Abstracts Archive - Page 1303 of 2607 - ACR Meeting Abstracts

Abstract Number: 1750 • 2018 ACR/ARHP Annual Meeting
Rheumatoid Factor Titer Is Inversely Correlated with ANCA Titer and Relates to Characteristic Manifestations in Patients with Eosinophilic Granulomatosis with Polyangiitis
Jun Inamo, Yuko Kaneko, Yuichiro Ota and Tsutomu Takeuchi, Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
Background/Purpose: Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), which is characterized by vasculitis with allergic features such as…
Abstract Number: 1751 • 2018 ACR/ARHP Annual Meeting
Interstitial Lung Disease during ANCA-Associated Vasculitis: A Poor-Prognosis Factor
Thibault Maillet¹, Tiphaine Goletto², Guillaume Beltramo³, Henry Dupuy⁴, Stéphane Jouneau⁵, Raphaël Borie⁶, Bruno Crestani⁶, Vincent Cottin⁷, Daniel Blockmans⁸, Estibaliz Lazaro⁴, Jean-Marc Naccache⁹, Grégory Pugnet¹⁰, Hilario Nunes¹¹, Mathilde De Menthon¹², Hervé Devilliers¹³, Philippe Bonniaud³, Xavier Puéchal¹⁴, Luc Mouthon¹⁴, Bernard Bonnotte¹, Loïc Guillevin¹⁵, Benjamin Terrier¹⁴ and Maxime Samson¹, ¹Service de Médecine Interne et Immunologie Clinique, CHU de Dijon, Dijon, France, ²Service de Pneumologie, Hôpital Saint-Louis, APHP, Paris, France, ³Service de Pneumologie, CHU de Dijon, Dijon, France, ⁴Service de Médecine Interne et Maladies Infectieuses, Hôpital Haut-Lévêque, Bordeaux, France, ⁵Service de Pneumologie, CHU de Rennes; IRSET UMR 1085, Université de Rennes 1, Rennes, France, ⁶Service de Pneumologie, Hôpital Bichat, APHP, Paris, France, ⁷Service de Pneumologie, Hôpital Louis-Pradel, Bron, France, ⁸Rheumatology, UZ Leuven, Leuven, Belgium, ⁹Service de Pneumologie, Hôpital Tenon, APHP, Paris, France, ¹⁰Service de Médecine Interne, CHU de Toulouse, Toulouse, France, ¹¹Pulmonary diseases department, Avicenne Hospital (AP-HP), Bobigny, France, ¹²Service de Médecine Interne, Hôpital Bicêtre, APHP, Le Kremlin-Bicêtre, France, ¹³Service de Médecine Interne et Maladies Systémiques, CHU de Dijon, Dijon, France, ¹⁴Centre de Référence des Maladies Auto-immunes et Systémiques Rares, Vascularites Nécrosantes et Sclérodermie Systémique, Service de Médecine Interne, Hôpital Cochin, APHP, INSERM U1016, Université Paris Descartes, Paris, France, ¹⁵Department of Internal Medicine, INSERM Unité 1016, Centre de Référence pour les Maladies Auto-immunes Rares, National Referral Center for Rare Systemic Autoimmune Diseases, Paris Cochin, France, Paris, France
Background/Purpose: Interstitial lung disease (ILD), rarely described in ANCA-associated vasculitis (AAV) patients, was mainly associated with anti-MPO ANCA. ILD’s prognostic value remains unclear. This study…
Abstract Number: 1752 • 2018 ACR/ARHP Annual Meeting
Asthma in Eosinophilic Granulomatosis with Polyangiitis Treated with Rituximab
Marta Casal Moura¹, Alvise Berti², Karina Keogh², Gerald Volcheck³, Ulrich Specks⁴ and Misbah Baqir⁵, ¹Pulmonary and Critical Care, Thoracic Disease Research Unit, Mayo Clinic College of Medicine, Rochester, MN, ²Pulmonary and Critical Care, Mayo Clinic College of Medicine, Rochester, MN, ³Allergic Diseases, Internal Medicine Department, Mayo Clinic College of Medicine, Rochester, MN, ⁴Mayo Clinic College of Medicine, Rochester, MN, ⁵Pulmonary/Critical Care, Mayo Clinic College of Medicine, Rochester, MN
Background/Purpose: Eosinophilic Granulomatosis with Polyangiitis (EGPA) is a rare systemic small-vessel necrotizing vasculitis presenting with asthma and eosinophilia. Anti-neutrophil cytoplasmic antibodies (ANCA) association may influence…
Abstract Number: 1753 • 2018 ACR/ARHP Annual Meeting
Interstitial Lung Disease in ANCA-Associated Vasculitis Defines a Unique Subgroup of Patients at High Risk for Respiratory Death: A Cluster Analysis
Zachary Wallace¹, Yuqing Zhang², John H. Stone³ and Hyon K. Choi⁴, ¹Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ²Department of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Boston, MA, ³Home Address, Sudbury, MA, ⁴Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Boston, MA
Background/Purpose: ANCA-associated vasculitis (AAV) has a propensity for heterogeneous organ involvement. ANCA specificity has increasingly been favored over clinical diagnosis (e.g., microscopic polyangiitis) for subgrouping…
Abstract Number: 1754 • 2018 ACR/ARHP Annual Meeting
Clinical and Economic Characteristics of Patients Diagnosed with Eosinophilic Granulomatosis with Polyangiitis (EGPA, formerly Churg-Strauss Syndrome) in the United States
Christopher F Bell¹, Matthew Lau¹ and Qin Shen², ¹GlaxoSmithKline, Research Triangle Park, NC, ²GlaxoSmithKline, Collegeville, PA
Background/Purpose: Eosinophilic granulomatosis with polyangiitis (EGPA), formerly Churg-Strauss Syndrome, is a rare, complex multisystem disorder belonging to a group of autoimmune inflammatory diseases characterized by…
Abstract Number: 1755 • 2018 ACR/ARHP Annual Meeting
Burden of Illness Associated with Eosinophilic Granulomatosis with Polyangiitis (EGPA, formerly Churg-Strauss Syndrome): Evidence from a Managed Care Database in the United States
Christopher F Bell¹, Cori Blauer-Peterson² and Jianbin Mao², ¹GlaxoSmithKline, Research Triangle Park, NC, ²Optum, Eden Prairie, MN
Background/Purpose: Eosinophilic granulomatosis with polyangiitis (EGPA), is a rare, complex multisystem disorder, characterized by vascular inflammation and multisystem organ damage. EGPA manifests as asthma, rhinosinusitis,…
Abstract Number: 1756 • 2018 ACR/ARHP Annual Meeting
Systematic Review of the Clinical Effectiveness of Treatments in Eosinophilic Granulomatosis with Polyangiitis
Scott Doyle¹, Annete Njue², Matthew Lyall², Rebecca Rushton², Anne Heyes² and Maebh Kelly³, ¹Value Evidence and Outcomes, GlaxoSmithKline, London, United Kingdom, ²RTI Health Solutions, Manchester, United Kingdom, ³Pope Woodhead, London, United Kingdom
Background/Purpose: To better understand the available clinical effectiveness data in eosinophilic granulomatosis with polyangiitis (EGPA), a systematic literature review was undertaken. The primary objective of…
Abstract Number: 1757 • 2018 ACR/ARHP Annual Meeting
An Economic Systematic Literature Review of Eosinophilic Granulomatosis with Polyangiitis
Scott Doyle¹, Emily Moss², Louise Hartley², Chris Knight², Judith Bell², Outi Ahdesmäki² and Maebh Kelly³, ¹Value Evidence and Outcomes, GlaxoSmithKline, London, United Kingdom, ²RTI Health Solutions, Manchester, United Kingdom, ³Pope Woodhead, London, United Kingdom
Background/Purpose: To better understand the available economic evaluations in eosinophilic granulomatosis with polyangiitis (EGPA), a systematic literature review was undertaken. The primary objective of this…
Abstract Number: 1758 • 2018 ACR/ARHP Annual Meeting
A 24 Month Analysis of Rituximab Safety and Efficacy in Eosinophilic Granulomatosis with Polyangiitis
Vítor Teixeira^1,2, Aladdin Mohammad^1,3 and David Jayne¹, ¹Department of Medicine, University of Cambridge, Cambridge, United Kingdom, ²Rheumatology Department, CHLN - Santa Maria Hospital, Lisbon Academic Medical Center, Lisbon, Portugal, ³Rheumatology, Department of Clinical Sciences, Lund, Lund University, Lund, Sweden
Background/Purpose: Eosinophilic granulomatosis with polyangiitis (EGPA) frequently pursues a refractory course leading to high glucocorticoid exposure and toxicity. A previous retrospective study found rituximab (RTX)…
Abstract Number: 1759 • 2018 ACR/ARHP Annual Meeting
Eosinophilic Granulomatosis with Polyangiitis: A Monocentric Cohort Analysis of Manifestations and Relapses of ANCA-Positive and ANCA-Negative Patients
Juliane Mahrhold¹, Bernhard Hellmich² and Elena Csernok², ¹Rheumatology, Klinik für Innere Medizin, Rheumatologie und Immunologie. Vaskulitis Zentrum Süd, medius KLINIK Kirchheim, Akademisches Lehrkrankenhaus der Universität Tübingen, Kirchheim unter Teck, Germany, ²Klinik für Innere Medizin, Rheumatologie und Immunologie. Vaskulitis Zentrum Süd, medius KLINIK Kirchheim, Akademisches Lehrkrankenhaus der Universität Tübingen, Kirchheim unter Teck, Germany
Background/Purpose: To compare clinical features at diagnosis, relapse rates, therapy as well as long-term outcome of a cohort of patients with Eosinophilic Granulomatosis with Polyangiitis…
Abstract Number: 1760 • 2018 ACR/ARHP Annual Meeting
Fungal Composition of the Nasal Mucosa in Patients with Granulomatosis with Polyangiitis
Rennie L. Rhee¹, Antoine G. Sreih¹, Catherine E. Najem², Peter C. Grayson³, Chunyu Zhao⁴, Kyle Bittinger⁴, Ronald Collman⁵ and Peter A. Merkel⁶, ¹Rheumatology, Division of Rheumatology, University of Pennsylvania, Philadelphia, PA, ²Rheumatology, University of Pennsylvania, Philadelphia, PA, ³National Institute of Arthritis, Musculoskeletal and Skin Disease, National Institutes of Health, Bethesda, MD, ⁴Gastroenterology, Hepatology, and Nutrition, Children's Hospital of Philadelphia, Philadelphia, PA, ⁵University of Pennsylvania, Philadelphia, PA, ⁶Division of Rheumatology, Division of Rheumatology, University of Pennsylvania, Philadelphia, PA
Background/Purpose: While prior studies have demonstrated that granulomatosis with polyangiitis (GPA; Wegener’s) is associated with an altered composition of nasal bacteria and that use of…
Abstract Number: 1761 • 2018 ACR/ARHP Annual Meeting
Evaluation of the Functional Activity of Endothelial Progenitor Cells in Patients with ANCA-Associated Vasculitis
Ana Paula Toledo Del Rio¹, Stephanie Ospina Prieto¹, Bruno Kosa Lino Duarte¹, Manoel Barros Bertolo^1,2, Margareth de Castro Ozelo¹ and Zoraida Sachetto¹, ¹Internal Medicine, Faculty of Medical Science - State University of Campinas/Unicamp, Campinas, Brazil, ²INTERNAL MEDICINE, DISCIPLINE OF RHEUMATOLOGY, Faculty of Medical Sciences, State University of Campinas (UNICAMP), Campinas, Brazil
Background/Purpose: ANCA-associated vasculitis (AAV) are relapsing diseases with high morbidity and mortality. The vascular damage present in these patients requires continuous repair with the participation…
Abstract Number: 1762 • 2018 ACR/ARHP Annual Meeting
Plasma iC3b Level As a Biomarker of Disease Relapse in ANCA-Associated Vasculitis
Catherine E. Najem¹, Martin Schmidt², Chad Stiening³, David Cuthbertson⁴, Simon Carette⁵, Nader A. Khalidi⁶, Curry L. Koening⁷, Carol Langford⁸, Carol A. McAlear⁹, Paul A. Monach¹⁰, Larry W. Moreland¹¹, Christian Pagnoux¹², Philip Seo¹³, Ulrich Specks¹⁴, Antoine G. Sreih¹, Steven R. Ytterberg¹⁵ and Peter A. Merkel^16,17, ¹Rheumatology, Division of Rheumatology, University of Pennsylvania, Philadelphia, PA, ²Kypha, Inc., St. Louis, MO, ³Kypha, Inc., St Louis, MO, ⁴Biostatistics and Informatics, Department of Pediatrics, Department of Biostatistics and Informatics, Department of Pediatrics, University of South Florida, Tampa, FL, ⁵Division of Rheumatology, Mount Sinai Hospital, Toronto, ON, Canada, ⁶Rheumatology, McMaster University, Hamilton, ON, Canada, ⁷Rheumatology, Division of Rheumatology, University of Utah, Salt Lake City, UT, ⁸Rheumatic and Immunologic Diseases, Department of Rheumatic and Immunologic Diseases, Cleveland Clinic, Cleveland, OH, ⁹Division of Rheumatology, University of Pennsylvania; Perelman School of Medicine, Philadelphia, PA, ¹⁰Section of Rheumatology, Boston University School of Medicine, Boston, MA, ¹¹Division of Rheumatology and Clinical Immunology, Division of Rheumatology, University of Pittsburgh, Pittsburgh, PA, ¹²Division of Rheumatology, Division of Rheumatology, Mount Sinai Hospital, Toronto, ON, Canada, ¹³Medicine, Division of Rheumatology, Johns Hopkins University, Baltimore, MD, ¹⁴Mayo Clinic College of Medicine, Rochester, MN, ¹⁵Rheumatology, Division of Rheumatology, Mayo Clinic College of Medicine, Rochester, MN, ¹⁶Division of Rheumatology, Division of Rheumatology, University of Pennsylvania, Philadelphia, PA, ¹⁷Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, PA
Background/Purpose:C3, the central protein of the complement cascade, participates in an amplification loop that can lead to complement deposition and host tissue damage. If elevated,…
Abstract Number: 1763 • 2018 ACR/ARHP Annual Meeting
Characterizing the Gut and Plasma Metabolomes in Patients with ANCA-Associated Vasculitis
Catherine E. Najem¹, Jung-Jin Lee², Ceylan Tanes², Cassidy Strange², Elliot Friedman², Antoine G. Sreih¹, Rennie L. Rhee¹, Abdallah Geara³, Hongzhe Li⁴, Kyle Bittinger², James D. Lewis⁵, Gary Wu⁵ and Peter A. Merkel⁴, ¹Rheumatology, Division of Rheumatology, University of Pennsylvania, Philadelphia, PA, ²Division of Gastroenterology, Hepatology, and Nutrition, Children's Hospital of Philadelphia, Philadelphia, PA, ³Division of Nephrology and Hypertension, University of Pennsylvania, Philadelphia, PA, ⁴Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, PA, ⁵Division of Gastroenterology, University of Pennsylvania, Philadelphia, PA
Background/Purpose:To explore the mechanisms by which an altered gut microbiota might predispose to ANCA-associated vasculitis (AAV), a comprehensive metabolic profiling of fecal and plasma bile…
Abstract Number: 1764 • 2018 ACR/ARHP Annual Meeting
The Utility of Serum Angiopoietin-1 and Angiopoietin-2 in Patients with Anti-Neutrophil Cytoplasmic Autoantibody-Associated Vasculitis
Yoko Wada¹, Takeshi Kuroda², Masaaki Nakano³ and Ichiei Narita¹, ¹Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan, ²Health Administration Center, Niigata University, Niigata, Japan, ³Department of Medical Technology, School of Health Sciences, Faculty of Medicine, Niigata University, Niigata, Japan
Background/Purpose: Angiopoietin-1 (Ang-1) and Angiopoietin-2 (Ang-2) are antagonistic ligands which bind with similar affinity to the extracellular domain of the tyrosine kinase with Ig-like and…

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