Abstracts Archive - Page 1280 of 2607 - ACR Meeting Abstracts

Abstract Number: 1405 • 2018 ACR/ARHP Annual Meeting
Assessment of the Psychometric Properties of Patient-Reported Outcomes of Depression in SLE
Andrew Kwan¹, Sherief Marzouk², Helia Ghanean², Michelle Vitti³, Kishwar Ali³, Dennisse Bonilla³, Nicole Anderson³, Jiandong Su³ and Zahi Touma³, ¹Faculty of Medicine, Queen's University, Kingston, ON, Canada, ²Psychiatry, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ³University of Toronto, Toronto Western Hospital, Toronto, ON, Canada
Background/Purpose: Mood disorders, including depression, are amongst the most common manifestations of neuro-psychiatric SLE. Currently, the screening and diagnosis for depression in ambulatory settings are…
Abstract Number: 1406 • 2018 ACR/ARHP Annual Meeting
Longitudinal Construct Validity of the Psaid Individual Items: Can We Eliminate Other Questionnaires If Using the Psaid?
Jessica Walsh¹, Jose U. Scher², Soumya M. Reddy³, M. Elaine Husni⁴ and Alexis Ogdie⁵, ¹University of Utah School of Medicine, Salt Lake City, UT, USA, Salt Lake City, UT, ²New York University School of Medicine, New York, NY, ³Department of Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, ⁴Orthopedic and Rheumatologic Institute, Cleveland Clinic, Cleveland, OH, ⁵Medicine/Rheumatology and Epidemiology, University of Pennsylvania, Philadelphia, PA
Background/Purpose: The Psoriatic Arthritis Impact of Disease (PsAID) questionnaire is a patient reported measure of disease impact. The 12-item questionnaire has many advantages including demonstrated…
Abstract Number: 1407 • 2018 ACR/ARHP Annual Meeting
Differences in the Measurement Properties of the Patient-Reported Outcomes Measurement Information System Physical Function Short-Form 10a Among Racial/Ethnic Minorities with Rheumatoid Arthritis
Zara Izadi¹, Patricia Katz², Gabriela Schmajuk³, Julie Gandrup⁴, Jing Li⁵, Milena Gianfrancesco⁶ and Jinoos Yazdany⁷, ¹Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, ²University of California San Francisco, San Francisco, CA, ³Medicine/Rheumatology, University of California - San Francisco, San Francisco, CA, ⁴Rheumatology, Odense University Hospital, Odense, Denmark, ⁵Medicine, UC San Francisco, San Francisco, CA, ⁶Medicine/Rheumatology, University of California, San Francisco, San Francisco, CA, ⁷University of California, San Francisco, San Francisco, CA
Background/Purpose: Most studies evaluating patient-reported outcomes such as the PROMIS Physical Function Short Form 10a (PF10a) in rheumatoid arthritis (RA) have been performed in white…
Abstract Number: 1408 • 2018 ACR/ARHP Annual Meeting
Using Patient Reported Outcomes at Point of Care in Immune Mediated Diseases: Minimal Clinically Important Differences
M. Elaine Husni¹, Chad Deal², Leonard H. Calabrese³, Greg Strnad⁴, James Bena⁵ and Abby Abelson⁶, ¹Orthopedic and Rheumatologic Institute, Cleveland Clinic, Cleveland, OH, ²Cleveland Clinic, Shaker Heights, OH, ³Rheumatology, Cleveland Clinic, Cleveland, OH, ⁴Cleveland Clinic, Cleveland, OH, ⁵Quantitative Health Science, QHS Cleveland Clinic, Cleveland, OH, ⁶Department of Rheumatologic & Immunologic Disease, Cleveland Clinic, Cleveland, OH
Background/Purpose: Patient reported measures of global health and disease activity are increasingly used in routine care; however, detecting meaningful change in clinical status (responsiveness) is difficult…
Abstract Number: 1409 • 2018 ACR/ARHP Annual Meeting
Empowerment in Hispanic Rheumatoid Arthritis Patients: A Validation Study
Emmanuel Ruiz-Medrano¹, Irazú Contreras-Yáñez², Luz del Carmen Hernández³ and Virginia Pascual-Ramos⁴, ¹Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, ²Inmunología y Reumatología, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, ³UCB Pharmaceutical, Mexico City, Mexico, ⁴Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico
Background/Purpose: The World Health Organization describes empowerment in health promotion work as a process in which the person receives more control over decisions and actions…
Abstract Number: 1410 • 2018 ACR/ARHP Annual Meeting
Assessment of Work Outcomes with Truncation from Job Loss in an Arthritis Randomized Clinical Trial
Michael P. LaValley¹, Carrie Brown^1,2, David T. Felson^3,4 and Julie Keysor⁵, ¹Biostatistics, Boston University School of Public Health, Boston, MA, ²The Emmes Corporation, Rockville, MD, ³ARC Epidemiology Unit, University of Manchester, Manchester, MA, ⁴Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, ⁵Physical Therapy, MGH Institute of Health Professions, Boston, MA
Background/Purpose: Methods for causal analysis in randomized clinical trials (RCT) where functional outcomes may be truncated by death of participants have been developed but are…
Abstract Number: 1411 • 2018 ACR/ARHP Annual Meeting
Long-Term Safety of Different Doses of Canakinumab (<2, 2–<4, and 4–<8 mg/kg) in Patients Aged <4–≥65 Years: Results from the β-Confident Registry
Jasmin B. Kuemmerle-Deschner¹, Ulrich A. Walker², Hugh H. Tilson³, Philip N. Hawkins⁴, Tom van der Poll⁵, Kristina Franke⁶, Antonio Speziale⁷, Eleni Vritzali⁷ and Hal M. Hoffman⁸, ¹Pediatrics, University Hospital Tübingen, Tübingen, Germany, ²Department of Rheumatology, University Hospital Basel, Basel, Switzerland, ³University of North Carolina, Gillings School of Global Public Health, Chapel Hill, NC, ⁴University College London Medical School, London, United Kingdom, ⁵Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, ⁶IQVIA, Durham, NC, ⁷Novartis Pharma AG, Basel, Switzerland, ⁸University of California, San Diego, San Diego, CA
Background/Purpose: Canakinumab (CAN), a human anti-interleukin-1 monoclonal antibody, has shown to be efficacious and safe in the treatment of all phenotypes of cryopyrin-associated periodic syndrome…
Abstract Number: 1412 • 2018 ACR/ARHP Annual Meeting
A Systematic Literature Review of Efficacy and Safety of Current Therapies for the Treatment of Hyperimmunoglobulinemia D Syndrome and TNF Receptor-Associated Periodic Syndrome
Jasmin B. Kuemmerle-Deschner¹, Raju Gautam², Aneesh Thomas George², Syed Raza², Kathleen Graham Lomax³ and Peter Hur³, ¹Division of Pediatric Rheumatology, Department of Pediatrics, University Hospital, Tuebingen, Germany, Tuebingen, Germany, ²Novartis Healthcare Pvt. Ltd., Hyderabad, India, Hyderabad, India, ³Novartis Pharmaceuticals Corporation, East Hanover, New Jersey, USA, East Hanover, NJ
Background/Purpose: Hyperimmunoglobulinemia D syndrome (HIDS), also known as mevalonate kinase deficiency (MKD), and TNF receptor-associated periodic syndrome (TRAPS) are rare auto-inflammatory diseases grouped as periodic…
Abstract Number: 1413 • 2018 ACR/ARHP Annual Meeting
Safety of Tocilizumab in Patients Aged <2 Years with Active Systemic Juvenile Idiopathic Arthritis Treated for One Year
Sunethra Wimalasundera¹, Inmaculada Calvo², Rubén J. Cuttica³, Hans-Iko Huppertz⁴, Rik Joos⁵, Diana Milojevic⁶, Margalit Rosenkranz⁷, Kenneth Schikler⁸, Tamás Constantin⁹, Wendy Douglass¹, Chris Wells¹, Yukiko Kimura¹⁰ and Carine Wouters¹¹, ¹Roche Products Ltd., Welwyn Garden City, United Kingdom, ²Hospital Universitario La Fe, Valencia, Spain, ³Hospital General de Niños Pedro de Elizalde, Buenes Aires, Argentina, ⁴Professor Hess Children's Hospital, Bremen, Germany, ⁵ZNA, Antwerp, and UZ, Gent, Belgium, ⁶Tufts Medical Center, Boston, MA, ⁷Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, ⁸University of Louisville Medical School, Louisville, KY, ⁹Semmelweis University, Budapest, Hungary, ¹⁰Hackensack University Medical Center, Hackensack, NJ, ¹¹University Hospital Gasthuisberg, Leuven, Belgium
Background/Purpose: The US Food and Drug Administration approved intravenous (IV) tocilizumab (TCZ) for patients (pts) ≥2 years of age with systemic JIA (sJIA) in 2011…
Abstract Number: 1414 • 2018 ACR/ARHP Annual Meeting
Pharmacovigilance of Biologics for Systemic Juvenile Idiopathic Arthritis Patients By the German Biologics Registry
Gerd Horneff¹, Gerd Ganser², Toni Hospach³, Ivan Foeldvari⁴, Michael Borte⁵, Frank Weller-Heinemann⁶, Kirsten Minden⁷ and Ariane Klein⁸, ¹Asklepios Kinderklinik St. Augustin GmbH, Sankt Augustin, Germany, ²Klinik für Kinder-und Jugendrheumatologie, Nordwestdeutsches Rheumazentrum, Sendenhorst, Germany, ³Pediatrics, Olgahospital, Klinikum Stuttgart, Stuttgart, Germany, ⁴Hamburg Centre for Pediatric Rheumatology, Hamburg, Germany, ⁵St Georg Hospital, Leipzig, Germany, ⁶PRINTO, Genoa, Italy, ⁷Charité–Universitätsmedizin Berlin, Berlin, Germany, ⁸Center of Pediatrics and Neonatology, Asklepios Clinic Sankt Augustin, Sankt Augustin, Germany
Background/Purpose: Long-term surveillance of biologic drugs is particularly important in pediatric patients(pts). Since 2001, the German Biologics JIA Registry (BIKER) is allowing to follow up…
Abstract Number: 1415 • 2018 ACR/ARHP Annual Meeting
Emapalumab, an Anti-Interferon Gamma Monoclonal Antibody in Two Patients with NLRC4-Related Disease and Severe Hemophagocytic Lymphohistiocytosis (HLH)
Claudia Bracaglia¹, Giusi Prencipe¹, Antonella Insalaco¹, Ivan Caiello², Giulia Marucci¹, Raffaele Pecoraro³, Manuela Pardeo¹, Pavla Dolezalova⁴, Sarka Fingerhutova⁴, Maria Ballabio⁵, Cristina de Min⁵ and Fabrizio De Benedetti⁶, ¹Division of Rheumatology, IRCCS Ospedale Pediatrico Bambino Gesù, Rome, Italy, ²Division of Rheumatology, IRCCS Ospedale Pediatrico Bambino Gesù, Roma, Italy, ³Pediatric Department, La Sapienza University of Rome, Rome, Italy, ⁴Paediatric Rheumatology Unit, General University Hospital in Prague and 1st Faculty of Medicine, Charles University, General University Hospital in Prague and 1st Faculty of Medicine, Prague, Czech Republic, ⁵NovImmune S.A., Geneva, Switzerland, ⁶IRCCS Ospedale Pediatrico Bambino Gesù, Roma, Italy
Background/Purpose: Interferon gamma (IFNγ) plays a pathogenic role in primary and secondary HLH. An ongoing phase 2/3 trial with emapalumab in primary HLH provides encouraging…
Abstract Number: 1416 • 2018 ACR/ARHP Annual Meeting
Risk Score of Macrophage Activation Syndrome in Patients with Systemic Juvenile Idiopathic Arthritis
Simone Carbogno¹, Denise Pires Marafon², Giulia Marucci³, Manuela Pardeo³, Antonella Insalaco³, Virginia Messia³, Rebecca Nicolai³, Fabrizio De Benedetti⁴ and Claudia Bracaglia³, ¹University of Milan, Milan, Italy, ²Pediatric Unit, Fondazione IRCCS Ca’ Grande Ospedale Maggiore Policlinico, Milan, Italy, ³Division of Rheumatology, IRCCS Ospedale Pediatrico Bambino Gesù, Rome, Italy, ⁴IRCCS Ospedale Pediatrico Bambino Gesù, Roma, Italy
Background/Purpose: Macrophage Activation Syndrome (MAS) is a severe, life-threatening, complication of rheumatic diseases in childhood, particularly of systemic Juvenile Idiopathic Arthritis (sJIA), occurring in approximately…
Abstract Number: 1417 • 2018 ACR/ARHP Annual Meeting
Hemophagocytic Lymphohistiocytosis (HLH) Mimickers: CXCL9 As a Potential Biomarker Distinguishing HLH from Other Hyperferritinemic Syndromes
Giulia Marucci¹, Ivan Caiello², Manuela Pardeo¹, Virginia Messia¹, Giusi Prencipe¹, Antonia Pascarella¹, Fabrizio De Benedetti³ and Claudia Bracaglia¹, ¹Division of Rheumatology, IRCCS Ospedale Pediatrico Bambino Gesù, Rome, Italy, ²Division of Rheumatology, IRCCS Ospedale Pediatrico Bambino Gesù, Roma, Italy, ³IRCCS Ospedale Pediatrico Bambino Gesù, Roma, Italy
Background/Purpose: Increased ferritin is considered biomarker highly suggestive of primary and secondary HLH and it is one of the HLH-2004 diagnostic and MAS guidelines (1,2),…
Abstract Number: 1418 • 2018 ACR/ARHP Annual Meeting
External Validation of the Autoinflammatory Disease Activity Index (AIDAI) in Patients with Colchicine-Resistant FMF, Hids/Mkd, and TRAPS: Results from a Pivotal, Phase 3 Trial of Canakinumab
Isabelle Koné-Paut¹, Maryam Piram², Susanne Benseler³, Jasmin B. Kuemmerle-Deschner⁴, Annette F. Jansson⁵, Itzhak Rosner⁶, Alberto Tommasini⁷, Sara Murias⁸, Omer Karadag⁹, Jeremy Levy¹⁰, Serge Smeets¹¹ and Fabrizio De Benedetti¹², ¹APHP, CHU de Bicêtre, University of Paris SUD, Paris, France, ²Pediatrics, APHP, CHU de Bicêtre, University of Paris SUD, Paris, France, ³Alberta Children's Hospital, Calgary, AB, Canada, ⁴Pediatrics, University Hospital Tübingen, Tübingen, Germany, ⁵Ludwig Maximilian University, Munich, Germany, ⁶Bnai-Zion Medical Center, Haifa, Israel, ⁷Department of Internal Medicine, Università Cattolica Sacro Cuore, Rome, Italy, ⁸Hospital Infantil La Paz, Madrid, Spain, ⁹Rheumatology, Hacettepe University, Faculty of Medicine, Ankara, Turkey, ¹⁰BIOP, Reinach, AR, Switzerland, ¹¹Novartis Pharma B.V., Arnhem, Netherlands, ¹²IRCCS Ospedale Pediatrico Bambino Gesù, Roma, Italy
Background/Purpose: AIDAI is a novel and unique, validated patient (pt)-reported assessment tool to evaluate disease activity in familial Mediterranean fever (FMF), hyper-IgD syndrome/mevalonate kinase deficiency…
Abstract Number: 1419 • 2018 ACR/ARHP Annual Meeting
Long-Term Outcome of 50 Patients with Linear Scleroderma Treated with Methotrexate
Giorgia Martini¹, Gloria Fadanelli¹, Anna Agazzi¹, Fabio Vittadello¹, Alessandra Meneghel² and Francesco Zulian², ¹Department of Woman and Child Health, University of Padua, Padua, Italy, ²University of Padua, Department of Woman and Child Health, Padua, Italy
Background/Purpose: Linear Scleroderma (LS) is the most common subtype of localized Scleroderma in children and the one most frequently associated with tissue damage and functional…

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