Date: Monday, November 6, 2017
Session Type: ACR Poster Session B
Session Time: 9:00AM-11:00AM
To assess the associations between the 6-minute walk distance (6MWD) and various disease parameters in patients with systemic sclerosis (SSc).
Consecutive patients followed in our SSc National Reference Centre were included in this cross-sectional study if they fulfilled the 2013 ACR/EULAR criteria for SSc. Data were prospectively collected during a comprehensive evaluation that included a 6-minute walk test, clinical assessment, biological results, pulmonary function tests, transthoracic echocardiography, composite scores (EScSG-AI, Medsger, HAQ-DI) and treatments.
Associations of the 6MWD with various disease parameters were assessed by linear regression in univariate analyses, then in several multivariate models.
The study population comprised 298 patients (females: 81%; mean age: 58.2 ± 13.3 years old; limited cutaneous SSc: 82%; interstitial lung disease (ILD): 42%; pulmonary arterial hypertension (PAH): 6%). The 6MWD was significantly and independently associated with gender, age, initial heart rate, heart rate variation during the test, PAH and CRP levels. Muscle involvement, joint involvement and ILD were not independently associated with the 6MWD.
During SSc, the 6MWD is independently associated with heart rate variation (possibly implying a role for chronotropic incompetence in exercise intolerance), with PAH but not ILD (suggesting that pulmonary vasculopathy may have a greater impact than parenchymal involvement on functional limitation), and with global markers of disease activity. These results give further insight to clinicians on how to interpret the 6MWD in the context of SSc.
To cite this abstract in AMA style:Sanges S, Giovannelli J, Sobanski V, Podevin C, Dubois-Morell S, Maillard H, Lambert M, Lamblin N, De Groote P, Bervar JF, Hatron PY, Hachulla E, Launay D. Factors Associated with the 6-Minute Walk Distance in Patients with Systemic Sclerosis [abstract]. Arthritis Rheumatol. 2017; 69 (suppl 10). https://acrabstracts.org/abstract/factors-associated-with-the-6-minute-walk-distance-in-patients-with-systemic-sclerosis/. Accessed September 24, 2021.
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ACR Meeting Abstracts - https://acrabstracts.org/abstract/factors-associated-with-the-6-minute-walk-distance-in-patients-with-systemic-sclerosis/