Abstract Number: 862 • 2017 ACR/ARHP Annual Meeting
iNKT Mediated Immunoregulatory Feedback Control Development of Autoimmune Arthritis in Mice
Background/Purpose: Invariant Natural Killer T cells (iNKT) express an invariant T cell receptor (TCR) alpha chain and recognize lipid antigens – such as alpha-GalCer (aGC),…Abstract Number: 863 • 2017 ACR/ARHP Annual Meeting
Functionally Distinct Pathogenic Subsets of Fibroblasts Exist within the Inflamed Synovial Membrane and Mediate Specific Aspects of Inflammatory Disease Pathology
Background/Purpose: Fibroblasts are key effector cells in the persistence of synovial inflammation and joint damage. It is not yet known whether specific subsets of synovial…Abstract Number: 864 • 2017 ACR/ARHP Annual Meeting
IL-9-Producing Innate Lymphoid Cells – Keyplayers That Orchestrate Resolution of Chronic Inflammation in Arthritis
Background/Purpose: Transition from acute to chronic inflammation is a key step in the pathogenesis of inflammatory disease but incompletely characterized to date. Similar to the…Abstract Number: 865 • 2017 ACR/ARHP Annual Meeting
Lasp-1 Regulates Cell-Matrix and Cell-Cell Contacts in Arthritic Mouse Models
Background/Purpose: In rheumatoid arthritis (RA) the attachment of synovial fibroblasts (SF) to articular cartilage is an important prerequisite in the process of cartilage degradation. The…Abstract Number: 866 • 2017 ACR/ARHP Annual Meeting
Interferon-Alpha Overexpression Triggers an Expansion of Highly Suppressive Regulatory T Lymphocytes Protecting Against Experimental Arthritis
Background/Purpose: Type I interferons (IFN-I) can be both anti- and pro-inflammatory. Among them, IFN-α inhibits normal Th17 differentiation, whereas it is pathogenic in lupus. The…Abstract Number: 867 • 2017 ACR/ARHP Annual Meeting
Highly Sensitive Cardiac Troponin-I in Peripheral Blood Predicts Cardiovascular Events in Patients with Rheumatoid Arthritis
Background/Purpose: Cardiac troponins (cTn) are specific biomarkers of myocardial injury; their measurement with highly-sensitive assays and at subthreshold levels for myocardial infarction (MI) diagnosis, predicts…Abstract Number: 868 • 2017 ACR/ARHP Annual Meeting
Baseline Troponin Levels Are Associated with Mortality in a Cohort of Patients with Inflammatory Polyarthritis: Results from the Norfolk Arthritis Register
Background/Purpose: Serum troponin is used in clinical practice in the diagnosis of acute myocardial infarction. Recent studies have found that high sensitivity assays can predict…Abstract Number: 869 • 2017 ACR/ARHP Annual Meeting
Utility of Carotid Ultrasound Compared to Framingham Risk Score in Predicting Cardiovascular Mortality in Rheumatoid Arthritis
Background/Purpose: Rheumatoid arthritis (RA) patients have a greater risk of cardiovascular (CV) mortality compared to general population. Traditional CV risk factors may be less accurate…Abstract Number: 870 • 2017 ACR/ARHP Annual Meeting
Detection of Left Ventricular Regional Function in Rheumatoid Arthritis Patients without Cardiac Symptons, As Assessed By Feature Tracking Cardiac Magnetic Resonance Imaging
Background/Purpose: Cardiac involvements cause of morbidity and mortality globally in rheumatoid arthritis (RA). Myocardial disease is typically clinically silent, only manifesting as myocardial dysfunction after…Abstract Number: 871 • 2017 ACR/ARHP Annual Meeting
Coronary Microvascular Dysfunction in Rheumatoid Arthritis Compared to Diabetes Mellitus in Patients without Obstructive Coronary Artery Disease
Background/Purpose: Patients with DM have increased coronary microvascular dysfunction (CMD) compared to the general population, leading to higher rates of cardiac death despite normal perfusion…Abstract Number: 872 • 2017 ACR/ARHP Annual Meeting
Myocardial Abnormalities Improve in RA Patients Treated Actively – a Cardiac MRI Follow-up Study
Background/Purpose: Patients with RA are prone to develop myocardial dysfunction, in which chronic inflammation is suggested to play an important role. We have previously shown…Abstract Number: 873 • 2017 ACR/ARHP Annual Meeting
Type I High-IFN Gene Signature in Associated with Higher Essdai at Enrollmment and Follow-up in the Prospective Multicenter Assess Cohort of 395 Patients
Background/Purpose: The type I interferon (IFN) signature is a hallmark of the pathogenesis of primary Sjögren’s syndrome (pSS). However, little is known regarding the clinical…Abstract Number: 874 • 2017 ACR/ARHP Annual Meeting
Effect of Rituximab on a Salivary Gland Ultrasound Score in Primary Sjögren’s Syndrome: Results of Multicentre Double-Blind Randomised Controlled Trial Sub-Study
Background/Purpose: B lymphocytes are important in the pathogenesis of primary Sjögren’s syndrome (PSS), but two phase III trials (TEARS and TRACTISS) of the B cell…Abstract Number: 875 • 2017 ACR/ARHP Annual Meeting
Serum Autoantibody Profiling of Primary Sjoegren’s Syndrome Patients Reveals Novel Biomarkers Associated with the Disease, Disease Activity, and Clinical Response to VAY736
Background/Purpose: Overexpression of B cell activating factor (BAFF) in salivary glands contributes to the pathogenesis of primary Sjögren’s syndrome (pSS) by promoting autoantibody (AAB) production.…Abstract Number: 876 • 2017 ACR/ARHP Annual Meeting
Epidemiologic Subsets Drive a Differentiated Clinical and Immunological Presentation of Primary Sjögren Syndrome: Analysis of 9302 Patients from the Big Data International Sjögren Cohort
Background/Purpose: To analyse whether epidemiologic factors (such as gender or age at diagnosis of the disease) are associated with particular disease expressions and define some…
ACR Meeting Abstracts