Abstracts Archive - Page 1249 of 2425 - ACR Meeting Abstracts

Abstract Number: 652 • 2017 ACR/ARHP Annual Meeting
Investigating the Role of Mechanical Stress in Spondyloarthritis Pathogenesis
Breanna Nguyen¹, Robert Colbert² and Gerlinde Layh-Schmitt¹, ¹National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ²NIAMS/NIH, Bethesda, MD
Background/Purpose: Mechanotransduction is a cell’s ability to translate mechanical stimuli into biochemical signals and has been implicated in signaling pathways involving differentiation and proliferation. Mechanical…
Abstract Number: 653 • 2017 ACR/ARHP Annual Meeting
Reduced Ubiquitination of Misfolded HLA-B27 Is Associated with Inefficient Degradation By ERAD and Autophagy
Fatemeh Navid¹, Gerlinde Layh-Schmitt¹, Keith A. Sikora² and Robert Colbert¹, ¹National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ²Pediatric Translational Research Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD
Background/Purpose: The HLA class I allele, HLA-B27, is associated with spondyloarthritis (SpA), an immune-mediated inflammatory disease affecting the axial skeletal, skin, gut and eyes. HLA-B27…
Abstract Number: 654 • 2017 ACR/ARHP Annual Meeting
Effect of Anti Tnfα Drugs on the Frequency of Circulating CD19+CD24hiCD38hi Breg Cells in Ankylosing Spondylitis
M. Belén Bautista-Caro¹, Eugenio De Miguel¹, Diana Peiteado¹, Alejandro Villalba¹, Irene Monjo¹, Amaya Puig-Kröger², Paloma Sanchez-Mateos³, Emilio Martín-Mola¹ and Maria Eugenia Miranda-Carus¹, ¹Rheumatology, Hospital La Paz-IdiPAZ, Madrid, Spain, ²Immuno-oncology, Hospital Gregorio Marañon, Madrid, Spain, ³Immunology, Hospital Gregorio Marañon, Madrid, Spain
Background/Purpose: CD19+CD24hiCD38hi B cells demonstrate a regulatory capacity and their frequency is altered in the peripheral blood of patients with various autoimmune diseases. The pathogenic…
Abstract Number: 655 • 2017 ACR/ARHP Annual Meeting
Innate Lymphoid Cells – New Players in Psoriatic Arthritis
Alina Soare¹, Stefanie Weber², Lisa Maul³, Ana Maria Gheorghiu⁴, Ismail Housni⁵, Arnd Kleyer⁶, Markus Luber², Simon Rauber², David Simon⁶, Juergen Rech⁶, Georg Schett⁶, Jörg Distler¹ and Andreas Ramming⁷, ¹Department of Internal Medicine 3 – Rheumatology and Immunology, Universitätsklinikum Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany, ²Department of Internal Medicine 3, Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany, ³Department of Internal Medicine 3 – Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany, ⁴Carol Davila University of Medicine and Pharmacy,Internal Medicine and Rheumatology Department ,,Dr.I.Cantacuzino'' Clinical Hospital, Bucharest, Romania, ⁵Department of Internal Medicine 3 – Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen, Erlangen, Germany, ⁶Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Department of Internal Medicine 3 – Rheumatology and Immunology, Universitätsklinikum Erlangen, Erlangen, Germany., Erlangen, Germany, ⁷Department of Internal Medicine 3 – Rheumatology and Immunology, Universitätsklinikum Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany
Background/Purpose: Innate lymphoid cells (ILCs) produce disease-related cytokines including IL-17 and IL-22 and are therefore of substantial interest in PsA. Spreading the disease from the…
Abstract Number: 656 • 2017 ACR/ARHP Annual Meeting
Prostaglandin E2 and Its Receptor Subtype EP4 Are Involved in Ankylosing Spondylitis Disease Progression
Archita Srinath^1,2,3, Giuliana Guggino⁴, Ismail Sari⁵, Fanxing Zeng⁶, Francesco Ciccia⁴ and Nigil Haroon⁵, ¹Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada, ²Genes and Development, University Health Network, Toronto, ON, Canada, ³Krembil Discovery Tower, Toronto, ON, Canada, ⁴Rheumatology Unit, University of Palermo, Palermo, Italy, ⁵Rheumatology, Toronto Western Hospital, University of Toronto, Spondylitis Clinic, Toronto, ON, Canada, ⁶University Health Network, Toronto, ON, Canada
Background/Purpose: Single Nucleotide Polymorphisms (SNPs) in PTGER4 were found to be associated with Ankylosing spondylitis (AS) in GWAS. PTGER4 codes for the prostaglandin-E2 receptor EP4.…
Abstract Number: 657 • 2017 ACR/ARHP Annual Meeting
Dyslipidemia Management Is Insufficient in Psoriatic Arthritis Despite Increased Cardiovascular Morbidity and Mortality
Richard Koch¹, JEAN BERNARD RUIDAVETS Sr.², Yannick Degboe³, Alain Cantagrel³, Adeline Ruyssen-Witrand⁴, JEAN FERRIERES⁵ and Arnaud Constantin³, ¹Department of Rheumatology, Purpan Hospital, Toulouse III University, Toulouse, France, TOULOUSE, France, ²DEPARTMENT OF EPIDEMIOLOGY, URM 1027 INSERM, TOULOUSE UNIVERSITY HOSPITAL, TOULOUSE, France, ³Department of Rheumatology, Purpan Hospital, Toulouse III University, Toulouse, France, Toulouse, France, ⁴Rheumatology, Purpan Hospital, Toulouse III University, Toulouse, France, ⁵DEPARTMENT OF CARDIOLOGY, URM 1027 INSERM, TOULOUSE UNIVERSITY HOSPITAL, TOULOUSE, France
Background/Purpose: Psoriatic arthritis (PsA) is associated with increased cardiovascular (CV) morbidity and mortality. Assessing individual CV risk and achieving the recommended LDL-cholesterol (LDL-C) target could…
Abstract Number: 658 • 2017 ACR/ARHP Annual Meeting
Functionally Active MAIT Cells in Psoriatic Arthritis: A New Member of the IL-23/IL-17 Cytokine Network
Siba P. Raychaudhuri¹ and Smriti K. Raychaudhuri², ¹Rheumatology Section, Sacramento Veterans Affairs Medical Center, Sacramento, CA, ²Rheumatology/Immunology, VA Sacramento Medical Center, Davis, CA
Background/Purpose: The mucosal-associated invariant T (MAIT) cells recently have been implicated in autoimmune diseases. Murine model experiments also suggest that MAIT cells are capable…
Abstract Number: 659 • 2017 ACR/ARHP Annual Meeting
IL-17 Producing T Cells and Its Dichotomy: A Mixed Response of the Innate and Acquired Immune System in Psoriatic Arthritis
Siba P. Raychaudhuri¹ and Smriti K. Raychaudhuri², ¹Rheumatology Section, Sacramento Veterans Affairs Medical Center, Sacramento, CA, ²Rheumatology/Immunology, VA Sacramento Medical Center, Davis, CA
Background/Purpose: Source of IL-17 in human has been mainly attributed to ab T cells, more specifically to the Th17 cells. However, some reports suggest…
Abstract Number: 660 • 2017 ACR/ARHP Annual Meeting
Strain-Dependent IL-17A Secretion By CD4-CD8- DN αβ T Cells Correlates with Disease Susceptibility in Murine Spondyloarthritis
Imtiyaz Hossain, Mederbek Matmusaev and Joerg Ermann, Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA
Background/Purpose: Hydrodynamic injection of IL-23 minicircles into adult B10.RIII mice induces an inflammatory disease with phenotypic features of human spondyloarthritis. Tissue-resident CD4-CD8- double negative (DN)…
Abstract Number: 661 • 2017 ACR/ARHP Annual Meeting
Normal Human Enthesis Contains a Resident Population of γδT-Cells
Richard Cuthbert¹, Evangelos M. Fragkakis¹, Robert Dunsmuir², Peter Giannoudis³, Elena Jones¹, Darren Newton⁴ and Dennis McGonagle¹, ¹Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ²Department of Spinal Surgery, National Health Service, Leeds, United Kingdom, ³Academic Department of Trauma and Orthopaedics, University of Leeds, Leeds, United Kingdom, ⁴Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, United Kingdom
Background/Purpose: Recent animal studies have suggested that γδT-cells accumulate at enthesis, secrete IL-17 and are responsible for driving the spondyloarthritis (SpA) phenotype resulting from IL-23…
Abstract Number: 662 • 2017 ACR/ARHP Annual Meeting
Clinical Significance of Non-Albumin Proteinuria for Severity Assessment of Tubulointerstitial Inflammation in Lupus Nephritis
Oh Chan Kwon¹, Seokchan Hong¹, Jung Sun Lee², Byeongzu Ghang¹, Doo-Ho Lim³, Wook Jang Seo⁴, Yong-Gil Kim¹, Chang Keun Lee¹ and Bin Yoo¹, ¹Division of Rheumatology, Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea, Republic of (South), ²Internal medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea, Republic of (South), ³Division of Rheumatology, Department of Internal Medicine, University of Ulsan College of Medicine, Ulsan University Hospital, Ulsan, Korea, Republic of (South), ⁴Seoul Veterans Hospital, Seoul, Korea, Republic of (South)
Background/Purpose: Tubulointerstitial inflammation (TI) has been shown to have prognostic significance in renal outcome of lupus nephritis. Considering that the type of protein excreted in…
Abstract Number: 663 • 2017 ACR/ARHP Annual Meeting
Urinary Tumor-Necrosis Factor-like Weak Inducer of Apoptosis Is an Important Biomarker for Renal Lupus
Michelle Petri¹, Daniel Goldman², Linda Burkly³, Nicolas Wisniacki⁴, Chris Stebbins³ and Laurence S Magder⁵, ¹Medicine (Rheumatology), Division of Rheumatology, Johns Hopkins University School of Medicine, MD, USA, Baltimore, MD, ²Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ³Biogen, Cambridge, MA, ⁴GlaxoSmithKline, London, United Kingdom, ⁵Epidemiology and Public health, University of Maryland School of Medicine, Baltimore, MD
Background/Purpose: Tumor-necrosis factor (TNF)-like weak inducer of apoptosis (TWEAK) drives release of proinflammatory mediators from renal tubular and mesangial cells, and has been implicated in…
Abstract Number: 664 • 2017 ACR/ARHP Annual Meeting
Low Vitamin D Is Associated with Thrombosis in Systemic Lupus Erythematosus
Michelle Petri¹, Wei Fu² and Daniel Goldman², ¹Medicine (Rheumatology), Division of Rheumatology, Johns Hopkins University School of Medicine, MD, USA, Baltimore, MD, ²Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD
Background/Purpose: Low vitamin D is common in systemic lupus erythematosus (SLE). It is also found in antiphospholipid syndrome. Vitamin D has effects on tissue factor,…
Abstract Number: 665 • 2017 ACR/ARHP Annual Meeting
Low Vitamin D Is Associated with End Stage Renal Disease in Systemic Lupus Erythematosus
Michelle Petri¹, Wei Fu² and Daniel Goldman², ¹Medicine (Rheumatology), Division of Rheumatology, Johns Hopkins University School of Medicine, MD, USA, Baltimore, MD, ²Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD
Background/Purpose: Vitamin D insufficiency/deficiency is common in SLE. Replacement therapy may help renal disease activity. We asked whether low vitamin D predicted later organ damage.…
Abstract Number: 666 • 2017 ACR/ARHP Annual Meeting
Vitamin D Deficiency Is Associated with Increased Serum Cholesterol Among Patients with Systemic Lupus Erythematosus
Michelle Petri¹, Daniel Goldman² and Laurence S Magder³, ¹Medicine (Rheumatology), Division of Rheumatology, Johns Hopkins University School of Medicine, MD, USA, Baltimore, MD, ²Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ³Epidemiology and Public health, University of Maryland School of Medicine, Baltimore, MD
Background/Purpose: Vitamin D insufficiency/deficiency is common in SLE. In other populations, vitamin D has been associated with cardiovascular risk factors such as blood pressure and…

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