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  • Abstract Number: 1282 • 2017 ACR/ARHP Annual Meeting

    Assessing the Prevalence of Juvenile Systemic Sclerosis in Childhood Using Administrative Claims Data from the United States

    Ivan Foeldvari1, Timothy Beukelman2 and Fenglong Xie3, 1Hamburg Center for Pediatric and Adolescent Rheumatology, Hamburg, Germany, 2Pediatric Rheumatology, University of Alabama at Birmingham, Birmingham, AL, 3Division of Clinical Immunology & Rheumatology, University of Alabama at Birmingham, Birmingham, AL

    Background/Purpose: Juvenile systemic Sclerosis (jSSc) is an orphan disease. There are some data regarding the incidence, but nearly no data exist regarding the prevalence of…
  • Abstract Number: 1283 • 2017 ACR/ARHP Annual Meeting

    Male Patients Have a More Severe Course As Female Patients with Diffuse Juvenile Systemic Scleroderma? Results from the Juvenile Scleroderma Inception Cohort Www.Juvenile-Scleroderma.Com

    Ivan Foeldvari1, Jens Klotsche2, Ozgur Kasapcopur3, Amra Adrovic4, Valda Stanevicha5, Maria Teresa Terreri6, Ekaterina Alexeeva7, Maria M. Katsicas8, Vanessa Smith9, Rolando Cimaz10, Mikhail Kostik11, Thomas J. A. Lehman12, Jordi Anton13, Walter A. Sifuentes-Giraldo14, Flavio Sztajnbok15, Tadey Avcin16, Mahesh Janarthanan17, Maria José Santos18, Dana Nemkova19, Cristina Battagliotti20, Despina Eleftheriou21, Liora Harel22, Tilmann Kallinich23, K Minden24, Susan Mary Nielsen25, Kathryn S. Torok26, Yosef Uziel27, Anne Stevens28, Clarissa Pilkington29 and Nicola Helmus1, 1Hamburg Center for Pediatric and Adolescent Rheumatology, Hamburg, Germany, 2Epidemiology unit, German Rheumatism Research Center, Berlin, Germany, 3Pediatric Rheumatology, Istanbul University, Cerrahpasa Medical School, Department of Pediatric Rheumatology, Istanbul, Turkey, 4Department of Pediatric Rheumatology, Istanbul University, Cerrahpasa Medical School, Istanbul, Turkey, 5Pediatric cathedra, Riga Stradiņš University, Riga, Latvia, 6Pediatric Rheumatology Unit, Federal University of São Paulo (UNIFESP - Universidade Federal de São Paulo), São Paulo, Brazil, 7Children's Health of RAMS and IM Sechenov First Moscow State Medical University, Moscow, Russian Federation, 8Service of Immunology & Rheumatology., Hospital de Pediatría Prof Dr JP Garrahan, Buenos Aires, Argentina, 9Faculty of Internal Medicine, Ghent University, Ghent, Belgium, 10Pediatrics, Ospedale Pediatrico Anna Meyer, Florence, Italy, 11Hospital Pediatrics, State Pediatric Medical University, Saint-Petersburg, Russia, 12Pediatric Rheumatology, Hospital for Special Surgery Weill Cornell Medical College, New York, NY, 13pediatric Rheumatology, University Childrenxs Hospital, Barcelona, Spain, 14Rheumatology, Hospital Universitario Ramón y Cajal, Madrid, Spain, 15Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil, 16University Children's Hospital, Ljubljana, Slovenia, 17Pediatric Rheumatology, Chennai, India, 18Reuma.pt, Almada, Portugal, Almada, Portugal, 19Pediatric Rheumatology Unit, Department of Pediatrics and Adolescent Medicine, General University Hospital in Prague, Prague, Czech Republic, 20Hospital de Niños Dr Orlando Alasia, Santa Fé, Argentina, 21Infection, Inflammation and Rheumatology, UCL Institute of Child Health, London, United Kingdom, 22Schneider Children's Medical Center of Israel, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel, 23Charité, Humbolt University Medicine Berlin, Berlin, Germany, 24Charité – University of Medicine Berlin, Berlin, Germany, 25Rigshospitalet, Copenhagen, Denmark, 26Pediatric Rheumatology, University of Pittsburgh Med Ctr, Pittsburgh, PA, 27Meir Medical Center, Kfar Saba, Israel, 28University of Washington, Department of Pediatrics, Seattle, WA, 29Paediatric Rheumatology, Great Ormond Street Hospital for Children NHS Trust, London, United Kingdom

    Background/Purpose: In adult systemic scleroderma patients male have a more sever course. This issue was never evaluated in a larger juvenile scleroderma cohort. Methods: Patients…
  • Abstract Number: 1284 • 2017 ACR/ARHP Annual Meeting

    The Localized Scleroderma Quality of Life Instrument (LoSQI): Initial Validation in Pediatric Localized Scleroderma

    Christina K. Zigler1, Kaveh Ardalan2, Kaila Schollaert-Fitch3, Heidi Jacobe4 and Kathryn S. Torok3, 1Physical Medicine & Rehabilitation, University of Pittsburgh, Pittsburgh, PA, 2Division of Rheumatology, Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL, 3Pediatric Rheumatology, University of Pittsburgh Med Ctr, Pittsburgh, PA, 4Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, TX

    Background/Purpose: There is a current need to integrate health related quality of life (HRQoL) into outcomes for clinical trials (Chang & Reeve, 2005). For pediatric…
  • Abstract Number: 1285 • 2017 ACR/ARHP Annual Meeting

    Extracutaneous Involvement Is Common in Juvenile Localized Scleroderma and Associated with a Higher Level of Perceived Disease Impact

    Suzanne C. Li1, Tracy Andrews2, Mallory Chen3, Kathryn S. Torok4, Elena Pope5, Katie G. Stewart6, Gloria C. Higgins7, C. Egla Rabinovich8, Ronald M. Laxer9, Kathleen Haines10, Marilynn Punaro11, Heidi Jacobe12 and Kathleen O'Neil13, 1Pediatrics, Joseph M Sanzari Children's Hospital, Hackensack Meridian Health, Hackensack, NJ, 2Research, Hackensack University Medical Center, Hackensack Meridian Health, Hackensack, NJ, 3Williams College, williamstown, MA, 4Pediatric Rheumatology, University of Pittsburgh Med Ctr, Pittsburgh, PA, 5Section of Dermatology, The Hospital for Sick Children, Hospital for Sick Children, Toronto, ON, Canada, 6Pediatric Rheumatology, Texas Scottish Rite Hospital, Dallas, TX, 7Pediatric Rheumatology Ohio State University, Nationwide Childrens Hospital, Columbus, OH, 8Pediatric Rheumatology, Duke University Medical Center, Durham, NC, 9Div of Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada, 10Joseph M Sanzari Children’s Hospital, Hackensack Meridian Health, Hackensack, NJ, 11Texas Scottish Rite Hospital for Children, Dallas, TX, 12Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, TX, 13Pediatric Rheumatology, RIley Hospital for Children, Indianapolis, IN

    Background/Purpose: Juvenile localized scleroderma (jLS) is often associated with deep tissue and extracutaneous involvement (ECI), putting children at risk for severe morbidity such as hemiatrophy,…
  • Abstract Number: 1286 • 2017 ACR/ARHP Annual Meeting

    Performance of Juvenile Scleroderma Classification Criteria for Juvenile Systemic Sclerosis. Results from the Jssc Inception Cohort

    Jens Klotsche1, Ivan Foeldvari2, Ozgur Kasapcopur3, Vanessa Smith4, Flavio Sztajnbok5, Maria M. Katsicas6, Rolando Cimaz7, Mahesh Janarthanan8, Jordi Anton9, Mikhail Kostik10, Dana Nemkova11, Walter A. Sifuentes-Giraldo12, Valda Stanevicha13, Kathryn S. Torok14, Simone Appenzeller15, Tadey Avcin16, Lillemor Berntson17, Liora Harel18, Tilmann Kallinich19, Maria José Santos20, Maria Teresa Terreri21, Yosef Uziel22 and Nicola Helmus2, 1Epidemiology unit, German Rheumatism Research Center, Berlin, Germany, 2Hamburg Center for Pediatric and Adolescent Rheumatology, Hamburg, Germany, 3Pediatric Rheumatology, Istanbul University, Cerrahpasa Medical School, Department of Pediatric Rheumatology, Istanbul, Turkey, 4Faculty of Internal Medicine, Ghent University, Ghent, Belgium, 5Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil, 6Service of Immunology & Rheumatology., Hospital de Pediatría Prof Dr JP Garrahan, Buenos Aires, Argentina, 7Pediatrics, Ospedale Pediatrico Anna Meyer, Florence, Italy, 8Pediatric Rheumatology, Chennai, India, 9pediatric Rheumatology, University Childrenxs Hospital, Barcelona, Spain, 10Hospital Pediatrics, State Pediatric Medical University, Saint-Petersburg, Russia, 11Pediatric Rheumatology Unit, Department of Pediatrics and Adolescent Medicine, General University Hospital in Prague, Prague, Czech Republic, 12Rheumatology, Hospital Universitario Ramón y Cajal, Madrid, Spain, 13Pediatric cathedra, Riga Stradiņš University, Riga, Latvia, 14Pediatric Rheumatology, University of Pittsburgh Med Ctr, Pittsburgh, PA, 15Pediatric Rheumatology Unit, State University of Campinas, Campinas, Brazil, 16University Children's Hospital, Ljubljana, Slovenia, 17Dept. of Pediatrics, Uppsala University Hospital, Uppsala, Sweden, 18Schneider Children's Medical Center of Israel, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel, 19Charité, Humbolt University Medicine Berlin, Berlin, Germany, 20Reuma.pt, Almada, Portugal, Almada, Portugal, 21Pediatric Rheumatology Unit, Federal University of São Paulo (UNIFESP - Universidade Federal de São Paulo), São Paulo, Brazil, 22Meir Medical Center, Kfar Saba, Israel

    Background/Purpose: Juvenile systemic sclerosis (jSSc) is a rare disease during childhood. Classification criteria for jSSc were published in 2007. They include a major criterion that…
  • Abstract Number: 1287 • 2017 ACR/ARHP Annual Meeting

    Cone Beam Computed Tomography for the Assessment of Linear Scleroderma of the Face

    Francesco Zulian1, Chiara Di Giovanni2, Stafano Puggina3, Alessandra Meneghel1, Sabina Trainito4 and Giorgia Martini2, 1University of Padua, Department of Woman and Child Health, Padua, Italy, 2Department of Woman and Child Health, University of Padua, Padua, Italy, 3Unix Radiology Service, Affidea Group inc., Piove di Sacco, Italy, 4Division of Physical Medicine and Rehabilitation, University of Padua, Padua, Italy

    Background/Purpose: Linear scleroderma of the face (LSF) is a very disabling condition and, to date, standardized and validated methods for assessing and monitoring the disease…
  • Abstract Number: 1288 • 2017 ACR/ARHP Annual Meeting

    Renal Disease Course in Pediatric Anti-Neutrophil Cytoplasmic Antibody Associated Vasculitis in the First 12-Months – a Pediatric Vasculitis Initiative (PedVas) Study

    Kimberly Morishita1, Audrea Chen2, Cherry Mammen1, Angelyne Rivera3 and David Cabral1, 1BC Children's Hospital and University of British Columbia, Vancouver, BC, Canada, 2Medicine, University of British Columbia, Vancouver, BC, Canada, 3Pediatrics, BC Children's Hospital and University of British Columbia, Vancouver, BC, Canada

    Background/Purpose: Renal disease is the most common manifestation of pediatric anti-neutrophil cycloplasmic antibody (ANCA) associated vasculitis (AAV). Renal disease course and early trajectories have not…
  • Abstract Number: 1289 • 2017 ACR/ARHP Annual Meeting

    Assessing ACR/EULAR Provisional 2017 Classification Criteria for Granulomatosis with Polyangiitis (GPA) in a Cohort of 376 Children with Small to Medium Vessel Chronic Vasculitis – a Pediatric Vasculitis Initiative (PedVas) Study

    Angelyne Rivera1, Kimberly Morishita2, David Cabral2 and Raashid Luqmani3, 1Pediatrics, BC Children's Hospital and University of British Columbia, Vancouver, BC, Canada, 2BC Children's Hospital and University of British Columbia, Vancouver, BC, Canada, 3Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom

     Background/Purpose: Classification of chronic vasculitis to clinically or etiologically meaningful groups has been challenging.  In 2008, the 1990 ACR classification criteria for GPA was adapted…
  • Abstract Number: 1290 • 2017 ACR/ARHP Annual Meeting

    Preterm Birth Phenotypes in Women with Autoimmune Diseases

    Kathleen D. Kolstad1, Jonathan A. Mayo2, Lorinda Chung3, Yashaar Chaichian4, Victoria M. Kelly5, Maurice Druzin6, David K. Stevenson7, Gary M. Shaw8 and Julia F Simard9, 1Rheumatology, Stanford University Medical Center, Stanford, CA, 2Stanford University Medical Center, Stanford, CA, 3Rheumatology, Stanford University Medical Center, Palo Alto, CA, 4Medicine, Immunology & Rheumatology Division, Stanford School of Medicine, Stanford, CA, 5Palo Alto Medical Foundation, Palo Alto, CA, 6Obstetrics & Gynecology, Stanford School of Medicine, Stanford, CA, 7Pediatrics - Neonatology, Stanford University, Stanford, CA, 8Pediatrics, Division of Neonatology and Developmental Medicine, Stanford School of Medicine, Stanford, CA, 9Division of Epidemiology, Health Research and Policy Department, Stanford School of Medicine, Stanford, CA

    Background/Purpose: Systemic autoimmune diseases expose patients to chronic inflammation, immune dysregulation, and vascular abnormalities; complications that can impact obstetric outcomes. The goal of this study…
  • Abstract Number: 1291 • 2017 ACR/ARHP Annual Meeting

    Preterm Delivery Phenotypes in SLE Pregnancies

    Julia F Simard1, Yashaar Chaichian2, Marios Rossides3, Anna-Karin Wikstrom4, Gary M. Shaw5 and Maurice Druzin6, 1Medicine, Division of Immunology & Rheumatology, Stanford School of Medicine, Stanford, CA, 2Medicine, Immunology & Rheumatology Division, Stanford School of Medicine, Stanford, CA, 3Medicine Solna, Clinical Epidemiology Unit, Karolinska Institutet, Stockholm, Sweden, 4Department of Women’s and Children’s Health, Uppsala University, Uppsala, Sweden, 5Pediatrics, Division of Neonatology and Developmental Medicine, Stanford School of Medicine, Stanford, CA, 6Obstetrics & Gynecology, Stanford School of Medicine, Stanford, CA

    Background/Purpose: Women with systemic lupus erythematosus (SLE) are at greater risk of preterm delivery compared to women without lupus. A significant proportion of SLE pregnancies…
  • Abstract Number: 1292 • 2017 ACR/ARHP Annual Meeting

    Long-Term Follow-up of 320 Chilren Born to Mothers with Systemic Autoimmune Diseases: A Multicentre Survey from 24 Rheumatology Centers in Italy

    Maria Grazia Lazzaroni1, Cecilia Nalli1, Laura Andreoli1, Chiara Carini1, Marilia Rodrigues2, Francesca Dall'Ara1, Elena Bartoloni-Bocci3, Roberto Gerli3, Maria Gerosa4, Cecilia B. Chighizola5, Pier Luigi Meroni4, Luigi Sinigaglia6, Paola Conigliaro7, Roberto Perricone7, Ada Corrado8, Francesco Paolo Cantatore8, Salvatore D'Angelo9, Ignazio Olivieri9, Maria Favaro10, Maddalena Larosa10, Andrea Doria10, Amelia Ruffatti11, Elena Generali12, Carlo Selmi13, Marianna Meroni14, Maurizio Cutolo15, Melissa Padovan16, Marcello Govoni16, Giulia Pazzola17, Carlo Salvarani18, Susanna Peccatori19, Giuseppe Paolazzi19, Imma Prevete20, Giovanni Minisola20, Gian Domenico Sebastiani21, Antonio Brucato22, Véronique Ramoni23, Roberto Caporali24, Carlomaurizio Montecucco24, Viola Signorini25, Chiara Tani26, Marta Mosca25, Marica Trevisani27, Nazzarena Malavolta27, Marta Vadacca28, Antonella Afeltra29, Ester Vivaldelli30, Armin Maier30, Elisa Visalli31, Rosario Foti31, Carolina Benigno32, Lucia Zuliani33, Armando Gabrielli33, Corrado Campochiaro34, Elena Baldissera35, Maria Grazia Sabbadini36, Nicoletta Romeo37 and Angela Tincani1, 1University and Spedali Civili of Brescia, Brescia, Italy, 2Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal, 3University and Azienda Ospedaliera of Perugia, Perugia, Italy, 4Istituto Ortopedico Gaetano Pini, University of Milan, Milano, Italy, 5Rheumatology, Istituto Auxologico Italiano, University of Milan, Cusano Milanino, Italy, 6Istituto Ortopedico Gaetano Pini, University of Milan, Italy, Milan, Italy, 7Policlinico Tor Vergata of Rome, Rome, Italy, 8Ospedali Riuniti of Foggia, Foggia, Italy, 9San Carlo Hospital of Potenza, Potenza, Italy, 10University and Azienda Ospedaliera of Padova, Padova, Italy, 11Unità di Reumatologia, Dipartimento di Medicina-DIMED, Università di Padova., Padova, Italy, 12Rheumatology and Clinical Immunology, Humanitas Research Hospital, Rozzano (MI), Italy, 13Humanitas Research Hospital of Milan, Rozzano, Italy, 14Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, IRCCS A.O.U. San Martino-IST, University of Genova, Genoa, Italy, Genova, Italy, 15Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, IRCCS San Martino, Genoa, Italy, Genoa, Italy, 16UOC of Rheumatology, University Hospital S. Anna, Cona Ferrara, Italy, 17Azienda Ospedaliera ASMN, Istituto di Ricovero e Cura a Carattere Scientifico of Reggio-Emilia, Reggio-Emilia, Italy, 18Rheumatology Unit, Arcispedale Santa Maria Nuova - IRCCS; Università di Modena e Reggio Emilia, Reggio-Emilia, Italy, 19Azienda Provinciale Servizi Sanitari of Trento, Trento, Italy, 20Azienda Ospedaliera San Camillo of Rome, Roma, Italy, 21Rheumatology, San Camillo Forlanini Hospital, Roma, Italy, 22Struttura Complessa Medicina Interna, ASST Papa Giovanni XXIII, Bergamo, Italy, 23Ospedale Papa Giovanni XXIII of Bergamo, Policlinico San Matteo of Pavia, Bergamo, Pavia, Italy, 24University and Policlinico San Matteo of Pavia, Pavia, Italy, 25University of Pisa, Pisa, Italy, 26Rheumatology Unit, University of Pisa, Pisa, Italy, 27Policlinico S.Orsola-Malpighi, Azienda Ospedaliero-Universitaria of Bologna, Bologna, Italy, 28University Campus Biomedico of Rome, Roma, Italy, 29University Campus Biomedico of Rome, roma, Italy, 30Ospedale of Bolzano, Bolzano, Italy, 31Policlinico Vittorio Emanuele-Ferrarotto-Bambin Gesù of Catania, Catania, Italy, 32University Federico II of Napoli, Napoli, Italy, 33Ospedali Riuniti of Ancona, Ancona, Italy, 34Centre for Rheumatology and Connective Tissue Diseases, UCL Division of Medicine, London, United Kingdom, 35Ospedale San Raffaele of Milan, Milan, Italy, 36Unit of Medicine and Clinical Immunology, Ospedale San Raffaele of Milano, Milan, Italy, 37Ospedale S.Croce e Carle of Cuneo, Cuneo, Italy

    Background/Purpose: Rheumatic Diseases (RD) frequently affect women during reproductive age, therefore counseling on family planning is crucial for their quality of life. Children's outcome is…
  • Abstract Number: 1293 • 2017 ACR/ARHP Annual Meeting

    Indications for Cesarean Delivery in Systemic Lupus Erythematosus Pregnancies

    Evelyne Vinet1, Paul R. Fortin2, Stéphanie Roberge3, Emmanuel Bujold4 and Nils Chaillet5, 1Divisions of Rheymatology and Clinical Epidemiology, McGill University Health Centre, Montreal, QC, Canada, 2Infectious Diseases and Immunity Research Division, CHU de Québec-Université Laval Research Center, Québec, QC, Canada, 3Centre de recherche du CHU de Québec-Université Laval, Québec, QC, Canada, 4Reproduction, mother and youth health, Centre Hospitalier de l'Université Laval (CHUL), Québec, QC, Canada, 5Département d’obstétrique et gynécologie et département de Médecine de famille et médecine d’urgence, Université de Sherbrooke, Sherbrooke, QC, Canada

    Background/Purpose: Pregnant SLE women are at increased risk of cesarean delivery compared to pregnant women from the general population. Yet, to date, no one has…
  • Abstract Number: 1294 • 2017 ACR/ARHP Annual Meeting

    Time to Pregnancy in Women with Systemic Lupus Erythematosus

    Meriem El bakali1, Sasha Bernatsky2, Christian A. Pineau3 and Evelyne Vinet4, 1Division of Rheumatology, McGill University Health Centre, Montreal, QC, Canada, 2Divisions of Rheumatology and Clinical Epidemiology, Research Institute of the McGill University Health Centre, Montreal, QC, Canada, 3McGill University Health Centre, Montreal, QC, Canada, 4Divisions of Rheymatology and Clinical Epidemiology, McGill University Health Centre, Montreal, QC, Canada

    Background/Purpose: Women diagnosed with systemic lupus erythematosus (SLE) during the reproductive period have fewer children than unaffected women. Multiple disease-related factors might influence family size…
  • Abstract Number: 1295 • 2017 ACR/ARHP Annual Meeting

    Pregnancy Outcome in Patients with SLE Compared to Patients with Other Inflammatory Rheumatic Diseases: Real World Data from a Prospective Pregnancy Register

    Rebecca Fischer-Betz1, Christina Bungartz2, Matthias Schneider1, Jutta Richter1, Anja Weiss2, Angela Zink3 and Anja Strangfeld4, 1Policlinic for Rheumatology & Hiller Research Centre for Rheumatology, Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany, 2German Rheumatism Research Center, Berlin, Germany, 3Epidemiology Unit / Rheumatology and Clinical Immunology, German Rheumatism Research Centre (DRFZ) / Charité University Hospital, Berlin, Germany, 4Epidemiology, German Rheumatism Research Center, Berlin, Germany

    Background/Purpose: SLE pregnancies are complicated due to risk for maternal disease exacerbation and potential for fetal and neonatal complications. With careful pre-pregnancy counseling and monitoring…
  • Abstract Number: 1296 • 2017 ACR/ARHP Annual Meeting

    Hydroxychloroquine Level Decreases throughout Pregnancy: Implications for Maternal and Neonatal Outcomes

    Stephen Balevic1, Michael Cohen-Wolkowiez2, Amanda M. Eudy3, Laura E. Schanberg4 and Megan E. B. Clowse5, 1Rheumatology, Adult and Pediatric, Duke University Medical Center, Durham, NC, 2Pharmacometrics Center, Duke Clinical Research Institute, Durham, NC, 3Duke University Medical Center, Chapel Hill, NC, 4Pediatrics, Duke University Medical Center, Durham, NC, 5Duke University Medical Center, Durham, NC

    Background/Purpose: Pregnancies in women with active rheumatic disease often result in poor neonatal outcomes. Prior data suggests that hydroxychloroquine (HCQ) can reduce disease activity and…
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