ACR Meeting Abstracts

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  • Abstract Number: 1762 • 2017 ACR/ARHP Annual Meeting

    Association of ETS1 Polymorphism in 3’ Untranslated Region with Susceptibility to Granulomatosis with Polyangiitis and Proteinase 3-ANCA Positive Vasculitis in a Japanese Population

    Aya Kawasaki1, Keita Yamashita2, Fumio Hirano3, Ken-ei Sada4, Daisuke Tsukui5, Yuya Kondo6, Yoshitaka Kimura5, Kurumi Asako5, Shigeto Kobayashi7, Hidehiro Yamada8, Hiroshi Furukawa1, Kenji Nagasaka9, Takahiko Sugihara10, Kunihiro Yamagata11, Takayuki Sumida6, Shigeto Tohma12, Hajime Kono5, Shoichi Ozaki8, Seiichi Matsuo13, Hiroshi Hashimoto14, Hirofumi Makino15, Yoshihiro Arimura16, Masayoshi Harigai17 and Naoyuki Tsuchiya1, 1Molecular and Genetic Epidemiology Laboratory, University of Tsukuba, Faculty of Medicine, Tsukuba, Japan, 2Molecular and Genetic Epidemiology, University of Tsukuba, Faculty of Medicine, Tsukuba, Japan, 3Departments of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan, 4Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan, 5Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan, 6Department of Internal Medicine, University of Tsukuba, Faculty of Medicine, Tsukuba, Japan, 7Department of Internal Medicine, Juntendo University Koshigaya Hospital, Koshigaya, Japan, 8Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Japan, 9Department of Rheumatology, Ome Municipal General Hospital, Ome, Japan, 10Department of Medicine and Rheumatology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan, 11Department of Nephrology, University of Tsukuba, Faculty of Medicine, Tsukuba, Japan, 12Clinical Research Center for Allergy and Rheumatology, Sagamihara Hospital, National Hospital Organization, Sagamihara, Japan, 13Department of Nephrology, Nagoya University Graduate School of Medicine, Nagoya, Japan, 14Juntendo University School of Medicine, Tokyo, Japan, 15Okayama University Hospital, Okayama, Japan, 16First Department of Internal Medicine, Kyorin University School of Medicine, Tokyo, Japan, 17Division of Epidemiology and Pharmacoepidemiology of Rheumatic Diseases, Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan

    Background/Purpose: ETS Proto-oncogene 1, transcription factor (ETS1) is a transcription factor involved in immune responses. Genome-wide association studies on systemic lupus erythematosus (SLE) in Chinese…
  • Abstract Number: 1763 • 2017 ACR/ARHP Annual Meeting

    Time to Diagnosis of ANCA-Associated Vasculitides : Data from French Vasculitis Study Group Registry

    Caroline Morbieu, Maher Banjari, Benjamin Terrier, Pascal Cohen, Claire Le Jeunne, Luc Mouthon, Xavier Puéchal and Loïc Guillevin for the French Vasculitis Study Group, National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France

    Background/Purpose: Diagnosing ANCA-associated vasculitides (AAVs) can be challenging. Their clinical presentations are numerous and the time to diagnosis may range from days to years.1,2 The…
  • Abstract Number: 1764 • 2017 ACR/ARHP Annual Meeting

    Small RNA Sequencing Shows Differential Plasma Microrna Expression in Patients with ANCA-Associated Vasculitis: A Pilot Study

    Kevin Byram1, Joseph F. Solus1, Quanhu Sheng1, Yan Guo1, C Michael Stein1 and Michelle J. Ormseth2, 1Vanderbilt University Medical Center, Nashville, TN, 2Rheumatology, Vanderbilt Medical Center, Nashville, TN

    Background/Purpose: MicroRNAs (miRNAs) are small RNA molecules (~22 nucleotides) that participate in post-transcriptional gene regulation. miRNAs have potential both as biomarkers for diagnosis and prognosis…
  • Abstract Number: 1765 • 2017 ACR/ARHP Annual Meeting

    Validation of the ACR EULAR Provisional 2017 Classification Criteria of Granulomatosis with Polyangiitis (GPA) Amongst Patients with ANCA Associated Vasculitis

    Aman Sharma1, Adarsh MB2, Shankar Naidu3, Manish Rathi4, Benzeeta Pinto5, Varun Dhir6, Roshan Verma7, Kusum Sharma8, Ritambhra Nada9, Sanjay Jain5 and Ranjana Minz10, 1Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India, 2Internal Medicine, PGIMER, Chandigarh, India, 3PGIMER, cHANDIGARH, India, 4Department of Nephrology,, Postgraduate Institute of Medical Education and Research, Chandigarh, India, 5PGIMER, CHANDIGARH, India, 6Internal Medicine (Rheumatology Unit), Postgraduate Institute of Medical Education and Research, Chandigarh, India, 7PGIMER, Chandigarh, India, 8Department of Medical Microbiology,, PGIMER,, Chandigarh, India, 9Histopathology, Professor, Chandigarh, India, 10Department of Immunopathology,, PGIMER,, Chandigarh, India

    Background/Purpose: The purpose of this study was to validate the recently proposed ACR EULAR 2017 classification criteria of GPA in a real life cohort of…
  • Abstract Number: 1766 • 2017 ACR/ARHP Annual Meeting

    Increased Renal Damage in Hypocomplementemic Patients with ANCA- Associated Vasculitis

    Lucila García1, Claudia Elizabeth Pena2, Mariana Pera3, Mercedes Garcia2, Valeria Arturi3, Viviana Nagua1, Rodrigo Aguila Maldonado2, Ana Carolina Costi2, Adriana Testi1, Ariel Vulcano1, Pierina Sansinanea1, Martin Mamberti4, Maria Elena Bruzzone4, Carolina Barabani4 and Jimena Salomone4, 1Rheumatology, HIGA General San Martin La Plata, la plata, Argentina, 2Rheumatology, HIGA General San Martin La Plata, La Plata, Argentina, 3HIGA General San Martin La Plata, la plata, Argentina, 4Nephrology, HIGA General San Martin La Plata, la plata, Argentina

    Background/Purpose: The pauci-immune nature of typical lesions in ANCA associated vasculitis (AAV) has led to the belief that complement does not play a role in…
  • Abstract Number: 1767 • 2017 ACR/ARHP Annual Meeting

    The Effect on Health-Related Quality of Life of Treatment for Remission Maintenance in ANCA-Associated Vasculitis Beyond 18 Months

    Gunnar Tomasson1, Antoine G. Sreih2, David Cuthbertson3, Simon Carette4, Nader A. Khalidi5, Curry L. Koening6, Carol A. Langford7, Carol A. McAlear8, Paul A. Monach9, Larry W. Moreland10, Philip Seo11, Ulrich Specks12, Steven R. Ytterberg13 and Peter A. Merkel14, 1University of Iceland, Faculty of Medicine, Reykjavik, IS, 2Rheumatology, University of Pennsylvania, Philadelphia, PA, 3Biostatistics and Informatics, Department of Pediatrics, University of South Florida, Tampa, FL, 4Division of Rheumatology, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada, 5Rheumatology, McMaster University, Hamilton, ON, Canada, 6Rheumatology, University of Utah, Salt Lake City, UT, 7Rheumatic and Immunologic Diseases, Cleveland Clinic, Cleveland, OH, 8University of Pennsylvania, Philadelphia, PA, 9Boston University School of Medicine, Boston, MA, 10Rheumatology & Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, 11Medicine, Johns Hopkins University, Baltimore, MD, 12Mayo Clinic College of Medicine, Rochester, MN, 13Rheumatology, Mayo Clinic, Rochester, MN, 14Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, PA

    Background/Purpose: Standard management of ANCA-associated vasculitis (AAV) involves treatment with immunosuppressive agents for at least 18 months.  Treatment beyond 18 months reduces the rates of…
  • Abstract Number: 1768 • 2017 ACR/ARHP Annual Meeting

    Cocaine and ANCA Associated Vasculitis-like Syndromes – a Case Series

    Sujith Subesinghe1, Sander van Leuven2, Leena Yalakki3, Shirish Sangle (Joint First Author)3 and David P. D'Cruz3, 1Rheumatology and Lupus, Guy's and St Thomas' Hospitals NHS Foundation Trust, London, United Kingdom, 2Rheumatology, Radboud University, Nijmegen, Netherlands, 3Louise Coote Lupus Unit, Rheumatology and Lupus, Guy's and St Thomas' Hospitals NHS Foundation Trust, London, United Kingdom

    Background/Purpose: Cocaine is a potent illicit stimulant and may trigger a ÔpseudovasculitisÕ mimicking idiopathic ANCA vasculitis. We describe the clinical and serological manifestations of patients…
  • Abstract Number: 1769 • 2017 ACR/ARHP Annual Meeting

    Incidence, Predictors, and Outcome of Diffuse Alveolar Hemorrhage in Patients with MPO-ANCA Positive Microscopic Polyangiitis: A Multi-Center Retrospective Cohort Study

    Takashi Kida, Shunya Kaneshita, Takuya Inoue, Amane Nakabayashi, Yuji Kukida, Kazuki Fujioka, Hidetake Nagahara, Makoto Wada, Takahiro Seno, Masataka Kohno and Yutaka Kawahito, Inflammation and Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan

    Background/Purpose: In patients with microscopic polyangiitis (MPA), a variety of pulmonary lesions including diffuse alveolar hemorrhage (DAH), airways disease and interstitial lung disease (ILD) have…
  • Abstract Number: 1770 • 2017 ACR/ARHP Annual Meeting

    ANCA-Associated Vasculitis (AAV) in Younger Vs Older Patients:  Comparison of Clinical, Serologic and Outcome Differences and Their Implications for Management

    Priya Chokshi1, Olufemi Aina2, Naveed Masani2, Melissa Fazzari3, Elise Belilos1, Kristina Belostocki1, Gary Rosenblum1, Tobin Abraham4, Daniil Shimonov4, Zinal Patel4 and Steven E. Carsons1, 1Rheumatology, NYU Winthrop Hospital, Mineola, NY, 2Nephrology, NYU Winthrop Hospital, Mineola, NY, 3Biostatistics, NYU Winthrop Hospital, Mineola, NY, 4Medicine, NYU Winthrop Hospital, Mineola, NY

    Background/Purpose: ANCA-associated vasculitis (AAV) is a cause of multi-organ disease in all ages, but peaks at ages 65-74. Limited data is available on the characteristics…
  • Abstract Number: 1771 • 2017 ACR/ARHP Annual Meeting

    Prevalence and Prognostic Relevance of Cardiovascular Involvement in ANCA-Associated Vasculitis: A Retrospective Cohort Study

    Qin Huang1, Hao Ren1, Yaping Zhan2, Shenyi Yu2 and Min Yang1, 1Department of Rheumatology, Nanfang Hospital,Southern Medical University, Guangzhou, China, 2Department of rheumatology, Nanfang Hospital,Southern Medical University, Guangzhou, China

    Background/Purpose: Cardiovascular involvement in ANCA-associated vasculitis (AAV) including microscopic polyangiitis (MPA), eosinophilic granulomatosis with polyangiitis (EGPA) and granulomatosis with polyangiitis (GPA), has long been regarded…
  • Abstract Number: 1772 • 2017 ACR/ARHP Annual Meeting

    Non-Protocolized Re-Biopsy in Patients with ANCA-Associated Glomerulonephritis: ¿Is It Necessary?

    Valeria Scaglioni1, Marina Scolnik2, Florencia Pierini2, Luis J. Catoggio3, Silvia Beatriz Christiansen4, Carlos Federico Varela5, Gustavo Greloni5, Guillermo Rosa-Diez5 and Enrique R Soriano6, 1Rheumatology Unit, Internal Medicine Service. Hospital Italiano de Buenos Aires, CABA, Argentina, 2Rheumatology Unit, Internal Medicine Service, Hospital Italiano de Buenos Aires, CABA, Argentina, 3Rheumatology Unit, Internal Medicine Service. Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, 4Pathology Service. Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, 5Nephrology Service. Hospital Italiano de Buenos Aires, Argentina, Buenos Aires, Argentina, 6Argentina, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina

    Background/Purpose: Protocolized and non-protocolized repeat renal biopsies are rarely performed in ANCA glomerulonephritis. Their role in predicting long term renal outcomes and aiding in clinical…
  • Abstract Number: 1773 • 2017 ACR/ARHP Annual Meeting

    New Use for an Old Drug: Hydroxychloroquine for the Treatment of ANCA Associated Vasculitis

    Alina Casian1, Rachel Jones2, Ruzaika Cader3, Alan D. Salama4, Shirish Sangle5, David Jayne6 and David P. D'Cruz7, 1Lupus Unit, Guy's Hospital, London, United Kingdom, 2Nephrology, Addenbrooke's Hospital, Cambridge, United Kingdom, 3Nephrology, Norfolk and Norwich Hospitals, Norfolk, United Kingdom, 4Centre for Nephrology, University College London, London, United Kingdom, 5Louise Coote Lupus Unit, Guy's and St Thomas' Hospital, London, United Kingdom, 6Vasculitis and Lupus Clinic, Department of Medicine, University of Cambridge, Cambridge, United Kingdom, 7Louise Coote Lupus Unit, Rheumatology and Lupus, Guy's and St Thomas' Hospitals NHS Foundation Trust, London, United Kingdom

    Background/Purpose: To assess retrospectively the efficacy and safety of hydroxychloroquine in patients with ANCA associated vasculitis. There is an unmet need for a corticosteroid sparing, non-toxic…
  • Abstract Number: 1774 • 2017 ACR/ARHP Annual Meeting

    Serum Periostin As a Biomarker in Eosinophilic Granulomatosis with Polyangiitis

    Rennie L. Rhee1, Cecile TJ Holweg2, David Cuthbertson3, Simon Carette4, Nader A. Khalidi5, Curry L. Koening6, Jeffrey Krischer7, Carol A. Langford8, Carol A. McAlear9, Paul A. Monach10, Larry W. Moreland11, Christian Pagnoux4, Philip Seo12, Ulrich Specks13, Antoine G. Sreih1, Steven R. Ytterberg14 and Peter A. Merkel15, 1Rheumatology, University of Pennsylvania, Philadelphia, PA, 2Genentech, Inc, South San Francisco, CA, 3Biostatistics and Informatics, Department of Pediatrics, University of South Florida, Tampa, FL, 4Division of Rheumatology, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada, 5Rheumatology, McMaster University, Hamilton, ON, Canada, 6Rheumatology, University of Utah, Salt Lake City, UT, 7University of South Florida, Tampa, FL, 8Rheumatic and Immunologic Diseases, Cleveland Clinic, Cleveland, OH, 9University of Pennsylvania, Philadelphia, PA, 10Boston University School of Medicine, Boston, MA, 11Division of Rheumatology and Clinical Immunology, UPMC / University of Pittsburgh, Pittsburgh, PA, 12Medicine, Johns Hopkins University, Baltimore, MD, 13Mayo Clinic College of Medicine, Rochester, MN, 14Rheumatology, Mayo Clinic, Rochester, MN, 15Division of Rheumatology, University of Pennsylvania, Philadelphia, PA

    Background/Purpose: Identification of a biomarker to predict relapse in eosinophilic granulomatosis with polyangiitis (EGPA; Churg-Strauss) would enhance the ability to personalize treatment options and improve…
  • Abstract Number: 1775 • 2017 ACR/ARHP Annual Meeting

    The Utility of the ACR/EULAR 2017 Provisional Classification Criteria for Granulomatosis with Polyangiitis in Korean Patients with Antineutrophil Cytoplasmic Antibody-Associated Vasculitis

    Juyoung Yoo, Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea, Seoul, Korea, Republic of (South)

    Background/Purpose:  We applied the ACR/ EULAR 2017 provisional classification criteria for granulomatosis with polyangiitis (GPA) to 150 Korean patients with previously diagnosed Antineutrophil cytoplasmic antibody…
  • Abstract Number: 1776 • 2017 ACR/ARHP Annual Meeting

    Adverse Events for Discontinuation of Immunosuppressants and Outcome of Their Re-Administration in Patients with Antineutrophil Cytoplasmic Antibody-Associated Vasculitis: A Single Center Study in Japan

    Takamasa Murosaki, Takeo Sato, Yoichiro Akiyama, Katsuya Nagatani and Seiji Minota, Department of Internal Medicine, Division of Rheumatology/Clinical Immunology, Jichi Medical University, Shimotsuke, Japan

    Background/Purpose: The combination of immunosuppressants and glucocorticoid is recommended for the treatment of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). However, adverse events of immunosuppressants sometimes…
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