Abstract Number: 2051 • 2018 ACR/ARHP Annual Meeting
Rheumatoid Factor Peptide Expression By Quantitative Proteomics Delineates Responsive and Resistant Clones after Treatment of Early Rheumatoid Arthritis
Background/Purpose: Rheumatoid factors (RFs) are associated with disease activity and joint damage in rheumatoid arthritis (RA) and thought to play a pathogenic role in disease.…Abstract Number: 2052 • 2018 ACR/ARHP Annual Meeting
Immune Therapy of Rheumatoid Arthritis Patients with a Microbiome-Derived, Self/Non-Self Peptide Induces Clinically Relevant Immune Tolerance Pivoting on Immune Checkpoint-Expressing, Therapy-Induced Tregs
Background/Purpose: We have previously reported in patients with RA abnormal inflammatory T cell responses to an E. coli peptide (dnaJP1) which shares homology with the…Abstract Number: 2053 • 2018 ACR/ARHP Annual Meeting
Global Mirna Expression and Transcriptomic Profiling of Monocytes from RA Patients
Background/Purpose: Infiltration of the synovium by mononuclear cells, including monocytes, is one of the main features of RA. Monocytes are the first immune cells which…Abstract Number: 2054 • 2018 ACR/ARHP Annual Meeting
In Rheumatoid Arthritis, Changes in Autoantibody Levels Do Not Associate with Treatment Response, but Are a Reflection of Treatment Intensity
Background/Purpose: Rheumatoid arthritis (RA) is characterized by the presence of autoantibodies like rheumatoid factor (RF), anti-cyclic citrullinated peptide-2 (anti-CCP2), & anti-carbamylated protein (anti-CarP) antibodies. It…Abstract Number: 2055 • 2018 ACR/ARHP Annual Meeting
Laser Capture Microdissection to Interrogate B Cells in RA Synovial Tissue
Background/Purpose: Rheumatoid arthritis is an autoimmune disease characterized by immune cell infiltration in synovial tissue and progressive bone damage. B cells are abundant in the…Abstract Number: 2056 • 2018 ACR/ARHP Annual Meeting
Citrullination Is Not a Determinant in the Lack of Tolerance to Peptidylarginine Deiminase 2 and 4 in Rheumatoid Arthritis
Background/Purpose: Peptidylarginine deiminase (PAD) 2 and 4 are targets of the humoral response in RA. However, the mechanisms by which these enzymes become immunogenic in…Abstract Number: 2057 • 2018 ACR/ARHP Annual Meeting
Alterations of the Splicing Machinery in Leukocyte Subsets of Rheumatoid Arthritis Patients Modulate Their Inflammatory, Autoimmune and Atherothrombotic Profiles
Background/Purpose: 1) To identify and characterize the alterations present in the splicing machinery in leukocyte subsets of Rheumatoid Arthritis (RA) patients, and 2) To evaluate…Abstract Number: 2058 • 2018 ACR/ARHP Annual Meeting
Effects of Fatty Acid Supplementation in Modulation of Gut Microbiome and T-Regulatory Cells in Health and Psoriatic Disease
Background/Purpose: Psoriatic Arthritis (PsA) affects up to 30% patients with psoriasis and is characterized by widespread synovio-entheseal inflammation. Physiologically, the human gut microbiota metabolizes dietary…Abstract Number: 2059 • 2018 ACR/ARHP Annual Meeting
Inhibition of the Transcription Factor That Drives IL-17 Expression Suppresses Inflammation, Joint Damage, and New Bone Formation in Experimental Spondyloarthritis in HLA-B27 Transgenic Rats
Background/Purpose: The IL-17 axis has been identified as a central pathway in SpA pathogenesis. Targeting this axis in AS and PsA significantly suppresses inflammation and…Abstract Number: 2060 • 2018 ACR/ARHP Annual Meeting
Comparative Histologic and Molecular Analysis of Synovial Tissue in Early Treatment-Naïve Psoriatic and Rheumatoid Arthritis
Background/Purpose: Rheumatoid Arthritis (RA) and Psoriatic Arthritis (PsA) are chronic joint conditions characterised by persistent inflammation of the synovial tissue (ST). Previous reports suggested less…Abstract Number: 2061 • 2018 ACR/ARHP Annual Meeting
Genome-Wide DNA Methylation Analysis in Ankylosing Spondylitis
Background/Purpose: Ankylosing spondylitis is a chronic inflammatory disease characterized by inflammation of the sacroiliac joints and the spine leading to significant immobility. A subset of…Abstract Number: 2062 • 2018 ACR/ARHP Annual Meeting
Omentin-1: Potential Biomarker of Cardiovascular Risk in Axial Spondyloarthritis? a Serological and Genetic Study
Background/Purpose: Cardiovascular (CV) disease (mainly due to accelerated atherosclerosis) is one of the main causes of mortality in axial spondyloarthritis (axSpA). The higher incidence of…Abstract Number: 2063 • 2018 ACR/ARHP Annual Meeting
Early Injection of TNF Inhibitor Prevents Spinal Inflammation and Deformity in Curdlan-Induced Spondyloarthritis Animal Model
Background/Purpose: TNF inhibitors are highly efficient in controlling disease activity and improving functional outcomes as well as quality of life in most ankylosing spondylitis patients;…Abstract Number: 2064 • 2018 ACR/ARHP Annual Meeting
Aberrant Distribution and Function of Plasmacytoid Dendritic Cells in Patients with Ankylosing Spondylitis Are Associated with Unfolded Protein Response
Background/Purpose: Although human leukcocyte antigen (HLA)-B27 is strongly associated with ankylosing spondylitis (AS) and HLA-B27 misfolding induces unfolded protein response (UPR), whether UPR is associated…Abstract Number: 2065 • 2018 ACR/ARHP Annual Meeting
Blockade of the JAK/STAT Pathway Inhibits Inflammation and Bone Formation in Two Murine Models of Spondyloarthritis
Background/Purpose: Spondyloarthritis (SpA) results in significant pain and loss of function due to inflammation and resulting enthesial/periosteal bone formation. Inhibition of the Janus kinase (JAK)/STAT…
ACR Meeting Abstracts