Abstract Number: 1672 • 2017 ACR/ARHP Annual Meeting
Cytokines and Autoantibody Cluster-Interaction in Systemic Lupus Erythematosus. a Systems Medicine Approach
Background/Purpose: Evidence supports the existence of different sub-phenotypes and the pivotal role of cytokines and autoantibodies in systemic lupus erythematosus (SLE). Cytokines interact in a…Abstract Number: 1673 • 2017 ACR/ARHP Annual Meeting
Human C4 Gene Copy Number Influences Cell-Bound Complement Activation Product (CB-CAP) C4d in Systemic Lupus Erythematosus
Background/Purpose: Human complement C4 protein is the product of two isotypic genes C4A and C4B that are located on chromosome 6 in various copy numbers.…Abstract Number: 1674 • 2017 ACR/ARHP Annual Meeting
Combining Medications That Lower Systemic Oxidative Stress Is Associated with Less Atherosclerosis in Systemic Lupus Erythematosus
Background/Purpose: No single medication has been demonstrated as effective in reducing atherosclerosis or cardiovascular events in systemic lupus erythematosus (SLE), possibly due to the…Abstract Number: 1675 • 2017 ACR/ARHP Annual Meeting
SLE Comprises Four Immune-Phenotypes, Which Differ Regarding HLA-DRB1 and Clinical Associations
Background/Purpose: SLE is a remarkably heterogeneous disease including diverging clinical symptoms, autoantibodies and genetic susceptibility. Hitherto unrecognized patterns may define sub-phenotypes with different pathogenesis and…Abstract Number: 1676 • 2017 ACR/ARHP Annual Meeting
Improving Sensitivity to Change of the Modified Rodnan Skin Score over Time
Background/Purpose: The Modified Rodnan Skin Score (MRSS) assesses global dermal thickness through the examination of 17 body areas scored by clinical palpation using a 4…Abstract Number: 1677 • 2017 ACR/ARHP Annual Meeting
Low Baseline Impedance in Proximal Esophagus and Decreased Pspw Index May Related with Pathogenesis of Interstitial Lung Disease in Systemic Sclerosis
Background/Purpose: Interstitial lung disease (ILD) is a common but fatal complication of systemic sclerosis (SSc). Gastroesophageal reflux disease (GERD) may be related to pathogenesis of…Abstract Number: 1678 • 2017 ACR/ARHP Annual Meeting
Pathogenic Mechanisms of Esophageal Peristaltic Dysfunction By High Resolution Manometry in Patients with Systemic Sclerosis
Background/Purpose: Pathogenic mechanisms of esophageal involvement in systemic sclerosis (SSc) were suggested as neural dysfunction due to impairment of microcirculation to intramural neuron in early…Abstract Number: 1679 • 2017 ACR/ARHP Annual Meeting
Different Cut-Offs for Renal Resistive Index Reflect Renal and Other Organ Involvement and Predict Worsening in SSc Patients
Background/Purpose: Renal Resistive Index (RRI), measured by Doppler ultrasound, reflects changes in both renal vascular and tubular-interstitial compartments and systemic vascular compliance related to age…Abstract Number: 1680 • 2017 ACR/ARHP Annual Meeting
Higher Baseline Monocyte Count Is Associated with More Extensive Skin Involvement and Higher Mortality in Systemic Sclerosis
Background/Purpose: Macrophages are the primary inflammatory cell type present in the systemic sclerosis (SSc) skin. Circulating monocytes can give rise to profibrotic inflammatory cells such…Abstract Number: 1681 • 2017 ACR/ARHP Annual Meeting
An Evaluation of Two Novel Techniques Utilising a Smartphone Digital Camera in the Assessment of Nailfold Capillaries in Suspected Scleroderma-Spectrum Disorders: A Single-Center Cross-Sectional Study
Background/Purpose: Nailfold capillaroscopy is a non-invasive, sensitive and specific technique used in the diagnosis of scleroderma-spectrum disorders. Abnormalities predict progression from Raynauds phenomenon to connective…Abstract Number: 1682 • 2017 ACR/ARHP Annual Meeting
Significance of Anti-Topoisomerase I Antibodies in Routine Clinical Testing
Background/Purpose: The 2013 classification criteria for systemic sclerosis (SSc) provide 3 points (towards a 9 point diagnosis) for patients who have an anti-topoisomerase I (anti-Scl-70)…Abstract Number: 1683 • 2017 ACR/ARHP Annual Meeting
Smoking Behaviour and the Progression of Organ Manifestations in Systemic Sclerosis: A Longitudinal European Scleroderma Trials and Research Group Study
Background/Purpose: Systemic sclerosis (SSc) is a rare, multisystem autoimmune disorder. It is characterized by generalized microangiopathy, in the pathogenesis of which hypoxia and oxidative stress…Abstract Number: 1684 • 2017 ACR/ARHP Annual Meeting
Effectiveness and Safety of Tacrolimus Following Intravenous Cyclophosphamide Pulse Therapy As the Treatment of Systemic Sclerosis-Associated Interstitial Lung Disease
Background/Purpose: Systemic sclerosis (SSc) is the disease characterized by organ fibrosis with unknown etiology, and pulmonary involvement is one of major cause of death. However,…Abstract Number: 1685 • 2017 ACR/ARHP Annual Meeting
Factors Associated with the 6-Minute Walk Distance in Patients with Systemic Sclerosis
Background/Purpose: To assess the associations between the 6-minute walk distance (6MWD) and various disease parameters in patients with systemic sclerosis (SSc). Methods: Consecutive patients followed…Abstract Number: 1686 • 2017 ACR/ARHP Annual Meeting
Topical Nitroglycerine (NTG) Vs Matching Vehicle in Secondary Raynaud Phenomenon (RP) – a Double-Blind Crossover Study of Subjective and Physiologic Responses to Controlled Cold Challenge
Background/Purpose: A topical therapy for either prevention or palliation of attacks would offer unique advantages to selected patients with Raynaud phenomenon (RP). This study used…
ACR Meeting Abstracts