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  • Abstract Number: 847 • 2017 ACR/ARHP Annual Meeting

    The Mediational Role of Helplessness in Psychological Outcomes in Systemic Lupus Erythematosus

    Desiree R Azizoddin1, Sarah D. Mills2, Perry M. Nicassio3, Geraldine Zamora Racaza4 and Michael Weisman5, 11611 W Harrison, 1611 W Harrison, Chicago, IL, 2SDSU/UC San Diego Joint Doctoral Program in Clinical Psychology, San Diego, CA, 3Cousins Center for PNI, UCLA, LA, CA, 4Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, 5Cedars-Sinai Medical Center Division of Rheumatology, Los Angeles, CA

    Background/Purpose: Systemic lupus erythematosus (SLE) is a chronic, autoimmune disease affecting multiple organs, leading to a significant impact on health-related quality of life. Theoretical models…
  • Abstract Number: 848 • 2017 ACR/ARHP Annual Meeting

    “Suddenly You Are a Person at Risk of Developing Rheumatoid Arthritis!” Different Perspectives of Individuals on Predictive Testing – Results of an International Qualitative Interview Study

    Erika Mosor1, Michaela Stoffer2, Günter Steiner3, Karim Raza4, Rebecca J Stack4, Gwenda Simons4, Marie Falahee4, Georg Schett5, Matthias Englbrecht6, Josef S. Smolen2, Axel J. Hueber6 and Tanja Stamm7, 1Section for Outcomes Research, Center for Medical Statistics, Informatics, and Intelligent Systems, Medical University of Vienna, Vienna, Austria, 1090 Vienna, Austria, 2Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria, Vienna, Austria, 3Rheumatology, Medical University of Vienna, Vienna, Austria, 4Department of Rheumatology, University of Birmingham and Sandwell & West Birmingham Hospitals NHS Trust, Birmingham, UK, Birmingham, United Kingdom, 5Rheumatology and Immunology, Department of Internal Medicine 3, Universitätsklinikum Erlangen, Erlangen, Germany, Erlangen, Germany, 6Department of Medicine 3, Rheumatology and Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, 7Section for Outcomes Research, Center for Medical Statistics, Informatics, and Intelligent Systems, Medical University of Vienna, Vienna, Vienna, Austria

    Background/Purpose: People at risk of developing rheumatoid arthritis (RA) may be candidates for interventions aimed at preventing RA development [1]. The identification of such at…
  • Abstract Number: 849 • 2017 ACR/ARHP Annual Meeting

    Tumor TIF1 Mutations and Loss of Heterozygosity Related to Cancer Associated Myositis

    Iago Pinal-Fernandez1, Berta Ferrer-Fabregas2, Ernesto Trallero-Araguas1, Eva Balada1, Maria Angeles Martinez3, Jose Cesar Milisenda4, Gloria Aparicio-Español5, Moises Labrador-Horrillo1, Vicente Garcia-Patos1, Josep Maria Grau-Junyent4 and Albert Selva O'Callaghan6, 1Internal Medicine, Autoimmune Diseases Unit. Vall d´Hebron Hospital, Barcelona, Spain, 2Pathology, Vall d´Hebron, Barcelona, Spain, 3Immunology, Immunology Department, Barcelona, Spain, 4Muscle Research Group and Ciberer, Hospital Clinic Provincial, Barcelona, Spain, 5Dermatology, Vall d´Hebron Hospital, Barcelona, Spain, 6Internal Medicine, Hospital Universitari General Vall d'Hebron, Barcelona, Spain

    Background/Purpose: To analyze the influence of genetic alterations and differential expression of the TIF1 genes in the pathophysiology of cancer-associated myositis (CAM). Methods: Whole exome…
  • Abstract Number: 850 • 2017 ACR/ARHP Annual Meeting

    Immune Checkpoint Inhibitors and Inflammatory Myopathies: Data from the US Food and Drug Administration Adverse Event Reporting System

    Xerxes Pundole, Mohsin Shah, Noha Abdel-Wahab and Maria Suarez-Almazor, Section of Rheumatology and Clinical Immunology, Department of General Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA, Houston, TX

    Background/Purpose: Immune checkpoint inhibitors have become standard of care for many malignancies. Although these therapies are effective, they can activate the immune system resulting in…
  • Abstract Number: 851 • 2017 ACR/ARHP Annual Meeting

    Autoantibodies Predict Long Term Survival in Myositis Associated Interstitial Lung Disease

    Silvia Martinez1, Rohit Aggarwal2,3 and Chester V. Oddis4, 1Internal Medicine, UPMC, pittsburgh, PA, 2Department of Medicine / Rheumtology, University of Pittsburgh Medical Center, Pittsburgh, PA, 3Rheumatology, University of Pittsburgh, Pittsburgh, PA, 4Rheumatology/Clinical Immunology, Unviersity of Pittsburgh/University of Pittsburgh Medical Center, Pittsburgh, PA

    Background/Purpose: Interstitial lung disease (ILD) significantly contributes to morbidity and mortality in adult polymyositis (PM) and dermatomyositis (DM). Myositis associated autoantibodies (MAA) are associated with…
  • Abstract Number: 852 • 2017 ACR/ARHP Annual Meeting

    RNAseq Detection of Gene Dysregulation in PBMCs from Juvenile Dermatomyositis, Positive for p155/140 Myositis Specific Antibody

    Chiang-Ching Huang1, Victoria Hans2, Dong Xu3, Megan L. Curran4,5, Gabrielle A. Morgan6, Elisha D.O. Roberson7 and Lauren M. Pachman8,9, 1Biostatistics, Joseph J. Zilber School of Public Health,, Milwaukee, WI, 2CureJM Center of Excellence, Stanly Manne Research Center, Chicago, IL, 3Pediatric Rheumatology, Stanley Manne Research Center, Chicago, IL, 4Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL, 5Division of Rheumatology, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, 6Cure JM Program of Excellence in Myositis Research, Chicago, IL, 7Depts. of Medicine and Genetics, Division of Rheumatology, Washington University, St. Louis, MO, 8Cure JM Program of Excellence in Juvenile Myositis Research, Stanley Manne Children’s Research Institute, affiliated with Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL, 9Pediatric Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL

    Background/Purpose: Children with Juvenile Dermatomyositis (JDM) have variable responses to the available immunosuppressive drugs, with less than optimal outcomes, making it essential to characterize their…
  • Abstract Number: 853 • 2017 ACR/ARHP Annual Meeting

    Anti-TIF-1 Antibody Positivity Is Associated with a Five-Fold Increase in Cancer Risk in the Idiopathic Inflammatory Myopathies

    Alexander Oldroyd1,2, Jamie C Sergeant1,3, Paul New4, Neil J. McHugh5,6, Zoe Betteridge5, Janine Lamb7, William Ollier7, Robert Cooper4,7,8 and Hector Chinoy2,9, 1Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, Manchester Academic Health Science Centre, University of Manchester, Manchester, United Kingdom, 2NIHR Manchester Biomedical Research Centre, Central Manchester NHS Foundation Trust, Manchester, United Kingdom, 3Centre for Biostatistics, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom, 4MRC/ARUK Centre for Integrated Research into Musculoskeletal Ageing, University of Liverpool, Liverpool, United Kingdom, 5Department of Pharmacy and Pharmacology, The University of Bath, Bath, United Kingdom, 6Royal National Hospital for Rheumatic Diseases, Bath, UK, Bath, United Kingdom, 7Division of Population Health, Health Services Research and Primary Care, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom, 8Department of Rheumatology, Aintree University Hospital, Liverpool, United Kingdom, 9Department of Rheumatology, Salford Royal NHS Foundation Trust, Manchester Academic Health Science Centre, Salford, United Kingdom

    Background/Purpose: There is an increased cancer risk associated with the idiopathic inflammatory myopathies (IIM). Studies have identified that positivity for the autoantibody against transcriptional intermediary…
  • Abstract Number: 854 • 2017 ACR/ARHP Annual Meeting

    Predictive Modeling of Mortality in Polymyositis/Dermatomyositis Patients with Interstitial Lung Disease Based on Combination of Serum Myositis-Specific Autoantibodies and Conventional Biomarkers

    Takahisa Gono1, Kenichi Masui2, Yasushi Kawaguchi3, Kei Ikeda4, Atsushi Kawakami5, Maasa Tamura6, Yoshinori Tanino7, Takahiro Nunokawa8, Yuko Kaneko9, Shinji Sato10, Katsuaki Asakawa11, Naoshi Nishina9 and Masataka Kuwana1, 1Department of Allergy and Rheumatology, Nippon Medical School Graduate School of Medicine, Tokyo, Japan, 2Department of Anesthesiology, National Defense Medical College School of Medicine, Tokorozawa, Japan, 3Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan, 4Department of Allergy and Clinical Immunology, Chiba University Hospital, Chiba, Japan, 5Department of Immunology and Rheumatology, Division of Advanced Preventive Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki City, Japan, 6Department of Stem Cell and Immune Regulation, Yokohama City University Graduate School of Medicine, Yokohama, Japan, 7Department of Pulmonary Medicine, Fukushima Medical University School of Medicine, Fukushima, Japan, 8Department of Rheumatic Diseases, Tokyo Metropolitan Tama Medical Center, Tokyo, Japan, 9Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan, 10Division of Rheumatology, Department of Internal Medicine, Tokai University School of Medicine, Isehara, Japan, 11Division of Respiratory Medicine, Niigata University Medical and Dental Hospital, Niigata, Japan

    Background/Purpose: Interstitial lung disease (ILD) is one of the leading causes of mortality in patients with polymyositis or dermatomyositis (PM/DM). Since clinical courses and outcomes…
  • Abstract Number: 855 • 2017 ACR/ARHP Annual Meeting

    Rapid and Sustained Pain Improvement in Rheumatoid Arthritis Patients Treated with Baricitinib Compared to Adalimumab or Placebo

    Peter C. Taylor1, Roy Fleischmann2, Elizabeth Perkins3, Jeffrey Lisse4, Baojin Zhu4, Carol L Gaich4, Xiang Zhang4, Douglas E. Schlichting4, Christina L. Dickson4 and Tsutomu Takeuchi5, 1NDORMS, University of Oxford, Oxford, United Kingdom, 2University of Texas Southwestern Medical Center, Dallas, TX, 3Rheumatology, Rheumatology Care Center, Birmingham, AL, 4Eli Lilly and Company, Indianapolis, IN, 5Keio University School of Medicine, Tokyo, Japan

    Background/Purpose: Assessment of pain improvement during treatment for rheumatoid arthritis (RA) may help frame patient expectations and may be useful to clinical decision-making and discussions…
  • Abstract Number: 856 • 2017 ACR/ARHP Annual Meeting

    Trends and Predictors of Chronic Opioid Use in Individuals with RA

    Yvonne C. Lee1, Joel Kremer2, Hongshu Guan3, Jeffrey D Greenberg4 and Daniel H. Solomon5, 1Rheumatology Immunology & Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 2The Center for Rheumatology, Albany Medical College, Albany, NY, 3Rheumatology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 4NYU School of Medicine, New York, NY, 5Brigham and Women's Hospital and Harvard Medical School, Boston, MA

    Background/Purpose: The opioid epidemic is a major public health concern, requiring urgent action. However, little is known about chronic opioid use among individuals with RA.…
  • Abstract Number: 857 • 2017 ACR/ARHP Annual Meeting

    Relation of Pain Sensitization to Low Physical Function: The Multicenter Osteoarthritis Study

    Joshua Stefanik1,2, Daniel White3, Carrie Brown4, Laura Frey-Law5, Michael Nevitt6, Cora E. Lewis7 and Tuhina Neogi2, 1Physical Therapy, Northeastern University, Boston, MA, 2Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, 3Department of Physical Therapy, University of Delaware, Newark, DE, 4Boston University School of Public Health, Boston, MA, 5University of Iowa, Iowa City, IA, 6Department of Epidemiology & Biostatistics, University of California San Francisco School of Medicine, San Francisco, CA, 7University of Alabama Birmingham, Birmingham, AL

    Background/Purpose: Peripheral and central sensitization (alterations in pain signaling) are related to heightened pain severity and can be present in knee osteoarthritis (OA). Sensory input…
  • Abstract Number: 858 • 2017 ACR/ARHP Annual Meeting

    Identification of Clinically Relevant Pain Profiles in Individuals with Active RA

    Alyssa Wohlfahrt1, Zhi Zhang1, Bing Lu2, Clifton O. Bingham III3, Marcy B. Bolster4, Wendy Marder5, Larry W. Moreland6, Kristine Phillips7, Tuhina Neogi8 and Yvonne C. Lee9, 1Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, 2Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 3Rheumatology, Johns Hopkins University, Baltimore, MD, 4Division of Rheumatology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 5Internal Medicine-Rheumatology, University of Michigan, Ann Arbor, MI, 6Rheumatology & Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, 7Rheumatology, Vanderbilt University Medical Center, Nashville, TN, 8Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, 9Rheumatology Immunology & Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA

    Background/Purpose: Despite DMARD treatment, many RA patients continue to suffer from pain. Defining distinct pain phenotypes may advance the use of therapies targeted at specific…
  • Abstract Number: 859 • 2017 ACR/ARHP Annual Meeting

    Identifying Pain Susceptibility Phenotypes in Those Free of Knee Pain with or at Risk for Knee Osteoarthritis and Their Relation to Developing Knee Pain

    Lisa Carlesso1, Neil Segal2, Laura Frey-Law3, Yuqing Zhang4, Na Lu5, Cora E. Lewis6, Michael C. Nevitt7 and Tuhina Neogi5, 1School of Rehabilitation, Université de Montréal, Montreal, QC, Canada, 2University of Kansas, Shawnee, KS, 3UIowa, Iowa City, IA, 4Clinical Edpidemiology Reserach and Training Unit, Boston University School of Medicine, Boston, MA, 5Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, 6University of Alabama Birmingham, Birmingham, AL, 7Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA

    Background/Purpose: It is well recognized that factors beyond structural features contribute to the pain experience in people with knee osteoarthritis (OA). Independent of structural pathology,…
  • Abstract Number: 860 • 2017 ACR/ARHP Annual Meeting

    Effective Treatment of Persistent Arthritis Pain Requires Co-Modulation of TNF and Type I Interferon

    Sarah Woller1, Tony Yaksh2 and Maripat Corr3, 1Anesthesiology, UCSD, La Jolla, CA, 2Anesthesiology 0818, UCSD, La Jolla, CA, 3Division of Rheumatology, Allergy, and Immunology, UCSD, La Jolla, CA

    Background/Purpose: Pain persisting beyond the resolution or control of clinical signs of rheumatoid arthritis (RA) decreases quality of life for millions of people. Unfortunately, this…
  • Abstract Number: 861 • 2017 ACR/ARHP Annual Meeting

    CD11b+Gr1dim tolerogenic Dendritic Cell-like Cells Suppress the Progression of Interstitial Lung Disease in SKG Mice

    Sho Sendo1, Jun Saegusa1, Hirotaka Yamada2, Yoshihide Ichise2, Ikuko Naka3, Yo Ueda2, Takaichi Okano2, Soshi Takahashi4, Kengo Akashi5, Akira Onishi6 and Akio Morinobu4, 1Rheumatology and Clinical Immunology, Kobe University Graduate School of Medicine, Kobe, Japan, 2Department of Rheumatology and Clinical immunology, Kobe University Graduate School of Medicine, Kobe, Japan, 3Department of Clinical Pathology and Immunology, Kobe University Graduate School of Medicine, Kobe, Japan, 4Department of Rheumatology and Clinical Immunology, Kobe University Graduate School of Medicine, Kobe, Japan, 5Department of Rheumatology and Clinical Immnology, Kobe University Graduate School of Medicine, Kobe, Japan, 6Department for Rheumatology and Clinical Immunology, Kobe University Graduate School of Medicine, Kobe, Japan

    CD11b+Gr1dim tolerogenic Dendritic Cell-like Cells Suppress the Progression of Interstitial Lung Disease in SKG Mice Background/Purpose: SKG mice develop interstitial lung disease (ILD) resembling rheumatoid arthritis-associated…
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