Abstracts Archive - Page 1265 of 2425 - ACR Meeting Abstracts

Abstract Number: 892 • 2017 ACR/ARHP Annual Meeting
Health-Related Quality of Life in Patients with Giant Cell Arteritis Treated with Tocilizumab in a Randomized Controlled Phase 3 Trial
Vibeke Strand¹, Sophie Dimonaco², Katie Tuckwell², Micki Klearman³, Neil Collinson² and John H. Stone⁴, ¹Division of Immunology/Rheumatology, Stanford University, Stanford, CA, ²Roche Products, Ltd., Welwyn Garden City, United Kingdom, ³Genentech, South San Francisco, CA, ⁴Massachusetts General Hospital Rheumatology Unit, Harvard Medical School, Boston, MA
Background/Purpose: Superior rates of sustained glucocorticoid (GC)–free remission were shown in patients with giant cell arteritis (GCA) treated with weekly (QW) or every-other-week (Q2W) subcutaneous…
Abstract Number: 893 • 2017 ACR/ARHP Annual Meeting
Efficacy and Safety of Belimumab in Combination with Azathioprine for Remission Maintenance in Granulomatosis with Polyangiitis and Microscopic Polyangiitis: A Multicenter Randomized, Placebo-Controlled Study
David Jayne¹, Daniel Blockmans², Raashid Luqmani³, Beulah Ji⁴, Yulia Green⁵, Leanne Hall⁶, David Roth⁷ and Peter A. Merkel⁸, ¹Vasculitis and Lupus Clinic, Department of Medicine, University of Cambridge, Cambridge, United Kingdom, ²General Internal Medicine, University Hospital Gasthuisberg, Leuven, Belgium, ³Botnar Research Centre, University of Oxford, Oxford, United Kingdom, ⁴GSK Stockley Park, Uxbridge, United Kingdom, ⁵GSK Stockley Park, Stockley Park, United Kingdom, ⁶GSK Stevenage, Stevenage, United Kingdom, ⁷GSK Collegeville, Collegeville, PA, ⁸Division of Rheumatology, University of Pennsylvania, Philadelphia, MN
Background/Purpose: GPA (Wegener’s) and MPA are organ- and life-threatening systemic vasculitides characterized by the presence of ANCA-associated vasculitis (AAV), implicating B cells in disease pathogenesis.…
Abstract Number: 894 • 2017 ACR/ARHP Annual Meeting
All Oral Interferon-Free Antivirals for Hepatitis C Virus Cryoglobulinemia Vasculitis: A Long Term Follow up Multicenter International Study
Patrice Cacoub¹, Si Nafa Si Ahmed², Yasmina FerFar³, SN Pol⁴, Dominique Thabut⁵, Christophe Hezode⁶, Laurent Albric⁷, Cloé Comarmond^8,9,10, Gafaar Ragab¹¹, Luca Quartuccio¹², Mohamed Hegazy¹³, Thierry Poynard⁵, Mathieu Resche-Rigon¹⁴ and David Saadoun¹⁵, ¹Department of Internal Medicine and Clinical Immunology, Groupe Hospitalier Pitié-Salpêtrière, Paris, France, ²Hôpital Orléans, Orléans, France, ³Internal Medicine, Hopital Pitié-Salpetrière, Paris, France, ⁴Department of Hepatology, APHP, Hôpital Cochin, Paris, paris, France, ⁵Groupe Hospitalier Pitié-Salpétrière, Paris, France, ⁶Hôpital Henri Mondor, Creteil, France, ⁷Centre hospitalier universitaire Purpan, Purpan, France, ⁸Internal Medicine and Clinical Imunology, Referal Center for Autoimmune diseases, Internal Medicine and Clinical Imunology, Hôpital Pitié Salpétrière, Paris, France, ⁹DHU 2iB Internal Medicine Referal Center for Autoimmune diseases Pitie Hospital, Paris, France, ¹⁰Internal Medicine, Hôpital Pitié Salpétrière, Paris, France, ¹¹Cairo University, Cairo, Egypt, ¹²University Hospital "Santa Maria della Misericordia, Udine, Italy, ¹³Faculty of Medicine – Cairo University, Cairo, El Salvador, ¹⁴Hôpital Saint-Louis, Paris, France, ¹⁵Sorbonne Universités, UPMC Univ Paris 06, UMR 7211, and Inflammation-Immunopathology-Biotherapy Department (DHU i2B), F-75005, Paris, France; INSERM, UMR_S 959, F-75013, Paris, France; CNRS, FRE3632, F-75005, Paris, France; AP-HP, Groupe Hospitalier, Paris, France
Background/Purpose: Interferon (IFN) containing regimens used for hepatitis C virus (HCV)-cryoglobulinemia vasculitis (CryoVas) are poorly effective and associated with important side effects. In small-size and…
Abstract Number: 895 • 2017 ACR/ARHP Annual Meeting
Temporal Trends in Incidence and Outcomes of End-Stage Renal Disease Due to Granulomatosis with Polyangiitis in the US from 1995-2014
Zachary S. Wallace¹, Yuqing Zhang², Leo Lu³, John H. Stone⁴ and Hyon K. Choi⁵, ¹Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ²Department of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ³Allergy, Immunology, and Rheumatology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ⁴Massachusetts General Hospital Rheumatology Unit, Harvard Medical School, Boston, MA, ⁵Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA
Temporal Trends in Incidence and Outcomes of End-Stage Renal Disease due to Granulomatosis with Polyangiitis in the US from 1995-2014 Background/Purpose: Granulomatosis with polyangiitis (GPA)…
Abstract Number: 896 • 2017 ACR/ARHP Annual Meeting
The Steroid Tapering in ANCA Vasculitis Evaluation Study (STAVE) 2: A Systematic Review and Meta-Analysis
Jennifer Rodrigues¹, David Collister¹, Amy Archer², Kim Cheema³, Paul Alexander⁴, Christian Pagnoux⁵, Lehana Thabane⁴, Peter A. Merkel⁶, David Jayne⁷ and Michael Walsh¹, ¹Nephrology, McMaster University, Hamilton, ON, Canada, ²Rheumatology, Northwestern University, Chicago, IL, ³Nephrology, University of Calgary, Calgary, AB, Canada, ⁴Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada, ⁵Division of Rheumatology, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada, ⁶Division of Rheumatology, University of Pennsylvania; Perelman School of Medicine, Philadelphia, PA, ⁷Vasculitis and Lupus Clinic, Department of Medicine, University of Cambridge, Cambridge, United Kingdom
Background/Purpose: Relapses of ANCA-associated vasculitis (AAV) are associated with death, decreased renal function, and end-stage renal disease. Whether longer-term treatment with glucocorticoids (GC) reduces the…
Abstract Number: 897 • 2017 ACR/ARHP Annual Meeting
Cutaneous Lupus Is Driven By an Exaggerated Interferon Kappa Loop Which Primes for Interferon Alpha Responses
Johann Gudjonsson¹, Mrinal Sarkar¹, Alex Tsoi², Celine C. Berthier³, Grace Hile⁴, Yun Liang⁴, Jianhua Liu⁵, Paul Harms⁶ and J. Michelle Kahlenberg⁷, ¹Dermatology, University of Michigan, Ann Arbor, MI, ²Departments of Dermatology and Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, ³Nephrology, Division of Nephrology, University of Michigan Medical Center, Ann Arbor, MI, ⁴University of Michigan, Ann Arbor, MI, ⁵Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor, MI, ⁶Pathology, University of Michigan, Ann Arbor, MI, ⁷Internal Medicine, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI
Background/Purpose: Cutaneous inflammation is a common and disfiguring manifestation for 70% of patients with systemic lupus erythematosus, yet our understanding of the pathogenesis of cutaneous…
Abstract Number: 898 • 2017 ACR/ARHP Annual Meeting
B Cell Specific TLR9 Suppresses Disease in Murine Lupus
Jeremy Tilstra¹, Rachael Gordon², Shinu John³, Brady Marburger², Sheldon Bastacky⁴, Kevin Nickerson² and Mark Shlomchik⁵, ¹Rheumatology, Univ of Pittsburgh Medical Center, Pittsburgh, PA, ²University of Pittsburgh, Pittsburgh, PA, ³Moderna Therapeutics, Cambridge, MA, ⁴Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, ⁵Immunology, University of Pittsburgh, Pittsburgh, PA
Background/Purpose: Toll-like receptor (TLR) signaling is a central to lupus pathogenesis. GWAS studies have repeatedly identified components of TLR signaling pathway in SLE patients. Furthermore,…
Abstract Number: 899 • 2017 ACR/ARHP Annual Meeting
Neutrophil Gene Signature and Low Density Granulocyte Subsets Associate with Coronary Plaque Burden and Vascular Inflammation in Systemic Lupus Erythematosus
Philip Carlucci¹, Monica Purmalek¹, Simantini Sakhardande¹, Yenealem Temesgen-Oyelakin¹, Amit K. Dey², Aditya A. Joshi², Joseph B. Lerman³, Alice Fike¹, Michael Davis⁴, Hong-Wei Sun¹, Jonathan H. Chung², Martin P. Playford², Pragnesh Mistry¹, Gustavo Gutierrez-Cruz¹, Stefania Dell'Orso¹, Faiza Naz¹, Heather Teague², Zerai G. Manna⁵, Peter C. Grayson¹, Mohammad Naqi¹, Marcus Chen², Sarfaraz A. Hasni¹, Nehal N. Mehta² and Mariana J. Kaplan¹, ¹NIH/NIAMS, Bethesda, MD, ²NIH/NHLBI, Bethesda, MD, ³NIH/CC, Bethesda, MD, ⁴NIH/NIAMS, Bethesda, IA, ⁵NIH/NIAMS, Bethesda, MD, Afghanistan
Background/Purpose: Systemic lupus erythematosus (SLE) increases a young woman’s risk of myocardial infarction by up to 50-fold. This marked increase in cardiovascular disease (CVD) risk…
Abstract Number: 900 • 2017 ACR/ARHP Annual Meeting
Choroid Plexus Tertiary Lymphoid Structures in Lupus: A Novel Neuro-Immune Interface
Ariel Stock¹, Evan Der², Sivan Gelb³, Ayal Ben-Zvi³ and Chaim Putterman⁴, ¹Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, ²Albert Einstein College of Medicine, Bronx, NY, ³Hebrew University, Jerusalem, Israel, ⁴Division of Rheumatology, Albert Einstein College of Medicine, Bronx, NY, USA, Bronx, NY
Background/Purpose: The central nervous system (CNS) manifestations of SLE remain poorly understood. Although potentially neuropathic autoantibodies have been identified in the serum, lupus patients show…
Abstract Number: 901 • 2017 ACR/ARHP Annual Meeting
Role of Epstein Barr Virus Serologic Reactivation in Transitioning to Systemic Lupus Erythematosus in at Risk Individuals
Neelakshi R. Jog¹, Kendra A. Young², Melissa E. Munroe¹, Michael T Harmon³, Joel M. Guthridge⁴, Diane L. Kamen⁵, Gary S. Gilkeson⁶, Michael Weisman⁷, David Karp⁸, John B. Harley^9,10, Daniel J. Wallace¹¹, Jill M. Norris¹² and Judith A. James^13,14, ¹Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Epidemiology, Colorado School of Public Health, Aurora, CO, ³Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁴Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, OKC, OK, ⁵Medicine/Rheumatology & Immunology, Medical University of South Carolina, Charleston, SC, ⁶Department of Medicine, Medical University of South Carolina, Charleston, SC, ⁷Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, ⁸Rheumatology, UT Southwestern Med Ctr, Dallas, TX, ⁹US Department of Veterans Affairs Medical Center, Cincinnati, OH, ¹⁰Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ¹¹Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, ¹²Department of Epidemiology, Colorado School of Public Health, Aurora, CO, ¹³Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ¹⁴Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK
Background/Purpose: Systemic Lupus Erythematosus (SLE) is a systemic autoimmune disease characterized by autoantibody production and periods of elevated and suppressed disease activity. Various genetic and…
Abstract Number: 902 • 2017 ACR/ARHP Annual Meeting
Evidence for Inhibition of Osteoclastogenesis By Cytomegalovirus Infection: Implication in RA Bone Erosion and Identification of a Cellular Protein As a Therapeutic Target
Benjamin Rauwel¹, Michel Baron¹, Adeline Ruyssen-Witrand², Delphine Nigon³, Yannick Degboé², Jacques Izopet¹, Alain Cantagrel¹ and Jean-Luc Davignon¹, ¹CPTP, INSERM UMR 1043, Toulouse, France, ²Rheumatology, Purpan Hospital, Toulouse III University, Toulouse, France, ³Rheumatology, Purpan University Hospital, Toulouse Cedex 9, France
Background/Purpose: Exacerbated differentiation of monocytes into osteoclasts (OC) contributes to the pathogenesis of rheumatoid arthritis (RA) resulting in severe bone erosion and functional damage. Osteoclastogenesis…
Abstract Number: 903 • 2017 ACR/ARHP Annual Meeting
Increased Expression of CCN4/WISP1 in Osteoarthritic Articular Cartilage Is Epigenetically Regulated and Disrupts Cartilage Homeostasis
Martijn H. van den Bosch¹, Yolande F. Ramos², Wouter den Hollander², Nils Bömer², Rob G. Nelissen³, Judith V. Bovée⁴, Peter L. van Lent¹, Arjen B. Blom¹, Peter M. van der Kraan¹ and Ingrid Meulenbelt², ¹Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ²Department of Molecular Epidemiology, Leiden University Medical Center, Leiden, Netherlands, ³Department of Orthopedics, Leiden University Medical Center, Leiden, Netherlands, ⁴Department of Pathology, Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: Previously, we described increased expression of Wnt-1-induced signaling protein 1 (Wisp1) in murine synovium and cartilage after induction of experimental osteoarthritis (OA) models. WISP1…
Abstract Number: 904 • 2017 ACR/ARHP Annual Meeting
Deficient Autophagy Induces Lamin a/C Accumulation in Aging and Osteoarthritis
Paloma Lopez de Figueroa¹, Uxia Nogueira-Recalde², Fernando Osorio³, Martin Lotz⁴, Carlos Lopez-Otin³, Francisco J Blanco² and Beatriz Carames¹, ¹Cartilage Biology Group. Rheumatology Division, INIBIC-CHUAC, A Coruña, Spain, A Coruña, Spain, ²Cartilage Biology Group. Rheumatology Division, INIBIC-CHUAC, A Coruña, A Coruña, Spain, ³Degradome Lab, Universidad de Oviedo, Oviedo, Spain, ⁴Department of Molecular & Experience Medicine, Scripps Research Institute, LaJolla, CA
Background/Purpose: Autophagy, an essential chondrocyte homeostasis mechanism, is defective in Aging and Osteoarthritis (OA). However, the targets regulating this mechanism are still unknown. Here, we…
Abstract Number: 905 • 2017 ACR/ARHP Annual Meeting
Regenerating Cartilage and Reversing Osteoarthritis (OA) Stimulation of Adenosine A2A Receptors (A2AR) Increases Cartilage Volume and Matrix in Vitro and In Vivo
Carmen Corciulo¹, Cristina Castro², Thomas Coughlin³, Tuere Wilder¹, Oran Kennedy⁴ and Bruce Cronstein⁵, ¹Department of Medicine, Division of Rheumatology, NYU School of Medicine, New York, NY, ²Medicine, NYU School of Medicine, New York, NY, ³Orthopaedic Surgery, NYU School of Medicine, New York, NY, ⁴Department of Anatomy, Royal College of Surgeons, Dublin, Ireland, ⁵Rheumatology, New York University School of Medicine, Division of Rheumatology, New York, NY
Background/Purpose: We have recently reported that endogenously produced adenosine, interacting with A2AR, is a critical autocrine factor for maintenance of chondrocyte and cartilage homeostasis and…
Abstract Number: 906 • 2017 ACR/ARHP Annual Meeting
Anp32a Is a Critical Regulator of Oxidative Stress in Cartilage and Protects Against Osteoarthritis
Frederique Cornelis¹, Silvia Monteagudo¹, Wouter den Hollander², Tine Peeters³, Laura-An Guns¹, Lies Storms¹, Ingrid Meulenbelt² and Rik Lories¹, ¹Skeletal Biology and Engineering Research Center, KU Leuven, Leuven, Belgium, ²Department of Molecular Epidemiology, Leiden University Medical Center, Leiden, Netherlands, ³Skeletal Biology and Engineering Research Center, KU Leuven, 3000, Belgium
Background/Purpose: We described an association between polymorphisms in the ANP32a gene and osteoarthritis. Osteoarthritis is one of the most common chronic musculoskeletal disorders and a…

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