5,6, Elizabeth Karlson⁷ and Karen H. Costenbader⁷, ¹Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ²Division of Rheumatology, Immunology and Allergy,, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ³Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ⁴Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ⁵Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ⁶Department of Nutrition, Harvard School of Public Health, Boston, MA, ⁷Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA
Background/Purpose: Prior studies suggest that high intake of antioxidants, fish, olive oil, and nuts may decrease risk of chronic inflammatory diseases and reduce inflammatory biomarkers.…
Abstract Number: 1954 • 2017 ACR/ARHP Annual Meeting
Association of CRP with BMI in Males and Females
Taik Kim¹, Stephen J. Ganocy², Maria Antonelli³, Douglas Einstadter⁴ and Stanley Ballou¹, ¹Rheumatology, Case Western Reserve University/MetroHealth Medical Center, Cleveland, OH, ²Case Western Reserve University, Cleveland, OH, ³Department of Medicine/Division of Rheumatology, Case Western Reserve University School of Medicine, MetroHealth Medical Center, Cleveland, OH, ⁴Case Western Reserve University at MetroHealth Medical Center, Cleveland, OH
Background/Purpose: C-reactive Protein (CRP) is an inflammatory marker commonly used to help aid in diagnosis, assess disease activity or monitor response to therapy. It is…
Abstract Number: 1955 • 2017 ACR/ARHP Annual Meeting
Health Care Provider Advice for Weight Loss Among US Adults with Arthritis, National Health Interview Survey, 2014
Jennifer M. Hootman¹, Miriam G. Cisternas², Louise Murphy³ and Teresa J. Brady⁴, ¹Centers for Disease Control and Prevention, Kennesaw, GA, ²MGC Data Services, Carlsbad, CA, ³Division of Population Health, Centers for Disease Control and Prevention, Atlanta, GA, ⁴Arthritis Program, Centers for Disease Control and Prevention, Atlanta, GA
Background/Purpose: Most clinical practice guidelines for the management of osteoarthritis recommend weight loss for adults with arthritis who are overweight or obese. A health care…
Abstract Number: 1956 • 2017 ACR/ARHP Annual Meeting
An Approach to Linkage of Registry Data to Medicare Claims Using Multiple Non-Unique Identifiers
Fenglong Xie¹, Lang Chen¹, Huifeng Yun², Jeffrey D Greenberg³ and Jeffrey R. Curtis⁴, ¹Division of Clinical Immunology & Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ²University of Alabama at Birmingham, Birmingham, AL, ³NYU School of Medicine, New York, NY, ⁴Rheumatology & Immunology, University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: Registries and claims data can complement each other to facilitate observational studies. However, methods to link on multiple non-unique identifiers (MNUI) are limited and…

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