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  • Abstract Number: 1072 • 2017 ACR/ARHP Annual Meeting

    Mutated Peptidylarginine Deiminase from Porphyromonas Gingivalis Is a Target in Rheumatoid Arthritis and Citrullinates Major RA-Autoantigens

    Madeleine Jenning1, Bianka Marklein1, Jimmy Ytterberg2, Gerd R. Burmester1 and Karl Skriner1, 1Department of Rheumatology and Clinical Immunology, Charité - University Medicine Berlin, Free University and Humboldt University Berlin, Berlin, Germany, 2Dept. of Medicine, Rheumatology Unit, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden

    Background/Purpose: Previous reports showed that peptidylarginine deiminase (PPAD) form Porphyromonas gingivalis (P.g.) is not able to citrullinate proteins internally. Mutated PPAD (mPPAD) from P.g. involved…
  • Abstract Number: 1073 • 2017 ACR/ARHP Annual Meeting

    Aberrant Cell Signaling in Peripheral Blood Mononuclear Cells upon Interferon Alpha Stimulation in Patients with Primary Sjögren’s Syndrome Associates with Type I Interferon Signature

    Richard Davies1, Daniel Hammenfors1,2, Brith Bergum1, Petra Vogelsang1, Sonia Gavasso3, Johan G. Brun2,4, Roland Jonsson5,6 and Silke Appel1, 1Broegelmann Research Laboratory, Department of Clinical Science, University of Bergen, Bergen, Norway, 2Department of Rheumatology, Haukeland University Hospital, Bergen, Norway, 3Department of Neurology, Haukeland University Hospital, Bergen, Norway, 4Department of Clinical Science, University of Bergen, Bergen, Norway, 5Broegelmann Research laboratory, Department of Clinical Science, University of Bergen, Bergen, Norway, 6Department of Rheumatology, Haukeland University Hospital, Bergen, Bergen, Norway

    Background/Purpose: Primary Sjögren’s syndrome (pSS) is a complex heterogeneous systemic autoimmune disease. Biomarkers for patient stratification are scarce. Several single nucleotide polymorphisms within type I…
  • Abstract Number: 1074 • 2017 ACR/ARHP Annual Meeting

    High Cholesterol Levels By ApoE Defenciency Reduce Bone Destruction in Murine Antigen-Induced Arthritis Via Inhibition of Osteoclastogenesis

    Giuliana Ascone1, Irene Di Ceglie1, Arjen B. Blom1, Birgitte Walgreen2, Annet W. Sloetjes1, Peter M. van der Kraan1, Ernst Lindhout3, Mike Martens3 and Peter L. van Lent4, 1Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, 2Experimental, Radboud university medical center, Nijmegen, Netherlands, 3Future Diagnostics Solutions (FDs), Wijchen, Netherlands, 4Experimental Rheumatology (272), Radboud university medical center, Nijmegen, Netherlands

    Background/Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by immune complex- deposition in the synovium, leading to increased bone destruction. In RA, joint…
  • Abstract Number: 1075 • 2017 ACR/ARHP Annual Meeting

    Higher Frequencies of Lymphocytes Expressing the Natural Killer Group 2D Receptor and Cytotoxic Potential of NK Cells in Patients with Behcet Disease

    Martina Bonacini1, Stefania Croci1, Alessandra Soriano2,3, Eleonora Calò1, Alessandro Zerbini1, Luca Cimino4, Francesco Muratore2,5, Luigi Fontana6, Maria Parmeggiani1 and Carlo Salvarani2,5, 1Unit of Clinical Immunology, Allergy and Advanced Biotechnologies, Arcispedale Santa Maria Nuova-IRCCS, Reggio Emilia, Italy, Reggio Emilia, Italy, 2Unit of Rheumatology, Arcispedale Santa Maria Nuova-IRCCS, Reggio Emilia, Italy, Reggio Emilia, Italy, 3Campus Bio-Medico, University of Rome, Italy, Roma, Italy, 4Unit of Ocular Immunology, Arcispedale Santa Maria Nuova-IRCCS, Reggio Emilia, Italy, Reggio Emilia, Italy, 5University of Modena and Reggio Emilia, Italy, Modena, Italy, 6Unit of Ophthalmology, Arcispedale Santa Maria Nuova-IRCCS, Reggio Emilia, Italy, Reggio Emilia, Italy

    Background/Purpose: Behçhet disease (BD) is a rare, systemic, inflammatory disorder with multiorgan damage and various clinical manifestations such as oral ulcers, genital ulcers and uveitis.…
  • Abstract Number: 1076 • 2017 ACR/ARHP Annual Meeting

    TGF-β1 Induces AXL in Murine and Human Synovium and Protects Ankle Joints, but Not Knee Joints, during Murine Inflammatory Arthritis

    Claire E.J. Waterborg, Mathijs G.A. Broeren, Esmeralda N. Blaney Davidson, Marije I. Koenders, Peter L. van Lent, Peter M. van der Kraan and Fons A.J. van de Loo, Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands

    Background/Purpose: Rheumatoid arthritis (RA) manifests in a symmetrical fashion in anatomically distinct synovial joints. The innate immune system, which plays a crucial role in the…
  • Abstract Number: 1077 • 2017 ACR/ARHP Annual Meeting

    The Lectin Pathway of the Complement System Is Activated in Patients with Systemic Lupus Erythematosus

    Anne Troldborg1,2, Steffen Thiel3, Marten Trendelenburg4, Justa Friebus-Kardash5, Josephine Nehring5, Rudi Steffensen6, Søren Werner Karlskov Hansen7, Magdalena Janina Laska1, Bent Deleuran8, Jens Christian Jensenius1, Anne Voss9 and Kristian Stengaard-Pedersen10, 1Biomedicine, Aarhus University, Aarhus, Denmark, 2clinical medicine, Aarhus University, Aarhus, Denmark, 3Institute of Biomedicine, Aarhus University, Aarhus, DK, Aarhus, Denmark, 4Department of Biomedicine, Division of Internal Medicine, Basel, Switzerland, 5University Hospital Basel, Division of Internal Medicine, Basel, Switzerland, 6Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark, 7Department of Cancer and Inflammation Research, University of Souther Denmark, Odense, Denmark, 8Department of Biomedicine, Aarhus University, Aarhus, Denmark, 9Rheumatology, Odense University Hospital, Odense, Denmark, 10Department of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark

    Background/Purpose: The pathogenesis of Systemic Lupus Erythematosus (SLE) involves complement activation. It is well established that activation of complement through the classical pathway (CP) and…
  • Abstract Number: 1078 • 2017 ACR/ARHP Annual Meeting

    Initial Combination Therapy Versus Step-up Therapy Is More Effective and Less Costly As a Treat to Target Strategy for RA: A Markov Model Based upon the Dutch Rheumatoid Arthritis Monitoring Registry Cohorts

    Celine J. van de Laar1, Laura M.M. Steunebrink2, Martijn A.H. Oude Voshaar3 and Harald E. Vonkeman4, 1Transparency in Healthcare B.V., Hengelo, Netherlands, 2Medisch Spectrum Twente - Arthritis Center Twente, Enschede, Netherlands, 3University of Twente, Department of Psychology, Health and Technology, Enschede, Netherlands, 4koningsplein, Medisch Spectrum Twente - Arthritis Center Twente, Enschede, Netherlands

    Background/Purpose: Adjusting medication of patients with rheumatoid arthritis (RA) until predefined disease activity targets are met, i.e. Treat to Target (T2T), is the currently recommended…
  • Abstract Number: 1079 • 2017 ACR/ARHP Annual Meeting

    Treat to Target Adherence Measurement Tool Performance in Rheumatoid Arthritis

    Rodrigo Garcia Salinas1, Sebastian Magri2 and Facundo Salvatori3, 1Section of Rheumatology, Hospital Italiano de La Plata, Buenos Aires, Argentina, La Plata, Argentina, 2Section of Rheumatology, Hospital Italiano de La Plata, La Plata, Argentina, 3Rheumatology, Hospital Italiano de La Plata, La Plata, Argentina

    Background/Purpose: The purpose of the T2T approach in RA is to achieve remission or LDA according to results from objective activity measurements. This strategy has…
  • Abstract Number: 1080 • 2017 ACR/ARHP Annual Meeting

    Electronic Patient Reported Outcomes Increase Pediatric Rheumatology Clinic Operations Efficiency While Increasing Patient and Caregiver Satisfaction

    Y. Ingrid Goh1, Talia Goldberg2, Nicholas Lao3 and Brian M. Feldman4, 1Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, ON, Canada, 2University of Toronto, Toronto, ON, Canada, 3University of Western Ontario, London, ON, Canada, 4Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada

    Electronic Patient Reported Outcomes Increase Pediatric Rheumatology Clinic Operations Efficiency While Increasing Patient and Caregiver SatisfactionBackground/Purpose: Patient reported outcomes (PROs) are powerful tools that facilitate…
  • Abstract Number: 1081 • 2017 ACR/ARHP Annual Meeting

    Improving Patient-Reported Outcomes Collection and Documentation for Patients with Rheumatoid Arthritis at Multilingual, Safety Net Hospital Rheumatology Clinic

    Todd Liou1, Omotoke Odimayomi1, Laura Trupin2, Jinoos Yazdany2 and Mary Margaretten3, 1University of California San Francisco, San Francisco, CA, 2Medicine/Rheumatology, University of California San Francisco, San Francisco, CA, 3Medicine, University of California San Francisco, San Francisco, CA

    Background/Purpose: The Patient-Reported Outcomes Measurement Information System (PROMIS) Physical Function-10a (PF10a) survey is a reliable and valid measure of function in patients with rheumatoid arthritis…
  • Abstract Number: 1082 • 2017 ACR/ARHP Annual Meeting

    Responsiveness and Minimally Clinically Important Differences of Promis Measures in Rheumatoid Arthritis

    Susan J. Bartlett1, Michelle Jones2 and Clifton O. Bingham III3, 1Department of Medicine, Division of ClinEpi, Rheumatology, Respirology, McGill University, Montreal, QC, Canada, 2Johns Hopkins University School of Medicine, Baltimore, MD, 3Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD

    Responsiveness and Minimally Clinically Important Differences of PROMIS Measures in Rheumatoid ArthritisBackground/Purpose: The ability to detect meaningful change in clinical status (responsiveness) is an important…
  • Abstract Number: 1083 • 2017 ACR/ARHP Annual Meeting

    Rheumatoid Arthritis Patients Achieved Better Quality of Life Than Systemic Lupus Erythematosus Patients at Sustained Remission: The Impact of Disease Diagnosis on Health-Related Quality of Life Outcomes

    Virginia Pascual-Ramos1, Irazú Contreras-Yáñez2, Katya Valencia-Quiñones3 and Juanita Romero-Diaz4, 1Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, 2Inmunología y Reumatología, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, 3Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, 4Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico city, Mexico

    Background/Purpose: Patients with Systemic Lupus Erythematous (SLE) and Rheumatoid Arthritis (RA) had profound negative effects on their health-related quality of life (HRQoL) that can be…
  • Abstract Number: 1084 • 2017 ACR/ARHP Annual Meeting

    Emdhaq: (electronic multidimensional health assessment questionnaire) to Record and Document eRAPID3 (electronic routine assessment of patient index data3) and eFAST3 (electronic fibromyalgia assessment screening tool3) in Routine Rheumatology Care

    Theodore Pincus1, Jacquelin R. Chua2, Shakeel M. Jamal2, Nathaniel Cook3, Niels Steen Krogh4, Anne-Marie Malfait1 and Joel A. Block2, 1Rheumatology, Rush University Medical Center, Chicago, IL, 2Division of Rheumatology, Rush University Medical Center, Chicago, IL, 3Infectious Disease, Rush University Medical Center, Chicago, IL, 4ZiteLab ApS, Copenhagen, Denmark

    Background/Purpose: RAPID3 (routine assessment of patient index data) on a multi-dimensional health assessment questionnaire (MDHAQ) distinguishes active from control treatments in RA clinical trials as…
  • Abstract Number: 1085 • 2017 ACR/ARHP Annual Meeting

    Application of Lupus Nephritis Quality Measures to Understand Gaps in Care for SLE

    Lisa Gaynon1, Maria Dall'Era2, Patricia P. Katz2, Lindsey A. Criswell2, Cristina Lanata2, Laura Trupin3, Charles G. Helmick4 and Jinoos Yazdany3, 1Internal Medicine, California Pacific Medical Center, San Francisco, CA, 2Medicine/Rheumatology, University of California, San Francisco, San Francisco, CA, 3Medicine/Rheumatology, University of California San Francisco, San Francisco, CA, 4Centers for Disease Control and Prevention, Atlanta, GA

    Background/Purpose: In 2012, the ACR released guidelines for monitoring and treatment of lupus nephritis (LN), but studies have yet to evaluate adherence to these recommendations.…
  • Abstract Number: 1086 • 2017 ACR/ARHP Annual Meeting

    Screening and Intervention of Depression in Rheumatoid Arthritis and Systemic Lupus Erythematosus

    Rui Zhang1, Priya Prakash2, Amy Wasserman3, Kirk Sperber4 and Julia Ash5, 1Medicine -Rheumatology, New York Medical College / Westchester Medical Center, valhalla, NY, 2Rheumatology, NYMC /WMC, VALHALLA, NY, 3Medicine - Rheumatology, New York Medical College / Westchester Medical Center, VALHALLA, NY, 4New York Medical College / Westchester Medical Center, Valhalla, NY, 5Medicine -Rheumatology, New York Medical College / Westchester Medical Center, Valhalla, NY

    Background/Purpose: Depression is common and associated with worse outcomes among patients with RA and SLE. Our study assessed depression using Patient Help Questionnaire (PHQ-9) and…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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