Abstracts Archive - Page 1253 of 2607 - ACR Meeting Abstracts

Abstract Number: 1000 • 2018 ACR/ARHP Annual Meeting
Surface Adenosine Monophosphate Deaminase 2 As a Novel Regulator Modifying Ectonucleotidase-Driven Generation of Anti-Inflammatory Extracellular Adenosine
Lisa Ehlers^1,2, Aditi Kuppe^1,2, Alexandra Damerau^3,4, Yuling Chen^1,2, Cindy Strehl^3,5, Marieluise Kirchner⁶, Frank Buttgereit¹ and Timo Gaber^3,5, ¹Department of Rheumatology and Clinical Immunology, Charité University Hospital Berlin, Berlin, Germany, ²German Rheumatism Research Centre Berlin, Berlin, Germany, ³Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany, ⁴Deutsches Rheuma-Forschungszentrum Berlin, Berlin, Germany, ⁵Deutsches Rheuma Forschungszentrum (DRFZ) Berlin, Berlin, Germany, ⁶BIH Core Facility Proteomics, Max Delbrück Centre for Molecular Medicine, Berlin, Germany
Background/Purpose: Extracellular ATP and adenosine are potent immunomodulatory molecules that accumulate in states of inflammation. ATP/ADP are released from damaged or stressed cells and sequentially…
Abstract Number: 1001 • 2018 ACR/ARHP Annual Meeting
Anti-Fractalkine Monoclonal Antibody Dislodges Intravascular Monocytes Involved in Exacerbation of Synovial Inflammation in Collagen-Induced Arthritis Model
Wataru Ikeda¹, Kana Hoshino-Negishi¹, Eri Fusaoka-Nishioka¹, Tomoya Nakatani¹, Yoshikazu Kuboi¹, Naoto Ishii¹, Nobuyuki Yasuda¹ and Toshio Imai², ¹KAN Research Institute, Inc., Kobe, Japan, ²President & CEO, Chief Scientific Officer, KAN Research Institute, Inc., Kobe, Japan
Background/Purpose: In the Phase 1/2 clinical study, E6011, a novel humanized anti-fractalkine (FKN) mAb demonstrated a promising efficacy in active RA patients who were inadequately…
Abstract Number: 1002 • 2018 ACR/ARHP Annual Meeting
Pkcα Deficiency Protected Mice from UVB Induced-Skin Inflammation through Attenuation of Neutrophil Netosis
Yubin Li^1,2, Jeffrey B. Travers^3,4, Victoria P. Werth^5,6 and Ming-Lin Liu^1,2, ¹Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, ²Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, ³Departments of Pharmacology & Toxicology, Boonshoft School of Medicine, Wright State University, Dayton, OH, ⁴Departments of Dermatology, Boonshoft School of Medicine, Wright State University, Dayton, OH, ⁵Philadelphia Veterans Affairs Medical Center, Philadelphia, PA, ⁶University of Pennsylvania, Philadelphia, PA
Background/Purpose: Neutrophil NETosis is a form of cell death characterized by nuclear envelope rupture, nuclear chromatin release, and neutrophil extracellular trap formation. NETosis is important…
Abstract Number: 1003 • 2018 ACR/ARHP Annual Meeting
Neutrophil Response to Ultraviolet Light in Normal and Lupus Conditions
Sladjana Skopelja-Gardner¹, Xizhang Sun², Joyce Tai³, Lucrezia Colonna³, Lena Tanaka⁴ and Keith B. Elkon⁵, ¹Division of Rheumatology, Department of Medicine, University of Washington, Seattle, WA, ²Rheumatology, University of Washington, Seattle, WA, ³Division of Rheumatology, University of Washington, Seattle, WA, ⁴Medicine/Rheumatology, University of Washington, Seattle, WA, ⁵University of Washington, Seattle, WA
Background/Purpose: Two-thirds of systemic lupus erythematosus (SLE) patients are sensitive to sunlight and artificial light. Ultraviolet (UV) B light induces sterile inflammation in the skin…
Abstract Number: 1004 • 2018 ACR/ARHP Annual Meeting
Reevaluating Citrullination and Peptidylarginine Deiminases in Neutrophil Extracellular Trap-like Structures
Caitlyn L. Holmes¹, Daeun Shim², John Kernien¹, Chad J. Johnson¹, Jeniel E. Nett³ and Miriam A. Shelef^4,5, ¹University of Wisconsin - Madison, Madison, WI, ²Medicine, University of Wisconsin - Madison, Madison, WI, ³Medicine and Medical Microbiology and Immunology, University of Wisconsin - Madison, Madison, WI, ⁴Department of Medicine, Division of Rheumatology, University of Wisconsin - Madison, Madison, WI, ⁵William S. Middleton Memorial Veterans Hospital, Madison, WI
Background/Purpose: Neutrophil extracellular traps (NETs) are webs of chromatin and proteins extruded from neutrophils during NETosis. NETs are increased and display citrullinated proteins that are…
Abstract Number: 1005 • 2018 ACR/ARHP Annual Meeting
Regulation of Neutrophil Activation in Systemic Lupus Erythematosus
Neelakshi R. Jog¹, Teresa Aberle¹, Eliza Chakravarty¹, Cristina Arriens¹, Joel M. Guthridge¹, Melissa E. Munroe¹ and Judith A. James^2,3, ¹Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Arthritis & Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ³Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK
Background/Purpose: Systemic Lupus Erythematosus (SLE) is a systemic autoimmune disease characterized by immune dysfunction and autoantibody production. In addition to the adaptive immune system, neutrophils…
Abstract Number: 1006 • 2018 ACR/ARHP Annual Meeting
Physical Activity at Lower Intensities Reduces Localized IL-1b in a Murine Model of Gout By Systemically Down-Regulating TLR2 Expression on Circulating Neutrophils and Suppressing CXCL1 Expression
Kyle Jablonski¹, Nicholas A. Young², Bianca Sandoval³, Ifeoma Okafor⁴, Emily Schwarz³, Caitlin Henry³, Peter Harb³, Anuradha Kalyanasundaram⁵, Wael Jarjour⁶ and Naomi Schlesinger⁷, ¹The Ohio State University Wexner Medical Center, Columbus, OH, ²Immunology and Rheumatology, The Ohio State University Wexner Medical Center, Columbus, OH, ³Rheumatology and Immunology, Columbus, OH, ⁴Rheumatology and Immunology, The Ohio State University Wexner Medical Center, Columbus, OH, ⁵Physiology and Cell Biology, The Ohio State University, Columbus, OH, ⁶Department of Rheumatology and Immunology, The Ohio State University Wexner Medical Center, Columbus, OH, ⁷Department of Medicine/Rheumatology Division, Rutgers- Robert Wood Johnson Medical School, New Brunswick, New Brunswick, NY
Background/Purpose: Exercise was originally believed to exacerbate inflammation in rheumatic disease, however, recent studies have shown that regular physical activity is anti-inflammatory. In gout, there…
Abstract Number: 1007 • 2018 ACR/ARHP Annual Meeting
Macrophage Mediators of Autoimmune Valvular Carditis and Fibrosis
Lee Meier¹, Mayra Gonzalez-Torres², Jennifer L. Auger², Aubyn Marath³ and Bryce A. Binstadt², ¹Department of Pediatrics and Center for Immunology, University of Minnesota, Minneapols, MN, ²Department of Pediatrics and Center for Immunology, University of Minnesota, Minneapolis, MN, ³CardioStart International, Tampa, FL
Background/Purpose: K/B.g7 TCR transgenic mice spontaneously develop both autoimmune arthritis and valvular carditis. We utilize this model to define mediators of rheumatic disease-associated cardiovascular inflammation…
Abstract Number: 1008 • 2018 ACR/ARHP Annual Meeting
Presence of a Specific Defect in M2 Polarization of Blood Monocytes from Patients with Rheumatoid Arthritis, Associated with Increased microRNA-155
Audrey Paoletti¹, Julien Rohmer², Juliette Pascaud³, Bineta Oumouly¹, Elodie Rivière³, Samuel Bitoun⁴, Gaetane Nocturne⁵ and Xavier Mariette⁶, ¹U1184 IMVA, INSERM U1184, IMVA, Paris Sud University,LabEx LERMIT, le kremlin bicetre, France, ²National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, Internal medicine, France, Paris, France, ³Immunology of viral Infections and Autoimmune Diseases, IDMIT, CEA - Université Paris Sud - INSERM U1184, Le Kremlin Bicêtre & Fontenay aux Roses, France, ⁴INSERM U1184, IMVA, Paris Sud University,LabEx LERMIT, le kremlin bicetre, France, ⁵INSERM U1184, IMVA, Paris Sud University,LabEx LERMIT, Le Kremlin Bicêtre, France, ⁶Rheumatology department, Center for Immunology of Viral Infections and Autoimmune Diseases, Assistance Publique- Hôpitaux de Paris, Hôpitaux Universitaires Paris-Sud, Le Kremlin-Bicêtre, Université Paris Sud, INSERM, Paris, Paris, France
Background/Purpose: Macrophages contribute in situ to the RA pathogenesis. Two distinct states of polarization for macrophages have been recognized: the classically activated macrophage phenotype (M1),…
Abstract Number: 1009 • 2018 ACR/ARHP Annual Meeting
Monocytes Membrane TNF Expression and Anti-TNF Treatment in Rheumatoid Arthritis
Audrey Paoletti¹, Julien Rohmer², Juliette Pascaud³, Bineta Oumouly¹, Elodie Rivière³, Samuel Bitoun⁴, Gaetane Nocturne² and Xavier Mariette⁵, ¹U1184 IMVA, INSERM U1184, IMVA, Paris Sud University,LabEx LERMIT, le kremlin bicetre, France, ²INSERM U1184, IMVA, Paris Sud University,LabEx LERMIT, Le Kremlin Bicêtre, France, ³Immunology of viral Infections and Autoimmune Diseases, IDMIT, CEA - Université Paris Sud - INSERM U1184, Le Kremlin Bicêtre & Fontenay aux Roses, France, ⁴INSERM U1184, IMVA, Paris Sud University,LabEx LERMIT, le kremlin bicetre, France, ⁵Rheumatology department, Center for Immunology of Viral Infections and Autoimmune Diseases, Assistance Publique- Hôpitaux de Paris, Hôpitaux Universitaires Paris-Sud, Le Kremlin-Bicêtre, Université Paris Sud, INSERM, Paris, Paris, France
Background/Purpose: Three monocyte subsets have been described based on their CD14 and CD16 expression profiles. The subpopulation CD14+CD16+ being expanded in rheumatoid arthritis (RA) patient.…
Abstract Number: 1010 • 2018 ACR/ARHP Annual Meeting
Inhibition of Bruton’s Tyrosine Kinase (BTK) Prevents Inflammatory Macrophage Differentiation: A Potential Role in RA and SLE
Yasemin Beguem Alankus¹, Roland Grenningloh², Philipp Haselmayer¹, Andrew Bender³ and Julia Bruttger¹, ¹Merck KGaA, Darmstadt, Germany, ²EMD Serono Research and Development Institute, Billerica, MA, ³TIP Immunology, EMD Serono Research and Development Institute, Billerica, MA
Background/Purpose: Bruton’s Tyrosine Kinase (BTK) mediates B cell receptor (BCR) and Fc receptor (FcR) signalling in several hematopoietic cell lineages, including B cells, macrophages and…
Abstract Number: 1011 • 2018 ACR/ARHP Annual Meeting
Tissue Resident Macrophages Establish a Niche That Limits Monocyte to Macrophage Differentiation in Synovial Tissue during Homeostasis
Qi Quan Huang¹, Renee E. Doyle², Alexander Misharin³, Shang-Yang Chen⁴, Deborah R. Winter⁵ and Richard M. Pope², ¹Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ²Medicine/Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ³Medicine/pulmonary, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁴Medicine/Rheumatology, Northwestern University Feinberg School of Medicine, chicago, IL, ⁵Department of Medicine Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose: Monocytes and Macrophages play critical roles in immune homeostasis and host defense. Recent studies identified that macrophages are highly heterogeneous in terms of location,…
Abstract Number: 1012 • 2018 ACR/ARHP Annual Meeting
Inhibition of Inflammation and Oxidative Stress in Systemic Sclerosis (SSc) Macrophages
Rajan Bhandari¹, Michael Ball², Saemi Han², Kathleen Aren³, Mary A. Carns³, Monique Hinchcliff⁴, Michael L. Whitfield⁵, Karen Liby⁶ and Patricia A. Pioli⁷, ¹Geisel School of Medicine at Dartmouth, lebanon, NH, ²Geisel School of Medicine at Dartmouth, Lebanon, NH, ³Northwestern University, Feinberg School of Medicine Scleroderma Program, Chicago, IL, ⁴Rheumatology, Northwestern University, Chicago, IL, ⁵Biomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, NH, ⁶Michigan State University, East Lansing, MI, ⁷Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, NH
Background/Purpose: Systemic sclerosis (SSc) is a chronic autoimmune disease of unknown etiology that is characterized by vasculopathy, fibrosis, and inflammation. Our work and that of…
Abstract Number: 1013 • 2018 ACR/ARHP Annual Meeting
Circulating Hybrid M1/M2 Monocytes/Macrophages in Systemic Sclerosis Patients with Lung Involvement
Maurizio Cutolo¹, Amelia Chiara Trombetta², Veronica Tomatis³, Sabrina Paolino⁴, Carmen Pizzorni¹, Vanessa Smith⁵, Paola Contini⁶, Paola Montagna³, Renata Brizzolara² and Stefano Soldano³, ¹Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, San Martino Polyclinic Hospital, Genoa, Italy, Genoa, Italy, ²Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, IRCCS Polyclinic San Martino, University of Genoa, Genoa, Italy, ³Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, IRCCS Polyclinic San Martino, University of Genoa, Genova, Italy, ⁴Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, San Martino Polyclinic Hospital, Genoa, Italy, Genova, Italy, ⁵Department of Rheumatology, Ghent University Hospital, Ghent, Belgium, ⁶Division of Clinical Immunology, Department of Internal Medicine, University of Genova, IRCCS Polyclinic San Martino, Genova, Italy, Genova, Italy
Background/Purpose: Systemic sclerosis (SSc) is an autoimmune disease characterized by immune system alterations, vasculopathy and fibrosis [1]. SSc-related interstitial lung disease (ILD) represents a common…
Abstract Number: 1014 • 2018 ACR/ARHP Annual Meeting
Distinct Macrophage Phenotype and Bioenergetic Profiles in Rheumatoid Arthritis
Megan M. Hanlon¹, Mary Canavan¹, Trudy McGarry¹, Candice Low², Siobhan C. Wade¹, Douglas J. Veale² and Ursula Fearon¹, ¹Molecular Rheumatology, School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland, ²Centre for Arthritis and Rheumatic Diseases, Dublin Academic Medical Centre, University College Dublin, Dublin, Ireland
Background/Purpose: Synovial macrophages play a key role in RA disease progression, yet the diversity of macrophage subsets within the joint remains unknown. The concept of…

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM CT on October 25. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].