Abstracts Archive - Page 1293 of 2425 - ACR Meeting Abstracts

Abstract Number: 1312 • 2017 ACR/ARHP Annual Meeting
Pregnancy Outcomes in Male Patients Using Anti-Tumor Necrosis Factor Alpha Patients with Inflammatory Arthritis; Hur-BIO Real Life Experiences
Oguz Abdullah Uyaroglu¹, Emrah Seyhoglu¹, Abdulsamet Erden², Levent Kilic², Berkan Armagan², Alper Sari², Omer Karadag³, Ali Akdogan², Sule Apras Bilgen³, Sedat Kiraz², Ihsan Ertenli³ and Umut Kalyoncu³, ¹Internal Medicine, Hacettepe University Faculty of Medicine, Ankara, Turkey, ²Rheumatology, Hacettepe University Faculty of Medicine, Ankara, Turkey, ³Department of Internal Medicine, Divison of Rheumatology, Hacettepe University Faculty of Medicine, Ankara, Turkey
Background/Purpose: A significant part of patients with inflammatory arthritis are at their reproductive ages. Anti-tumor necrosis factor-alpha (Anti-TNF) agents are one of the relevant treatment…
Abstract Number: 1313 • 2017 ACR/ARHP Annual Meeting
Oral Corticosteroid Use during Pregnancy and Risk of Preterm Birth in Women with Rheumatoid Arthritis
Kristin Palmsten¹, Gretchen Bandoli², Diana L Johnson¹, Ronghui Xu^3,4 and Christina D Chambers¹, ¹Department of Pediatrics, University of California, San Diego, La Jolla, CA, ²Pediatrics, University of California, San Diego, La Jolla, CA, ³Department of Family Medicine and Public Health, University of California, San Diego, La Jolla, CA, ⁴Department of Mathematics, University of California, San Diego, La Jolla, CA
Background/Purpose: There are limited data regarding gestational timing of oral corticosteroid (OCS) use during pregnancy and risk of preterm birth. The objective was to compare…
Abstract Number: 1314 • 2017 ACR/ARHP Annual Meeting
Pregnancy Outcomes in Patients with Psoriasis: A Nationwide Population-Based Study
Meng-Jiun Chiou¹, Yu-Hui Huang², Chang-Fu Kuo¹, Kuang-Hui Yu¹, Shue-Fen Luo¹ and Yao-Fan Fang¹, ¹Division of Rheumatology, Allergy and Immunology, Chang Gung Memorial Hospital, Taoyuan, Taiwan, ²Department of Dermatology, Chang Gung Memorial Hospital, Taoyuan, Taiwan
Background/Purpose: The pregnancy outcomes in women with psoriasis have rarely been investigated. This nationwide population study aimed to estimate the risks of adverse maternal and…
Abstract Number: 1315 • 2017 ACR/ARHP Annual Meeting
Influence of Rheumatoid Arthritis and Axial Spondyloarthritis on Pregnancy Complications, Pregnancy Outcome and Delivery Mode
Frauke Förger¹, Stephanie van den Brandt², Astrid Zbinden³, Monika Ostensen³ and Peter M. Villiger³, ¹Inselspital, University of Bern, Bern, Switzerland, ²Clinical Immunology and Rheumatology, University of Amsterdam, Amsterdam, Netherlands, ³Rheumatology, Immunology and Allergology, Inselspital, University of Bern, Bern, Switzerland
Background/Purpose: To analyze pregnancy complications, pregnancy outcome and delivery mode in patients with rheumatoid arthritis (RA) and axial spondyloarthritis (axSpA).Methods: Patients with RA and axSpA…
Abstract Number: 1316 • 2017 ACR/ARHP Annual Meeting
Risk of Preterm Delivery Associated with Perinatal Exposure to Dmards in Women with Inflammatory Arthritis: A Population-Based Cohort Study
Nicole W. Tsao^1,2, Eric C. Sayre², Mohsen Sadatsafavi¹, J. Antonio Avina-Zubieta^2,3, Stephanie Ensworth⁴ and Mary A. De Vera^1,2, ¹Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada, ²Arthritis Research Canada, Richmond, BC, Canada, ³Division of Rheumatology, Department of Medicine, University of British Columbia, Vancouver, BC, Canada, ⁴University of British Columbia, Vancouver, BC, Canada
Background/Purpose: Given the limited data on impacts of perinatal medication use, our objective was to investigate the association between conventional synthetic DMARD (csDMARD) use preconception…
Abstract Number: 1317 • 2017 ACR/ARHP Annual Meeting
Obstetric Outcomes in Women with Rheumatoid Arthritis: Results from Nationwide Inpatient Sample Database 2003-2011
Shweta Kishore¹, Varun Mittal², Venkataraman Palabindala³, Shradha Ahuja³ and Vikas Majithia^1,4, ¹Division of Rheumatology, University of Mississippi, Jackson, MS, ²Division of Hematology and Oncology, Albert Einstein Healthcare Network, Philadelphia, PA, ³Division of Hospital Medicine, University of Mississippi, Jackson, MS, ⁴Jackson VA Medical Center and University of Mississippi, Jackson, MS
Background/Purpose: Fertility is reduced in patients with Rheumatoid Arthritis (RA) due to unknown cause. Few studies mostly involving single center cohorts have addressed pregnancy outcomes…
Abstract Number: 1318 • 2017 ACR/ARHP Annual Meeting
Abnormal Cerviovaginal Cytology in Adolescents with Systemic Lupus Erythematosus: A Retrospective Case Series
Jennifer Kurkowski¹, Martha Curry², Marietta deGuzman³, Jane Geyer⁴ and Oluyemisi Adeyemi-Fowode⁵, ¹Department of Obstetrics and Gynecology, Baylor College of Medicine, Texas Childrens Hospital, Houston, TX, ²Pediatric rheumatology, Baylor College of Medicine and Texas Childrens Hospital, Houston, TX, ³Baylor College of Medicine, Division of Pediatric Rheumatology, Houston, TX, ⁴Baylor College of Medicine, Division of Pediatric and Adolescent Gynecology, Houston, TX, ⁵Department of Obstetrics and Gynecology, Baylor College of Medicine and Texas Childrens Hospital, Houston, TX
Background/Purpose: Guidelines recommend screening for cervical cancer in women starting at age 21 but according to the American Congress of Obstetricians and Gynecologists, exceptions should…
Abstract Number: 1319 • 2017 ACR/ARHP Annual Meeting
TAS05567 Is a Novel Potent and Selective Spleen Tyrosine Kinase Inhibitor That Attenuates Disease Severity in Animal Models of Autoimmune Diseases
Hiroaki Hayashi, Ryuusuke Kaneko, Manabu Tayama, Shunsuke Demizu, Daichi Akasaka, Hiroki Irie, Aki Kawagishi, Yoshio Ogino, Teruhiro Utsugi, Eiji Sasaki and Yoshikazu Iwasawa, TAIHO PHARMACEUTICAL CO., LTD., Tsukuba, Japan
Background/Purpose: Spleen tyrosine kinase (Syk) is a non-receptor cytoplasmic tyrosine kinase. B-cell receptor (BCR) and Fc receptor-mediated syk signaling pathways lead to activation of several…
Abstract Number: 1320 • 2017 ACR/ARHP Annual Meeting
TAS5315, a Novel Bruton’s Tyrosine Kinase Inhibitor, Ameliorates Inflammation and Bone Erosion in Murine Model for Rheumatoid Arthritis
Yohei Yoshiga¹, Fumihito Hosoi¹, Satoru Iguchi¹, Ryuusuke Kaneko², Yoshinori Nakachi¹, Daichi Akasaka², Kenji Tanaka², Kazuhiko Yonekura², Teruhiro Utsugi², Eiji Sasaki² and Yoshikazu Iwasawa², ¹TAIHO PHARMACEUTICAL CO., LTD., TSUKUBA, Japan, ²TAIHO PHARMACEUTICAL CO., LTD., Tsukuba, Japan
Background/Purpose: The erosions of bone and cartilage are a cardinal feature of rheumatoid arthritis (RA) and associated with disease severity and poor functional outcome. Although…
Abstract Number: 1321 • 2017 ACR/ARHP Annual Meeting
Inhibition of the Mechanistic Target of Rapamycin Pathway and Glutaminolysis Facilitates the Expansion of Myeloid-Derived Suppressor Cells and Synergistically Ameliorates Arthritis in SKG Mice
Yo Ueda¹, Takaichi Okano¹, Hirotaka Yamada¹, Yoshihide Ichise¹, Ikuko Naka², Soshi Takahashi³, Sho Sendo⁴, Kengo Akashi², Akira Onishi⁵, Jun Saegusa⁴ and Akio Morinobu³, ¹Department of Rheumatology and Clinical immunology, Kobe University Graduate School of Medicine, Kobe, Japan, ²Kobe University Graduate School of Medicine, Kobe, Japan, ³Department of Rheumatology and Clinical Immunology, Kobe University Graduate School of Medicine, Kobe, Japan, ⁴Rheumatology and Clinical Immunology, Kobe University Graduate School of Medicine, Kobe, Japan, ⁵Rheumaology and Clinical Immunology, Kobe University Graduate School of Medicine, Kobe, Japan
Background/Purpose: Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature cells that increase in the pathological state such as tumor or inflammation and have…
Abstract Number: 1322 • 2017 ACR/ARHP Annual Meeting
Tissue Folate Dysregulation Is Associated with Disease Activity and Methotrexate Response in Collagen-Induced Arthritis
Leon van Haandel¹, Rakesh Singh², Paul Kiptoo³, Teruna Siahaan³, Mara L Becker⁴ and Ryan Funk⁵, ¹2401 Gillham Road, Children's Mercy, Kansas City, MO, ²Department of Pharmacy Practice, University of Kansas Medical Center, Kansas City, KS, ³Department of Pharmaceutical Chemistry, University of Kansas, Lawrence, KS, ⁴Rheumatology, Children's Mercy Kansas City, Kansas City, MO, ⁵University of Kansas Medical Center, Kansas City, KS
Background/Purpose: Methotrexate (MTX) is an anti-metabolite inhibitor of folate-dependent biochemical pathways and is effective in reducing disease activity in autoimmune arthritis. This work seeks to…
Abstract Number: 1323 • 2017 ACR/ARHP Annual Meeting
Crucial Roles for Toll-like Receptor 9 in the Pathogenesis of Erosive Autoimmune Arthritis and during Osteoclastogenesis
Anita Fischer¹, Brigitte Meyer¹, Birgit Niederreiter², Erik Lönnblom³, Rikard Holmdahl⁴ and Günter Steiner², ¹Internal Medicine III, Division of Rheumatology, Medical University Vienna, Vienna, Austria, ²Rheumatology, Medical University of Vienna, Vienna, Austria, ³Department of Medical Biochemistry & Biophysics, Karolinska Institute, Stockholm, Sweden, ⁴Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden
Background/Purpose: Release and insufficient removal of endogenous nucleic acids may be involved in triggering harmful autoimmune reactions important in the initiation of systemic autoimmune diseases…
Abstract Number: 1324 • 2017 ACR/ARHP Annual Meeting
Angiotensin II Type I Receptor Deficiency Exacerbates Erosive Bone Destruction of hTNF-Transgenic Arthritis Mice
Takafumi Mito¹, Tomoyuki Mukai¹, Shunichi Fujita¹, Shoko Kodama¹, Akiko Nagasu¹, Teruki Sone² and Yoshitaka Morita¹, ¹Department of Rheumatology, Kawasaki Medical School, Kurashiki, Okayama, Japan, ²Department of Nuclear Medicine, Kawasaki Medical School, Kurashiki, Okayama, Japan
Background/Purpose: Angiotensin II (Ang II) is known to function on various organs including kidneys, adrenal glands as well as the nervous and cardiovascular systems through…
Abstract Number: 1325 • 2017 ACR/ARHP Annual Meeting
Immune Responses to Peptides Containing Homocitrulline or Citrulline in the DR4-Transgenic Mouse Model of Rheumatoid Arthritis
Patrick Lac¹, Sheri Saunders¹, Elena Tutunea-Fatan¹, Lillian Barra², David Bell³ and Ewa Cairns², ¹Microbiology and Immunology, The University of Western Ontario, London, ON, Canada, ²Medicine, Microbiology and Immunology, The University of Western Ontario, London, ON, Canada, ³Medicine, The University of Western Ontario, London, ON, Canada
Background/Purpose: Antibodies to proteins/peptides containing citrulline (commonly measured using cyclic citrullinated peptide, CCP2) are hallmarks of Rheumatoid Arthritis (RA). These antibodies are strongly associated with…
Abstract Number: 1326 • 2017 ACR/ARHP Annual Meeting
Alpha-Glucosidase Inhibitors Alter Gut Microbiota and Ameliorate Collagen-Induced Arthritis
Lingshu Zhang^1,2, Pingfang Song², Xiaowei Zhang², Christina Metea², Matthew Schleisman², Lisa Karstens², Eric Leung², Jun Zhang³, Qiang Xu^2,4, Yi Liu⁵, Mark Asquith² and Cong-Qiu Chu^6,7, ¹Department of Rheumatology, West China Hospital, Sichuan University, Chengdu, China, ²Oregon Health & Science University, Portland, OR, ³MD Anderson Cancer Center, Houston, TX, ⁴Guangzhou University of Chinese Medicine, Guangzhou, China, ⁵Department of Rheumatology and Immunology, West China Hospital of Sichuan University, Chengdu, China, ⁶Rheumatology, Oregon Health & Science University, Portland, OR, ⁷Rheumatology, VA Portland Health Care System, Portland, OR
Background/Purpose: Acarbose, an alpha-glucosidase inhibitor anti-diabetic drug exhibited anti-arthritic effects. The mechanism that acarbose exerts its anti-arthritic effects is not fully understood. Since > 90%…

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