ACR Meeting Abstracts

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  • Abstract Number: 0133 • ACR Convergence 2025

    Differences in cardiovascular risk factor control between primary and systemic lupus erythematosus-related antiphospholipid syndrome in a multiethnic cohort of 1003 patients with antiphospholipid syndrome: the SUrvey of cardiovascular disease Risk Factors (SURF) in SLE and APS project

    Eleana Bolla1, Anne Grete Semb2, Michelle Petri3, Petros Sfikakis4, Bahar Artim Esen5, Gabriela Hernandez-Molina6, Eric Hachulla7, Haner Direskeneli8, George Karpouzas9, Marta Mosca10, Mohit Goyal11, Nathalie Costedoat-Chalumeau12, Angela Tincani13, Ayten Yazici14, Karoline Lerang15, Anne Troldborg16, Sofia Ajeganova17, Tatiana Popkova18, Elisabet Svenungsson19, Nikos Pantazis20 and Maria Tektonidou21, 1Rheumatology Unit, First Department of Propaedeutic Internal Medicine, Joint Academic Rheumatology Program, Medical School, National and Kapodistrian University of Athens, Laiko General Hospital, Athens, Greece, 2Preventive Cardio-Rheuma clinic, Dept Rheum, Diakonhjemmet Hospital, Oslo, Norway, Oslo, Norway, 3Johns Hopkins University School of Medicine, Timonium, MD, 4NKUA - SCHOOL OF MEDICINE, Athens, Greece, 5Istanbul University, Istanbul, Istanbul, Turkey, 6Instituto Nacional de Ciencias Medicas y Nutricion, Mexico City, Federal District, Mexico, 7University of Lille, LILLE, France, 8Marmara University, ISTANBUL, Turkey, 9Harbor-UCLA Medical Center, Torrance, CA, 10University of Pisa, Pisa, Pisa, Italy, 11CARE Pain & Arthritis Centre, Udaipur, Rajasthan, India, 12Inserm DR Paris 5, Paris, France, 13ASST Spedali Civili-University of Brescia, Gussago, Brescia, Italy, 14Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey, 15Department of Rheumatology, Oslo University Hospital, Oslo, Norway, 16Aarhus University Hospital, Aarhus, Denmark, 17Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden, 18V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia, 19Karolinska Institutet, Stockholm, Stockholms Lan, Sweden, 20Department of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, Athens, Greece, 21National and Kapodistrian University of Athens, Athens, Greece

    Background/Purpose: Cardiovascular disease (CVD) in antiphospholipid syndrome (APS) is driven by antiphospholipid antibody-mediated immunothrombotic mechanisms and traditional cardiovascular risk factors (CVRFs). Although the EULAR recommendations…
  • Abstract Number: 0121 • ACR Convergence 2025

    The Prevalence and Clinical Significance of IgA Anticardiolipin and Anti-β2-Glycoprotein-I Antibody Isotypes in Antiphospholipid Antibody Positive Patients: Descriptive Results from the Antiphospholipid Syndrome Alliance for Clinical Trials and International Networking Registry

    Emre Sahin1, Yu (Ray) Zuo2, Danieli Andrade3, Maria Tektonidou4, Vittorio Pengo5, Massimo Radin6, Chary López pedrera7, Diana Paredes-Ruiz8, H Michael Belmont9, Paul Fortin10, Denis WAHL11, Ware Branch12, Maria Gerosa13, Guilherme Ramires de Jesus14, Tatsuya Atsumi15, Maria Efthymiou16, Angela Tincani17, Esther Rodriguez-Almaraz18, Michelle Petri19, Ricard Cervera20, Rohan Willis21, Katrien Devreese22, Maria Laura Bertolaccini23, Hannah Cohen24, Jason S. Knight2 and Doruk Erkan1, 1Hospital for Special Surgery, New York, NY, 2University of Michigan, Ann Arbor, MI, 3University of Sao Paulo, São Paulo, São Paulo, Brazil, 4National and Kapodistrian University of Athens, Athens, Greece, 5Padova University Hospital, Padova, Italy, 6University of Turin, Turin, Turin, Italy, 7Rheumatology service/Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)/ Reina Sofia University Hospital/ University of Cordoba, Spain, Cordoba, Spain, 8Biobizkaia Health Research Institute, Barakaldo, Spain, 9NYU School of Medicine, New York, NY, 10Centre ARThrite - CHU de Québec - Université Laval, Quebec, QC, Canada, 11University of Lorraine, Nancy, France, 12University of Utah Health Sciences Center, Salt Lake City, UT, 13University of Milan, Milano, Italy, 14Universidade do Estado do Rio de Janeiro, Rio De Janeiro, Rio de Janeiro, Brazil, 15Hokkaido University, Sapporo, Japan, 16University College London, London, United Kingdom, 17ASST Spedali Civili-University of Brescia, Gussago, Brescia, Italy, 18Hospital Universitario 12 de Octubre, Madrid, Spain, 19Johns Hopkins University School of Medicine, Timonium, MD, 20Hospital Clinic Barcelona, Barcelona, Spain, 21University of Texas Medical Branch, Galveston, TX, 22Ghent University, Gent, Belgium, 23King's College London, London, United Kingdom, 24University College London Hospitals NHS Foundation Trust, London, United Kingdom

    Background/Purpose: The 2023 ACR/EULAR Antiphospholipid Syndrome (APS) Classification Criteria (CC) focus on IgG and IgM anticardiolipin (aCL) and anti-β2-glycoprotein-I antibodies (aβ2GPI). IgA isotypes were excluded…
  • Abstract Number: 0149 • ACR Convergence 2025

    Effect Of Osteoporosis And Opioid Use On Mortality And Unplanned Healthcare Utilization Among Patients With Rheumatoid Arthritis

    Viengneesee Thao, Molly Moore Jeffery, Nafisseh Warner and Elena myasoedova, Mayo Clinic, Rochester, MN

    Background/Purpose: Patients with rheumatoid arthritis (RA) have a 2-fold increase in risk for osteoporosis compared to the general population. About 30-50% of RA patients experience…
  • Abstract Number: 0135 • ACR Convergence 2025

    Rituximab in Antiphospholipid Syndrome: aPL Titer Decline and Clinical Outcomes

    Omer Uludag1, Soner Altın2, Gamze Kemec2, yasemin yalcinkaya3, Ahmet Gul3, Murat Inanc3 and Bahar Artim Esen4, 1Istanbul University, Istanbul Faculty of Medicine, Division of Rheumatology, Istanbul, Turkey, 2Istanbul University, Istanbul Faculty of Medicine, Department of Internal Medicine, Istanbul, Turkey, 3Istanbul University, Istanbul Faculty of Medicine, Division of Rheumatology, Istanbul, Istanbul, Turkey, 4Istanbul University, Istanbul, Istanbul, Turkey

    Background/Purpose: Rituximab treatment has been shown to be effective in non-thrombotic manifestations of APS and refractory catastrophic APS (CAPS). However, there are conflicting results regarding…
  • Abstract Number: 0130 • ACR Convergence 2025

    Plasminogen activator inhibitor 1 increases thrombotic risk in Antiphospholipid syndrome

    Koshy Nithin Thomas1, Pratibha Singh2, Anu Balakrishnan3, Amita Aggarwal4 and Able Lawrence5, 1Christian Medical College, Vellore, Tamil Nadu, India, 2Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India, 3Sanjay Gandhi Post Graduate Institute, India, Lucknow, Uttar Pradesh, India, 4Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India, Lucknow, Uttar Pradesh, India, 5SGPGIMS, Lucknow, Lucknow, Uttar Pradesh, India

    Background/Purpose: Antiphospholipid antibody syndrome (APS) is a common cause for acquired thrombophilia. The group termed ‘seronegative’ APS has not made any headway in the revised…
  • Abstract Number: 0028 • ACR Convergence 2025

    Computational and Laboratory Identification of Risk-Driving Alleles on Juvenile Idiopathic Arthritis (JIA)-Associated Haplotypes

    Adam He1, Hannah Ainsworth2, Kaiyu Jiang3, Ekaterina Khtovatkova2, Yanmin Chen3, Carl Langefeld4, Charles G Danko1 and James N. Jarvis5, 1Cornell University Baker School of Veterinary Medicine, Ithaca, NY, 2Wake Forest University, Winston-Salem, NC, 3University of Washington School of Medicine, Seattle, WA, 4Wake Forest University School of Medicine, Winston Salem, NC, 5University of Washington Center for Indigenous Health, Seattle, WA

    Background/Purpose: Multiple genomic regions are known to confer risk for JIA. However, identifying the SNPs that exert the biological effects that confer risk, and therefore…
  • Abstract Number: 2275 • ACR Convergence 2025

    Agreement Between Two Rheumatoid Arthritis Response Measures Across b/ts DMARD Treatment Classes in a Large, Prospective Observational Study Supporting the Development and Clinical Validation of a Novel Blood-based Precision Medicine Test

    Peter Taylor1, Jason Carlson2, Shirley Vu2, Signe Fransen3, Diana Abdueva4 and Jeffrey Curtis5, 1University of Oxford, Oxford, United Kingdom, 2Aqtual Inc, Hayward, CA, 3Aqtual, sf, CA, 4Aqtual, Hayward, CA, 5Foundation for Advancing Science, Technology, Education and Research, Birmingham, AL

    Background/Purpose: Contemporary pharmacological management of rheumatoid arthritis (RA) is set within a treat-to-target framework. This requires quantitative, longitudinal assessments of disease activity with a view…
  • Abstract Number: 0050 • ACR Convergence 2025

    TL1A expression is upregulated in rheumatic diseases and anti-TL1A antibody reduces disease symptoms and pathological changes in rat collagen-induced arthritis

    Preeyam Patel1, Matthew Siegel2, Emily Lewis3, David Giles3, Justin LaFountaine3, Joshua Friedman3 and Andy Spencer3, 1Spyre Therapeutics, Waltham, 2Spyre Therapeutics, Menlo Park, CA, 3Spyre Therapeutics, Waltham, MA

    Background/Purpose: The development of disease-modifying anti-rheumatic drugs (DMARDs) has reduced disease activity in patients living with rheumatic diseases. Despite this, there is continued unmet need…
  • Abstract Number: 0043 • ACR Convergence 2025

    Single-cell and Spatial Transcriptomic Profiling of Muscle Reveals Inflammatory Mechanisms in Anti-glycyl tRNA Synthetase Syndrome

    Takuya Harada1, Hiroyuki Yamashita1, Ami Isoda1, Ken Kawaue1, Mayuko Hayashi1, Yutaro Misawa1, Aruto Yamamoto1, Miyu Wakatsuki1, Yuya Akiyama1, Setsuko Oyama1, Kyoko Motomura1, Hiroyuki Takahashi1, Akiko Mitsuo2, Yuichi Goto3, Eisei Noiri3 and Hiroshi Kaneko1, 1Division of Rheumatic Diseases, National Center for Global Health and Medicine, Japan Institute for Health Security, Tokyo, Japan, 2Division of Clinical Laboratory Medicine, National Center for Global Health and Medicine, Japan Institute for Health Security, Tokyo, Japan, 3National Center Biobank Network, Tokyo, Japan

    Background/Purpose: We characterized the spatial distribution of immune cells and identified hub genes within activated molecular networks in key immune cell populations, based on the…
  • Abstract Number: 0019 • ACR Convergence 2025

    Single cell characterization of the circulating immune system in Sjögren’s Syndrome

    Alejandro Gómez Gómez1, Héctor Corominas2, Rosario Garcia Vicuña3, Mercedes Freire González4, Sheila Melchor-Díaz5, Paloma Vela Casasempere6, Paula Estrada-Alarcón7, Jose Luis Tandaipan8, Monica Fernandez Castro9, Sara Maria Rojas Herrera10, Marina Rodríguez López11, Beatriz Paredes-Romero12, Santiago Muñoz13, Marta López14, Ignacio Braña15, Gema Bonilla16, Raúl Menor Almagro17, Sara Manrique-Arija18, Mª Angeles Blazquez Cañamero19, Lilian López-Núñez20, Carles Galisteo Veiga21, Juan José Alegre-Sancho22, Jose Rosas Gómez de Salazar23, Jose Javier Pérez Venegas24, Judit Font-Urgelles25, José Andrés Román Ivorra26, José Miguel Sequí-Sabater27, Rafaela Ortega-Castro28, Clara Moriano29, Guadalupe Manzano-Canabal30, Cilia Peralta-Ginés31, Javier Narváez32, Rafael Cáliz-Cáliz33, Javier Martínez-Ferrin34, Lara Sánchez Bilbao35, Belén Serrano-Benavente36, Natalia Boix- Martí37, Ares Selles-Rius38, Maribel Pérez39, Juan Cañete40, Núria Palau Balaña38, Damiana Alvarez Errico39, Yolanda Guillén41, Juan Ángel Patiño Galindo41, Antonio Julià1, Sara Marsal Barril42 and Jose Luis Andreu43, 1Vall d'Hebron Hospital Research Institute, Rheumatology Research Group, Barcelona, Spain, 2Hospital de la Santa Creu i Sant Pau, Rheumatology, Barcelona, Barcelona, Spain, 3Hospital Universitario de la Princesa, Madrid, Spain, 44 Hospital Universitario A Coruña, Rheumatology, A Coruña, La coruna, Spain, 5Hospital Universitario 12 de Octubre, Rheumatology, Madrid, Madrid, 6Hospital General Universitario Alicante, Alicante, Comunidad Valenciana, Spain, 7Hospital de San Juan Despí Moisès Broggi, Barcelona, Spain, 8Rheumatology. Hospital Universitario de la Santa Creu i Sant Pau, Barcelona, Spain, 9PUERTA DE HIERRO HOSPITAL, Madrid, Spain, 10Hospital de Mérida, Rheumatology, Badajoz, Badajoz, Spain, 11Complejo Hospitalario Universitario de Santiago, Rheumatology, Santiago de Compostela., Santiago de Compostela, Spain, 12Hospital Universitario Infanta Sofía;Universidad Europea de Madrid. Faculty of Medicine, Health and Sports. Department of Medicine; FIIB HUIS-HUHEN, San Sebastian de los Reyes, Spain, 13Hospital Universitario Infanta Sofía;Universidad Europea de Madrid. Faculty of Medicine, Health and Sports. Department of Medicine; FIIB HUIS-HUHEN, Madrid, Spain, 14Complex Hospitalari Universitari Moisés Broggi, Barcelona, Spain, 15Hospital Universitario Central de Asturias, Oviedo, Spain, 16Hospital Universitario La Paz, Rheumatology, Madrid, Madrid, Spain, 17Department of Rheumatology, Hospital de Jerez, Spain, Puerto De Santa María, Spain, 18Hospital Regional Universitario Málaga, Malaga, Spain, 19Hospital Ramon y Cajal, Madrid, Spain, 20Hospital Son Llatzer, Rheumatology, Palma de Mallorca, Palma de Mallorca, Spain, 21Hospital Parc Taulí, Rheumatology, Sabadell, Sabadell, Spain, 22Hospital Universitario Doctor Peset, Valencia, Spain, 23Hospital Marina Baixa, PALMA DE MALLORCA, Spain, 24Virgen Macarena University Hospital, Sevilla, Spain, Sevilla, Spain, 25Hospital Universitari Germans Trias i Pujol, Badalona, Spain, 26Hospital Universitari i Politècnic La Fe, Valencia, Spain, 27Hospital Universitario La Fe (Valencia), Valencia, Spain, 28Rheumatology service/Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)/ Reina Sofia University Hospital/ University of Cordoba, Spain, Cordoba, Andalucia, Spain, 29Hospital León, LEON, Castilla y Leon, Spain, 30Hospital Virgen de la Concha (Zamora), Zamora, Spain, 31Hospital Clínico Universitario Lozano Blesa, Zaragoza, Spain, 32Hospital Universitario de Bellvitge, Barcelona, Spain, 33Hospital Universitario Virgen de las Nieves, Rheumatology, Granada, Granada, Spain, 34Hospital Universitario Virgen de la Arrixaca, Rheumatology, Murcia, Murcia, Spain, 35Rheumatology Division, Hospital Universitario Marqués de Valdecilla, IDIVAL, Immunopathology Group, Santander, Spain, Santander, Cantabria, Spain, 36Hospital Gregorio Marañon, Madrid, Spain, 37Hospital Univetsitari Vall d'Hebron, Rheumatology Department, Barcelona, Spain, 38Rheumatology Research Group, Vall d'Hebron University Hospital, Barcelona, Spain, 39IMIDomics, Barcelona, Barcelona, Spain, 40Rheumatology Department, Hospital Clínic and IDIBAPS, Barcelona, Spain, Barcelona, Spain, 41IMIDomics, Barcelona, Spain, 42Vall Hebron Hospital Research Institute, Barcelona, Spain, 43Hospital Universitario Puerta de Hierro, Majadahonda, Spain

    Background/Purpose: Sjögren’s syndrome (SS) is a chronic autoimmune disease characterized by the infiltration of circulating immune cells into the salivary and lacrimal glands. The properties…
  • Abstract Number: 0046 • ACR Convergence 2025

    Association of Genetic Variation in XIST and FTX with Susceptibility to Female-Biased Systemic Autoimmune Disease

    Thomas Riley1, Dana DiRenzo1, Ellen Romich2, Michael Levin3, Scott Damrauer3, Michael George1, Montserrat Anguera1, Joshua Baker1 and Nikhil Jiwrajka1, 1University of Pennsylvania, Philadelphia, PA, 2University of Pennsylvania, Media, PA, 3University of Pennsylvania / Corporal Michael J. Crescenz VAMC, Philadelphia, PA

    Background/Purpose: The mechanisms underlying female sex bias in autoimmune diseases remain unclear. Recent work has suggested that impaired maintenance of X-chromosome inactivation (XCI) in female…
  • Abstract Number: 0032 • ACR Convergence 2025

    Protein Language Model-Guided Homology Identifies Microbial Enzymes Linked to Fibrosis-Prone IgG4-RD and Crohn’s Disease

    Kumar Thurimella1, Ahmed Mohamed2, Chenhao Li3, Tommi Vatanen4, Daniel Graham3, Roisin Owens5, Sabina Leanti La Rosa6, Damian Plichta3, Sergio Bacallado5 and Ramnik Xavier7, 1University of Colorado School of Medicine, Aurora, CO, 2Broad Institute, Boston, 3Broad Institute, Cambridge, MA, 4University of Helsinki, Helsinki, Finland, 5University of Cambridge, Cambridge, United Kingdom, 6NMBU, As, Norway, 7Harvard Medical School, Boston, MA

    Background/Purpose: Uncharacterized microbial enzymes in metagenomics are difficult to annotate, especially in fibrosis-prone conditions like IgG4-related disease (IgG4-RD) and Crohn’s disease (CD), where microbial carbohydrate…
  • Abstract Number: 0002 • ACR Convergence 2025

    KITE-363: An Autologous Anti-CD19/CD20 CAR-T Product for the Treatment of Autoimmune Rheumatic Diseases

    Brian Kim, Christine Lowe, Francisco Flores, Jeremy Margaitis, Alessandro Calo, Stacey Valny, Anna Konecny, Eva Jaghatspanyan, Sean Yoder, Kenneth Ertel, Simone Filosto, Jodi Murakami and David Barrett, Kite, a Gilead Company, Santa Monica, CA

    Background/Purpose: B-cell dysregulation is a key factor in the development and progression of autoimmune diseases, and B-cell inhibition has been a cornerstone of treatment for…
  • Abstract Number: 0021 • ACR Convergence 2025

    DoCTIS: A Single Cell RNA-Seq Atlas of Drug Response To Targeted Therapies

    Antonio Julià1, Yolanda Guillén2, Paloma Vela Casasempere3, Antonio Fernández Nebro4, Carlos Marras5, Santos Castañeda6, Jaime Calvo Alén7, Jesús Tornero Molina8, Juan Cañete9, Eugeni Domènech10, Javier Gisbert11, Jose M. Carrascosa12, Eduardo Fonseca13, Luis Bujanda Fernández De pierola14, Valle García Sánchez15, Britta Siegmund16, Giampiero Girolomoni17, Holger Heyn18, Laura Jiménez Gracia18, Pere Santamaria19, Edgar Angelats20, Richard Myers21, Sergio H. Martínez Mateu2, Juan Ángel Patiño Galindo2, Ernest Choy22 and Sara Marsal1, 1Vall d'Hebron Hospital Research Institute, Rheumatology Research Group, Barcelona, Spain, 2IMIDomics, Barcelona, Spain, 3Hospital General Universitario de Alicante, Rheumatology, Alicante, Spain, 4Hospital Regional Universitario Carlos Haya, Rheumatology, Málaga, Spain, 5Hospital Universitario Virgen de la Arrixaca, Rheumatology, Murcia, Spain, 6Hospital Universitario de La Princesa, IIS-Princesa, Madrid, Madrid, Spain, 7Hospital Universitario de Araba, Rheumatology, Vitoria, Spain, 8Hospital Universitario de Guadalajara, Rheumatology, Guadalajara, Spain, 9Rheumatology Department, Hospital Clínic and IDIBAPS, Barcelona, Spain, Barcelona, Spain, 10Hospital Universitari Germans Trias i Pujol, Gastroenterology, Badalona, Spain, 11Hospital Universitario La Princesa, Rheumatology, Madrid, Spain, 12Hospital Universitari Germans Trias i Pujol, Dermatology, Badalona, Spain, 13Complejo Hospitalario Universitario de A Coruña, Dermatology, A Coruña, Spain, 14Hospital Universitario de Donostia, Gastroenterology, San Sebastián, Spain, 15Hospital Universitario Reina Sofía, Gastroenterology, Córdoba, Spain, 16Charité-Universitätsmedizin Berlin, Gastroenterology, Berlin, Germany, 17University of Verona, Dermatology, Verona, Spain, 18Centre for Genomic Regulation (CNAG-CRG), Barcelona, Spain, 19Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelonoa, Spain, 20Hospital Clínic-IDIBAPS, Barcelona, Spain, 21HudsonAlpha Institute for Biotechnology, Huntsville, AL, 22Division of Infection and Immunity, CREATE Centre, Cardiff University, Cardiff, United Kingdom

    Background/Purpose: Targeted therapies have revolutionized the management of immune-mediated inflammatory diseases (IMIDs), however, there is a substantial number of patients who respond poorly to a…
  • Abstract Number: 0105 • ACR Convergence 2025

    Inflammatory Cytokines, Matrix Metalloproteinases and Bone Markers Expressions Are Modulated in the Joints in the Chronic Murine Model of Imiquimod-Induced Psoriasis

    Guillaume LARID1, Cassandre Dumonteix Moreau2, Adrien JAMAI2, Hanitriniaina Rabeony2, Jean Claude LECRON2, Elisabeth Gervais1, Jean François JEGOU2 and franck MOREL2, 1Poitiers University Hospital - Poitiers University - LITEC Laboratory UR 15560, Poitiers, France, 2Poitiers University - LITEC Laboratory UR 15560, Poitiers, France

    Background/Purpose: Psoriatic disease is a systemic inflammatory condition which encompasses both cutaneous psoriasis (PsO), psoriatic arthritis (PsA) and multiple comorbidities. The chronic Imiquimod (IMQ) induced…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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