Abstracts Archive - Page 1247 of 2607 - ACR Meeting Abstracts

Abstract Number: 910 • 2018 ACR/ARHP Annual Meeting
In Diagnostic Prevalence and Treatment Patterns of Male and Female Ankylosing Spondylitis Patients in the United States, 2006-2016
Jessica Walsh¹, Theresa Hunter², Rebecca Bolce², David Sandoval Calderon² and Krista Schroeder², ¹University of Utah School of Medicine, Salt Lake City, UT, USA, Salt Lake City, UT, ²Eli Lilly and Company, Indianapolis, IN
Background/Purpose: This study aimed to analyze the prevalence rates and treatment patterns of male and female ankylosing spondylitis (AS) patients in the United States (US)…
Abstract Number: 911 • 2018 ACR/ARHP Annual Meeting
Demographic and Clinical Characteristics Reflect Differences in Osteoarthritis Phenotypes of the Lumbar Spine: The Johnston County Osteoarthritis Project
Adam P. Goode¹, Becki Cleveland², Todd Schwartz³, Steven Z. George⁴, Virginia B. Kraus⁵, Richard Gracely⁶, Jun Chen⁴, Joanne M. Jordan⁷ and Yvonne M. Golightly⁸, ¹O, Duke University, Durham, NC, ²University of North Carolina at Chapel Hill, Chapel Hill, NC, ³Department of Biostatistics, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, ⁴Department of Orthopedic Surgery, Duke University, Durham, NC, ⁵Duke Molecular Physiology Institute, Duke University, Durham, NC, ⁶University of North Carolina, Chapel Hill, North Carolina, Chapel Hill, NC, ⁷Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, ⁸Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC
Background/Purpose: Spine osteoarthritis (OA) has been defined by the presence of: 1) disc space narrowing (DSN) and vertebral osteophytes (OST), or 2) facet joint OA…
Abstract Number: 912 • 2018 ACR/ARHP Annual Meeting
Association of Adiposity Measures in Childhood and Adulthood with Knee Cartilage Thickness, Volume and Bone Area in Young Adults
Tao Meng¹, Alison Venn¹, Felix Eckstein^2,3, Wolfgang Wirth^2,3, Flavia Cicuttini⁴, Lyn March⁵, Terence Dwyer^1,6, Marita Cross⁵, Laura Laslett¹, Graeme Jones¹, Changhai Ding^1,7 and Benny Samuel Eathakkattu Antony¹, ¹Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia, ²Chondrometrics GmbH, Ainring, Germany, ³Institute of Anatomy, Paracelsus Medical University, Salzburg, Austria, ⁴Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia, ⁵Institute of Bone and Joint Research, University of Sydney, Sydney, Australia, ⁶The George Institute for Global Health, Nuffield Department of Obstetrics & Gynaecology, University of Oxford, Oxford, United Kingdom, ⁷Clinical Research Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, China
Background/Purpose: Adiposity is associated with increased risk of knee osteoarthritis; cartilage thickness, cartilage volume and subchondral bone area are established biomarkers in knee osteoarthritis. We…
Abstract Number: 913 • 2018 ACR/ARHP Annual Meeting
Risk Factors for Knee Pain Exacerbation on Walking: A within-Person Knee-Matched Study
Qiang Liu^1,2, David J. Hunter³, Manuela Ferreira⁴, Barton L Wise⁵, Ke Tao¹, Yuqing Zhang⁶ and Jianhao Lin¹, ¹Arthritis Clinic and Research Center, Peking University People's Hospital, Beijing, China, ²Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ³Rheumatology, Institute of Bone and Joint Research, Kolling Institute, University of Sydney, Sydney, Australia, ⁴Institute of Bone and Joint Research | The Kolling Institute, Sydney Medical School, Sydney, Australia, ⁵Orthopaedics, Internal Medicine, University of California, Davis School of Medicine, Sacramento, CA, ⁶Department of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Boston, MA
Background/Purpose: Pain exacerbation on walking is common among patients with knee osteoarthritis and often lead to activity avoidance. To date, few risk factors for pain…
Abstract Number: 914 • 2018 ACR/ARHP Annual Meeting
Increased Adverse Childhood Experiences in Children with Arthritis: An Analysis of the National Survey of Children’s Health
Tamar Rubinstein¹, Danielle R. Bullock², Kaveh Ardalan³, Wenzhu B. Mowrey⁴, Nicole Brown⁵ and Ruth E K Stein⁶, ¹Pediatric Rheumatology, Albert Einstein College of Medicine, Children's Hospital at Montefiore, Bronx, NY, ²Pediatrics, University of Minnesota, Minneapolis, MN, ³Division of Rheumatology, Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL, ⁴Albert Einstein College of Medicine, Bronx, NY, ⁵Albert Einstein College of Medicine/ Children's Hospital at Montefiore, Bronx, NY, ⁶Pediatrics, Albert Einstein College of Medicine, Bronx, NY
Background/Purpose: Adverse Childhood Experiences (ACEs) are associated with increased risk of chronic disease and poorer health in children and adults. Emerging data suggest an association…
Abstract Number: 915 • 2018 ACR/ARHP Annual Meeting
The Association between Structural and Symptomatic Progression in Knee Osteoarthritis
Jamie E. Collins¹, Swastina Shrestha² and Elena Losina³, ¹Department of Orthopedic Surgery, Orthopedic and Arthritis Center for Outcomes Research, Brigham and Women's Hospital, Boston, MA, ²Orthopaedic and Arthritis Center for Outcomes Research, Brigham and Women's Hospital, Boston, MA, ³Harvard Medical School, Boston, MA
Background/Purpose: The link between progression of structure and symptoms in knee osteoarthritis (OA) is not well understood. This uncertainty hinders the effort to develop therapies…
Abstract Number: 916 • 2018 ACR/ARHP Annual Meeting
Integrative Analysis of Multi-Omics Data in an Ethnically Diverse Lupus Cohort Identifies Distinct Molecular Subtypes of SLE
Cristina Lanata¹, Ishan Paranjpe², Joanne Nitiham³, Kimberly Taylor⁴, Brooke Rhead⁵, Milena Gianfrancesco⁶, Lisa Barcellos⁷, Louise Murphy⁸, Patricia Katz⁹, Laura Trupin⁶, Jinoos Yazdany², Maria Dall'Era², Marina Sirota¹⁰ and Lindsey A. Criswell⁹, ¹Rosalind Russell Medical Research Center for Arthritis, Department of Medicine, Division of Rheumatology, University of California, San Francisco, San Francisco, CA, ²University of California, San Francisco, San Francisco, CA, ³Rosalind Russell / Ephraim P. Engleman Rheumatology Research Center, University of California, San Francisco, San Francisco, CA, ⁴University of California, San Francisco, Rosalind Russell / Ephraim P. Engleman Rheumatology Research Center, San Francisco, CA, ⁵University of California, Berkeley, Berkeley, CA, ⁶Medicine/Rheumatology, University of California, San Francisco, San Francisco, CA, ⁷School of Public Health, UC Berkeley, Berkeley, CA, ⁸Arthritis Program, Centers for Disease Control and Prevention, Atlanta, GA, ⁹University of California San Francisco, San Francisco, CA, ¹⁰Pediatrics, Institute for Computational Health Sciences, University of California, San Francisco, San Francisco, CA
Background/Purpose: Systemic Lupus Erythematous (SLE) is a chronic autoimmune disease with heterogeneous disease manifestations and outcomes. We aimed to define how molecular differences underlie this…
Abstract Number: 917 • 2018 ACR/ARHP Annual Meeting
Type 1 Interferon Levels Correlates with Age of Diagnosis and Ethnicity in Systemic Lupus Erythematous
Majid Abedi¹, Lilian Borisov², Allison Doyle¹, Francisco Flores², June Fujimoto², Aviva Jacobs¹, Pramod Naranatt¹, Liuliu Pan², William Ricketts³, Jacob Spangler¹, Kristen Warren² and Robert Terbrueggen², ¹DxTerity, Rancho Domiquez, CA, ²DxTerity, Rancho Dominguez, CA, ³Clinical Operations, DxTerity, Rancho Domiquez, CA
Background/Purpose: Low cost, patient-administered, “from home” genomic tests for monitoring disease activity and therapy response could revolutionize treatment and management of Systemic Lupus Erythematous (SLE)…
Abstract Number: 918 • 2018 ACR/ARHP Annual Meeting
A Novel Familial RELA Truncation Is Associated with Behçet’s-like Mucocutaneous Ulceration Syndrome
Emma Dorris¹, Fahd Adeeb², Eoin Cummins³, Sinisa Savic⁴, Sandy Fraser⁵ and Anthony G. Wilson⁶, ¹UCD Conway Institute,, UCD Centre for Arthritis Research, Dublin 4, Ireland, ²Department of Rheumatology, University of Limerick, LIMERICK, Ireland, ³School of Medicine, Dublin 4, Ireland, ⁴Leeds Institute of Rheumatic and Musculoskeletal Medicine, The University of Leeds, Leeds, United Kingdom, ⁵Rheumatology, Croom Orthopedic Hospital, Ireland, Limerick, Ireland, ⁶UCD School of Medicine and Medical Science, Conway Institute, University College Dublin, Dublin, Ireland
Background/Purpose: Bechet’s disease (BD) is a heterogeneous multifactorial auto-inflammatory condition characterized by recurrent episodes of oral and genital ulceration, uveitis and skin lesions, with less…
Abstract Number: 919 • 2018 ACR/ARHP Annual Meeting
A Machine Learning Classifier for Assigning Individual Patients with Systemic Sclerosis to Intrinsic Molecular Subsets
Jennifer Franks¹, Viktor Martyanov¹, Guoshuai Cai², Yue Wang³, Tammara A. Wood¹ and Michael L. Whitfield⁴, ¹Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, ²Environmental Health Sciences, Arnold School of Public Health at University of South Carolina, Columbia, SC, ³Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, ⁴Biomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, NH
Background/Purpose: High-throughput gene expression profiling of skin biopsies from patients with systemic sclerosis (SSc) has identified four “intrinsic” gene expression subsets conserved across multiple cohorts…
Abstract Number: 920 • 2018 ACR/ARHP Annual Meeting
Rheumatoid Arthritis Patient-Specific Therapeutic Target Identification Using Integrative Epigenetic Profiling
Richard Ainsworth¹, Kai Zhang², Lina Zheng³, Gary S. Firestein⁴ and Wei Wang⁵, ¹UC San Diego, La Jolla, CA, ²UCSD School of Engineering, San Diego, CA, ³Chemistry and Biochemistry, UC San Diego, La Jolla, CA, ⁴Medicine, UC San Diego, La Jolla, CA, ⁵Chemistry and Biochemistry, University of California San Diego, La Jolla, CA
Background/Purpose: To explain the complex regulatory changes associated with RA synovitis and the diversity of responses to targeted therapies, we developed and applied a novel…
Abstract Number: 921 • 2018 ACR/ARHP Annual Meeting
Multi-Omics Analysis Identifies a Gene Signature Associated with the Clinical Response to Anti-TNF Therapy in Rheumatoid Arthritis
Adrià Aterido¹, Jesús Tornero², Francisco J Blanco³, Benjamin Fernandez Gutierrez⁴, Antonio Gonzalez⁵, Juan D. Cañete⁶, Joan Maymó⁷, Mercedes Alperi-López⁸, Alejandro Olivé-Marqués⁹, Hector Corominas¹⁰, Víctor Martínez-Taboada¹¹, Isidoro Gonzalez-Alvaro¹², Antonio Fernandez-Nebro¹³, Alba Erra¹⁴, Simón Sánchez-Fernández¹⁵, María López-Lasanta¹, Mireia López-Corbeto¹, Raül Tortosa¹, Laia Codó¹⁶, Sara Marsal¹ and Antonio Julià¹, ¹Rheumatology Research Group, Vall d'Hebron Hospital Research Institute, Barcelona, Spain, ²Rheumatology Department, Hospital Universitario Guadalajara, Guadalajara, Spain, ³Rheumatology Department, INIBIC-Hospital Universitario A Coruña, A Coruña, Spain, ⁴Rheumatology Department, Hospital Clínico San Carlos, Madrid, Spain, ⁵Laboratorio Investigación 10 and Rheumatology Unit, Instituto de Investigacion Sanitaria-Hospital Clinico Universitario de Santiago, Santiago de Compostela, Spain, ⁶Rheumatology Service, Hospital Clínic of Barcelona, Barcelona, Spain, ⁷Rheumatology Department, Hospital del Mar, Barcelona, Spain, ⁸Department of Rheumatology, Hospital Universitario Central de Asturias, Asturias, Spain, ⁹Hospital Universitari Germans Trias i Pujol, Badalona, Spain, ¹⁰Rheumatology, Hospital Universitari de la Santa Creu i Sant Pau, Barcelona, Spain, ¹¹Rheumatology Department, Hospital Universitario Marqués de Valdecilla, Santander, Spain, ¹²Rheumatology Department, Hospital Universitario de La Princesa, IIS-IP, Madrid, Spain, ¹³UGC de Reumatología, Instituto de Investigación Biomédica de Málaga (IBIMA) Hospital Regional Universitario de Málaga Departamento de Medicina y Dermatología, Universidad de Málaga, MÁLAGA, Spain, ¹⁴Rheumatology Service, Hospital San Rafael, Barcelona, Spain, ¹⁵Rheumatology Department, Hospital General La Mancha Centro, Ciudad Real, Spain, ¹⁶Life Sciences Department, Barcelona Supercomputing Centre, Barcelona, Spain
Background/Purpose: Rheumatoid arthritis (RA) is the most common inflammatory arthritis affecting up to 1% of the population. Tumor Necrosis Factor (TNF) inhibitors have significantly improved…
Abstract Number: 922 • 2018 ACR/ARHP Annual Meeting
Anakinra Treatment Prevents Myocardial Mechanical Dysfunction and Inhibits Histologic Evidence of Myocardial Inflammation in the Mouse Model of Kawasaki Disease
Mark Gorelik^1,2, Youngho Lee³, Masanori Abe⁴, Thomas Andrews⁵, Jean Patterson¹, Magali Noval Rivas⁴, Gregory Aune⁵ and Moshe Arditi⁴, ¹Immunology and Virology, Texas Biomedical Research Institute, San Antonio, TX, ²Pediatrics, Baylor College of Medicine, Houston, TX, ³Department of Cell Biology, Hospital for Sick Children, Toronto, ON, Canada, ⁴Pediatrics, Cedars Sinai, Beverly Hills, CA, ⁵Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX
Background/Purpose: Kawasaki disease (KD) is an acute, febrile illness of childhood with sequelae of coronary artery aneurysms and cardiac fibrosis, and is the most common…
Abstract Number: 923 • 2018 ACR/ARHP Annual Meeting
Neutrophils from Children with Systemic JIA Exhibit Persistent Proinflammatory Activation Despite Long-Standing Clinically Inactive Disease
Rachel Brown¹, Maggie Henderlight¹, Thuy Do¹, Shima Yasin², Monica DeLay¹, Alexei A. Grom^3,4 and Grant Schulert^2,5, ¹Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ²Rheumatology, Divisions of Rheumatology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, ³Pediatrics, University of Cincinnati, CINCINNATI, OH, ⁴Rheumatology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, ⁵Pediatrics, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH
Background/Purpose: Systemic juvenile idiopathic arthritis (SJIA) is a chronic childhood arthropathy with features of autoinflammation. New-onset SJIA is associated with expansion and activation of neutrophils…
Abstract Number: 924 • 2018 ACR/ARHP Annual Meeting
10X Genomics-Based Single-Cell RNA-Seq and Low Input RNA-Seq Identify a Transcriptional Landscape Supporting Interferon in the Pathogenesis of Autoimmune-Associated Congenital Heart Block
Hemant Suryawanshi¹, Jill P. Buyon², Miao Chang², Thomas Tuschl¹ and Robert M. Clancy², ¹Howard Hughes Medical Institute and The Rockefeller University, New York, NY, ²NYU School of Medicine, New York, NY
Background/Purpose: Towards understanding the molecular mechanisms that link maternal anti-Ro antibodies to the development of conduction system disease in a second trimester fetus, single cell…

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