Abstracts Archive - Page 1234 of 2607 - ACR Meeting Abstracts

Abstract Number: 715 • 2018 ACR/ARHP Annual Meeting
Septic Shock Among Patients with Systemic Lupus Erythematosus: Short and Long-Term Outcome and Cost. Analysis of the French Nationwide Database
Arthur Mageau¹, Karim Sacre², Anne Perozziello¹, Stephane Ruckly¹, Claire Dupuis¹, Lila Bouadma¹, Thomas Papo¹ and Jean Francois Timsit¹, ¹Université Paris-Diderot, Paris, France, ²Bichat Hospital, Paris Diderot University, Paris, France
Background/Purpose: Infection is a leading cause of death and ICU admission in systemic lupus erythematosus (SLE) patients. Our aim was to investigate the outcome and…
Abstract Number: 716 • 2018 ACR/ARHP Annual Meeting
Soluble CD163 Is a Biomarker Associated with Accelerated Carotid Atheroma in SLE Patients at Otherwise Low Risk for Cardiovascular Disease
Clemence David¹, Gillian Divard¹, Rachid Abbas¹, Brigitte Escoubet¹, Marie-Paule Chauveheid¹, Diane Rouzaud¹, Anne Boutten¹, Thomas Papo¹, Monique Dehoux¹ and Karim Sacre², ¹Université Paris-Diderot, Paris, France, ²Bichat Hospital, Paris Diderot University, Paris, France
Background/Purpose: Our study aimed to determine whether sCD163, a soluble macrophage marker upregulated in numerous inflammatory disorders, might be predictive of accelerated atherosclerosis associated with…
Abstract Number: 717 • 2018 ACR/ARHP Annual Meeting
The Burden of Chronic Kidney Disease in Systemic Lupus Erythematosus (SLE): A Nationwide Epidemiologic Study
Arthur Mageau¹, Jean Francois Timsit¹, Anne Perozziello¹, Stephane Ruckly¹, Claire Dupuis¹, Lila Bouadma¹, Thomas Papo¹ and Karim Sacre², ¹Université Paris-Diderot, Paris, France, ²Bichat Hospital, Paris Diderot University, Paris, France
Background/Purpose: Lupus nephritis occurs in about 50% of SLE patients. We aimed to analyze the impact of chronic kidney disease (CKD) on major clinical outcomes…
Abstract Number: 718 • 2018 ACR/ARHP Annual Meeting
Assessing Dyspnea in Patients with Systemic Lupus Erythematosus
Chia-Chi J. Lee¹, Lindsy J. Forbess², Daniel J. Wallace², Caroline Jefferies² and Mariko Ishimori³, ¹Cedars-Sinai Medical Center, Los Angeles, CA, ²Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, ³Medicine, Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA
Background/Purpose: Lungs can be affected in up to 50% of systemic lupus erythematosus (SLE) patients. Our aim was to assess the prevalence and degree of…
Abstract Number: 719 • 2018 ACR/ARHP Annual Meeting
Men and Sexual Function: An Overlooked Issue in Systemic Lupus Erythematosus
Jonathan Campos-Guzmán¹, Ana Barrera-Vargas¹, Diana Gómez-Martín², Jorge Alcocer-Varela², Samuel Govea-Peláez¹, Miguel Angel Gómez-Sámano³, Daniel Cuevas-Ramos³, Diana Marcela Padilla-Ortíz⁴ and Javier Merayo-Chalico¹, ¹Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, ²Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, ³Endocrinology and Metabolism, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, ⁴Universidad de la Sabana, Bogotá, Colombia
Background/Purpose: Whereas SLE is uncommon in men, the disease is usually more severe and requires more aggressive immunosuppression in male patients. There are multiple studies…
Abstract Number: 720 • 2018 ACR/ARHP Annual Meeting
Interkeukin-6 Level in Cerebrospinal Fluid As a Biomarker for Systemic Lupus Erythematosus Patients with Longitudinally Extensive Transverse Myelitis like Neuromyelitis Optica Spectrum Disease
Yasuhiro Hasegawa¹, Yoshiyuki Arinuma¹, Kazuma Ino¹, Takumi Muramatsu¹, Junichi Kondo¹, Yu Matsueda¹, Takayuki Hoshiyama¹, Toshihiro Tono¹, Tatsuhiko Wada¹, Tatsuo Nagai² and Sumiaki Tanaka¹, ¹Department of Rheumatology and Infectious Diseases, Kitasato University School of Medicine, Sagamihara, Japan, ²Kitasato University, Department of Rheumatology and Infectious Diseases, Sagamihara, Japan
Background/Purpose: Demyelinating syndrome in NPSLE includes the wide range of lesions similar to multiple sclerosis (MS). Recently, the diagnostic criteria for neuromyelitis optica spectrum disease…
Abstract Number: 721 • 2018 ACR/ARHP Annual Meeting
The Burden of Renal Arteriosclerosis in Lupus Nephritis: A Cohort Study Examining Prevalence and Predictors of Renal Arteriosclerosis
Shivani Garg¹, Sarah Panzer², Mike Semanik³ and Christie M. Bartels⁴, ¹Rheumatology/ Medicine, University of Wisconsin - Madison, Fitchburg, WI, ²Nephrology/ Medicine, University of Wisconsin, Madison, WI, ³Nephrology/ Pediatrics, University of Wisconsin, Madison, WI, ⁴Rheumatology/Medicine, University of Wisconsin - Madison, Madison, WI
Background/Purpose: Cardiovascular disease (CVD) is significantly accelerated in young systemic lupus erythematous (SLE) patients including those with lupus nephritis (LN). Despite literature suggesting that renal…
Abstract Number: 722 • 2018 ACR/ARHP Annual Meeting
Increased Blood Pressure Visit-to-Visit Variability in Patients with Systemic Lupus Erythematosus: Association with Inflammation, Comorbidities and Increased Mortality
Tyler Reese¹, Alyson Dickson¹, Jacquelyn E. Neal², Jocelyn S. Gandelman³, Omair A. Khan², April Barnado⁴, William Dupont², C. Michael Stein¹ and Cecilia P. Chung¹, ¹Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, ²Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, ³Vanderbilt University School of Medicine, Nashville, TN, ⁴Division of Rheumatology and Immunology, Vanderbilt University Medical Center, Nashville, TN
Background/Purpose: Patients with systemic lupus erythematosus (SLE) have increased mortality compared to the general population. As outcomes related to disease control have improved, this mortality…
Abstract Number: 723 • 2018 ACR/ARHP Annual Meeting
Patient-Reported Cognitive Screen Does Not Identify Cognitive Sub-Domains: Exploration of the Subscale Structure of the Perceived Deficits Questionnaire in a Systemic Lupus Erythematosus Cohort
Lisa Engel¹, Jiandong Su¹, Emily Nalder², Yael Goverover³, Monique Gignac⁴, Carmela Tartaglia⁵, Nicole Anderson¹ and Zahi Touma¹, ¹University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ²Department of Occupational Science and Occupational Therapy, University of Toronto, Toronto, ON, Canada, ³Department of Occupational Therapy, New York University, New York, NY, ⁴Instititue for Work and Health, Toronto, ON, Canada, ⁵University of Toronto, Krembil Neurosciences Centre, Toronto, ON, Canada
Background/Purpose: Identifying patients with Systemic Lupus Erythematosus related cognitive impairment (SLE-CI) is critical as SLE-CI can negatively affect employment, quality of life, and disease self-management.…
Abstract Number: 724 • 2018 ACR/ARHP Annual Meeting
Are Traditional Biomarkers of Lupus Associated with Renal Pathology in Lupus Nephritis?
Kelly Liang¹, Kimberly P. Liang², Yaming Li³, Alex Hurd³, Douglas Landsittel⁴ and Sheldon Bastacky⁵, ¹Medicine, Renal-Electrolyte Division, University of Pittsburgh, Pittsburgh, PA, ²Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ³Biostatistics, University of Pittsburgh, Pittsburgh, PA, ⁴Biomedical Informatics, University of Pittsburgh, Pittsburgh, PA, ⁵Pathology, University of Pittsburgh, Pittsburgh, PA
Background/Purpose: Traditional biomarkers for systemic lupus erythematosus (SLE) and lupus nephritis (LN) include serum creatinine (Cr), complement levels (C3/C4), double-stranded DNA antibody (dsDNA), erythrocyte sedimentation…
Abstract Number: 725 • 2018 ACR/ARHP Annual Meeting
Preliminary Population-Based Incidence and Prevalence Estimates of Primary Discoid Lupus and Cutaneous Lupus Erythematosus from the Manhattan Lupus Surveillance Program
Peter M. Izmirly¹, Jill P. Buyon², H. Michael Belmont³, Sara Sahl⁴, Isabella Wan⁵, Jane E. Salmon⁶, Anca Askanase⁷, Joan Bathon⁸, Laura Geraldino-Pardilla⁷, Yousaf Ali⁹, Ellen M. Ginzler¹⁰, Chaim Putterman¹¹, Caroline Gordon¹², Charles G. Helmick¹³ and Hilary Parton¹⁴, ¹NYU Langone Health, New York, NY, ²Medicine, New York University School of Medicine, New York, NY, ³Medicine, NYU Langone Health, New York, NY, ⁴Pediatrics, Harbor-University of California at Los Angeles Medical Center, Torrance, CA, ⁵Medicine/Rheumatology, New York University School of Medicine, New York, NY, ⁶Medicine/Rheumatology, Hospital for Special Surgery, New York, NY, ⁷Rheumatology, Columbia University, College of Physicians & Surgeons, New York, NY, ⁸Division of Rheumatology, Columbia University, College of Physicians & Surgeons, New York, NY, ⁹Rheumatology, Mount Sinai Medical Center, New York, NY, ¹⁰Rheumatology, SUNY Downstate Medical Center, Brooklyn, NY, ¹¹Rheumatology, Albert Einstein College of Medicine, Bronx, NY, ¹²Rheumatology Research Group, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, United Kingdom, ¹³Arthritis Program, Centers for Disease Control and Prevention, Atlanta, GA, ¹⁴Bureau of Epidemiology Services, New York City Department of Health and Mental Hygiene, Long Island City, NY
Background/Purpose: The extant epidemiologic data of primary discoid lupus erythematosus (DLE) and primary cutaneous lupus erythematosus (CLE) remains limited with few published estimates for the…
Abstract Number: 726 • 2018 ACR/ARHP Annual Meeting
Anti-Retinoblastoma Protein Antibody Is Protective Against Lupus Nephritis
Jessica Li¹, Andreas Goules², Daniel Goldman¹, Antony Rosen³, Livia Casciola-Rosen⁴ and Michelle Petri¹, ¹Medicine (Rheumatology), Johns Hopkins University School of Medicine, Baltimore, MD, ²Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ³Division of Rheumatology, The Johns Hopkins University School of Medicine, Baltimore, MD, ⁴Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD
Background/Purpose: Retinoblastoma protein (RB) regulates nucleosome/chromatin structures and is linked to tumor suppression. It regulates the cell cycle by repression of E2F transcription factor and…
Abstract Number: 727 • 2018 ACR/ARHP Annual Meeting
Increased Risk of Coronary Artery Disease Among Patients with Class III Lupus Nephritis: A Retrospective Study of Patients at the University of North Carolina at Chapel Hill
Enid Y Sun¹, Carolina Alvarez² and Saira Z Sheikh³, ¹Internal Medicine, University of North Carolina, Chapel Hill, NC, ²Thurston Arthritis Research Center, Department of Medicine, University of North Carolina, Chapel Hill, NC, ³University of North Carolina at Chapel Hill, Chapel Hill, NC
Background/Purpose: Patients with systemic lupus erythematosus (SLE) are at an increased risk for developing coronary artery disease (CAD) compared to their cohorts without lupus. There…
Abstract Number: 728 • 2018 ACR/ARHP Annual Meeting
A Higher Activity Index at Initial Renal Biopsy Is Associated with Rapid Progression to Renal Failure in Patients with Refractory Lupus Nephritis
Shuwei Wang¹, Stacy Tanner², Teja Kapoor³, Thania Perez⁴, Vivette D D'Agati⁵, Anca Askanase⁴, Robert Winchester³ and Laura Geraldino-Pardilla³, ¹Rheumatology, Columbia University, College of Physicians & Surgeons, New York City, NY, ²Division of Rheumatology, Columbia University, College of Physicians & Surgeons, Winnipeg, DC, Canada, ³Rheumatology, Columbia University, College of Physicians & Surgeons, New York, NY, ⁴Columbia University, College of Physicians & Surgeons, New York, NY, ⁵Pathology & Cell Biology, Columbia University, College of Physicians & Surgeons, New York City, NY
Background/Purpose: Lupus nephritis (LN) is a major cause of morbidity and mortality affecting ~50% of systemic lupus erythematosus (SLE) patients. Up to 30% of patients…
Abstract Number: 729 • 2018 ACR/ARHP Annual Meeting
Atherosclerotic Vascular Events in SLE – an Evolving Story
Murray Urowitz¹, Jiandong Su¹ and Dafna D Gladman^1,2, ¹University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ²Krembil Research Institute, Toronto Western Hospital, Toronto, ON, Canada
Background/Purpose: Atherosclerotic vascular events (AVEs) are a major cause of mortality and morbidity in systemic lupus erythematosus (SLE) with a prevalence of 8-12%. We aimed…

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