Abstracts Archive - Page 1294 of 2425 - ACR Meeting Abstracts

Abstract Number: 1327 • 2017 ACR/ARHP Annual Meeting
Decreased Inflammatory Arthritis in Human Serum Paraoxonase 1 Transgenic Mice
Christina Charles-Schoeman¹, Ani Shahbazian², Jennifer Wang³, Victor Grijalva⁴ and Srinivasa T. Reddy⁴, ¹University of California, Los Angeles, Los Angeles, CA, ²Medicine-Rheumatology, University of California, Los Angeles, Los Angeles, CA, ³UCLA, Los Angeles, CA, ⁴Medicine-Cardiology, University of California, Los Angeles, Los Angeles, CA
Background/Purpose: Paraoxonase 1 (PON1) is an HDL-associated protein, which hydrolyzes biologically active oxidized phospholipids and prevents oxidation of lipids in LDL and HDL. Increased lipid…
Abstract Number: 1328 • 2017 ACR/ARHP Annual Meeting
A Dual ICOS/CD28 Antagonist ICOSL Variant Ig Domain (vIgDTM) Potently Suppresses Mouse Collagen-Induced Arthritis and Human Xenograft Graft Vs. Host Disease (GvHD)
Stacey Dillon¹, Katherine Lewis¹, Ryan Swanson², Lawrence Evans², Michael Kornacker³, Steve Levin², Martin Wolfson⁴, Erika Rickel², Susan Bort², Sherri Mudri¹, Aaron Moss¹, Michelle Seaberg¹, Janhavi Bhandari⁴, Sean MacNeil⁴, Joe Hoover⁴, Mark Rixon⁴ and Stanford Peng⁵, ¹Translational Sciences, Alpine Immune Sciences, Seattle, WA, ²Immunology, Alpine Immune Sciences, Seattle, WA, ³Protein Engineering, Alpine Immune Sciences, Seattle, WA, ⁴Protein Therapeutics, Alpine Immune Sciences, Seattle, WA, ⁵Clinical, R&D, Alpine Immune Sciences, Seattle, WA
Background/Purpose: Our proprietary variant Ig domain (vIgD) platform creates novel, therapeutically-applicable protein domains with tailored specificity and affinity. These vIgDs are created through directed…
Abstract Number: 1329 • 2017 ACR/ARHP Annual Meeting
A Quantitative Framework for Evaluating Drug Combination Treatment in Rat Collagen-Induced-Arthritis Model
Amy Meng¹, Julie Di Paolo², Shringi Sharma³ and Anita Mathias³, ¹Clinical Pharmacology, Gilead Sciences, Foster City, CA, ²Immunology and Inflammation Biology, Gilead Sciences, Foster City, CA, ³Gilead Sciences, Foster City, CA
Background/Purpose: Filgotinib (FIL), a JAK1 inhibitor, and GS-9876, a SYK inhibitor, are currently being evaluated as once-daily monotherapy in subjects with rheumatoid arthritis (RA). A…
Abstract Number: 1330 • 2017 ACR/ARHP Annual Meeting
Rhesus Theta Defensin 1 (RTD-1) Suppresses Disease-Associated Genes and Induces Anti-Inflammatory Expression Signature in Synovial Tissues of Rat Model of Rheumatoid Arthritis
Prasad Tongaonkar¹, Vasu Punj², Akshay Subramanian³, Dat Tran³, Katie Trinh⁴, Justin Schaal¹, Percio S. Gulko⁵, Andre Oullette³ and Michael Selsted³, ¹Pathology and Laboratory Medicine, Keck School of Medicine University of Southern California, Los Angeles, CA, ²Medicine, Keck School of Medicine University of Southern California, Los Angeles, CA, ³Keck School of Medicine University of Southern California, Los Angeles, CA, ⁴Pathology, Keck School of Medicine University of Southern California, Los Angeles, CA, ⁵Medicine/Rheumatology, Icahn School of Medicine at Mount Sinai, New York, NY
Background/Purpose: Theta (θ) defensins are the only known macrocyclic peptides found in the Animal kingdom and are exclusively expressed in Old World monkeys. θ-defensins were…
Abstract Number: 1331 • 2017 ACR/ARHP Annual Meeting
A Pathogenic Role of Porphyomonas Gingivalis Fimbriae (FimA) in Periodontitis-Associated Rheumatoid Arthritis
Ji-Won Kim¹, Jennifer Lee², Yeon-Sik Hong³, Sung-Hwan Park² and Ji Hyeon Ju², ¹Medicine, Division of Rheumatology, Department of Internal Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of (South), ²Division of Rheumatology, Department of Internal Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of (South), ³Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of (South)
Background/Purpose: Periodontitis induced by oral pathogen Porphyromonas gingivalis (Pg) has been suggested to be associated with rheumatoid arthritis (RA). Pg peptidyl arginine deiminase -mediated citrullination…
Abstract Number: 1332 • 2017 ACR/ARHP Annual Meeting
Periostin Deficiency Exacerbates Joint Inflammation and Bone Destruction in Mouse Models of Rheumatoid Arthritis
Yun-Hong Cheon, Division of Rheumatology, Department of Internal Medicine, Gyeongsang National University School of Medicine, Jinju, Korea, Republic of (South)
Background/Purpose: Periostin (POSTN), a matricellular protein, is involved in many fundamental biological processes such as bone metabolism, cell proliferation, cell invasion, and angiogenesis. Also, POSTN…
Abstract Number: 1333 • 2017 ACR/ARHP Annual Meeting
Mortality of Tumor Necrosis Factor Transgenic Arthritic Mice with Interstitial Lung Disease Occurs with Pulmonary Arteriole Thickening and Right Ventricular Hypertrophy but Is Not Associated with Inducible Nitric Oxide Synthase Dependent Inflammatory Cell Infiltration
Richard Bell¹, Emily Wu^1,2, Homaira Rahimi³ and Edward Schwarz^1,4,5, ¹Center for Musculoskeletal Research, University of Rochester, Rochester, NY, ²Department of Immunology, Microbiology, and Virology, University of Rochester, Rochester, NY, ³Rheumatology, University of Rochester/Golisano Children's Hosp, Rochester, NY, ⁴University of Rochester, Rochester, NY, ⁵Univ of Rochester Med Ctr, University of Rochester School of Medicine and Dentistry, Rochester, NY
Background/Purpose: Rheumatoid arthritis associated interstitial lung disease (RA-ILD) occurs in up to 15% of RA patients, whose median survival expectancy after diagnosis is only 2.6…
Abstract Number: 1334 • 2017 ACR/ARHP Annual Meeting
Identification of Key Regulators for Resolution of Chronic Inflammatory Arthritis through a Systems Approach
Jin-Sun Kong Sr.¹, Ji-Hwan park², Seung-Ah Yoo Sr.¹, Jung Hee Koh³, Daehee Hwang⁴ and Wan-Uk Kim Sr.⁵, ¹The Catholic University of Korea, Center for Integrative Rheumatoid Transcriptomics and Dynamics, seoul, Korea, Republic of (South), ²Center for Plant Aging Research, DGIST, Daegu 42988, South Korea, Daegu, Korea, Republic of (South), ³Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of (South), ⁴Center for Plant Aging Research, DGIST, Daegu 42988, South Korea, Department of New Biology, DGIST, Daegu 42988, South Korea, Daegu, Korea, Republic of (South), ⁵The Catholic University of Korea, Department of Internal Medicine, seoul, Korea, Republic of (South)
Background/Purpose: Collagen-induced arthritis(CIA), a representative animal model of chronic inflammatory arthritis, follows phases of induction, peak of inflammation and resolution. This study aims to identify…
Abstract Number: 1335 • 2017 ACR/ARHP Annual Meeting
p62/SQSTM1 Modulates Bone Erosions in a Murine Model of Rheumatoid Arthritis
Adelheid Korb-Pap¹, Anja Römer-Hillmann¹, Marianne Heitzmann¹, Masaru Kato², Kerstin Klein², Caroline Ospelt², Steffen Gay³, Susanne Buergis⁴, Thomas Pap¹, Thomas Weide⁵, André Gessner⁴ and Hermann Pavenstädt⁵, ¹Institute of Musculoskeletal Medicine, University Hospital Muenster, Muenster, Germany, ²Center of Experimental Rheumatology, University Hospital Zürich, Zurich, Switzerland, ³Center of Experimental Rheumatology, University Hospital Zürich, Zürich, Switzerland, ⁴Department of Immunology, University Erlangen, Erlangen, Germany, ⁵Department of Nephrology and Rheumatology, University Hospital Muenster, Muenster, Germany
Background/Purpose: Rheumatoid arthritis (RA) is characterised by massive bone erosions leading to irreversible joint destructions. In this context, the multi-adapter protein p62/SQSTM1 is of interest…
Abstract Number: 1336 • 2017 ACR/ARHP Annual Meeting
Unique Role for miR429 in RA and Acute Model of Arthritis
Jonatan Hervoso¹, W. Alexander Stinson¹, Yuxuan Du², Sarah Arwani¹, Ellen Cealey¹, David A. Fox¹ and M. Asif Amin¹, ¹Division of Rheumatology and Clinical Autoimmune Center of Excellence, University of Michigan, Ann Arbor, MI, Ann Arbor, MI, ²Division of Rheumatology and Clinical Autoimmune Center of Excellence, University of Michigan, Ann Arbor, MI, Ann Arbor, MI, MI
Background/Purpose: Rheumatoid arthritis (RA) is characterized by inflammation and subsequent infiltration of peripheral blood monocytes (MNs) into the synovial tissue (ST). Micro (mi)RNAs are non-coding…
Abstract Number: 1337 • 2017 ACR/ARHP Annual Meeting
ASN002, a Novel Dual SYK/JAK Inhibitor, Demonstrates Strong Efficacy in a Rat Model of Collagen-Induced Arthritis
David Zammit¹, Sanjeeva Reddy¹, Roger Smith¹, Nitin Damle² and Sandeep Gupta¹, ¹Asana BioSciences LLC, Lawrenceville, NJ, ²Preclinical R&D, Sun Pharma Advanced Research Co. Ltd, Mumbai, India
Background/Purpose: Spleen tyrosine kinase (SYK) and Janus kinase (JAK) mediate signaling in immune cells and hematopoietic cells important for the initiation and progression of rheumatoid…
Abstract Number: 1338 • 2017 ACR/ARHP Annual Meeting
Important Role of CD11c+ Dendtritic Cells in Inflammatory Arthritis
Antonia Puchner¹, Victoria Saferding¹, Michael Bonelli², Harald Leiss³, Gerhard Krönke⁴, René Pfeifle⁵, Josef S. Smolen⁶, Kurt Redlich⁷ and Stephan Blüml⁶, ¹Medical University of Vienna, Austria, Vienna, Austria, ²Rheumatology, Medical University of Vienna, Vienna, Austria, ³Rheumatology, Medical University Vienna, Vienna, Austria, ⁴Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Department of Internal Medicine 3 – Rheumatology and Immunology, Universitätsklinikum Erlangen, Erlangen, Germany., Erlangen, Austria, ⁵Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ⁶Medical University Vienna, Division of Rheumatology, Department of Internal Medicine III, Vienna, Austria, ⁷Division of Rheumatology, Medical University of Vienna, Vienna, Austria
Background/Purpose: Dendritic cells (DCs) are important antigen presenting cells (APCs) and therefore they play an important role in bridging the innate and the adaptive immune…
Abstract Number: 1339 • 2017 ACR/ARHP Annual Meeting
Role of Hexokinase-2 in Synovial Lining Hypertrophy in Murine Arthritis
Marta Fernandez Bustmanate¹, Jeffrey Smith², Adam Paul Croft³, Gary S. Firestein⁴, Chris Buckley⁵, Shigeki Miyamoto² and Monica Guma⁶, ¹Medicine, UCSD, San Diego, CA, ²Pharmacology, UCSD, La Jolla, CA, ³Institute of Inflammation and Ageing, University of Birmingham, Birmingham, United Kingdom, ⁴Medicine, University of California San Diego, La Jolla, CA, ⁵University of Birmingham, Birmingham, United Kingdom, ⁶Medicine, UCSD, La Jolla, CA
Background/Purpose: Recent studies indicate that fibroblast-like synoviocyte (FLS) glucose metabolism is altered in rheumatoid arthritis (RA). Hexokinases (HKs) catalyze the first step in glucose metabolism.…
Abstract Number: 1340 • 2017 ACR/ARHP Annual Meeting
Is Depression in Patients with Rheumatoid Arthritis Associated with Disease Activity? Comparative Study between Germany and Brazil
Harriet Morf¹, Olga Seifert², Geraldo Castelar-Pinheiro³, Ana Beatriz Vargas-Santos⁴ and C Baerwald⁵, ¹Department of Internal Medicine, University Hospital, Erlangen, Germany, ²University of Leipzig, Leipzig, Germany, ³Universidade do Estado do Rio de Janeiro - UERJ, Rio de Janeiro, Brazil, ⁴Internal Medicine - Rheumatology, State University of Rio de Janeiro, Rio de Janeiro, Brazil, ⁵Department of Rheumatology, University of Leipzig, Germany, Leipzig, Germany
Background/Purpose: Rheumatoid Arthritis (RA) can be associated with psychologic disorders and especially depression. About 13–20% of patients have clinical significant depression (Matcham F et al,…
Abstract Number: 1341 • 2017 ACR/ARHP Annual Meeting
The Impact of Anti-Cyclic Citrullinated Peptide Seropositivity on Erosion Prevalence Among Patients with RA of Varying Disease Duration
Leslie R Harrold¹, K Price², Heather J. Litman³, SE Connolly², E Alemao², Sabrina Rebello⁴, W Hua³ and Joel Kremer⁵, ¹University of Massachusetts Medical School, Worcester, MA, ²Bristol-Myers Squibb, Princeton, NJ, ³Corrona, Southborough, MA, ⁴Corrona, LLC, Southborough, MA, ⁵Albany Medical College and The Center for Rheumatology, Albany, NY
Background/Purpose: Little is known regarding the prevalence of erosive disease in a contemporary cohort of patients with RA and whether erosive disease prevalence differs by…

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].