ACR Meeting Abstracts

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  • Abstract Number: 1327 • 2017 ACR/ARHP Annual Meeting

    Decreased Inflammatory Arthritis in Human Serum Paraoxonase 1 Transgenic Mice

    Christina Charles-Schoeman1, Ani Shahbazian2, Jennifer Wang3, Victor Grijalva4 and Srinivasa T. Reddy4, 1University of California, Los Angeles, Los Angeles, CA, 2Medicine-Rheumatology, University of California, Los Angeles, Los Angeles, CA, 3UCLA, Los Angeles, CA, 4Medicine-Cardiology, University of California, Los Angeles, Los Angeles, CA

    Background/Purpose: Paraoxonase 1 (PON1) is an HDL-associated protein, which hydrolyzes biologically active oxidized phospholipids and prevents oxidation of lipids in LDL and HDL. Increased lipid…
  • Abstract Number: 1328 • 2017 ACR/ARHP Annual Meeting

    A Dual ICOS/CD28 Antagonist ICOSL Variant Ig Domain (vIgDTM) Potently Suppresses Mouse Collagen-Induced Arthritis and Human Xenograft Graft Vs. Host Disease (GvHD)

    Stacey Dillon1, Katherine Lewis1, Ryan Swanson2, Lawrence Evans2, Michael Kornacker3, Steve Levin2, Martin Wolfson4, Erika Rickel2, Susan Bort2, Sherri Mudri1, Aaron Moss1, Michelle Seaberg1, Janhavi Bhandari4, Sean MacNeil4, Joe Hoover4, Mark Rixon4 and Stanford Peng5, 1Translational Sciences, Alpine Immune Sciences, Seattle, WA, 2Immunology, Alpine Immune Sciences, Seattle, WA, 3Protein Engineering, Alpine Immune Sciences, Seattle, WA, 4Protein Therapeutics, Alpine Immune Sciences, Seattle, WA, 5Clinical, R&D, Alpine Immune Sciences, Seattle, WA

    Background/Purpose:   Our proprietary variant Ig domain (vIgD) platform creates novel, therapeutically-applicable protein domains with tailored specificity and affinity. These vIgDs are created through directed…
  • Abstract Number: 1329 • 2017 ACR/ARHP Annual Meeting

    A Quantitative Framework for Evaluating Drug Combination Treatment in Rat Collagen-Induced-Arthritis Model

    Amy Meng1, Julie Di Paolo2, Shringi Sharma3 and Anita Mathias3, 1Clinical Pharmacology, Gilead Sciences, Foster City, CA, 2Immunology and Inflammation Biology, Gilead Sciences, Foster City, CA, 3Gilead Sciences, Foster City, CA

    Background/Purpose: Filgotinib (FIL), a JAK1 inhibitor, and GS-9876, a SYK inhibitor, are currently being evaluated as once-daily monotherapy in subjects with rheumatoid arthritis (RA). A…
  • Abstract Number: 1330 • 2017 ACR/ARHP Annual Meeting

    Rhesus Theta Defensin 1 (RTD-1) Suppresses Disease-Associated Genes and Induces Anti-Inflammatory Expression Signature in Synovial Tissues of Rat Model of Rheumatoid Arthritis

    Prasad Tongaonkar1, Vasu Punj2, Akshay Subramanian3, Dat Tran3, Katie Trinh4, Justin Schaal1, Percio S. Gulko5, Andre Oullette3 and Michael Selsted3, 1Pathology and Laboratory Medicine, Keck School of Medicine University of Southern California, Los Angeles, CA, 2Medicine, Keck School of Medicine University of Southern California, Los Angeles, CA, 3Keck School of Medicine University of Southern California, Los Angeles, CA, 4Pathology, Keck School of Medicine University of Southern California, Los Angeles, CA, 5Medicine/Rheumatology, Icahn School of Medicine at Mount Sinai, New York, NY

    Background/Purpose: Theta (θ) defensins are the only known macrocyclic peptides found in the Animal kingdom and are exclusively expressed in Old World monkeys. θ-defensins were…
  • Abstract Number: 1331 • 2017 ACR/ARHP Annual Meeting

    A Pathogenic Role of Porphyomonas Gingivalis Fimbriae (FimA) in Periodontitis-Associated Rheumatoid Arthritis

    Ji-Won Kim1, Jennifer Lee2, Yeon-Sik Hong3, Sung-Hwan Park2 and Ji Hyeon Ju2, 1Medicine, Division of Rheumatology, Department of Internal Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of (South), 2Division of Rheumatology, Department of Internal Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of (South), 3Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of (South)

    Background/Purpose: Periodontitis induced by oral pathogen Porphyromonas gingivalis (Pg) has been suggested to be associated with rheumatoid arthritis (RA). Pg peptidyl arginine deiminase -mediated citrullination…
  • Abstract Number: 1332 • 2017 ACR/ARHP Annual Meeting

    Periostin Deficiency Exacerbates Joint Inflammation and Bone Destruction in Mouse Models of Rheumatoid Arthritis

    Yun-Hong Cheon, Division of Rheumatology, Department of Internal Medicine, Gyeongsang National University School of Medicine, Jinju, Korea, Republic of (South)

    Background/Purpose: Periostin (POSTN), a matricellular protein, is involved in many fundamental biological processes such as bone metabolism, cell proliferation, cell invasion, and angiogenesis. Also, POSTN…
  • Abstract Number: 1333 • 2017 ACR/ARHP Annual Meeting

    Mortality of Tumor Necrosis Factor Transgenic Arthritic Mice with Interstitial Lung Disease Occurs with Pulmonary Arteriole Thickening and Right Ventricular Hypertrophy but Is Not Associated with Inducible Nitric Oxide Synthase Dependent Inflammatory Cell Infiltration

    Richard Bell1, Emily Wu1,2, Homaira Rahimi3 and Edward Schwarz1,4,5, 1Center for Musculoskeletal Research, University of Rochester, Rochester, NY, 2Department of Immunology, Microbiology, and Virology, University of Rochester, Rochester, NY, 3Rheumatology, University of Rochester/Golisano Children's Hosp, Rochester, NY, 4University of Rochester, Rochester, NY, 5Univ of Rochester Med Ctr, University of Rochester School of Medicine and Dentistry, Rochester, NY

    Background/Purpose: Rheumatoid arthritis associated interstitial lung disease (RA-ILD) occurs in up to 15% of RA patients, whose median survival expectancy after diagnosis is only 2.6…
  • Abstract Number: 1334 • 2017 ACR/ARHP Annual Meeting

    Identification of Key Regulators for Resolution of Chronic Inflammatory Arthritis through a Systems Approach

    Jin-Sun Kong Sr.1, Ji-Hwan park2, Seung-Ah Yoo Sr.1, Jung Hee Koh3, Daehee Hwang4 and Wan-Uk Kim Sr.5, 1The Catholic University of Korea, Center for Integrative Rheumatoid Transcriptomics and Dynamics, seoul, Korea, Republic of (South), 2Center for Plant Aging Research, DGIST, Daegu 42988, South Korea, Daegu, Korea, Republic of (South), 3Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of (South), 4Center for Plant Aging Research, DGIST, Daegu 42988, South Korea, Department of New Biology, DGIST, Daegu 42988, South Korea, Daegu, Korea, Republic of (South), 5The Catholic University of Korea, Department of Internal Medicine, seoul, Korea, Republic of (South)

    Background/Purpose: Collagen-induced arthritis(CIA), a representative animal model of chronic inflammatory arthritis, follows phases of induction, peak of inflammation and resolution. This study aims to identify…
  • Abstract Number: 1335 • 2017 ACR/ARHP Annual Meeting

    p62/SQSTM1 Modulates Bone Erosions in a Murine Model of Rheumatoid Arthritis

    Adelheid Korb-Pap1, Anja Römer-Hillmann1, Marianne Heitzmann1, Masaru Kato2, Kerstin Klein2, Caroline Ospelt2, Steffen Gay3, Susanne Buergis4, Thomas Pap1, Thomas Weide5, André Gessner4 and Hermann Pavenstädt5, 1Institute of Musculoskeletal Medicine, University Hospital Muenster, Muenster, Germany, 2Center of Experimental Rheumatology, University Hospital Zürich, Zurich, Switzerland, 3Center of Experimental Rheumatology, University Hospital Zürich, Zürich, Switzerland, 4Department of Immunology, University Erlangen, Erlangen, Germany, 5Department of Nephrology and Rheumatology, University Hospital Muenster, Muenster, Germany

    Background/Purpose: Rheumatoid arthritis (RA) is characterised by massive bone erosions leading to irreversible joint destructions. In this context, the multi-adapter protein p62/SQSTM1 is of interest…
  • Abstract Number: 1336 • 2017 ACR/ARHP Annual Meeting

    Unique Role for miR429 in RA and Acute Model of Arthritis

    Jonatan Hervoso1, W. Alexander Stinson1, Yuxuan Du2, Sarah Arwani1, Ellen Cealey1, David A. Fox1 and M. Asif Amin1, 1Division of Rheumatology and Clinical Autoimmune Center of Excellence, University of Michigan, Ann Arbor, MI, Ann Arbor, MI, 2Division of Rheumatology and Clinical Autoimmune Center of Excellence, University of Michigan, Ann Arbor, MI, Ann Arbor, MI, MI

    Background/Purpose: Rheumatoid arthritis (RA) is characterized by inflammation and subsequent infiltration of peripheral blood monocytes (MNs) into the synovial tissue (ST). Micro (mi)RNAs are non-coding…
  • Abstract Number: 1337 • 2017 ACR/ARHP Annual Meeting

    ASN002, a Novel Dual SYK/JAK Inhibitor, Demonstrates Strong Efficacy in a Rat Model of Collagen-Induced Arthritis

    David Zammit1, Sanjeeva Reddy1, Roger Smith1, Nitin Damle2 and Sandeep Gupta1, 1Asana BioSciences LLC, Lawrenceville, NJ, 2Preclinical R&D, Sun Pharma Advanced Research Co. Ltd, Mumbai, India

    Background/Purpose: Spleen tyrosine kinase (SYK) and Janus kinase (JAK) mediate signaling in immune cells and hematopoietic cells important for the initiation and progression of rheumatoid…
  • Abstract Number: 1338 • 2017 ACR/ARHP Annual Meeting

    Important Role of CD11c+ Dendtritic Cells in Inflammatory Arthritis

    Antonia Puchner1, Victoria Saferding1, Michael Bonelli2, Harald Leiss3, Gerhard Krönke4, René Pfeifle5, Josef S. Smolen6, Kurt Redlich7 and Stephan Blüml6, 1Medical University of Vienna, Austria, Vienna, Austria, 2Rheumatology, Medical University of Vienna, Vienna, Austria, 3Rheumatology, Medical University Vienna, Vienna, Austria, 4Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Department of Internal Medicine 3 – Rheumatology and Immunology, Universitätsklinikum Erlangen, Erlangen, Germany., Erlangen, Austria, 5Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, 6Medical University Vienna, Division of Rheumatology, Department of Internal Medicine III, Vienna, Austria, 7Division of Rheumatology, Medical University of Vienna, Vienna, Austria

    Background/Purpose: Dendritic cells (DCs) are important antigen presenting cells (APCs) and therefore they play an important role in bridging the innate and the adaptive immune…
  • Abstract Number: 1339 • 2017 ACR/ARHP Annual Meeting

    Role of Hexokinase-2 in Synovial Lining Hypertrophy in Murine Arthritis

    Marta Fernandez Bustmanate1, Jeffrey Smith2, Adam Paul Croft3, Gary S. Firestein4, Chris Buckley5, Shigeki Miyamoto2 and Monica Guma6, 1Medicine, UCSD, San Diego, CA, 2Pharmacology, UCSD, La Jolla, CA, 3Institute of Inflammation and Ageing, University of Birmingham, Birmingham, United Kingdom, 4Medicine, University of California San Diego, La Jolla, CA, 5University of Birmingham, Birmingham, United Kingdom, 6Medicine, UCSD, La Jolla, CA

    Background/Purpose: Recent studies indicate that fibroblast-like synoviocyte (FLS) glucose metabolism is altered in rheumatoid arthritis (RA). Hexokinases (HKs) catalyze the first step in glucose metabolism.…
  • Abstract Number: 1340 • 2017 ACR/ARHP Annual Meeting

    Is Depression in Patients with Rheumatoid Arthritis Associated with Disease Activity? Comparative Study between Germany and Brazil

    Harriet Morf1, Olga Seifert2, Geraldo Castelar-Pinheiro3, Ana Beatriz Vargas-Santos4 and C Baerwald5, 1Department of Internal Medicine, University Hospital, Erlangen, Germany, 2University of Leipzig, Leipzig, Germany, 3Universidade do Estado do Rio de Janeiro - UERJ, Rio de Janeiro, Brazil, 4Internal Medicine - Rheumatology, State University of Rio de Janeiro, Rio de Janeiro, Brazil, 5Department of Rheumatology, University of Leipzig, Germany, Leipzig, Germany

    Background/Purpose:  Rheumatoid Arthritis (RA) can be associated with psychologic disorders and especially depression. About 13–20% of patients have clinical significant depression (Matcham F et al,…
  • Abstract Number: 1341 • 2017 ACR/ARHP Annual Meeting

    The Impact of Anti-Cyclic Citrullinated Peptide Seropositivity on Erosion Prevalence Among Patients with RA of Varying Disease Duration

    Leslie R Harrold1, K Price2, Heather J. Litman3, SE Connolly2, E Alemao2, Sabrina Rebello4, W Hua3 and Joel Kremer5, 1University of Massachusetts Medical School, Worcester, MA, 2Bristol-Myers Squibb, Princeton, NJ, 3Corrona, Southborough, MA, 4Corrona, LLC, Southborough, MA, 5Albany Medical College and The Center for Rheumatology, Albany, NY

    Background/Purpose: Little is known regarding the prevalence of erosive disease in a contemporary cohort of patients with RA and whether erosive disease prevalence differs by…
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