Abstracts Archive - Page 1320 of 2425 - ACR Meeting Abstracts

Abstract Number: 1717 • 2017 ACR/ARHP Annual Meeting
Skin Commensal Bacteria Might Affect Wound Repair in SSc By Preventing Fibroblast Activation and By Provoking Chronic Inflammatory Reaction
Masaya Yokota¹, Janine Schniering¹, Oliver Distler² and Britta Maurer³, ¹Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, Switzerland, Zurich, Switzerland, ²Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ³Department of Rheumatology, Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland
Background/Purpose: Chronic digital ulcers (DU) due to peripheral microangiopathy are a major complication in systemic sclerosis (SSc). Chronic wounds are often enriched in bacteria without…
Abstract Number: 1718 • 2017 ACR/ARHP Annual Meeting
The Role and Function of Monocyte-Derived Fibroblast-like Cells in Multi-Organ Fibrosis in Systemic Sclerosis
Michal Rudnik¹, Mara Stellato¹, Vincent Milleret², Przemyslaw Blyszczuk^1,3, Britta Maurer¹, Karin Klingel⁴, Joerg C. Henes⁵, Karl Sotlar⁶, Martin Ehrbar², Oliver Distler⁷ and Gabriela Kania¹, ¹Department of Rheumatology, Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland, ²Department of Obstetrics, University Hospital Zurich, Zurich, Switzerland, ³Department of Clinical Immunology, Jagiellonian University Medical College, Krakow, Poland, ⁴Department of Molecular Pathology, University Hospital Tuebingen, Tuebingen, Germany, ⁵Department of Internal Medicine II, Division of Rheumatology, University Hospital Tuebingen, Tuebingen, Germany, ⁶Institute of Pathology, Ludwig Maximilians University, Munich, Germany, ⁷Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland
Background/Purpose: Animal studies indicated bone marrow-derived cells as a source of pathological myofibroblasts in fibrosis of multiple organ including lungs, heart, skin and kidney. Monocytes…
Abstract Number: 1719 • 2017 ACR/ARHP Annual Meeting
Accelerated Wound Healing in Megakaryocyte/Platelet-Specific Fli1 Knockout Mice Due to the up-Regulated Expression of Interferon-γ
Megumi Hirabayashi¹, Yoshihide Asano², Takashi Yamashita¹, Ryosuke Saigusa¹, Shunsuke Miura³, Kouki Nakamura¹, Takuya Miyagawa¹, Takashi Taniguchi¹, Ayumi Yoshizaki¹ and Shinichi Sato⁴, ¹Dermatology, University of Tokyo, Graduate School of Medicine, Tokyo, Japan, ²Applied Chemistry, University of Tokyo, Graduate School of Medicine, Tokyo, Japan, ³University of Tokyo, Graduate School of Medicine, Tokyo, Japan, ⁴Department of Dermatology, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Japan
Background/Purpose: Fli1 deficiency, a potential predisposing factor of systemic sclerosis (SSc), induces SSc-like phenotypes in dermal fibroblasts, endothelial cells, keratinocytes, and macrophages. However, it is…
Abstract Number: 1720 • 2017 ACR/ARHP Annual Meeting
TGF-ß-Induced Tissue Fibrosis in TBRIcaCol1Cre Transgenic Mice Is Abrogated By the Second Generation Tyrosine Kinase Inhibitor SKI-606 (Bosutinib)
Peter J. Wermuth and Sergio A. Jimenez, Jefferson Institute of Molecular Medicine, Division of Connective Tissue Diseases and Scleroderma Center, Thomas Jefferson University, Philadelphia, PA
Background/Purpose: Bosutinib (SKI-606), a second-generation tyrosine kinase inhibitor that blocks the activity of the BCR-ABL kinase responsible for Philadelphia chromosome positive chronic myeloid leukemias, also…
Abstract Number: 1721 • 2017 ACR/ARHP Annual Meeting
Long Noncoding RNA H19X Is a Key Regulator of Apoptosis and Proliferation of Fibroblasts in Systemic Sclerosis and Other TGFβ-Driven Fibrotic Diseases
Elena Pachera¹, Adam Wunderlin¹, Shervin Assassi², Gloria Salazar², Mojca Frank Bertoncelj¹, Rucsandra Dobrota¹, Matthias Brock³, Carol A. Feghali-Bostwick⁴, Gerard Dijkstra⁵, Gerhard Rogler⁶, Tobias van Haaften Wouter⁶, Jörg Distler⁷, Gabriela Kania¹ and Oliver Distler¹, ¹Department of Rheumatology, Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland, ²Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, ³Department of Pulmonology, University Hospital Zurich, Zurich, Switzerland, ⁴Division of Rheumatology and Immunology, Division of Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC, United States, Charleston, SC, ⁵Department of Gastroenterology and Hepatology, University Medical Center Groningen, Groningen, Switzerland, ⁶Department of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland, ⁷Internal Medicine 3, University of Erlangen, Erlangen, Germany
Background/Purpose: Long noncoding RNAs (lncRNAs) are a class of transcripts regulating gene expression. We have recently identified a novel lncRNA, H19X, which was upregulated in…
Abstract Number: 1722 • 2017 ACR/ARHP Annual Meeting
Identification of a Sub-Population of Autoantibodies Targeting BICD2 Cross-Reacting with CENP-a Derived Peptides in Patients with Systemic Sclerosis
Michael Mahler¹, Chelsea Bentow¹, Jay Milo¹, May Choi², Mianbo Wang³, Petra Budde⁴, Murray Baron⁵, Marie Hudson⁶ and Marvin J. Fritzler⁷, ¹Research and Development, Inova Diagnostics, San Diego, CA, ²University of Calgary, Calgary, AB, Canada, ³Lady Davis Institute for Medical Research, Montreal, QC, Canada, ⁴Protagen AG, Dortmund, Germany, ⁵Rheumatology, Jewish General Hospital, Montreal, QC, Canada, ⁶Division of Rheumatology, Jewish General Hospital, Lady David Institute for Medical Research, Montreal, QC, Canada, ⁷Medicine, University of Calgary, Calgary, AB, Canada
Background/Purpose: Anti-nuclear antibodies (ANA) are present in approximately 90% of sera from systemic sclerosis (SSc) patients and play an important role in the diagnosis and…
Abstract Number: 1723 • 2017 ACR/ARHP Annual Meeting
Nuclear Magnetic Resonance Based Metabolomics Study Identifies Highly Discriminatory Metabolites in 87 Systemic Sclerosis Patients
Sakir Ahmed¹, Mohit Kumar Rai¹, Durgesh Dubey², Atul Rawat³, Dinesh Kumar³, Durga Prasanna Misra¹ and Vikas Agarwal¹, ¹Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India, ²Centre for Biomedical Research, PhD Student, Lucknow, India, ³Centre for Biomedical Research, Lucknow, India
Nuclear Magnetic Resonance based Metabolomics Study Identifies Highly Discriminatory Metabolites in 87 Systemic Sclerosis Patients Background/Purpose: Proton based Nuclear Magnetic Resonance (1H NMR) can identify…
Abstract Number: 1724 • 2017 ACR/ARHP Annual Meeting
Metabolic Regulation of Fibrosis in Systemic Sclerosis: The CD38-NAD+ Link
Bo Shi¹, Wenxia Wang¹, Jun Wei², Swati Bhattacharyya¹, Benjamin Korman³, Eduardo Chini⁴ and John Varga⁵, ¹Northwestern University, Chicago, IL, ²Northwestern University, chicago, IL, ³Department of Rheumatology, Northwestern University, Feinberg School of Medicine Scleroderma Program, Chicago, IL, ⁴Kogod Center on Aging, Mayo Clinic, Rochester, MN, ⁵Rheumatology and Dermatology, Northwestern University, Feinberg School of Medicine Scleroderma Program, Chicago, IL
Background/Purpose: The anti-aging deacetylase enzymes SIRT1 and SIRT3 show potent anti-fibrotic activity, and their expression and function are markedly deregulated in patients with systemic sclerosis…
Abstract Number: 1725 • 2017 ACR/ARHP Annual Meeting
Insulin-like Growth Factor Binding Protein-4 Exerts Anti-Fibrotic Effects and Its Levels Are Reduced in SSc-Associated Lung Fibrosis
Yunyun Su¹, Stanley Hoffman² and Carol A. Feghali-Bostwick³, ¹Medicine, Division of Rheumatology and Immunology, Medical University of South Carolina, charleston, SC, ²Division of Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC, ³Division of Rheumatology and Immunology, Division of Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC, United States, Charleston, SC
Background/Purpose: The Insulin-like growth factor (IGF) system plays an important role in cellular growth, proliferation, differentiation, apoptosis and transformation; IGF binding proteins (IGFBP) exert cell…
Abstract Number: 1726 • 2017 ACR/ARHP Annual Meeting
Human Skin in Organ Culture As an Ex Vivo Model for Assessing the Fibrotic Effects of Bleomycin
Tomoya Watanabe¹, Logan Mlakar², Jonathan Heywood³, Maya Malaab² and Carol A. Feghali-Bostwick⁴, ¹Rheumatology, Medical University of South Carolina, Charleston, SC, ²Medical University of South Carolina, Charleston, SC, ³Rheumataology, Medical University of South Carolina, Chareston, SC, ⁴Division of Rheumatology and Immunology, Division of Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC, United States, Charleston, SC
Background/Purpose: Systemic sclerosis (SSc) is a connective tissue disease of unknown etiology. Using human skin as an ex vivo organ model of fibrosis is an…
Abstract Number: 1727 • 2017 ACR/ARHP Annual Meeting
Genome-Wide DNA Methylation Analysis in Systemic Sclerosis Reveals Hypomethylation of Interferon-Associated Genes in CD4+ and CD8+ T Cells
Weilin Pu¹, Weifeng Ding², Lei Wang³, Shuai Jiang⁴, Wenzhen Tu³, Shicheng Guo⁵, Qingmei Liu⁶, Yanyun Ma⁴, Sidi Chen⁷, Wenyu Wu⁶, Xiaodong Zhou⁸, Maureen D. Mayes⁹, Shervin Assassi⁹, John D. Reveille⁹, Li Jin¹⁰ and Jiucun Wang¹⁰, ¹State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences,, State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai, China, Shanghai, China, ²Medical Laboratory Center, Medical Laboratory Center, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, China, Nantong, China, ³Division of Rheumatology, Division of Rheumatology, Shanghai TCM-integrated Hospital, Shanghai, China, Shanghai, China, ⁴Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, China, Shanghai, China, ⁵Department of Bioengineering, Department of Bioengineering, University of California at San Diego, CA, USA, San Diego, CA, ⁶Department of Dermatology, Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, China, Shanghai, China, ⁷State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences,, State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai, China, Shanghai, China, ⁸Internal Medicine-Rheumatology, University of Texas McGovern Medical School, Houston, TX, ⁹University of Texas McGovern Medical School, Houston, TX, ¹⁰State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai, China, Shanghai, China
Background/Purpose: Systemic sclerosis (SSc) is a complex systemic autoimmune disease caused by complicated interaction between genetic, epigenetic and environmental risk factors. Evidence showed epigenetic modifications,…
Abstract Number: 1728 • 2017 ACR/ARHP Annual Meeting
Interferon Gamma (IFN-γ) Subpopulations in Skin Homing T Cells of Localized Scleroderma
Claudia Macaubas¹, Emily Mirizio², Kaila Schollaert-Fitch³, Elizabeth D. Mellins⁴ and Kathryn S. Torok³, ¹Department of Pediatrics, Program in Immunology, Stanford University Med Ctr, Stanford, CA, ²Pediatric Rheumatology, Univ of Pittsburgh Med Ctr, Pittsburgh, PA, ³Pediatric Rheumatology, University of Pittsburgh Med Ctr, Pittsburgh, PA, ⁴Dept of Pediatrics CCSR, Stanford University Med Ctr, Stanford, CA
Background/Purpose: Localized scleroderma (LS) has both inflammatory and fibrotic components contributing to its effect on the skin and underlying tissue. The understanding of the pathophysiology…
Abstract Number: 1729 • 2017 ACR/ARHP Annual Meeting
Increased Serum Levels of Micro-RNA 30d and Micro-RNA 423-5p in 2 Independent Cohorts of Patients with Morphea
Jorre S. Mertens^1,2, Wiola Marut¹, Cornelis P.J. Bekker¹, Elke M.G.J. de Jong³ and Timothy R.D.J. Radstake^1,4, ¹Rheumatology and Clinical Immunology, Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ²Department of Dermatology, Radboud University Medical Center, Nijmegen, Netherlands, ³Radboud University Medical Center, Nijmegen, Netherlands, ⁴Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands
Background/Purpose : Morphea, also known as localized scleroderma, encompasses a group of idiopathic sclerotic skin diseases. MicroRNAs (miRNAs) are a large family of highly conserved…
Abstract Number: 1730 • 2017 ACR/ARHP Annual Meeting
IL-6 Mediates Activation of Macrophages in Patients with Systemic Sclerosis
Rajan Bhandari¹, Michael Ball², Viktor Martyanov³, Dillon Popovich⁴, Mary A. Carns⁵, Kathleen Aren⁵, Monique Hinchcliff⁶, Michael L. Whitfield⁷ and Patricia A. Pioli⁸, ¹Geisel School of Medicine at Dartmouth, lebanon, NH, ²Geisel School of Medicine at Dartmouth, Lebanon, NH, ³Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, ⁴Geisel School of Medicine at Dartmouth, hanover, NH, ⁵Northwestern University, Feinberg School of Medicine Scleroderma Program, Chicago, IL, ⁶Rheumatology, Northwestern Medicine, Chicago, IL, ⁷Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, ⁸Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, NH
Background/Purpose: Activated macrophages (MØs) have been implicated as regulators of fibrosis in patients with systemic sclerosis (SSc), and we have shown that MØs from SSc…
Abstract Number: 1731 • 2017 ACR/ARHP Annual Meeting
Abnormal Responses of γδ T Cell Subsets to Stimulation with Cardiolipin and Zoledronate in Systemic Sclerosis
Ilan Bank¹, Paul Fisch², Jose Villacorta Hidalgo³, Alexandra Balbir-Gurman⁴, Yolanda Braun-Moscovici⁵ and Helena Migalovich Sheikhet⁶, ¹Medicine, Maayenei Hayeshuah and Chaim Sheba Medical Center, Israel, Bnei Brak, Israel, ²3Department of Clinical Pathology, University of Freiburg Medical Center, Freiburg, Germany, ³Department of Clinical Pathology, University of Freiburg Medical Center, Freiburg, Germany, ⁴Rheumatology Unit, Rambam Health Care Campus, Rappaport Faculty of Medicine, Technion, Haifa, Israel, Haifa, Israel, ⁵B Shine Department of Rheumatology, Rambam Health Care Campus,. Rappaport Faculty of Medicine, Technion, Haifa, Israel, ⁶Medicine, Laboratory of Immunoregulation, Chaim Sheba Medical Center, Ramat Gan, Israel
Background/Purpose: Systemic sclerosis (SSc) is an auto-immune disorder leading to destructive tissue fibrosis. Abnormal responses of SSc T cells to lipid antigens and low molecular…

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